Incidental Mutation 'IGL01510:Or8g51'
ID 89158
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or8g51
Ensembl Gene ENSMUSG00000056961
Gene Name olfactory receptor family 8 subfamily G member 51
Synonyms GA_x6K02T2PVTD-32400678-32399743, Olfr919, MOR171-23
Accession Numbers
Essential gene? Probably non essential (E-score: 0.073) question?
Stock # IGL01510
Quality Score
Status
Chromosome 9
Chromosomal Location 38608725-38609672 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 38609201 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 158 (I158V)
Ref Sequence ENSEMBL: ENSMUSP00000071372 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071425] [ENSMUST00000215612] [ENSMUST00000217508]
AlphaFold Q8VF78
Predicted Effect probably benign
Transcript: ENSMUST00000071425
AA Change: I158V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000071372
Gene: ENSMUSG00000056961
AA Change: I158V

DomainStartEndE-ValueType
Pfam:7tm_4 35 312 9.8e-50 PFAM
Pfam:7tm_1 45 294 9e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215612
AA Change: I154V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect probably benign
Transcript: ENSMUST00000217508
AA Change: I154V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca1 T C 4: 53,143,979 (GRCm39) Q6R probably damaging Het
Adam5 A T 8: 25,294,481 (GRCm39) C373S probably damaging Het
Adgre4 T C 17: 56,125,760 (GRCm39) probably null Het
Akap10 A T 11: 61,768,846 (GRCm39) M614K possibly damaging Het
Amigo2 T C 15: 97,142,962 (GRCm39) T487A probably benign Het
Asap1 T C 15: 64,030,777 (GRCm39) D300G probably damaging Het
Atp4a C A 7: 30,420,216 (GRCm39) L788M probably benign Het
Bcl3 T A 7: 19,543,539 (GRCm39) H309L probably damaging Het
Cblc T C 7: 19,519,200 (GRCm39) N376S probably benign Het
Cd200r2 A T 16: 44,729,674 (GRCm39) I110L probably benign Het
Ceacam3 T C 7: 16,893,767 (GRCm39) M426T probably benign Het
Cep295 G A 9: 15,265,922 (GRCm39) R29* probably null Het
Ces1a G T 8: 93,771,726 (GRCm39) P24T probably damaging Het
Ctps1 G T 4: 120,416,041 (GRCm39) T194K probably damaging Het
Cul3 A G 1: 80,260,396 (GRCm39) S318P probably damaging Het
Fasl A T 1: 161,609,522 (GRCm39) S155T possibly damaging Het
Gldc C T 19: 30,091,121 (GRCm39) probably null Het
Gpr21 T A 2: 37,408,433 (GRCm39) C326* probably null Het
Gtf2a1 A G 12: 91,534,607 (GRCm39) S216P probably benign Het
Hoxb5 A T 11: 96,194,818 (GRCm39) S127C possibly damaging Het
Htt A T 5: 35,064,856 (GRCm39) Q3023L probably damaging Het
Kalrn T A 16: 34,055,700 (GRCm39) H855L possibly damaging Het
Lars1 T C 18: 42,375,174 (GRCm39) I289V probably benign Het
Lrig3 C A 10: 125,844,567 (GRCm39) T677K probably damaging Het
Mapk7 A T 11: 61,381,986 (GRCm39) W309R probably damaging Het
Mmp12 A G 9: 7,358,307 (GRCm39) T468A possibly damaging Het
Muc5b A T 7: 141,412,798 (GRCm39) N1915Y unknown Het
Naprt A G 15: 75,762,837 (GRCm39) probably benign Het
Nfatc1 T C 18: 80,741,403 (GRCm39) Y199C probably damaging Het
Or7e166 A T 9: 19,624,575 (GRCm39) I151F probably benign Het
Phip T A 9: 82,795,924 (GRCm39) I566F probably benign Het
Pnpla3 T A 15: 84,055,273 (GRCm39) probably benign Het
Ptpn13 C T 5: 103,710,166 (GRCm39) T1567I probably damaging Het
Ptpn20 A G 14: 33,360,343 (GRCm39) probably null Het
Ptprq G T 10: 107,547,909 (GRCm39) T163K probably damaging Het
Slc8a1 A G 17: 81,955,794 (GRCm39) C415R probably damaging Het
Slco4c1 A G 1: 96,795,678 (GRCm39) S127P probably damaging Het
Tcerg1l A T 7: 137,996,034 (GRCm39) probably benign Het
Thbd C T 2: 148,248,894 (GRCm39) V325M probably damaging Het
Trim37 G A 11: 87,068,686 (GRCm39) R344H probably damaging Het
Ttn T C 2: 76,703,109 (GRCm39) probably benign Het
Uvrag G A 7: 98,653,796 (GRCm39) Q65* probably null Het
Wrap53 G A 11: 69,453,566 (GRCm39) S342L possibly damaging Het
Zbtb11 T G 16: 55,810,706 (GRCm39) V288G probably damaging Het
Other mutations in Or8g51
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02515:Or8g51 APN 9 38,609,087 (GRCm39) missense probably benign 0.39
IGL02745:Or8g51 APN 9 38,609,494 (GRCm39) missense probably damaging 0.99
H8562:Or8g51 UTSW 9 38,609,206 (GRCm39) missense probably damaging 1.00
R1960:Or8g51 UTSW 9 38,609,500 (GRCm39) missense probably benign 0.28
R1973:Or8g51 UTSW 9 38,609,164 (GRCm39) missense probably damaging 0.96
R3119:Or8g51 UTSW 9 38,608,955 (GRCm39) nonsense probably null
R4543:Or8g51 UTSW 9 38,608,841 (GRCm39) missense possibly damaging 0.93
R4752:Or8g51 UTSW 9 38,609,266 (GRCm39) missense probably damaging 0.99
R5474:Or8g51 UTSW 9 38,609,609 (GRCm39) missense possibly damaging 0.69
R5532:Or8g51 UTSW 9 38,608,943 (GRCm39) missense probably damaging 1.00
R5635:Or8g51 UTSW 9 38,609,455 (GRCm39) missense possibly damaging 0.64
R5940:Or8g51 UTSW 9 38,609,007 (GRCm39) nonsense probably null
R6820:Or8g51 UTSW 9 38,608,771 (GRCm39) missense possibly damaging 0.88
R7164:Or8g51 UTSW 9 38,609,515 (GRCm39) missense possibly damaging 0.95
R7337:Or8g51 UTSW 9 38,609,161 (GRCm39) missense probably benign 0.12
R7806:Or8g51 UTSW 9 38,609,567 (GRCm39) missense probably benign 0.39
R8287:Or8g51 UTSW 9 38,609,633 (GRCm39) missense probably benign 0.06
R9120:Or8g51 UTSW 9 38,608,735 (GRCm39) missense probably benign 0.01
Z1176:Or8g51 UTSW 9 38,609,224 (GRCm39) missense possibly damaging 0.76
Posted On 2013-12-03