Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01467:Tmem270'

88134

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tmem270

Ensembl Gene

ENSMUSG00000040576

Gene Name

transmembrane protein 270

Synonyms

Wbscr28, 1700111I05Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.056) question?

Stock #

IGL01467

Quality Score

Status

Chromosome

Chromosomal Location

134930447-134935587 bp(-) (GRCm39)

Type of Mutation

intron

DNA Base Change (assembly)

G to T at 134930815 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000144496 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000047305] [ENSMUST00000201316]

AlphaFold

Q6UJB9

Predicted Effect

unknown
Transcript: ENSMUST00000047305
AA Change: N177K

SMART Domains

Protein: ENSMUSP00000045190
Gene: ENSMUSG00000040576
AA Change: N177K

Domain	Start	End	E-Value	Type
Pfam:WBS28	1	181	3.8e-76	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000201316

SMART Domains

Protein: ENSMUSP00000144496
Gene: ENSMUSG00000040576

Domain	Start	End	E-Value	Type
Pfam:WBS28	1	264	1.8e-123	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 35 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam1a	A	G	5: 121,657,791 (GRCm39)	C501R	probably damaging	Het
Atxn1	C	T	13: 45,720,669 (GRCm39)	V409I	probably damaging	Het
Cdkn2aip	T	C	8: 48,164,247 (GRCm39)	R489G	probably damaging	Het
Cgn	A	G	3: 94,686,898 (GRCm39)	S135P	probably damaging	Het
Cpne3	C	A	4: 19,553,737 (GRCm39)	C98F	probably benign	Het
Cyp2c23	T	C	19: 44,003,512 (GRCm39)	N221S	possibly damaging	Het
Dnah8	A	G	17: 30,998,890 (GRCm39)	N3525S	probably damaging	Het
Efr3b	T	C	12: 4,019,597 (GRCm39)	E560G	probably damaging	Het
Eif2b5	C	A	16: 20,327,714 (GRCm39)	C154*	probably null	Het
Eps8l2	A	G	7: 140,941,514 (GRCm39)	E595G	probably damaging	Het
Gm9839	A	T	1: 32,559,032 (GRCm39)	I350N	probably damaging	Het
Hdlbp	A	T	1: 93,345,420 (GRCm39)		probably benign	Het
Il18rap	A	T	1: 40,587,799 (GRCm39)	I466F	probably damaging	Het
Itpr1	T	A	6: 108,465,457 (GRCm39)	I2123N	probably damaging	Het
Jakmip2	A	G	18: 43,715,352 (GRCm39)	I58T	probably benign	Het
Kdm2a	A	G	19: 4,374,435 (GRCm39)	S899P	probably damaging	Het
Mmp15	T	A	8: 96,092,959 (GRCm39)	F113I	probably benign	Het
Neb	T	C	2: 52,049,499 (GRCm39)	H6448R	possibly damaging	Het
Or1j12	C	T	2: 36,342,656 (GRCm39)	R20*	probably null	Het
Or2m13	T	C	16: 19,226,539 (GRCm39)	T77A	probably benign	Het
Pdgfc	A	G	3: 81,116,398 (GRCm39)	T251A	probably damaging	Het
Pdgfra	T	C	5: 75,346,292 (GRCm39)		probably null	Het
Pdpk1	A	G	17: 24,307,144 (GRCm39)	S269P	probably damaging	Het
Pip4k2c	A	T	10: 127,035,498 (GRCm39)	F347L	probably benign	Het
Platr26	T	C	2: 71,553,656 (GRCm39)		noncoding transcript	Het
Pnisr	C	T	4: 21,874,650 (GRCm39)		probably benign	Het
Psma5-ps	A	G	10: 85,149,986 (GRCm39)		noncoding transcript	Het
Rab3gap1	T	A	1: 127,858,121 (GRCm39)		probably null	Het
Scn10a	C	T	9: 119,487,478 (GRCm39)	V619I	probably benign	Het
Slc38a11	T	A	2: 65,147,200 (GRCm39)	T426S	probably benign	Het
Son	T	C	16: 91,454,165 (GRCm39)	S971P	possibly damaging	Het
Stk33	T	A	7: 108,928,796 (GRCm39)	I239L	probably damaging	Het
Tiparp	G	T	3: 65,460,030 (GRCm39)	G442*	probably null	Het
Vmn2r4	A	T	3: 64,313,816 (GRCm39)	N388K	probably damaging	Het
Zfp750	A	T	11: 121,403,767 (GRCm39)	C369*	probably null	Het

Other mutations in Tmem270

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01402:Tmem270	APN	5	134,930,763 (GRCm39)	splice site	probably benign
R0126:Tmem270	UTSW	5	134,931,642 (GRCm39)	missense	probably benign	0.27
R2225:Tmem270	UTSW	5	134,935,492 (GRCm39)	missense	probably damaging	0.99
R4603:Tmem270	UTSW	5	134,930,482 (GRCm39)	nonsense	probably null
R5523:Tmem270	UTSW	5	134,931,636 (GRCm39)	missense	probably benign	0.16
R5859:Tmem270	UTSW	5	134,931,738 (GRCm39)	missense	probably benign	0.03
R7226:Tmem270	UTSW	5	134,930,538 (GRCm39)	missense	probably benign	0.43
R7883:Tmem270	UTSW	5	134,931,681 (GRCm39)	missense	possibly damaging	0.92
R8379:Tmem270	UTSW	5	134,930,557 (GRCm39)	missense	probably benign	0.00
R8719:Tmem270	UTSW	5	134,930,650 (GRCm39)	missense	probably damaging	1.00
R9253:Tmem270	UTSW	5	134,930,644 (GRCm39)	missense	probably damaging	0.98
Z1088:Tmem270	UTSW	5	134,935,510 (GRCm39)	missense	probably damaging	0.99
Z1177:Tmem270	UTSW	5	134,931,857 (GRCm39)	missense	probably damaging	0.99

Posted On

2013-11-18