Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01501:Adgre4'

88932

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Adgre4

Ensembl Gene

ENSMUSG00000032915

Gene Name

adhesion G protein-coupled receptor E4

Synonyms

EGF-TM7, Gpr127, FIRE, Emr4, D17Ertd479e

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01501

Quality Score

Status

Chromosome

Chromosomal Location

56056984-56160662 bp(+) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

T to G at 56109002 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000025004 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000025004]

AlphaFold

Q91ZE5

Predicted Effect

probably benign
Transcript: ENSMUST00000025004

SMART Domains

Protein: ENSMUSP00000025004
Gene: ENSMUSG00000032915

Domain	Start	End	E-Value	Type
signal peptide	1	36	N/A	INTRINSIC
Blast:EGF_like	38	76	2e-10	BLAST
Pfam:EGF_CA	77	117	3.6e-9	PFAM
GPS	288	338	4.03e-12	SMART
Pfam:7tm_2	343	588	5.7e-57	PFAM
low complexity region	613	628	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 21 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam32	T	A	8: 25,404,369 (GRCm39)	N212I	probably damaging	Het
Amer3	G	A	1: 34,627,398 (GRCm39)	V546M	probably benign	Het
Arfgef3	A	G	10: 18,476,308 (GRCm39)	S1504P	possibly damaging	Het
D630003M21Rik	G	A	2: 158,042,987 (GRCm39)	A851V	probably benign	Het
Ddhd2	A	T	8: 26,225,857 (GRCm39)	M500K	probably damaging	Het
Fig4	A	G	10: 41,146,370 (GRCm39)	S191P	probably benign	Het
Gabrg3	T	C	7: 56,374,214 (GRCm39)	T451A	probably damaging	Het
Gzme	T	A	14: 56,356,858 (GRCm39)	M35L	probably damaging	Het
Il6st	A	G	13: 112,616,593 (GRCm39)	I47V	probably benign	Het
Klk1b11	A	T	7: 43,649,258 (GRCm39)		probably benign	Het
Lztr1	G	A	16: 17,340,255 (GRCm39)		probably null	Het
Or4f14b	A	G	2: 111,774,863 (GRCm39)	*313Q	probably null	Het
Or5i1	T	A	2: 87,613,480 (GRCm39)	W199R	possibly damaging	Het
Ptprz1	A	T	6: 22,973,081 (GRCm39)	N283I	probably damaging	Het
Slc25a33	T	C	4: 149,840,615 (GRCm39)		probably benign	Het
Snap91	T	C	9: 86,720,178 (GRCm39)	M120V	probably damaging	Het
Tbc1d8	G	A	1: 39,428,416 (GRCm39)	R510C	probably damaging	Het
Thoc1	T	C	18: 9,986,321 (GRCm39)	L351P	possibly damaging	Het
Tmco5b	A	G	2: 113,121,726 (GRCm39)	K180R	probably null	Het
Zfp553	G	T	7: 126,835,387 (GRCm39)	S314I	probably damaging	Het
Zgrf1	G	A	3: 127,396,211 (GRCm39)		probably null	Het

