Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01509:Ifi206'

89137

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ifi206

Ensembl Gene

ENSMUSG00000037849

Gene Name

interferon activated gene 206

Synonyms

Pyblhin-C, Gm4955

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.175) question?

Stock #

IGL01509

Quality Score

Status

Chromosome

Chromosomal Location

173296051-173318607 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 173313142 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Leucine at position 109 (M109L)

Ref Sequence

ENSEMBL: ENSMUSP00000134646 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000160565]

AlphaFold

G3UZV2

Predicted Effect

probably benign
Transcript: ENSMUST00000160565
AA Change: M109L

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)

SMART Domains

Protein: ENSMUSP00000134646
Gene: ENSMUSG00000037849
AA Change: M109L

Domain	Start	End	E-Value	Type
PYRIN	6	84	5.7e-21	SMART
low complexity region	97	108	N/A	INTRINSIC
internal_repeat_1	154	349	6.25e-15	PROSPERO
internal_repeat_1	342	575	6.25e-15	PROSPERO

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 22 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A4gnt	T	A	9: 99,495,819 (GRCm39)	I85N	probably benign	Het
Bbof1	T	A	12: 84,457,859 (GRCm39)	N41K	possibly damaging	Het
Cdh10	A	G	15: 18,986,884 (GRCm39)	K372E	possibly damaging	Het
Clmn	T	A	12: 104,747,162 (GRCm39)	Q795L	probably benign	Het
Dnai4	G	A	4: 102,929,884 (GRCm39)	P369L	possibly damaging	Het
Enox1	T	C	14: 77,936,713 (GRCm39)	S583P	probably damaging	Het
Hmcn1	C	T	1: 150,485,382 (GRCm39)	G4407S	probably damaging	Het
Ighmbp2	A	G	19: 3,318,711 (GRCm39)	M455T	possibly damaging	Het
Inpp4b	T	C	8: 82,617,332 (GRCm39)		probably benign	Het
Mctp2	A	G	7: 71,909,017 (GRCm39)	S99P	probably benign	Het
Mrgprb2	G	A	7: 48,202,674 (GRCm39)	T17M	possibly damaging	Het
Ogdhl	T	A	14: 32,059,716 (GRCm39)	M410K	probably damaging	Het
Pard3b	A	T	1: 62,200,407 (GRCm39)	R315S	possibly damaging	Het
Pde3b	A	G	7: 114,117,645 (GRCm39)	Q625R	probably benign	Het
Plxna3	A	G	X: 73,376,039 (GRCm39)	Q355R	probably benign	Het
Ptprm	A	T	17: 67,069,208 (GRCm39)	F907I	possibly damaging	Het
Slc16a4	A	C	3: 107,218,750 (GRCm39)		probably null	Het
Tasor	T	C	14: 27,181,731 (GRCm39)		probably benign	Het
Vmn1r82	A	T	7: 12,039,096 (GRCm39)	H123L	probably damaging	Het
Vmn2r1	T	C	3: 64,010,466 (GRCm39)	I568T	probably benign	Het
Zfp7	G	A	15: 76,765,333 (GRCm39)	V9M	probably damaging	Het
Zfp759	A	G	13: 67,287,658 (GRCm39)	N403S	probably benign	Het

