Incidental Mutation 'IGL01480:Or10d5'
ID 88582
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or10d5
Ensembl Gene ENSMUSG00000043331
Gene Name olfactory receptor family 10 subfamily D member 5
Synonyms MOR224-2, GA_x6K02T2PVTD-33651220-33650288, Olfr975
Accession Numbers
Essential gene? Probably non essential (E-score: 0.062) question?
Stock # IGL01480
Quality Score
Status
Chromosome 9
Chromosomal Location 39861133-39862065 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 39861284 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Valine at position 261 (A261V)
Ref Sequence ENSEMBL: ENSMUSP00000150664 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000054067] [ENSMUST00000169307] [ENSMUST00000213171] [ENSMUST00000213246] [ENSMUST00000216647] [ENSMUST00000217630]
AlphaFold Q8VG91
Predicted Effect probably benign
Transcript: ENSMUST00000054067
AA Change: A261V

PolyPhen 2 Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000059776
Gene: ENSMUSG00000043331
AA Change: A261V

DomainStartEndE-ValueType
Pfam:7tm_4 29 304 1.9e-51 PFAM
Pfam:7TM_GPCR_Srsx 33 249 1.8e-7 PFAM
Pfam:7tm_1 39 286 3.6e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000169307
SMART Domains Protein: ENSMUSP00000133083
Gene: ENSMUSG00000047352

DomainStartEndE-ValueType
Pfam:7tm_4 43 318 1.5e-48 PFAM
Pfam:7TM_GPCR_Srsx 47 271 1.1e-5 PFAM
Pfam:7tm_1 53 300 2.8e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213171
Predicted Effect probably benign
Transcript: ENSMUST00000213246
Predicted Effect probably benign
Transcript: ENSMUST00000216647
AA Change: A261V

