Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01515:Cyp3a44'

89338

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Cyp3a44

Ensembl Gene

ENSMUSG00000054417

Gene Name

cytochrome P450, family 3, subfamily a, polypeptide 44

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.110) question?

Stock #

IGL01515

Quality Score

Status

Chromosome

Chromosomal Location

145710793-145742684 bp(-) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

A to T at 145736228 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Stop codon at position 74 (L74*)

Ref Sequence

ENSEMBL: ENSMUSP00000069932 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000067479]

AlphaFold

Q9EQW4

Predicted Effect

probably null
Transcript: ENSMUST00000067479
AA Change: L74*

SMART Domains

Protein: ENSMUSP00000069932
Gene: ENSMUSG00000054417
AA Change: L74*

Domain	Start	End	E-Value	Type
low complexity region	3	22	N/A	INTRINSIC
Pfam:p450	38	494	2.4e-133	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 28 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcd2	A	T	15: 91,047,289 (GRCm39)	V588E	probably damaging	Het
Ar	C	T	X: 97,295,453 (GRCm39)		probably benign	Het
B4galt7	C	A	13: 55,757,035 (GRCm39)	Q243K	probably damaging	Het
Cdhr2	A	T	13: 54,866,051 (GRCm39)	T284S	probably benign	Het
Chdh	G	A	14: 29,758,843 (GRCm39)	R596H	probably damaging	Het
Cyp2r1	T	C	7: 114,151,947 (GRCm39)		probably benign	Het
Dnah8	A	T	17: 30,867,459 (GRCm39)	I304L	probably benign	Het
Fam171b	G	A	2: 83,710,577 (GRCm39)	E750K	probably damaging	Het
Fbxo38	T	A	18: 62,651,642 (GRCm39)	E554D	probably benign	Het
Fnd3c2	T	C	X: 105,282,093 (GRCm39)	K721E	probably damaging	Het
Gpam	A	G	19: 55,075,883 (GRCm39)	L243P	probably damaging	Het
Heph	A	G	X: 95,601,706 (GRCm39)	E1032G	probably damaging	Het
Igf1r	T	A	7: 67,857,200 (GRCm39)	V1054E	probably damaging	Het
Inpp4b	A	G	8: 82,679,340 (GRCm39)	S331G	possibly damaging	Het
Ints11	A	T	4: 155,959,689 (GRCm39)	I99F	probably damaging	Het
Jak3	G	A	8: 72,133,206 (GRCm39)		probably null	Het
Ky	A	G	9: 102,419,304 (GRCm39)	Y437C	probably benign	Het
Lin28a	A	G	4: 133,746,020 (GRCm39)		probably null	Het
Macc1	A	C	12: 119,414,106 (GRCm39)	K761Q	probably damaging	Het
Myom2	A	G	8: 15,172,655 (GRCm39)	D1194G	probably benign	Het
Naga	C	A	15: 82,214,360 (GRCm39)	V384F	probably benign	Het
Necab3	A	T	2: 154,396,611 (GRCm39)	S72T	probably damaging	Het
Or4a27	G	A	2: 88,559,352 (GRCm39)	T197I	probably benign	Het
Or51i2	A	G	7: 103,689,183 (GRCm39)	Y60C	probably benign	Het
Ptpn13	C	T	5: 103,703,979 (GRCm39)	S1337L	probably benign	Het
Slitrk2	C	T	X: 65,699,248 (GRCm39)	P580S	probably damaging	Het
Tpsg1	A	G	17: 25,592,936 (GRCm39)	D67G	probably damaging	Het
Tsc22d1	T	C	14: 76,742,739 (GRCm39)		probably null	Het

