Incidental Mutation 'IGL01511:Or2y15'
ID 89206
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or2y15
Ensembl Gene ENSMUSG00000063386
Gene Name olfactory receptor family 2 subfamily Y member 15
Synonyms MOR256-22, GA_x6K02T2QP88-5975166-5974231, Olfr1387
Accession Numbers
Essential gene? Probably non essential (E-score: 0.090) question?
Stock # IGL01511
Quality Score
Status
Chromosome 11
Chromosomal Location 49350508-49351443 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 49351043 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 179 (E179G)
Ref Sequence ENSEMBL: ENSMUSP00000073494 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073824] [ENSMUST00000204518] [ENSMUST00000213674] [ENSMUST00000214541]
AlphaFold Q8VFA9
Predicted Effect probably damaging
Transcript: ENSMUST00000073824
AA Change: E179G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000073494
Gene: ENSMUSG00000063386
AA Change: E179G

DomainStartEndE-ValueType
Pfam:7tm_4 31 306 1e-49 PFAM
Pfam:7tm_1 41 289 5.8e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000204518
SMART Domains Protein: ENSMUSP00000145320
Gene: ENSMUSG00000108167

DomainStartEndE-ValueType
Pfam:7tm_4 31 306 1.2e-49 PFAM
Pfam:7TM_GPCR_Srsx 35 227 1.2e-5 PFAM
Pfam:7tm_1 41 289 7.4e-24 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213674
Predicted Effect probably damaging
Transcript: ENSMUST00000214541
AA Change: E179G

