Incidental Mutation 'IGL01480:Olfr406'
ID88578
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr406
Ensembl Gene ENSMUSG00000070375
Gene Nameolfactory receptor 406
SynonymsOlfr406-ps, GA_x6K02T2P1NL-4415162-4416133, MOR133-1
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.055) question?
Stock #IGL01480
Quality Score
Status
Chromosome11
Chromosomal Location74259808-74271625 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 74269601 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Leucine at position 71 (I71L)
Ref Sequence ENSEMBL: ENSMUSP00000148929 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000133561] [ENSMUST00000214303] [ENSMUST00000217016]
Predicted Effect noncoding transcript
Transcript: ENSMUST00000127098
Predicted Effect possibly damaging
Transcript: ENSMUST00000133561
AA Change: I71L

PolyPhen 2 Score 0.637 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000125963
Gene: ENSMUSG00000070375
AA Change: I71L

DomainStartEndE-ValueType
Pfam:7tm_4 31 310 3.5e-56 PFAM
Pfam:7tm_1 41 292 3e-27 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000214303
AA Change: I71L

PolyPhen 2 Score 0.637 (Sensitivity: 0.87; Specificity: 0.91)
Predicted Effect possibly damaging
Transcript: ENSMUST00000217016
AA Change: I71L

PolyPhen 2 Score 0.637 (Sensitivity: 0.87; Specificity: 0.91)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 26 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adck1 T A 12: 88,456,865 C379* probably null Het
Ankrd10 A G 8: 11,635,592 V9A probably benign Het
Ankrd13a A T 5: 114,800,818 probably benign Het
Bbs1 T C 19: 4,894,393 K403E probably damaging Het
Cd200r2 A G 16: 44,909,266 I95V probably null Het
Cyba T C 8: 122,424,945 E171G probably benign Het
Dnah2 T A 11: 69,458,371 M2480L possibly damaging Het
Fxyd7 A T 7: 31,047,374 Y20* probably null Het
Il22ra1 T C 4: 135,744,801 V216A probably benign Het
Mapk10 G A 5: 102,926,152 probably benign Het
Mgat5b C A 11: 116,978,452 T607K probably benign Het
Nov A G 15: 54,752,291 Y284C probably damaging Het
Olfr344 T A 2: 36,568,742 L48H probably damaging Het
Olfr8 T C 10: 78,956,144 probably benign Het
Olfr975 G A 9: 39,949,988 A261V probably benign Het
Optn G A 2: 5,046,018 S184L probably benign Het
Plxna1 A G 6: 89,344,096 L462P possibly damaging Het
Prkca A G 11: 107,986,289 F339L possibly damaging Het
Prkca C T 11: 108,192,201 V73M probably damaging Het
Ptch2 T C 4: 117,114,082 V1062A probably damaging Het
Serpina11 T A 12: 103,982,851 K354* probably null Het
Sf1 T C 19: 6,372,022 probably benign Het
Stam2 A G 2: 52,716,439 S112P probably benign Het
Tlr5 G A 1: 182,973,499 E123K probably benign Het
Tpp1 T C 7: 105,749,053 E301G probably damaging Het
Vmn2r58 T A 7: 41,864,692 I176F probably benign Het
Other mutations in Olfr406
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01370:Olfr406 APN 11 74269499 missense probably benign 0.01
IGL02138:Olfr406 APN 11 74269718 missense probably benign 0.01
IGL02986:Olfr406 APN 11 74270102 missense possibly damaging 0.82
R0018:Olfr406 UTSW 11 74270108 missense probably benign 0.39
R1822:Olfr406 UTSW 11 74270240 missense probably benign 0.11
R1823:Olfr406 UTSW 11 74270217 missense probably damaging 1.00
R1956:Olfr406 UTSW 11 74269844 missense probably damaging 1.00
R2017:Olfr406 UTSW 11 74270333 missense probably benign
R2879:Olfr406 UTSW 11 74270223 missense probably damaging 1.00
R3854:Olfr406 UTSW 11 74270279 nonsense probably null
R4750:Olfr406 UTSW 11 74269420 missense probably benign 0.00
R6076:Olfr406 UTSW 11 74270262 missense probably damaging 1.00
R6257:Olfr406 UTSW 11 74270007 missense probably damaging 1.00
R6431:Olfr406 UTSW 11 74269409 missense possibly damaging 0.95
R7032:Olfr406 UTSW 11 74269602 missense possibly damaging 0.95
R7216:Olfr406 UTSW 11 74269724 missense probably damaging 1.00
R7429:Olfr406 UTSW 11 74269753 missense probably damaging 1.00
Posted On2013-11-18