PolyPhen 2 Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
Predicted Effect probably benign
Transcript: ENSMUST00000217630
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 26 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adck1 T A 12: 88,423,635 (GRCm39) C379* probably null Het
Ankrd10 A G 8: 11,685,592 (GRCm39) V9A probably benign Het
Ankrd13a A T 5: 114,938,879 (GRCm39) probably benign Het
Bbs1 T C 19: 4,944,421 (GRCm39) K403E probably damaging Het
Ccn3 A G 15: 54,615,687 (GRCm39) Y284C probably damaging Het
Cd200r2 A G 16: 44,729,629 (GRCm39) I95V probably null Het
Cyba T C 8: 123,151,684 (GRCm39) E171G probably benign Het
Dnah2 T A 11: 69,349,197 (GRCm39) M2480L possibly damaging Het
Fxyd7 A T 7: 30,746,799 (GRCm39) Y20* probably null Het
Il22ra1 T C 4: 135,472,112 (GRCm39) V216A probably benign Het
Mapk10 G A 5: 103,074,018 (GRCm39) probably benign Het
Mgat5b C A 11: 116,869,278 (GRCm39) T607K probably benign Het
Optn G A 2: 5,050,829 (GRCm39) S184L probably benign Het
Or1j15 T A 2: 36,458,754 (GRCm39) L48H probably damaging Het
Or1p1c A T 11: 74,160,427 (GRCm39) I71L possibly damaging Het
Or7a42 T C 10: 78,791,978 (GRCm39) probably benign Het
Plxna1 A G 6: 89,321,078 (GRCm39) L462P possibly damaging Het
Prkca C T 11: 108,083,027 (GRCm39) V73M probably damaging Het
Prkca A G 11: 107,877,115 (GRCm39) F339L possibly damaging Het
Ptch2 T C 4: 116,971,279 (GRCm39) V1062A probably damaging Het
Serpina11 T A 12: 103,949,110 (GRCm39) K354* probably null Het
Sf1 T C 19: 6,422,052 (GRCm39) probably benign Het
Stam2 A G 2: 52,606,451 (GRCm39) S112P probably benign Het
Tlr5 G A 1: 182,801,064 (GRCm39) E123K probably benign Het
Tpp1 T C 7: 105,398,260 (GRCm39) E301G probably damaging Het
Vmn2r58 T A 7: 41,514,116 (GRCm39) I176F probably benign Het
Other mutations in Or10d5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01537:Or10d5 APN 9 39,861,921 (GRCm39) missense probably benign 0.00
IGL01963:Or10d5 APN 9 39,861,536 (GRCm39) missense probably damaging 1.00
IGL02400:Or10d5 APN 9 39,861,635 (GRCm39) missense probably benign
IGL03115:Or10d5 APN 9 39,862,040 (GRCm39) missense probably damaging 0.98
IGL03226:Or10d5 APN 9 39,861,719 (GRCm39) splice site probably null
R0088:Or10d5 UTSW 9 39,861,671 (GRCm39) missense probably benign 0.03
R0212:Or10d5 UTSW 9 39,861,236 (GRCm39) missense probably benign 0.44
R1668:Or10d5 UTSW 9 39,861,465 (GRCm39) missense possibly damaging 0.94
R1878:Or10d5 UTSW 9 39,862,053 (GRCm39) missense probably benign 0.35
R2225:Or10d5 UTSW 9 39,861,833 (GRCm39) missense possibly damaging 0.84
R2291:Or10d5 UTSW 9 39,861,630 (GRCm39) missense probably benign 0.19
R2420:Or10d5 UTSW 9 39,861,824 (GRCm39) missense possibly damaging 0.47
R2421:Or10d5 UTSW 9 39,861,824 (GRCm39) missense possibly damaging 0.47
R2422:Or10d5 UTSW 9 39,861,824 (GRCm39) missense possibly damaging 0.47
R2425:Or10d5 UTSW 9 39,861,137 (GRCm39) missense probably null 0.25
R2918:Or10d5 UTSW 9 39,861,660 (GRCm39) missense probably benign
R4536:Or10d5 UTSW 9 39,861,731 (GRCm39) missense probably damaging 1.00
R4709:Or10d5 UTSW 9 39,861,165 (GRCm39) missense probably damaging 0.97
R4831:Or10d5 UTSW 9 39,861,408 (GRCm39) missense probably benign 0.01
R4921:Or10d5 UTSW 9 39,861,521 (GRCm39) missense probably damaging 0.98
R5113:Or10d5 UTSW 9 39,861,221 (GRCm39) missense probably damaging 0.99
R5141:Or10d5 UTSW 9 39,861,170 (GRCm39) missense probably benign 0.07
R5195:Or10d5 UTSW 9 39,861,975 (GRCm39) missense probably benign
R5213:Or10d5 UTSW 9 39,861,389 (GRCm39) missense probably damaging 0.99
R5568:Or10d5 UTSW 9 39,861,983 (GRCm39) missense probably benign 0.05
R6993:Or10d5 UTSW 9 39,861,933 (GRCm39) missense probably benign
R7080:Or10d5 UTSW 9 39,861,444 (GRCm39) missense probably damaging 1.00
R7436:Or10d5 UTSW 9 39,861,349 (GRCm39) nonsense probably null
R8178:Or10d5 UTSW 9 39,861,708 (GRCm39) missense probably benign 0.05
R8179:Or10d5 UTSW 9 39,861,708 (GRCm39) missense probably benign 0.05
R8382:Or10d5 UTSW 9 39,861,455 (GRCm39) missense probably benign 0.21
R8402:Or10d5 UTSW 9 39,861,713 (GRCm39) missense probably benign 0.39
R8511:Or10d5 UTSW 9 39,861,455 (GRCm39) missense probably benign 0.21
R8798:Or10d5 UTSW 9 39,862,013 (GRCm39) missense probably benign 0.40
R9068:Or10d5 UTSW 9 39,862,087 (GRCm39) unclassified probably benign
Posted On 2013-11-18