Incidental Mutation 'IGL01476:Rnf169'
ID88455
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Rnf169
Ensembl Gene ENSMUSG00000058761
Gene Namering finger protein 169
Synonyms2900057K09Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.150) question?
Stock #IGL01476
Quality Score
Status
Chromosome7
Chromosomal Location99920254-99980448 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to C at 99955484 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Aspartic acid at position 174 (Y174D)
Ref Sequence ENSEMBL: ENSMUSP00000079631 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080817]
Predicted Effect probably damaging
Transcript: ENSMUST00000080817
AA Change: Y174D

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000079631
Gene: ENSMUSG00000058761
AA Change: Y174D

DomainStartEndE-ValueType
low complexity region 2 27 N/A INTRINSIC
low complexity region 32 46 N/A INTRINSIC
RING 61 96 3.16e-1 SMART
Blast:RING 133 176 7e-8 BLAST
low complexity region 302 314 N/A INTRINSIC
low complexity region 649 661 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000174264
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 A G 11: 9,403,834 T3719A probably damaging Het
Abcc10 A G 17: 46,327,937 probably benign Het
Atp13a2 G A 4: 141,000,770 C558Y probably damaging Het
BC017643 T C 11: 121,225,845 Y86C probably damaging Het
Btbd1 G A 7: 81,801,049 R328* probably null Het
Cdk8 A G 5: 146,295,163 probably null Het
Chd8 A T 14: 52,205,490 N534K probably benign Het
Dlgap2 C T 8: 14,778,301 R570* probably null Het
Eri2 A C 7: 119,790,249 F149V probably damaging Het
Esyt1 A G 10: 128,511,494 M1054T probably damaging Het
Gcm2 A G 13: 41,105,741 V84A probably damaging Het
Gm597 A T 1: 28,777,453 H499Q probably benign Het
Got1 A C 19: 43,524,409 V16G probably damaging Het
Itga9 C T 9: 118,607,111 R62C probably damaging Het
Kif21a T C 15: 90,943,864 R1232G possibly damaging Het
Map1a A G 2: 121,305,207 Y1930C probably damaging Het
Olfr344 T A 2: 36,568,742 L48H probably damaging Het
Olfr384 T C 11: 73,603,230 S217P probably damaging Het
Olfr701 G A 7: 106,818,620 C179Y probably damaging Het
Pclo A G 5: 14,521,108 K169R probably damaging Het
Sarm1 T C 11: 78,490,811 E282G probably damaging Het
Sec24a A G 11: 51,708,956 S840P possibly damaging Het
Skor2 A T 18: 76,858,667 Q28L unknown Het
Slc35f2 T C 9: 53,806,706 V168A possibly damaging Het
Slc6a7 A T 18: 61,005,773 L221Q probably damaging Het
Syt4 A T 18: 31,441,643 V307E probably damaging Het
Tasp1 A G 2: 140,008,773 L110S probably benign Het
Thnsl1 T A 2: 21,212,159 D241E probably benign Het
Tiparp G T 3: 65,552,609 G442* probably null Het
Tpbpb A T 13: 60,902,134 D60E probably benign Het
Trip11 T C 12: 101,898,911 I168V probably damaging Het
Vmn2r4 A T 3: 64,406,395 N388K probably damaging Het
Wscd2 A G 5: 113,572,321 D302G probably damaging Het
Other mutations in Rnf169
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02344:Rnf169 APN 7 99926435 missense probably damaging 1.00
IGL03066:Rnf169 APN 7 99925553 missense possibly damaging 0.85
R0201:Rnf169 UTSW 7 99926003 missense possibly damaging 0.85
R1087:Rnf169 UTSW 7 99942997 missense probably benign 0.01
R1289:Rnf169 UTSW 7 99925736 missense probably benign 0.01
R1476:Rnf169 UTSW 7 99925328 missense possibly damaging 0.72
R1912:Rnf169 UTSW 7 99926254 missense probably damaging 1.00
R1964:Rnf169 UTSW 7 99925525 missense probably damaging 1.00
R2057:Rnf169 UTSW 7 99925408 missense probably damaging 1.00
R2342:Rnf169 UTSW 7 99925445 missense possibly damaging 0.87
R4755:Rnf169 UTSW 7 99925723 missense probably benign 0.01
R4801:Rnf169 UTSW 7 99926446 missense probably damaging 1.00
R4802:Rnf169 UTSW 7 99926446 missense probably damaging 1.00
R5391:Rnf169 UTSW 7 99935160 critical splice donor site probably null
R5395:Rnf169 UTSW 7 99935160 critical splice donor site probably null
R5643:Rnf169 UTSW 7 99927131 missense possibly damaging 0.85
R5817:Rnf169 UTSW 7 99925769 missense probably benign 0.02
R5952:Rnf169 UTSW 7 99925633 missense probably damaging 1.00
R6009:Rnf169 UTSW 7 99927123 missense possibly damaging 0.92
R6453:Rnf169 UTSW 7 99935227 missense probably benign 0.01
R7238:Rnf169 UTSW 7 99925747 missense probably benign 0.10
Posted On2013-11-18