Incidental Mutation 'IGL01480:Ankrd10'
ID88583
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ankrd10
Ensembl Gene ENSMUSG00000031508
Gene Nameankyrin repeat domain 10
Synonyms4833425P12Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.087) question?
Stock #IGL01480
Quality Score
Status
Chromosome8
Chromosomal Location11611583-11635757 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 11635592 bp
ZygosityHeterozygous
Amino Acid Change Valine to Alanine at position 9 (V9A)
Ref Sequence ENSEMBL: ENSMUSP00000147295 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000033905] [ENSMUST00000169782] [ENSMUST00000209915] [ENSMUST00000210530] [ENSMUST00000210876] [ENSMUST00000211174]
Predicted Effect probably benign
Transcript: ENSMUST00000033905
AA Change: V9A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000033905
Gene: ENSMUSG00000031508
AA Change: V9A

DomainStartEndE-ValueType
Blast:ANK 20 49 2e-10 BLAST
ANK 56 85 2.66e-5 SMART
ANK 90 119 6.46e-4 SMART
ANK 123 152 1.03e-2 SMART
Blast:ANK 156 185 6e-6 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000169782
AA Change: V9A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000131657
Gene: ENSMUSG00000031508
AA Change: V9A

DomainStartEndE-ValueType
Blast:ANK 20 49 1e-10 BLAST
ANK 56 85 2.66e-5 SMART
ANK 90 119 6.46e-4 SMART
ANK 123 152 1.03e-2 SMART
Blast:ANK 156 185 4e-6 BLAST
Predicted Effect noncoding transcript
Transcript: ENSMUST00000198377
Predicted Effect noncoding transcript
Transcript: ENSMUST00000209605
Predicted Effect probably benign
Transcript: ENSMUST00000209915
Predicted Effect probably benign
Transcript: ENSMUST00000210530
AA Change: V9A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect probably benign
Transcript: ENSMUST00000210876
Predicted Effect probably benign
Transcript: ENSMUST00000211174
AA Change: V9A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000211389
Predicted Effect noncoding transcript
Transcript: ENSMUST00000211445
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 26 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adck1 T A 12: 88,456,865 C379* probably null Het
Ankrd13a A T 5: 114,800,818 probably benign Het
Bbs1 T C 19: 4,894,393 K403E probably damaging Het
Cd200r2 A G 16: 44,909,266 I95V probably null Het
Cyba T C 8: 122,424,945 E171G probably benign Het
Dnah2 T A 11: 69,458,371 M2480L possibly damaging Het
Fxyd7 A T 7: 31,047,374 Y20* probably null Het
Il22ra1 T C 4: 135,744,801 V216A probably benign Het
Mapk10 G A 5: 102,926,152 probably benign Het
Mgat5b C A 11: 116,978,452 T607K probably benign Het
Nov A G 15: 54,752,291 Y284C probably damaging Het
Olfr344 T A 2: 36,568,742 L48H probably damaging Het
Olfr406 A T 11: 74,269,601 I71L possibly damaging Het
Olfr8 T C 10: 78,956,144 probably benign Het
Olfr975 G A 9: 39,949,988 A261V probably benign Het
Optn G A 2: 5,046,018 S184L probably benign Het
Plxna1 A G 6: 89,344,096 L462P possibly damaging Het
Prkca A G 11: 107,986,289 F339L possibly damaging Het
Prkca C T 11: 108,192,201 V73M probably damaging Het
Ptch2 T C 4: 117,114,082 V1062A probably damaging Het
Serpina11 T A 12: 103,982,851 K354* probably null Het
Sf1 T C 19: 6,372,022 probably benign Het
Stam2 A G 2: 52,716,439 S112P probably benign Het
Tlr5 G A 1: 182,973,499 E123K probably benign Het
Tpp1 T C 7: 105,749,053 E301G probably damaging Het
Vmn2r58 T A 7: 41,864,692 I176F probably benign Het
Other mutations in Ankrd10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03029:Ankrd10 APN 8 11619304 splice site probably null
R0098:Ankrd10 UTSW 8 11612560 missense probably benign 0.01
R0393:Ankrd10 UTSW 8 11635482 missense possibly damaging 0.58
R2870:Ankrd10 UTSW 8 11615682 missense probably damaging 0.98
R2870:Ankrd10 UTSW 8 11615682 missense probably damaging 0.98
R4176:Ankrd10 UTSW 8 11612644 missense probably benign 0.00
R5985:Ankrd10 UTSW 8 11619077 nonsense probably null
R6999:Ankrd10 UTSW 8 11619106 missense probably damaging 1.00
R7108:Ankrd10 UTSW 8 11612624 missense probably damaging 1.00
R7322:Ankrd10 UTSW 8 11615841 missense probably damaging 0.97
R7522:Ankrd10 UTSW 8 11632910 missense probably damaging 1.00
R7559:Ankrd10 UTSW 8 11612548 missense probably damaging 0.97
Posted On2013-11-18