Incidental Mutation 'IGL01484:Prl7a2'
| ID |
88864 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Prl7a2
|
| Ensembl Gene |
ENSMUSG00000046899 |
| Gene Name |
prolactin family 7, subfamily a, member 2 |
| Synonyms |
Prlpf, PLP-F |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.050)
|
| Stock # |
IGL01484
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
13 |
| Chromosomal Location |
27842567-27852019 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 27843191 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Valine
at position 204
(D204V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000006660
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000006660]
|
| AlphaFold |
O54831 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000006660
AA Change: D204V
PolyPhen 2
Score 0.980 (Sensitivity: 0.75; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000006660
Gene: ENSMUSG00000046899
AA Change: D204V
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Hormone_1
|
17 |
244 |
6.9e-45 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 34 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Ankrd36 |
A |
G |
11: 5,579,006 (GRCm39) |
H90R |
possibly damaging |
Het |
| Arsj |
A |
G |
3: 126,158,685 (GRCm39) |
D88G |
probably damaging |
Het |
| Clca4b |
C |
T |
3: 144,633,996 (GRCm39) |
V140I |
probably benign |
Het |
| Dagla |
A |
C |
19: 10,225,884 (GRCm39) |
L760R |
possibly damaging |
Het |
| Dnah1 |
T |
C |
14: 31,021,897 (GRCm39) |
E1202G |
probably damaging |
Het |
| Hdac9 |
T |
C |
12: 34,487,164 (GRCm39) |
H100R |
probably damaging |
Het |
| Hhip |
T |
C |
8: 80,723,412 (GRCm39) |
H414R |
probably damaging |
Het |
| Hk2 |
G |
A |
6: 82,713,711 (GRCm39) |
T457M |
probably damaging |
Het |
| Iapp |
A |
G |
6: 142,249,165 (GRCm39) |
T73A |
possibly damaging |
Het |
| Ifit1 |
A |
G |
19: 34,626,243 (GRCm39) |
N460D |
probably damaging |
Het |
| Itpa |
T |
C |
2: 130,514,019 (GRCm39) |
F77L |
probably benign |
Het |
| Knop1 |
T |
C |
7: 118,452,032 (GRCm39) |
D229G |
probably damaging |
Het |
| Lrrc32 |
T |
C |
7: 98,143,442 (GRCm39) |
I5T |
probably damaging |
Het |
| Myo7a |
C |
T |
7: 97,734,629 (GRCm39) |
V622M |
probably damaging |
Het |
| N4bp1 |
T |
C |
8: 87,571,400 (GRCm39) |
E866G |
probably damaging |
Het |
| Or2t48 |
A |
T |
11: 58,420,222 (GRCm39) |
W197R |
probably benign |
Het |
| Palmd |
G |
A |
3: 116,746,794 (GRCm39) |
|
probably benign |
Het |
| Pcbp4 |
A |
G |
9: 106,337,848 (GRCm39) |
|
probably null |
Het |
| Pigf |
T |
C |
17: 87,316,308 (GRCm39) |
I157V |
probably benign |
Het |
| Pot1b |
G |
A |
17: 56,002,160 (GRCm39) |
T138M |
possibly damaging |
Het |
| Rfc3 |
A |
T |
5: 151,566,401 (GRCm39) |
D349E |
probably benign |
Het |
| Sarm1 |
A |
T |
11: 78,381,839 (GRCm39) |
C215S |
probably damaging |
Het |
| Serpine1 |
T |
C |
5: 137,092,326 (GRCm39) |
|
probably benign |
Het |
| Strip1 |
A |
G |
3: 107,520,575 (GRCm39) |
V825A |
probably damaging |
Het |
| Stx12 |
A |
G |
4: 132,611,673 (GRCm39) |
S2P |
probably damaging |
Het |
| Sycp1 |
A |
C |
3: 102,823,183 (GRCm39) |
S311R |
probably benign |
Het |
| Tfpi |
A |
T |
2: 84,275,169 (GRCm39) |
C139* |
probably null |
Het |
| Tmc5 |
T |
A |
