Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01472:Or5p4'

88282

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or5p4

Ensembl Gene

ENSMUSG00000054236

Gene Name

olfactory receptor family 5 subfamily P member 4

Synonyms

MOR204-39, MOR204-2, Olfr481, GA_x6K02T2PBJ9-10409785-10410723

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.079) question?

Stock #

IGL01472

Quality Score

Status

Chromosome

Chromosomal Location

107680003-107680941 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 107680411 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 137 (S137P)

Ref Sequence

ENSEMBL: ENSMUSP00000151152 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000067143] [ENSMUST00000213601]

AlphaFold

Q8VGI5

Predicted Effect

probably benign
Transcript: ENSMUST00000067143
AA Change: S137P

PolyPhen 2 Score 0.177 (Sensitivity: 0.92; Specificity: 0.87)

SMART Domains

Protein: ENSMUSP00000063555
Gene: ENSMUSG00000054236
AA Change: S137P

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	308	6.5e-51	PFAM
Pfam:7tm_1	41	290	1.4e-19	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000210338

Predicted Effect

probably benign
Transcript: ENSMUST00000213601
AA Change: S137P

PolyPhen 2 Score 0.177 (Sensitivity: 0.92; Specificity: 0.87)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 59 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acsm2	G	A	7: 119,153,759 (GRCm39)		probably null	Het
Adamts4	T	C	1: 171,080,419 (GRCm39)	F324S	probably damaging	Het
Alg10b	T	A	15: 90,111,900 (GRCm39)	L248Q	possibly damaging	Het
Antxr2	T	A	5: 98,175,358 (GRCm39)	T90S	probably benign	Het
Arhgap21	C	T	2: 20,854,392 (GRCm39)	E1657K	probably damaging	Het
Atp13a5	T	G	16: 29,094,175 (GRCm39)	D803A	probably damaging	Het
Bzw2	T	C	12: 36,159,795 (GRCm39)	D185G	probably damaging	Het
Camta2	A	G	11: 70,574,950 (GRCm39)	S62P	probably damaging	Het
Cep85	T	C	4: 133,861,477 (GRCm39)	Q599R	possibly damaging	Het
Chsy3	G	A	18: 59,309,439 (GRCm39)	V231I	probably damaging	Het
Cnbd2	C	T	2: 156,217,268 (GRCm39)	R457W	probably damaging	Het
Col20a1	A	G	2: 180,649,625 (GRCm39)	T1036A	probably benign	Het
Colgalt2	T	C	1: 152,382,629 (GRCm39)	Y494H	probably damaging	Het
Cox15	G	T	19: 43,732,104 (GRCm39)	Y237*	probably null	Het
Cpne9	C	A	6: 113,269,983 (GRCm39)	S281Y	possibly damaging	Het
D830013O20Rik	G	A	12: 73,411,090 (GRCm39)		noncoding transcript	Het
Dnah5	C	T	15: 28,331,872 (GRCm39)	R2153C	probably damaging	Het
Fam228a	A	G	12: 4,765,610 (GRCm39)	I267T	possibly damaging	Het
Fat4	G	A	3: 38,942,219 (GRCm39)	A371T	probably damaging	Het
Gm1818	T	C	12: 48,603,072 (GRCm39)		noncoding transcript	Het
Gm5592	T	C	7: 40,935,498 (GRCm39)		probably benign	Het
Golga4	C	A	9: 118,361,642 (GRCm39)	L207I	probably damaging	Het
Gtf3c1	A	G	7: 125,250,226 (GRCm39)		probably benign	Het
Hao1	C	T	2: 134,396,150 (GRCm39)	E35K	probably benign	Het
Iqch	T	C	9: 63,455,216 (GRCm39)	I194V	probably benign	Het
Ism1	A	T	2: 139,599,223 (GRCm39)	T392S	probably damaging	Het
Lcmt1	A	G	7: 123,027,376 (GRCm39)	Y313C	probably damaging	Het
Loxl4	A	G	19: 42,585,988 (GRCm39)	C718R	probably damaging	Het
Lyar	T	G	5: 38,382,066 (GRCm39)	I16R	possibly damaging	Het
Map3k20	T	C	2: 72,185,897 (GRCm39)		probably benign	Het
Mtus1	T	C	8: 41,455,449 (GRCm39)	T941A	probably benign	Het
Myh8	A	G	11: 67,179,205 (GRCm39)		probably benign	Het
Myof	T	C	19: 37,911,524 (GRCm39)	D1482G	probably benign	Het
Nr4a3	C	A	4: 48,071,133 (GRCm39)	A534D	probably damaging	Het
Oas1c	A	G	5: 120,940,986 (GRCm39)	V269A	probably damaging	Het
Odf2	T	A	2: 29,783,071 (GRCm39)	S5T	probably damaging	Het
Or5d36	T	A	2: 87,901,322 (GRCm39)	T135S	possibly damaging	Het
Or9s27	T	A	1: 92,516,694 (GRCm39)	M214K	possibly damaging	Het
Pbk	A	G	14: 66,054,159 (GRCm39)	T235A	probably benign	Het
Phrf1	T	C	7: 140,836,403 (GRCm39)		probably benign	Het
Prkci	A	G	3: 31,104,341 (GRCm39)	D568G	probably damaging	Het
Prom2	T	A	2: 127,374,802 (GRCm39)	Y578F	probably benign	Het
Prph	T	C	15: 98,956,474 (GRCm39)		probably benign	Het
Ryr3	A	G	2: 112,502,593 (GRCm39)	V3527A	probably benign	Het
Scn10a	C	T	9: 119,446,829 (GRCm39)	V1400I	probably damaging	Het
Slc10a2	A	G	8: 5,141,652 (GRCm39)	L244P	probably damaging	Het
Tardbp	A	G	4: 148,706,521 (GRCm39)	V96A	probably benign	Het
Tbc1d4	C	A	14: 101,727,300 (GRCm39)	E504*	probably null	Het
Tmed3	T	C	9: 89,584,928 (GRCm39)	E109G	probably benign	Het
Tnc	C	T	4: 63,924,656 (GRCm39)	R1014H	probably benign	Het
Tpcn2	C	T	7: 144,821,115 (GRCm39)	R313Q	probably damaging	Het
Trim45	A	G	3: 100,835,381 (GRCm39)	T455A	probably benign	Het
Txlna	A	G	4: 129,525,908 (GRCm39)	I313T	probably damaging	Het
Vmn1r202	A	T	13: 22,686,159 (GRCm39)	I86K	possibly damaging	Het
Vmn2r14	C	A	5: 109,364,180 (GRCm39)	E579*	probably null	Het
Wrn	T	A	8: 33,819,200 (GRCm39)	I8F	possibly damaging	Het
Zc3h18	A	G	8: 123,143,396 (GRCm39)		probably benign	Het
Zfyve26	A	T	12: 79,323,117 (GRCm39)	H876Q	probably benign	Het
Znrf2	C	T	6: 54,840,957 (GRCm39)	T177I	probably damaging	Het