Other mutations in Ifi206

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02044:Ifi206	APN	1	173,308,557 (GRCm39)	missense	probably benign	0.41
IGL02118:Ifi206	APN	1	173,309,334 (GRCm39)	missense	probably benign	0.05
IGL02476:Ifi206	APN	1	173,309,132 (GRCm39)	missense	probably benign	0.02
IGL02824:Ifi206	APN	1	173,309,438 (GRCm39)	missense	possibly damaging	0.95
IGL03375:Ifi206	APN	1	173,308,344 (GRCm39)	missense	probably benign	0.06
PIT4142001:Ifi206	UTSW	1	173,308,730 (GRCm39)	missense	probably benign	0.02
R0069:Ifi206	UTSW	1	173,314,413 (GRCm39)	missense	probably damaging	1.00
R0741:Ifi206	UTSW	1	173,301,315 (GRCm39)	missense	probably benign	0.41
R1572:Ifi206	UTSW	1	173,314,419 (GRCm39)	missense	probably benign	0.10
R1742:Ifi206	UTSW	1	173,309,537 (GRCm39)	missense	probably benign	0.06
R4109:Ifi206	UTSW	1	173,308,554 (GRCm39)	missense	probably benign	0.00
R4707:Ifi206	UTSW	1	173,308,432 (GRCm39)	missense	probably benign	0.00
R4783:Ifi206	UTSW	1	173,308,432 (GRCm39)	missense	probably benign	0.00
R4785:Ifi206	UTSW	1	173,308,432 (GRCm39)	missense	probably benign	0.00
R4805:Ifi206	UTSW	1	173,308,952 (GRCm39)	missense	possibly damaging	0.55
R4918:Ifi206	UTSW	1	173,309,610 (GRCm39)	missense	possibly damaging	0.73
R5043:Ifi206	UTSW	1	173,314,284 (GRCm39)	missense	probably damaging	1.00
R5080:Ifi206	UTSW	1	173,301,414 (GRCm39)	missense	possibly damaging	0.61
R5419:Ifi206	UTSW	1	173,308,797 (GRCm39)	missense	probably benign	0.05
R5420:Ifi206	UTSW	1	173,308,599 (GRCm39)	missense	possibly damaging	0.84
R5777:Ifi206	UTSW	1	173,308,928 (GRCm39)	missense	possibly damaging	0.55
R5988:Ifi206	UTSW	1	173,308,906 (GRCm39)	missense	possibly damaging	0.90
R6772:Ifi206	UTSW	1	173,308,773 (GRCm39)	missense	unknown
R6782:Ifi206	UTSW	1	173,308,923 (GRCm39)	missense	unknown
R6806:Ifi206	UTSW	1	173,309,137 (GRCm39)	missense	probably benign	0.06
R7042:Ifi206	UTSW	1	173,308,808 (GRCm39)	missense
R7091:Ifi206	UTSW	1	173,301,441 (GRCm39)	missense	unknown
R7292:Ifi206	UTSW	1	173,301,428 (GRCm39)	missense	unknown
R7429:Ifi206	UTSW	1	173,308,157 (GRCm39)	missense
R7499:Ifi206	UTSW	1	173,309,607 (GRCm39)	missense
R7772:Ifi206	UTSW	1	173,308,640 (GRCm39)	missense
R7853:Ifi206	UTSW	1	173,299,100 (GRCm39)	nonsense	probably null
R7971:Ifi206	UTSW	1	173,298,976 (GRCm39)	missense	unknown
R8079:Ifi206	UTSW	1	173,308,724 (GRCm39)	missense
R8205:Ifi206	UTSW	1	173,309,450 (GRCm39)	missense
R8289:Ifi206	UTSW	1	173,308,032 (GRCm39)	missense
R8390:Ifi206	UTSW	1	173,308,511 (GRCm39)	missense
R8500:Ifi206	UTSW	1	173,314,311 (GRCm39)	missense
R8712:Ifi206	UTSW	1	173,308,074 (GRCm39)	missense
R8753:Ifi206	UTSW	1	173,301,223 (GRCm39)	missense	unknown
R8875:Ifi206	UTSW	1	173,301,353 (GRCm39)	missense	unknown
R9128:Ifi206	UTSW	1	173,299,022 (GRCm39)	missense	unknown
R9369:Ifi206	UTSW	1	173,301,489 (GRCm39)	missense	unknown
R9569:Ifi206	UTSW	1	173,314,209 (GRCm39)	missense
R9676:Ifi206	UTSW	1	173,308,718 (GRCm39)	missense
R9695:Ifi206	UTSW	1	173,301,249 (GRCm39)	missense	unknown
R9776:Ifi206	UTSW	1	173,308,075 (GRCm39)	missense
X0052:Ifi206	UTSW	1	173,309,535 (GRCm39)	missense	possibly damaging	0.89
Z1088:Ifi206	UTSW	1	173,301,577 (GRCm39)	missense	probably damaging	1.00
Z1176:Ifi206	UTSW	1	173,309,614 (GRCm39)	missense

Posted On

2013-12-03