7: 118,256,010 (GRCm39) |
I695N |
probably damaging |
Het |
| Tmem169 |
T |
C |
1: 72,340,263 (GRCm39) |
V231A |
probably damaging |
Het |
| Ttbk2 |
T |
G |
2: 120,570,314 (GRCm39) |
S1211R |
possibly damaging |
Het |
| Ubr3 |
C |
T |
2: 69,851,888 (GRCm39) |
R1855* |
probably null |
Het |
| Urb1 |
A |
T |
16: 90,574,448 (GRCm39) |
S878T |
probably benign |
Het |
| Vmn1r174 |
T |
A |
7: 23,453,749 (GRCm39) |
Y138* |
probably null |
Het |
| Zfp282 |
A |
G |
6: 47,867,054 (GRCm39) |
N214D |
possibly damaging |
Het |
|
| Other mutations in Prl7a2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL02424:Prl7a2
|
APN |
13 |
27,851,953 (GRCm39) |
missense |
probably null |
0.08 |
|
IGL02734:Prl7a2
|
APN |
13 |
27,843,190 (GRCm39) |
missense |
probably benign |
0.38 |
|
IGL02823:Prl7a2
|
APN |
13 |
27,846,734 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
PIT4260001:Prl7a2
|
UTSW |
13 |
27,843,259 (GRCm39) |
nonsense |
probably null |
|
|
R0733:Prl7a2
|
UTSW |
13 |
27,846,671 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1371:Prl7a2
|
UTSW |
13 |
27,846,750 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1778:Prl7a2
|
UTSW |
13 |
27,843,254 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1857:Prl7a2
|
UTSW |
13 |
27,843,163 (GRCm39) |
nonsense |
probably null |
|
|
R2063:Prl7a2
|
UTSW |
13 |
27,844,870 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2064:Prl7a2
|
UTSW |
13 |
27,844,870 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2065:Prl7a2
|
UTSW |
13 |
27,844,870 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2067:Prl7a2
|
UTSW |
13 |
27,844,870 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2068:Prl7a2
|
UTSW |
13 |
27,844,870 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2176:Prl7a2
|
UTSW |
13 |
27,843,089 (GRCm39) |
missense |
probably benign |
0.10 |
|
R2213:Prl7a2
|
UTSW |
13 |
27,849,051 (GRCm39) |
missense |
probably benign |
0.06 |
|
R4111:Prl7a2
|
UTSW |
13 |
27,849,050 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R4459:Prl7a2
|
UTSW |
13 |
27,849,979 (GRCm39) |
missense |
probably benign |
0.21 |
|
R4483:Prl7a2
|
UTSW |
13 |
27,844,930 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R4722:Prl7a2
|
UTSW |
13 |
27,844,858 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5360:Prl7a2
|
UTSW |
13 |
27,843,143 (GRCm39) |
missense |
probably benign |
0.22 |
|
R5778:Prl7a2
|
UTSW |
13 |
27,844,983 (GRCm39) |
nonsense |
probably null |
|
|
R6667:Prl7a2
|
UTSW |
13 |
27,845,024 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7107:Prl7a2
|
UTSW |
13 |
27,843,076 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R7600:Prl7a2
|
UTSW |
13 |
27,843,264 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R8298:Prl7a2
|
UTSW |
13 |
27,844,994 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8447:Prl7a2
|
UTSW |
13 |
27,849,941 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R9009:Prl7a2
|
UTSW |
13 |
27,849,994 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9331:Prl7a2
|
UTSW |
13 |
27,849,062 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9624:Prl7a2
|
UTSW |
13 |
27,849,869 (GRCm39) |
nonsense |
probably null |
|
|
| Posted On |
2013-11-18 |
Incidental Mutation