Incidental Mutation 'IGL01477:Zfp277'
| ID |
88501 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zfp277
|
| Ensembl Gene |
ENSMUSG00000055917 |
| Gene Name |
zinc finger protein 277 |
| Synonyms |
NIRF4, 2410017E24Rik |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.061)
|
| Stock # |
IGL01477
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
12 |
| Chromosomal Location |
40365045-40495789 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 40370675 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Asparagine
at position 425
(Y425N)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000064226
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000069637]
[ENSMUST00000069692]
|
| AlphaFold |
E9Q6D6 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000069637
AA Change: Y299N
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000068032
Gene: ENSMUSG00000055917
AA Change: Y299N
| Domain | Start | End | E-Value | Type |
|---|
|
ZnF_C2H2
|
59 |
84 |
4.27e1 |
SMART |
|
coiled coil region
|
143 |
171 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
174 |
198 |
3.85e1 |
SMART |
|
ZnF_C2H2
|
225 |
249 |
2.24e-3 |
SMART |
|
low complexity region
|
280 |
292 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
303 |
326 |
1.91e1 |
SMART |
|
ZnF_C2H2
|
356 |
382 |
4.94e0 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000069692
AA Change: Y425N
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| SMART Domains |
Protein: ENSMUSP00000064226
Gene: ENSMUSG00000055917
AA Change: Y425N
| Domain | Start | End | E-Value | Type |
|---|
|
ZnF_C2H2
|
185 |
210 |
4.27e1 |
SMART |
|
coiled coil region
|
269 |
297 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
300 |
324 |
3.85e1 |
SMART |
|
ZnF_C2H2
|
351 |
375 |
2.24e-3 |
SMART |
|
low complexity region
|
406 |
418 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
429 |
452 |
1.91e1 |
SMART |
|
ZnF_C2H2
|
482 |
508 |
4.94e0 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000221604
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000222394
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a knock-out allele exhibit early cellular preplicative senescence in MEFs. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 26 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Armh3 |
A |
G |
19: 45,967,043 (GRCm39) |
F33S |
probably damaging |
Het |
| Aven |
T |
C |
2: 112,460,277 (GRCm39) |
S132P |
probably benign |
Het |
| Cadps2 |
G |
A |
6: 23,263,672 (GRCm39) |
T1233M |
probably damaging |
Het |
| Cdh16 |
T |
C |
8: 105,345,140 (GRCm39) |
E383G |
probably damaging |
Het |
| Cxxc1 |
A |
G |
18: 74,352,985 (GRCm39) |
K432E |
possibly damaging |
Het |
| Elapor2 |
A |
T |
5: 9,487,756 (GRCm39) |
K547N |
probably damaging |
Het |
| Eprs1 |
G |
T |
1: 185,143,572 (GRCm39) |
|
probably benign |
Het |
| Etv4 |
T |
C |
11: 101,667,954 (GRCm39) |
D74G |
possibly damaging |
Het |
| Glb1l |
A |
T |
1: 75,185,350 (GRCm39) |
I120N |
probably damaging |
Het |
| Grpel1 |
G |
A |
5: 36,627,986 (GRCm39) |
R89Q |
probably damaging |
Het |
| Ifi44 |
C |
T |
3: 151,451,635 (GRCm39) |
|
probably benign |
Het |
| Ikzf3 |
T |
C |
11: 98,379,683 (GRCm39) |
H195R |
probably damaging |
Het |
| Mug2 |
A |
G |
6: 122,058,643 (GRCm39) |
|
probably benign |
Het |
| Or1j15 |
T |
A |
2: 36,458,754 (GRCm39) |
L48H |
probably damaging |
Het |
| Or8c17 |
T |
A |
9: 38,180,615 (GRCm39) |
S269T |
possibly damaging |
Het |
| Pcnx1 |
A |
