Incidental Mutation 'IGL01475:Pate2'
ID 88414
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Pate2
Ensembl Gene ENSMUSG00000074452
Gene Name prostate and testis expressed 2
Synonyms LOC330921, mANLP1
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01475
Quality Score
Status
Chromosome 9
Chromosomal Location 35580935-35584185 bp(+) (GRCm39)
Type of Mutation start codon destroyed
DNA Base Change (assembly) T to A at 35580998 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Glutamine at position 1 (L1Q)
Gene Model predicted gene model for transcript(s): [ENSMUST00000098906] [ENSMUST00000118254]
AlphaFold Q3UW31
Predicted Effect probably damaging
Transcript: ENSMUST00000098906
AA Change: L4Q

PolyPhen 2 Score 0.974 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000096505
Gene: ENSMUSG00000074452
AA Change: L4Q

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000118254
AA Change: L4Q

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000113239
Gene: ENSMUSG00000074452
AA Change: L4Q

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000173488
Predicted Effect probably null
Transcript: ENSMUST00000217565
AA Change: L1Q
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700129C05Rik A T 14: 59,380,252 (GRCm39) N15K possibly damaging Het
Adam32 A T 8: 25,362,664 (GRCm39) I587K probably damaging Het
Adamtsl4 T C 3: 95,584,843 (GRCm39) S942G probably benign Het
Adamtsl5 A G 10: 80,180,750 (GRCm39) F104S probably damaging Het
Adgrf5 A G 17: 43,761,245 (GRCm39) D980G probably benign Het
Apba1 A T 19: 23,894,950 (GRCm39) D462V possibly damaging Het
Arhgef11 T C 3: 87,634,433 (GRCm39) probably benign Het
Cd74 T C 18: 60,943,393 (GRCm39) probably benign Het
Cdc16 T C 8: 13,831,542 (GRCm39) S592P probably benign Het
Cenpj A G 14: 56,802,502 (GRCm39) M21T possibly damaging Het
Col28a1 A G 6: 8,103,521 (GRCm39) L425S probably damaging Het
Dbt C T 3: 116,313,908 (GRCm39) T25I possibly damaging Het
Dguok C A 6: 83,467,552 (GRCm39) M98I possibly damaging Het
Dmxl1 T C 18: 50,004,781 (GRCm39) L943P probably damaging Het
Eloa G A 4: 135,738,231 (GRCm39) S243L probably benign Het
Enkur C A 2: 21,201,530 (GRCm39) A52S probably damaging Het
Ezh1 T C 11: 101,083,787 (GRCm39) E744G probably damaging Het
Fbxw11 T C 11: 32,672,101 (GRCm39) S190P possibly damaging Het
Foxb1 G A 9: 69,666,550 (GRCm39) probably benign Het
Gabra5 C T 7: 57,058,432 (GRCm39) G439S probably damaging Het
Gtf2h2 A T 13: 100,617,541 (GRCm39) V207D probably damaging Het
Hoatz A G 9: 51,011,358 (GRCm39) I93T probably benign Het
Krt76 A G 15: 101,796,948 (GRCm39) V317A probably benign Het
Lair1 C A 7: 4,012,683 (GRCm39) probably benign Het
Lrit2 T A 14: 36,791,051 (GRCm39) H243Q probably damaging Het
Mast3 C T 8: 71,232,174 (GRCm39) A1268T probably damaging Het
Matn2 G A 15: 34,316,671 (GRCm39) M4I possibly damaging Het
Mob1b T A 5: 88,897,502 (GRCm39) F137I probably damaging Het
