Incidental Mutation 'IGL01468:Or7a36'
ID 88167
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or7a36
Ensembl Gene ENSMUSG00000046493
Gene Name olfactory receptor family 7 subfamily A member 36
Synonyms GA_x6K02T2QGN0-2828447-2827518, MOR139-1, Olfr1352
Accession Numbers
Essential gene? Probably non essential (E-score: 0.072) question?
Stock # IGL01468
Quality Score
Status
Chromosome 10
Chromosomal Location 78816884-78820555 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 78819696 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Leucine at position 24 (Q24L)
Ref Sequence ENSEMBL: ENSMUSP00000054355 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000058991] [ENSMUST00000203973]
AlphaFold Q8VGX5
Predicted Effect probably damaging
Transcript: ENSMUST00000058991
AA Change: Q24L

PolyPhen 2 Score 0.961 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000054355
Gene: ENSMUSG00000046493
AA Change: Q24L

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 4.7e-52 PFAM
Pfam:7TM_GPCR_Srsx 35 305 9.1e-6 PFAM
Pfam:7tm_1 41 290 4.7e-28 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000203973
SMART Domains Protein: ENSMUSP00000144895
Gene: ENSMUSG00000046493

DomainStartEndE-ValueType
Pfam:7tm_4 1 122 6.1e-25 PFAM
Pfam:7TM_GPCR_Srx 1 123 7.5e-5 PFAM
Pfam:7TM_GPCR_Srsx 2 123 4.5e-8 PFAM
Pfam:7tm_1 8 123 2.1e-23 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000219714
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca7 G A 10: 79,839,711 (GRCm39) V781I probably benign Het
Aldh5a1 G T 13: 25,095,536 (GRCm39) probably benign Het
Arhgap12 T C 18: 6,057,576 (GRCm39) T435A probably benign Het
Atrnl1 G A 19: 57,688,144 (GRCm39) V870I probably benign Het
Cerkl A T 2: 79,173,559 (GRCm39) probably null Het
Cntnap2 T A 6: 47,248,305 (GRCm39) L13* probably null Het
Cr2 G A 1: 194,850,843 (GRCm39) P208S probably damaging Het
Dapk1 A G 13: 60,908,612 (GRCm39) D1075G probably benign Het
Dhx57 T A 17: 80,563,039 (GRCm39) K863* probably null Het
Dnaaf5 C A 5: 139,137,235 (GRCm39) probably null Het
Fbxw7 T A 3: 84,879,806 (GRCm39) I336K probably benign Het
Ftcd A G 10: 76,420,421 (GRCm39) D385G probably benign Het
Gm10153 T C 7: 141,743,778 (GRCm39) S117G unknown Het
Gzmb T C 14: 56,497,772 (GRCm39) Y156C probably benign Het
Herc3 T A 6: 58,831,880 (GRCm39) D83E probably benign Het
Kif2b A G 11: 91,467,191 (GRCm39) V364A probably damaging Het
Mknk2 A G 10: 80,503,498 (GRCm39) probably benign Het
Pgm1 A T 4: 99,819,367 (GRCm39) N197I possibly damaging Het
Prss39 C T 1: 34,538,481 (GRCm39) probably benign Het
Shroom3 T C 5: 93,088,201 (GRCm39) V236A probably damaging Het
Slc17a8 C T 10: 89,427,883 (GRCm39) probably null Het
Slc24a3 A G 2: 145,455,500 (GRCm39) Y463C probably benign Het
Slc4a7 A G 14: 14,737,480 (GRCm38) E149G probably damaging Het
Synj1 G A 16: 90,807,060 (GRCm39) probably benign Het
Tas2r138 T A 6: 40,589,410 (GRCm39) M279L probably benign Het
Terb1 A G 8: 105,208,799 (GRCm39) probably benign Het
Tiparp G T 3: 65,460,030 (GRCm39) G442* probably null Het
Trmt5 C T 12: 73,327,878 (GRCm39) V442I probably benign Het
Tsc2 T C 17: 24,840,071 (GRCm39) I383V possibly damaging Het
Uchl4 A G 9: 64,142,998 (GRCm39) T160A possibly damaging Het
Vmn2r3 A T 3: 64,182,382 (GRCm39) M439K possibly damaging Het
Vmn2r4 A T 3: 64,313,816 (GRCm39) N388K probably damaging Het
Vmn2r52 A T 7: 9,892,868 (GRCm39) L757Q probably damaging Het
Zfp518a T C 19: 40,904,475 (GRCm39) V1468A probably benign Het
Zxdc A T 6: 90,350,761 (GRCm39) E404V probably damaging Het
Other mutations in Or7a36
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01865:Or7a36 APN 10 78,820,512 (GRCm39) missense possibly damaging 0.94
R0196:Or7a36 UTSW 10 78,820,023 (GRCm39) missense possibly damaging 0.89
R0362:Or7a36 UTSW 10 78,820,220 (GRCm39) missense probably benign 0.00
R1574:Or7a36 UTSW 10 78,819,820 (GRCm39) missense probably damaging 1.00
R1574:Or7a36 UTSW 10 78,819,820 (GRCm39) missense probably damaging 1.00
R2982:Or7a36 UTSW 10 78,820,274 (GRCm39) missense probably damaging 1.00
R4724:Or7a36 UTSW 10 78,820,356 (GRCm39) missense probably damaging 1.00
R5000:Or7a36 UTSW 10 78,820,514 (GRCm39) missense probably benign 0.00
R5085:Or7a36 UTSW 10 78,819,928 (GRCm39) missense probably benign 0.03
R5145:Or7a36 UTSW 10 78,820,143 (GRCm39) missense probably benign 0.35
R5455:Or7a36 UTSW 10 78,820,371 (GRCm39) missense possibly damaging 0.59
R5777:Or7a36 UTSW 10 78,820,512 (GRCm39) missense possibly damaging 0.78
R5822:Or7a36 UTSW 10 78,820,023 (GRCm39) missense possibly damaging 0.89
R6283:Or7a36 UTSW 10 78,820,113 (GRCm39) missense probably benign 0.01
R7242:Or7a36 UTSW 10 78,820,331 (GRCm39) nonsense probably null
R7504:Or7a36 UTSW 10 78,820,494 (GRCm39) missense possibly damaging 0.78
R8198:Or7a36 UTSW 10 78,820,443 (GRCm39) missense probably benign 0.03
R8268:Or7a36 UTSW 10 78,819,831 (GRCm39) missense probably damaging 0.98
R8684:Or7a36 UTSW 10 78,820,212 (GRCm39) missense probably benign 0.06
R8928:Or7a36 UTSW 10 78,820,547 (GRCm39) missense
R9408:Or7a36 UTSW 10 78,820,220 (GRCm39) missense probably benign 0.01
R9626:Or7a36 UTSW 10 78,820,213 (GRCm39) missense probably benign 0.06
Posted On 2013-11-18