Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01519:Tars3'

89401

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tars3

Ensembl Gene

ENSMUSG00000030515

Gene Name

threonyl-tRNA synthetase 3

Synonyms

A530046H20Rik, Tarsl2

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.185) question?

Stock #

IGL01519

Quality Score

Status

Chromosome

Chromosomal Location

65294646-65341839 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 65313634 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Cysteine at position 351 (Y351C)

Ref Sequence

ENSEMBL: ENSMUSP00000032728 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000032728]

AlphaFold

Q8BLY2

Predicted Effect

probably damaging
Transcript: ENSMUST00000032728
AA Change: Y351C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000032728
Gene: ENSMUSG00000030515
AA Change: Y351C

Domain	Start	End	E-Value	Type
low complexity region	2	18	N/A	INTRINSIC
coiled coil region	44	68	N/A	INTRINSIC
Pfam:TGS	151	210	8.8e-14	PFAM
tRNA_SAD	316	365	1.26e-16	SMART
Pfam:tRNA-synt_2b	464	675	2.2e-35	PFAM
Pfam:HGTP_anticodon	687	778	1.1e-20	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000126941

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000206323

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 30 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Akap17b	T	C	X: 35,875,503 (GRCm39)	D668G	probably damaging	Het
Btbd3	A	G	2: 138,121,697 (GRCm39)	M127V	probably benign	Het
Btbd9	T	C	17: 30,518,575 (GRCm39)	T462A	possibly damaging	Het
Ces1a	G	T	8: 93,771,726 (GRCm39)	P24T	probably damaging	Het
Chd1	G	A	17: 17,598,831 (GRCm39)	G98R	probably damaging	Het
Ckap2	G	A	8: 22,658,914 (GRCm39)	R610C	probably benign	Het
Col18a1	C	T	10: 76,895,157 (GRCm39)	R1168H	probably damaging	Het
Csmd3	G	A	15: 47,460,246 (GRCm39)	T3515I	probably benign	Het
Dcn	A	G	10: 97,319,385 (GRCm39)	Q54R	probably damaging	Het
Dock11	A	G	X: 35,227,006 (GRCm39)	I86V	probably benign	Het
Dram2	T	A	3: 106,478,945 (GRCm39)	I179N	possibly damaging	Het
Fbn1	C	T	2: 125,158,939 (GRCm39)	M2275I	probably benign	Het
Gga2	A	G	7: 121,601,411 (GRCm39)	S231P	probably damaging	Het
Gk2	T	A	5: 97,603,646 (GRCm39)	L397F	probably damaging	Het
Gm8122	T	A	14: 43,092,696 (GRCm39)	I22L	unknown	Het
Golga4	A	G	9: 118,356,160 (GRCm39)	E104G	probably damaging	Het
Herc2	G	A	7: 55,753,698 (GRCm39)	R699H	probably damaging	Het
Hrh1	A	C	6: 114,457,262 (GRCm39)	E181A	probably damaging	Het
Lsm8	T	C	6: 18,851,699 (GRCm39)	F50S	probably damaging	Het
Or1f19	T	A	16: 3,410,398 (GRCm39)	I46N	probably damaging	Het
Pard6g	A	G	18: 80,123,071 (GRCm39)	D35G	probably benign	Het
Plod2	G	A	9: 92,477,348 (GRCm39)	V347I	probably benign	Het
Pramel51	T	C	12: 88,144,331 (GRCm39)	R161G	probably benign	Het
Snx13	T	C	12: 35,188,471 (GRCm39)		probably benign	Het
Taf1	T	A	X: 100,606,412 (GRCm39)		probably benign	Het
Tenm4	C	A	7: 96,544,384 (GRCm39)	D2133E	probably damaging	Het
Thap7	A	C	16: 17,346,609 (GRCm39)		probably benign	Het
Tpr	T	A	1: 150,306,919 (GRCm39)	S1505T	probably benign	Het
Trav9-2	C	T	14: 53,828,809 (GRCm39)	R60W	probably damaging	Het
Ttn	A	G	2: 76,708,692 (GRCm39)		probably benign	Het