T |
12: 82,020,015 (GRCm39) |
K1346I |
probably damaging |
Het |
| Pcnx2 |
C |
T |
8: 126,512,044 (GRCm39) |
V1421I |
probably damaging |
Het |
| Pnpla8 |
A |
G |
12: 44,330,441 (GRCm39) |
D331G |
probably damaging |
Het |
| Ppp1r3a |
A |
T |
6: 14,718,345 (GRCm39) |
N856K |
probably damaging |
Het |
| Ptk7 |
T |
C |
17: 46,887,806 (GRCm39) |
D542G |
possibly damaging |
Het |
| Slc4a2 |
A |
G |
5: 24,635,154 (GRCm39) |
|
probably benign |
Het |
| Smarce1 |
C |
T |
11: 99,101,013 (GRCm39) |
G373E |
possibly damaging |
Het |
| Speg |
A |
G |
1: 75,368,541 (GRCm39) |
N697S |
probably damaging |
Het |
| Supt5 |
T |
C |
7: 28,016,689 (GRCm39) |
H731R |
possibly damaging |
Het |
| Tmod2 |
T |
C |
9: 75,502,283 (GRCm39) |
H68R |
probably benign |
Het |
| Vmn2r68 |
A |
C |
7: 84,882,691 (GRCm39) |
C354G |
probably damaging |
Het |
|
| Other mutations in Zfp277 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01466:Zfp277
|
APN |
12 |
40,428,825 (GRCm39) |
missense |
probably benign |
0.24 |
|
IGL02081:Zfp277
|
APN |
12 |
40,378,795 (GRCm39) |
nonsense |
probably null |
|
|
IGL02165:Zfp277
|
APN |
12 |
40,365,802 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
IGL02613:Zfp277
|
APN |
12 |
40,379,514 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02688:Zfp277
|
APN |
12 |
40,378,687 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL02825:Zfp277
|
APN |
12 |
40,367,175 (GRCm39) |
missense |
probably benign |
0.06 |
|
R0194:Zfp277
|
UTSW |
12 |
40,428,876 (GRCm39) |
splice site |
probably benign |
|
|
R0226:Zfp277
|
UTSW |
12 |
40,414,161 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R0843:Zfp277
|
UTSW |
12 |
40,370,599 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1263:Zfp277
|
UTSW |
12 |
40,414,164 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1584:Zfp277
|
UTSW |
12 |
40,428,825 (GRCm39) |
missense |
probably benign |
0.12 |
|
R1609:Zfp277
|
UTSW |
12 |
40,378,719 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1644:Zfp277
|
UTSW |
12 |
40,379,609 (GRCm39) |
splice site |
probably null |
|
|
R1789:Zfp277
|
UTSW |
12 |
40,414,084 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1882:Zfp277
|
UTSW |
12 |
40,495,745 (GRCm39) |
missense |
probably benign |
0.03 |
|
R2011:Zfp277
|
UTSW |
12 |
40,367,217 (GRCm39) |
nonsense |
probably null |
|
|
R4884:Zfp277
|
UTSW |
12 |
40,413,152 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4976:Zfp277
|
UTSW |
12 |
40,378,687 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5119:Zfp277
|
UTSW |
12 |
40,378,687 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5532:Zfp277
|
UTSW |
12 |
40,385,308 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6340:Zfp277
|
UTSW |
12 |
40,368,548 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
R7191:Zfp277
|
UTSW |
12 |
40,379,561 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7378:Zfp277
|
UTSW |
12 |
40,365,852 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7446:Zfp277
|
UTSW |
12 |
40,378,729 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7564:Zfp277
|
UTSW |
12 |
40,379,594 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7861:Zfp277
|
UTSW |
12 |
40,365,880 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R8428:Zfp277
|
UTSW |
12 |
40,379,577 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9673:Zfp277
|
UTSW |
12 |
40,370,611 (GRCm39) |
missense |
probably benign |
0.15 |
|
| Posted On |
2013-11-18 |
Incidental Mutation