Mreg T C 1: 72,203,325 (GRCm39) probably benign Het
Nom1 T C 5: 29,651,272 (GRCm39) V684A possibly damaging Het
Pla2r1 T C 2: 60,271,425 (GRCm39) probably benign Het
Plxna1 A G 6: 89,331,870 (GRCm39) F447L possibly damaging Het
Pno1 A T 11: 17,160,992 (GRCm39) I114N probably damaging Het
Ppp1r7 T G 1: 93,288,540 (GRCm39) probably benign Het
Pprc1 T A 19: 46,059,968 (GRCm39) Y1503N probably benign Het
Rab30 T C 7: 92,484,930 (GRCm39) V132A probably damaging Het
Slc15a4 T C 5: 127,679,024 (GRCm39) T439A probably benign Het
Slc29a3 A G 10: 60,559,596 (GRCm39) V186A possibly damaging Het
Stxbp5l G A 16: 37,165,454 (GRCm39) T88I possibly damaging Het
Tarbp1 A G 8: 127,160,701 (GRCm39) V1250A probably benign Het
Tcte2 A T 17: 13,937,824 (GRCm39) probably benign Het
Trp53bp1 A T 2: 121,100,800 (GRCm39) probably null Het
Trpc4 A T 3: 54,173,828 (GRCm39) L407F possibly damaging Het
Vmn1r6 T C 6: 56,979,896 (GRCm39) F164S probably damaging Het
Zfp579 C A 7: 4,997,743 (GRCm39) R56L probably benign Het
Other mutations in Pate2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01729:Pate2 APN 9 35,581,888 (GRCm39) missense probably damaging 1.00
IGL03055:Pate2 APN 9 35,523,069 (GRCm39) splice site probably benign
foie_gras UTSW 9 35,581,797 (GRCm39) nonsense probably null
PIT4576001:Pate2 UTSW 9 35,581,889 (GRCm39) missense probably damaging 1.00
R1229:Pate2 UTSW 9 35,580,991 (GRCm39) missense probably damaging 0.98
R1397:Pate2 UTSW 9 35,580,991 (GRCm39) missense probably damaging 0.98
R2393:Pate2 UTSW 9 35,581,036 (GRCm39) splice site probably benign
R2426:Pate2 UTSW 9 35,581,776 (GRCm39) critical splice acceptor site probably null
R3407:Pate2 UTSW 9 35,582,262 (GRCm39) missense probably damaging 0.99
R4323:Pate2 UTSW 9 35,581,767 (GRCm39) splice site probably benign
R4574:Pate2 UTSW 9 35,596,969 (GRCm39) intron probably benign
R4716:Pate2 UTSW 9 35,596,978 (GRCm39) intron probably benign
R5023:Pate2 UTSW 9 35,597,407 (GRCm39) intron probably benign
R5057:Pate2 UTSW 9 35,597,407 (GRCm39) intron probably benign
R5384:Pate2 UTSW 9 35,581,837 (GRCm39) missense probably damaging 0.98
R5574:Pate2 UTSW 9 35,597,411 (GRCm39) intron probably benign
R5593:Pate2 UTSW 9 35,581,778 (GRCm39) missense possibly damaging 0.76
R5851:Pate2 UTSW 9 35,581,797 (GRCm39) nonsense probably null
R6510:Pate2 UTSW 9 35,581,018 (GRCm39) missense probably null 0.99
R6800:Pate2 UTSW 9 35,596,941 (GRCm39) intron probably benign
R6819:Pate2 UTSW 9 35,581,801 (GRCm39) missense probably damaging 1.00
R7531:Pate2 UTSW 9 35,582,008 (GRCm39) splice site probably null
R7765:Pate2 UTSW 9 35,581,197 (GRCm39) missense probably benign 0.15
R7842:Pate2 UTSW 9 35,581,829 (GRCm39) missense probably damaging 1.00
R8015:Pate2 UTSW 9 35,581,814 (GRCm39) missense probably damaging 0.99
R8957:Pate2 UTSW 9 35,596,911 (GRCm39) missense probably benign 0.03
R9126:Pate2 UTSW 9 35,581,908 (GRCm39) critical splice donor site probably null
Posted On 2013-11-18