Incidental Mutation 'IGL01479:Tmem125'
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tmem125
Ensembl Gene ENSMUSG00000050854
Gene Nametransmembrane protein 125
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.094) question?
Stock #IGL01479
Quality Score
Chromosomal Location118540941-118544044 bp(-) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) G to A at 118541623 bp
Amino Acid Change Glutamine to Stop codon at position 204 (Q204*)
Ref Sequence ENSEMBL: ENSMUSP00000063157 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000060214] [ENSMUST00000128098] [ENSMUST00000150044] [ENSMUST00000156191]
Predicted Effect probably null
Transcript: ENSMUST00000060214
AA Change: Q204*
SMART Domains Protein: ENSMUSP00000063157
Gene: ENSMUSG00000050854
AA Change: Q204*

Pfam:TMEM125 15 125 1.7e-55 PFAM
transmembrane domain 143 165 N/A INTRINSIC
low complexity region 191 204 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000128098
SMART Domains Protein: ENSMUSP00000115304
Gene: ENSMUSG00000050854

Pfam:TMEM125 14 125 4.5e-58 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000150044
SMART Domains Protein: ENSMUSP00000117871
Gene: ENSMUSG00000050854

Pfam:TMEM125 14 72 2e-31 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000154025
Predicted Effect probably benign
Transcript: ENSMUST00000156191
SMART Domains Protein: ENSMUSP00000117286
Gene: ENSMUSG00000050854

Pfam:TMEM125 14 55 4.7e-21 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 28 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akr1c12 T C 13: 4,272,935 K225R probably benign Het
Amn C A 12: 111,271,793 A47E probably damaging Het
Arhgef1 T C 7: 24,912,603 I137T probably benign Het
Cep57l1 T C 10: 41,728,639 K165E possibly damaging Het
Chfr A G 5: 110,144,993 probably benign Het
Dnah9 A G 11: 65,955,717 V2923A probably benign Het
Dnaja2 T C 8: 85,553,951 Y35C probably damaging Het
Dnajc2 T C 5: 21,757,893 T481A probably damaging Het
Foxred2 A G 15: 77,952,289 probably null Het
Gin1 C T 1: 97,792,372 T364I possibly damaging Het
Glt8d2 C T 10: 82,660,736 V163I probably damaging Het
Gm10118 T C 10: 63,926,820 probably benign Het
Hps5 C T 7: 46,762,942 probably null Het
Kdm4c A G 4: 74,343,501 K638E probably benign Het
L3mbtl2 A G 15: 81,676,392 T285A probably benign Het
Mab21l1 A G 3: 55,783,832 Y280C probably damaging Het
Mcoln2 T A 3: 146,175,652 probably benign Het
Myo9b G T 8: 71,359,342 R1926L probably damaging Het
Rrp12 A G 19: 41,865,202 V1251A probably benign Het
Rtn4rl1 A G 11: 75,265,342 D200G probably damaging Het
Sbsn G A 7: 30,752,357 A266T possibly damaging Het
Sgca A T 11: 94,963,378 C335* probably null Het
Spag1 T C 15: 36,233,199 probably benign Het
Sult6b1 A T 17: 78,905,576 V82D probably benign Het
Tigit T C 16: 43,659,522 T137A probably benign Het
Tmem59l C T 8: 70,486,098 R111Q probably benign Het
Vmn2r95 G A 17: 18,443,862 G448R probably damaging Het
Zfp64 T C 2: 168,951,679 H49R probably damaging Het
Other mutations in Tmem125
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0026:Tmem125 UTSW 4 118542073 missense possibly damaging 0.85
R1876:Tmem125 UTSW 4 118541904 missense probably damaging 1.00
R5711:Tmem125 UTSW 4 118542019 missense probably damaging 1.00
Posted On2013-11-18