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca6 A T 11: 110,135,136 (GRCm39) D216E probably benign Het
Abcc4 C A 14: 118,836,753 (GRCm39) L669F probably benign Het
Adam29 C T 8: 56,324,456 (GRCm39) G666D probably damaging Het
Adat2 T G 10: 13,435,982 (GRCm39) M109R probably null Het
Atf3 T A 1: 190,903,693 (GRCm39) T178S probably benign Het
Birc6 T A 17: 74,933,998 (GRCm39) Y2522* probably null Het
Ccr8 G A 9: 119,923,691 (GRCm39) G269R probably damaging Het
Ces1a G T 8: 93,771,726 (GRCm39) P24T probably damaging Het
Chrna4 C T 2: 180,670,461 (GRCm39) V432I probably benign Het
Commd8 A G 5: 72,322,722 (GRCm39) V65A probably benign Het
Cyp2j13 A G 4: 95,965,552 (GRCm39) F52L possibly damaging Het
Desi1 T A 15: 81,886,789 (GRCm39) K45* probably null Het
Dmbt1 T A 7: 130,718,457 (GRCm39) M1552K possibly damaging Het
Dna2 G A 10: 62,791,093 (GRCm39) M197I possibly damaging Het
Dnah7a A C 1: 53,458,754 (GRCm39) L3795V probably damaging Het
Dnai4 T C 4: 102,905,558 (GRCm39) D741G possibly damaging Het
Fam221b T C 4: 43,660,135 (GRCm39) probably null Het
Fbxw18 A T 9: 109,517,889 (GRCm39) S366T possibly damaging Het
Fzd8 A G 18: 9,213,293 (GRCm39) Y125C unknown Het
Gcsam T C 16: 45,436,315 (GRCm39) Y11H probably damaging Het
Gucy2f G T X: 140,944,730 (GRCm39) D410E probably damaging Het
Hdac3 C T 18: 38,085,648 (GRCm39) A53T probably benign Het
Lamp2 A G X: 37,520,752 (GRCm39) L244P probably damaging Het
Lrrk1 A T 7: 65,915,198 (GRCm39) F1630Y possibly damaging Het
M1ap C A 6: 83,005,393 (GRCm39) D434E probably benign Het
Mcmbp A G 7: 128,308,888 (GRCm39) Y378H probably damaging Het
Mvb12a T A 8: 71,997,946 (GRCm39) V120E probably damaging Het
Nbeal2 A C 9: 110,458,302 (GRCm39) W2063G probably damaging Het
Neto1 A C 18: 86,414,033 (GRCm39) H9P possibly damaging Het
Nmu C T 5: 76,488,668 (GRCm39) V126M probably damaging Het
Odf2 T C 2: 29,804,321 (GRCm39) probably benign Het
Pdzrn3 T C 6: 101,130,217 (GRCm39) H533R possibly damaging Het
Pikfyve G T 1: 65,298,028 (GRCm39) E1586* probably null Het
Plcb3 C A 19: 6,933,211 (GRCm39) R970L probably damaging Het
Plxna3 A G X: 73,378,914 (GRCm39) E686G probably damaging Het
Polrmt T A 10: 79,575,985 (GRCm39) Y586F probably benign Het
Ppt1 T A 4: 122,748,218 (GRCm39) F225I probably damaging Het
Prcc T G 3: 87,779,548 (GRCm39) D162A probably damaging Het
Ripor1 T C 8: 106,346,562 (GRCm39) probably benign Het
Rnaseh1 A G 12: 28,709,008 (GRCm39) H263R probably damaging Het
Rnf19b T A 4: 128,974,211 (GRCm39) S490R probably damaging Het
Slc15a2 T A 16: 36,605,088 (GRCm39) T23S probably damaging Het
Slc34a1 T C 13: 24,003,121 (GRCm39) probably null Het
Slc35f4 T C 14: 49,536,334 (GRCm39) M434V probably benign Het
Slc52a3 C T 2: 151,846,564 (GRCm39) T175I probably benign Het
Slc5a2 C T 7: 127,869,794 (GRCm39) T409M probably benign Het
Tbc1d24 A G 17: 24,400,892 (GRCm39) S108P probably benign Het
Thnsl2 T G 6: 71,116,777 (GRCm39) Q125P probably benign Het
Ttc13 T C 8: 125,403,110 (GRCm39) D672G probably damaging Het
Ttn G T 2: 76,584,089 (GRCm39) H14013N possibly damaging Het
Unc5a T C 13: 55,152,629 (GRCm39) F792L probably damaging Het
Vac14 T C 8: 111,439,430 (GRCm39) V669A possibly damaging Het
Vmn1r13 A T 6: 57,187,314 (GRCm39) M158L probably benign Het
Vmn1r220 A T 13: 23,368,384 (GRCm39) V104D probably damaging Het
Zfp738 A T 13: 67,831,520 (GRCm39) probably null Het
Zscan5b A C 7: 6,234,421 (GRCm39) H149P probably benign Het
Other mutations in Or2y15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01362:Or2y15 APN 11 49,351,270 (GRCm39) missense probably benign 0.05
IGL02322:Or2y15 APN 11 49,350,784 (GRCm39) missense probably benign 0.12
R1028:Or2y15 UTSW 11 49,351,047 (GRCm39) missense probably benign 0.03
R2173:Or2y15 UTSW 11 49,350,967 (GRCm39) missense probably benign 0.00
R3894:Or2y15 UTSW 11 49,350,766 (GRCm39) missense possibly damaging 0.60
R5860:Or2y15 UTSW 11 49,350,563 (GRCm39) missense probably damaging 1.00
R6279:Or2y15 UTSW 11 49,351,039 (GRCm39) missense probably damaging 1.00
R6300:Or2y15 UTSW 11 49,351,039 (GRCm39) missense probably damaging 1.00
R6621:Or2y15 UTSW 11 49,350,598 (GRCm39) missense probably benign 0.09
R6836:Or2y15 UTSW 11 49,350,904 (GRCm39) missense possibly damaging 0.90
R6888:Or2y15 UTSW 11 49,351,087 (GRCm39) missense probably damaging 0.97
R9238:Or2y15 UTSW 11 49,350,529 (GRCm39) missense probably benign
R9687:Or2y15 UTSW 11 49,350,518 (GRCm39) missense probably benign 0.03
Z1088:Or2y15 UTSW 11 49,351,283 (GRCm39) missense probably damaging 1.00
Posted On 2013-12-03