Other mutations in Cyp3a44

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00813:Cyp3a44	APN	5	145,711,157 (GRCm39)	makesense	probably null
IGL00972:Cyp3a44	APN	5	145,716,534 (GRCm39)	missense	possibly damaging	0.84
IGL01062:Cyp3a44	APN	5	145,731,149 (GRCm39)	missense	possibly damaging	0.88
IGL01072:Cyp3a44	APN	5	145,728,438 (GRCm39)	missense	probably benign	0.01
IGL01738:Cyp3a44	APN	5	145,731,745 (GRCm39)	missense	probably damaging	1.00
IGL01869:Cyp3a44	APN	5	145,727,496 (GRCm39)	missense	probably damaging	0.99
IGL02269:Cyp3a44	APN	5	145,742,547 (GRCm39)	missense	probably benign	0.23
IGL02284:Cyp3a44	APN	5	145,725,179 (GRCm39)	missense	possibly damaging	0.91
IGL02479:Cyp3a44	APN	5	145,727,477 (GRCm39)	missense	probably benign	0.01
IGL02480:Cyp3a44	APN	5	145,731,715 (GRCm39)	missense	possibly damaging	0.93
IGL02506:Cyp3a44	APN	5	145,736,198 (GRCm39)	missense	probably damaging	1.00
IGL02957:Cyp3a44	APN	5	145,716,472 (GRCm39)	nonsense	probably null
IGL02978:Cyp3a44	APN	5	145,725,208 (GRCm39)	missense	probably damaging	0.98
R0427:Cyp3a44	UTSW	5	145,716,412 (GRCm39)	missense	possibly damaging	0.85
R1240:Cyp3a44	UTSW	5	145,711,250 (GRCm39)	missense	probably benign	0.02
R1247:Cyp3a44	UTSW	5	145,728,477 (GRCm39)	missense	probably damaging	1.00
R1657:Cyp3a44	UTSW	5	145,716,553 (GRCm39)	missense	probably damaging	0.99
R2096:Cyp3a44	UTSW	5	145,725,215 (GRCm39)	missense	probably damaging	1.00
R2156:Cyp3a44	UTSW	5	145,740,480 (GRCm39)	nonsense	probably null
R2412:Cyp3a44	UTSW	5	145,716,389 (GRCm39)	nonsense	probably null
R4817:Cyp3a44	UTSW	5	145,740,565 (GRCm39)	missense	possibly damaging	0.64
R4884:Cyp3a44	UTSW	5	145,714,792 (GRCm39)	missense	probably damaging	1.00
R5266:Cyp3a44	UTSW	5	145,731,207 (GRCm39)	missense	possibly damaging	0.66
R5301:Cyp3a44	UTSW	5	145,725,326 (GRCm39)	missense	probably damaging	0.99
R5463:Cyp3a44	UTSW	5	145,740,554 (GRCm39)	missense	probably benign	0.00
R5625:Cyp3a44	UTSW	5	145,716,376 (GRCm39)	missense	possibly damaging	0.74
R5635:Cyp3a44	UTSW	5	145,738,124 (GRCm39)	missense	possibly damaging	0.90
R5924:Cyp3a44	UTSW	5	145,731,137 (GRCm39)	missense	possibly damaging	0.54
R5964:Cyp3a44	UTSW	5	145,725,277 (GRCm39)	missense	possibly damaging	0.95
R5988:Cyp3a44	UTSW	5	145,731,728 (GRCm39)	missense	probably damaging	1.00
R6011:Cyp3a44	UTSW	5	145,738,084 (GRCm39)	critical splice donor site	probably null
R6032:Cyp3a44	UTSW	5	145,714,756 (GRCm39)	missense	probably damaging	1.00
R6032:Cyp3a44	UTSW	5	145,714,756 (GRCm39)	missense	probably damaging	1.00
R6413:Cyp3a44	UTSW	5	145,731,254 (GRCm39)	missense	probably damaging	1.00
R6579:Cyp3a44	UTSW	5	145,727,516 (GRCm39)	missense	probably damaging	0.99
R6587:Cyp3a44	UTSW	5	145,742,569 (GRCm39)	missense	probably benign	0.23
R6709:Cyp3a44	UTSW	5	145,714,902 (GRCm39)	splice site	probably null
R6727:Cyp3a44	UTSW	5	145,731,781 (GRCm39)	nonsense	probably null
R6825:Cyp3a44	UTSW	5	145,716,396 (GRCm39)	missense	probably damaging	1.00
R7142:Cyp3a44	UTSW	5	145,714,771 (GRCm39)	missense	probably benign	0.24
R7352:Cyp3a44	UTSW	5	145,740,498 (GRCm39)	missense	probably benign	0.01
R7921:Cyp3a44	UTSW	5	145,728,498 (GRCm39)	missense	probably damaging	1.00
R7962:Cyp3a44	UTSW	5	145,738,135 (GRCm39)	missense	probably benign
R8099:Cyp3a44	UTSW	5	145,725,212 (GRCm39)	missense	probably benign	0.12
R8240:Cyp3a44	UTSW	5	145,725,257 (GRCm39)	missense	probably damaging	0.99
R8836:Cyp3a44	UTSW	5	145,731,728 (GRCm39)	missense	probably damaging	1.00
R8923:Cyp3a44	UTSW	5	145,736,171 (GRCm39)	missense	probably damaging	1.00
R8934:Cyp3a44	UTSW	5	145,731,786 (GRCm39)	missense	possibly damaging	0.70
R9019:Cyp3a44	UTSW	5	145,727,519 (GRCm39)	missense	probably damaging	1.00
R9287:Cyp3a44	UTSW	5	145,725,202 (GRCm39)	missense	possibly damaging	0.93
R9293:Cyp3a44	UTSW	5	145,711,187 (GRCm39)	missense	probably benign	0.00
R9425:Cyp3a44	UTSW	5	145,740,548 (GRCm39)	nonsense	probably null
Z1176:Cyp3a44	UTSW	5	145,728,474 (GRCm39)	missense	probably benign	0.03

Posted On

2013-12-03