Other mutations in Or5p4

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01570:Or5p4	APN	7	107,680,480 (GRCm39)	missense	probably benign	0.38
IGL02619:Or5p4	APN	7	107,680,949 (GRCm39)	utr 3 prime	probably benign
IGL03175:Or5p4	APN	7	107,680,925 (GRCm39)	missense	probably benign
R0401:Or5p4	UTSW	7	107,680,079 (GRCm39)	missense	possibly damaging	0.81
R0932:Or5p4	UTSW	7	107,680,727 (GRCm39)	missense	probably damaging	1.00
R1679:Or5p4	UTSW	7	107,680,859 (GRCm39)	missense	probably damaging	1.00
R2189:Or5p4	UTSW	7	107,680,243 (GRCm39)	missense	possibly damaging	0.47
R3804:Or5p4	UTSW	7	107,680,378 (GRCm39)	missense	probably damaging	1.00
R4532:Or5p4	UTSW	7	107,680,756 (GRCm39)	missense	probably benign	0.18
R4932:Or5p4	UTSW	7	107,680,781 (GRCm39)	missense	probably damaging	0.99
R5630:Or5p4	UTSW	7	107,680,323 (GRCm39)	missense	probably benign	0.05
R6155:Or5p4	UTSW	7	107,680,493 (GRCm39)	missense	probably benign	0.00
R6523:Or5p4	UTSW	7	107,680,762 (GRCm39)	missense	probably benign	0.34
R6987:Or5p4	UTSW	7	107,680,338 (GRCm39)	nonsense	probably null
R7378:Or5p4	UTSW	7	107,680,399 (GRCm39)	missense	not run
R7609:Or5p4	UTSW	7	107,680,753 (GRCm39)	missense	probably damaging	0.99
R8293:Or5p4	UTSW	7	107,680,269 (GRCm39)	missense	probably benign	0.00
R9322:Or5p4	UTSW	7	107,680,727 (GRCm39)	missense	probably damaging	1.00
R9449:Or5p4	UTSW	7	107,680,040 (GRCm39)	missense
R9659:Or5p4	UTSW	7	107,680,745 (GRCm39)	missense	probably damaging	1.00
R9788:Or5p4	UTSW	7	107,680,745 (GRCm39)	missense	probably damaging	1.00
V8831:Or5p4	UTSW	7	107,680,742 (GRCm39)	missense	probably benign	0.24
Z1177:Or5p4	UTSW	7	107,680,279 (GRCm39)	missense	probably benign	0.03

Posted On

2013-11-18