Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01486:Zfp446'

88761

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp446

Ensembl Gene

ENSMUSG00000033961

Gene Name

zinc finger protein 446

Synonyms

A630035I11Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.081) question?

Stock #

IGL01486

Quality Score

Status

Chromosome

Chromosomal Location

12711726-12718323 bp(+) (GRCm39)

Type of Mutation

critical splice donor site (2 bp from exon)

DNA Base Change (assembly)

T to A at 12713307 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000104177 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000045810] [ENSMUST00000108535] [ENSMUST00000108536] [ENSMUST00000108537]

AlphaFold

Q8C9M8

Predicted Effect

probably null
Transcript: ENSMUST00000045810

SMART Domains

Protein: ENSMUSP00000039073
Gene: ENSMUSG00000033961

Domain	Start	End	E-Value	Type
low complexity region	67	79	N/A	INTRINSIC
SCAN	122	234	1.29e-53	SMART
KRAB	299	360	3.96e-2	SMART
ZnF_C2H2	419	441	2.95e-3	SMART
ZnF_C2H2	468	490	8.47e-4	SMART
ZnF_C2H2	496	518	5.34e-1	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000108535

SMART Domains

Protein: ENSMUSP00000104175
Gene: ENSMUSG00000033961

Domain	Start	End	E-Value	Type
SCAN	22	134	1.29e-53	SMART
KRAB	199	254	1.14e0	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000108536

SMART Domains

Protein: ENSMUSP00000104176
Gene: ENSMUSG00000033961

Domain	Start	End	E-Value	Type
SCAN	22	134	1.29e-53	SMART
KRAB	199	260	3.96e-2	SMART
ZnF_C2H2	319	341	2.95e-3	SMART
ZnF_C2H2	368	390	8.47e-4	SMART
ZnF_C2H2	396	418	5.34e-1	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000108537

SMART Domains

Protein: ENSMUSP00000104177
Gene: ENSMUSG00000033961

Domain	Start	End	E-Value	Type
SCAN	22	128	7.37e-49	SMART
KRAB	124	185	3.96e-2	SMART
ZnF_C2H2	244	266	2.95e-3	SMART
ZnF_C2H2	293	315	8.47e-4	SMART
ZnF_C2H2	321	343	5.34e-1	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000128427

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000147996

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 24 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Alx3	G	T	3: 107,512,139 (GRCm39)	C259F	probably damaging	Het
Ampd3	G	T	7: 110,409,123 (GRCm39)		probably benign	Het
Atm	T	C	9: 53,421,513 (GRCm39)	I733V	probably benign	Het
Chrd	A	G	16: 20,552,890 (GRCm39)		probably null	Het
Ckm	G	A	7: 19,155,156 (GRCm39)	G262S	probably damaging	Het
Fbn1	A	G	2: 125,231,898 (GRCm39)	V412A	probably benign	Het
Fbxw22	G	T	9: 109,207,941 (GRCm39)	S443R	probably damaging	Het
Hdgfl2	G	T	17: 56,405,733 (GRCm39)	A481S	possibly damaging	Het
Hmcn2	G	A	2: 31,226,633 (GRCm39)	V203M	probably damaging	Het
Kdelr3	T	A	15: 79,407,048 (GRCm39)	V43D	probably damaging	Het
Klk1b8	A	G	7: 43,453,113 (GRCm39)	K235E	probably benign	Het
Macir	A	T	1: 97,573,731 (GRCm39)	S111R	probably damaging	Het
Mapk1	A	T	16: 16,836,144 (GRCm39)		probably benign	Het
Nfic	T	C	10: 81,243,478 (GRCm39)		probably null	Het
Pkd1l2	T	C	8: 117,786,331 (GRCm39)	T625A	probably benign	Het
Psd2	A	G	18: 36,113,388 (GRCm39)	S287G	probably benign	Het
Smap2	A	T	4: 120,830,395 (GRCm39)	F247I	probably damaging	Het
Spata4	T	C	8: 55,055,341 (GRCm39)		probably benign	Het
Tff2	T	G	17: 31,361,316 (GRCm39)	E79A	probably benign	Het
Thsd7a	C	T	6: 12,471,079 (GRCm39)	C513Y	probably damaging	Het
Tshz1	A	G	18: 84,031,634 (GRCm39)	S925P	possibly damaging	Het
Xrcc4	C	A	13: 90,210,151 (GRCm39)	E98*	probably null	Het
Ypel3	A	G	7: 126,377,033 (GRCm39)	T38A	probably damaging	Het
Zfhx2	C	T	14: 55,304,547 (GRCm39)	G1146R	probably damaging	Het

Other mutations in Zfp446

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01534:Zfp446	APN	7	12,713,493 (GRCm39)	missense	probably damaging	1.00
IGL02471:Zfp446	APN	7	12,716,181 (GRCm39)	missense	probably benign	0.41
IGL02888:Zfp446	APN	7	12,713,255 (GRCm39)	missense	probably damaging	1.00
IGL03153:Zfp446	APN	7	12,711,834 (GRCm39)	missense	probably benign	0.01
IGL03185:Zfp446	APN	7	12,712,925 (GRCm39)	missense	probably null	0.43
IGL03242:Zfp446	APN	7	12,713,252 (GRCm39)	missense	probably damaging	1.00
R0538:Zfp446	UTSW	7	12,713,516 (GRCm39)	missense	possibly damaging	0.94
R1809:Zfp446	UTSW	7	12,713,048 (GRCm39)	missense	probably damaging	1.00
R3686:Zfp446	UTSW	7	12,716,580 (GRCm39)	missense	probably damaging	0.97
R3701:Zfp446	UTSW	7	12,712,079 (GRCm39)	unclassified	probably benign
R5256:Zfp446	UTSW	7	12,713,231 (GRCm39)	nonsense	probably null
R5363:Zfp446	UTSW	7	12,711,984 (GRCm39)	missense	probably benign	0.20
R5377:Zfp446	UTSW	7	12,716,178 (GRCm39)	missense	possibly damaging	0.88
R6806:Zfp446	UTSW	7	12,713,043 (GRCm39)	missense	probably damaging	1.00
R7167:Zfp446	UTSW	7	12,712,049 (GRCm39)	unclassified	probably benign
R7988:Zfp446	UTSW	7	12,712,970 (GRCm39)	missense	possibly damaging	0.93
R8288:Zfp446	UTSW	7	12,711,885 (GRCm39)	missense	probably benign	0.00
R8487:Zfp446	UTSW	7	12,716,555 (GRCm39)	missense	possibly damaging	0.68
R8943:Zfp446	UTSW	7	12,713,564 (GRCm39)	nonsense	probably null
R9315:Zfp446	UTSW	7	12,713,397 (GRCm39)	missense	probably benign	0.28
Z1177:Zfp446	UTSW	7	12,712,093 (GRCm39)	unclassified	probably benign

Posted On

2013-11-18