Other mutations in Adgre4

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00089:Adgre4	APN	17	56,098,915 (GRCm39)	splice site	probably benign
IGL00228:Adgre4	APN	17	56,109,135 (GRCm39)	missense	probably damaging	1.00
IGL00572:Adgre4	APN	17	56,127,648 (GRCm39)	missense	probably benign	0.00
IGL01404:Adgre4	APN	17	56,104,639 (GRCm39)	missense	possibly damaging	0.63
IGL01420:Adgre4	APN	17	56,106,785 (GRCm39)	splice site	probably benign
IGL01510:Adgre4	APN	17	56,125,760 (GRCm39)	critical splice donor site	probably null
IGL01554:Adgre4	APN	17	56,124,090 (GRCm39)	missense	probably damaging	1.00
IGL01607:Adgre4	APN	17	56,101,748 (GRCm39)	splice site	probably benign
IGL01767:Adgre4	APN	17	56,104,740 (GRCm39)	missense	probably benign	0.19
IGL02253:Adgre4	APN	17	56,067,573 (GRCm39)	missense	probably benign	0.01
IGL02358:Adgre4	APN	17	56,150,209 (GRCm39)	missense	probably benign	0.15
IGL02466:Adgre4	APN	17	56,121,188 (GRCm39)	missense	probably benign	0.42
IGL03057:Adgre4	APN	17	56,106,602 (GRCm39)	splice site	probably benign
R0070:Adgre4	UTSW	17	56,109,154 (GRCm39)	missense	probably damaging	0.98
R0070:Adgre4	UTSW	17	56,109,154 (GRCm39)	missense	probably damaging	0.98
R0111:Adgre4	UTSW	17	56,124,073 (GRCm39)	missense	possibly damaging	0.92
R0311:Adgre4	UTSW	17	56,109,010 (GRCm39)	missense	probably benign	0.36
R0366:Adgre4	UTSW	17	56,099,001 (GRCm39)	nonsense	probably null
R0415:Adgre4	UTSW	17	56,159,288 (GRCm39)	missense	probably benign	0.03
R0465:Adgre4	UTSW	17	56,092,137 (GRCm39)	splice site	probably benign
R0619:Adgre4	UTSW	17	56,127,679 (GRCm39)	missense	possibly damaging	0.52
R0685:Adgre4	UTSW	17	56,099,035 (GRCm39)	missense	probably benign	0.05
R0724:Adgre4	UTSW	17	56,159,281 (GRCm39)	missense	probably benign	0.00
R0835:Adgre4	UTSW	17	56,106,637 (GRCm39)	missense	probably damaging	1.00
R1330:Adgre4	UTSW	17	56,085,814 (GRCm39)	missense	probably benign	0.36
R1452:Adgre4	UTSW	17	56,091,996 (GRCm39)	missense	probably benign	0.35
R1960:Adgre4	UTSW	17	56,098,497 (GRCm39)	missense	probably benign
R1961:Adgre4	UTSW	17	56,098,497 (GRCm39)	missense	probably benign
R2046:Adgre4	UTSW	17	56,085,847 (GRCm39)	missense	possibly damaging	0.82
R2421:Adgre4	UTSW	17	56,085,872 (GRCm39)	missense	probably benign	0.10
R2570:Adgre4	UTSW	17	56,085,878 (GRCm39)	missense	possibly damaging	0.54
R3162:Adgre4	UTSW	17	56,109,218 (GRCm39)	splice site	probably benign
R4222:Adgre4	UTSW	17	56,092,121 (GRCm39)	missense	probably damaging	1.00
R4526:Adgre4	UTSW	17	56,092,016 (GRCm39)	nonsense	probably null
R4631:Adgre4	UTSW	17	56,121,305 (GRCm39)	missense	probably null	1.00
R4689:Adgre4	UTSW	17	56,109,096 (GRCm39)	missense	probably damaging	1.00
R4701:Adgre4	UTSW	17	56,091,971 (GRCm39)	missense	probably damaging	1.00
R4792:Adgre4	UTSW	17	56,098,491 (GRCm39)	missense	probably benign	0.00
R5205:Adgre4	UTSW	17	56,101,727 (GRCm39)	nonsense	probably null
R5210:Adgre4	UTSW	17	56,092,029 (GRCm39)	missense	probably damaging	0.97
R5358:Adgre4	UTSW	17	56,125,758 (GRCm39)	missense	probably benign	0.00
R5873:Adgre4	UTSW	17	56,159,282 (GRCm39)	missense	probably benign	0.13
R6025:Adgre4	UTSW	17	56,099,013 (GRCm39)	missense	probably benign	0.00
R6257:Adgre4	UTSW	17	56,109,133 (GRCm39)	missense	possibly damaging	0.87
R6426:Adgre4	UTSW	17	56,109,196 (GRCm39)	missense	probably benign	0.18
R6440:Adgre4	UTSW	17	56,101,744 (GRCm39)	critical splice donor site	probably null
R6484:Adgre4	UTSW	17	56,109,036 (GRCm39)	missense	possibly damaging	0.52
R6680:Adgre4	UTSW	17	56,098,959 (GRCm39)	missense	probably benign	0.09
R7086:Adgre4	UTSW	17	56,127,649 (GRCm39)	missense	probably benign	0.00
R7442:Adgre4	UTSW	17	56,159,340 (GRCm39)	missense	probably benign	0.04
R7467:Adgre4	UTSW	17	56,098,952 (GRCm39)	missense	probably benign	0.00
R7875:Adgre4	UTSW	17	56,099,016 (GRCm39)	missense	probably benign	0.00
R8007:Adgre4	UTSW	17	56,121,233 (GRCm39)	missense	probably damaging	0.99
R8096:Adgre4	UTSW	17	56,127,700 (GRCm39)	missense	probably damaging	1.00
R8172:Adgre4	UTSW	17	56,104,769 (GRCm39)	missense	probably benign	0.00
R8512:Adgre4	UTSW	17	56,125,760 (GRCm39)	critical splice donor site	probably null
R8972:Adgre4	UTSW	17	56,109,189 (GRCm39)	missense	probably damaging	1.00
R9018:Adgre4	UTSW	17	56,098,993 (GRCm39)	missense	probably benign	0.00
R9049:Adgre4	UTSW	17	56,092,094 (GRCm39)	missense	probably benign	0.05
S24628:Adgre4	UTSW	17	56,159,288 (GRCm39)	missense	probably benign	0.03
X0010:Adgre4	UTSW	17	56,121,308 (GRCm39)	missense	probably damaging	1.00
Z1177:Adgre4	UTSW	17	56,121,152 (GRCm39)	critical splice acceptor site	probably null

Posted On

2013-12-03