Other mutations in Tars3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00092:Tars3	APN	7	65,302,007 (GRCm39)	critical splice acceptor site	probably null
IGL00470:Tars3	APN	7	65,338,656 (GRCm39)	missense	probably benign	0.03
IGL00594:Tars3	APN	7	65,325,880 (GRCm39)	critical splice donor site	probably null
IGL01352:Tars3	APN	7	65,308,658 (GRCm39)	missense	possibly damaging	0.80
IGL01726:Tars3	APN	7	65,332,566 (GRCm39)	missense	possibly damaging	0.46
IGL02370:Tars3	APN	7	65,310,913 (GRCm39)	missense	probably benign	0.17
IGL02729:Tars3	APN	7	65,332,567 (GRCm39)	missense	probably damaging	0.97
IGL03234:Tars3	APN	7	65,302,026 (GRCm39)	missense	probably benign	0.06
gary	UTSW	7	65,338,700 (GRCm39)	critical splice donor site	probably null
R8254_tarsl2_650	UTSW	7	65,325,809 (GRCm39)	missense	probably benign
smart_money	UTSW	7	65,327,890 (GRCm39)	missense	probably damaging	1.00
R0127:Tars3	UTSW	7	65,314,717 (GRCm39)	missense	probably benign	0.19
R0153:Tars3	UTSW	7	65,333,829 (GRCm39)	missense	probably damaging	1.00
R0605:Tars3	UTSW	7	65,327,819 (GRCm39)	missense	probably damaging	1.00
R1070:Tars3	UTSW	7	65,305,444 (GRCm39)	missense	probably damaging	1.00
R1450:Tars3	UTSW	7	65,297,244 (GRCm39)	missense	probably benign	0.01
R1467:Tars3	UTSW	7	65,305,444 (GRCm39)	missense	probably damaging	1.00
R1467:Tars3	UTSW	7	65,305,444 (GRCm39)	missense	probably damaging	1.00
R2142:Tars3	UTSW	7	65,308,645 (GRCm39)	missense	probably benign
R2143:Tars3	UTSW	7	65,305,539 (GRCm39)	missense	possibly damaging	0.57
R2144:Tars3	UTSW	7	65,305,539 (GRCm39)	missense	possibly damaging	0.57
R2145:Tars3	UTSW	7	65,305,539 (GRCm39)	missense	possibly damaging	0.57
R2208:Tars3	UTSW	7	65,332,596 (GRCm39)	missense	probably damaging	1.00
R3713:Tars3	UTSW	7	65,338,700 (GRCm39)	critical splice donor site	probably null
R3715:Tars3	UTSW	7	65,338,700 (GRCm39)	critical splice donor site	probably null
R3914:Tars3	UTSW	7	65,333,556 (GRCm39)	missense	probably benign	0.05
R3929:Tars3	UTSW	7	65,333,791 (GRCm39)	splice site	probably null
R4008:Tars3	UTSW	7	65,327,876 (GRCm39)	missense	probably damaging	1.00
R4064:Tars3	UTSW	7	65,302,018 (GRCm39)	missense	possibly damaging	0.90
R4367:Tars3	UTSW	7	65,332,567 (GRCm39)	missense	probably damaging	0.97
R4652:Tars3	UTSW	7	65,339,717 (GRCm39)	missense	probably damaging	1.00
R4825:Tars3	UTSW	7	65,297,302 (GRCm39)	missense	probably benign	0.38
R4901:Tars3	UTSW	7	65,341,042 (GRCm39)	missense	probably benign	0.05
R4999:Tars3	UTSW	7	65,308,683 (GRCm39)	missense	probably damaging	0.99
R5423:Tars3	UTSW	7	65,333,567 (GRCm39)	missense	probably benign	0.00
R5756:Tars3	UTSW	7	65,325,724 (GRCm39)	missense	probably benign	0.22
R5772:Tars3	UTSW	7	65,333,873 (GRCm39)	missense	probably damaging	1.00
R6160:Tars3	UTSW	7	65,332,527 (GRCm39)	missense	probably benign	0.32
R6230:Tars3	UTSW	7	65,336,184 (GRCm39)	splice site	probably null
R6424:Tars3	UTSW	7	65,305,487 (GRCm39)	missense	probably damaging	1.00
R6615:Tars3	UTSW	7	65,327,890 (GRCm39)	missense	probably damaging	1.00
R6792:Tars3	UTSW	7	65,312,051 (GRCm39)	missense	probably damaging	1.00
R7350:Tars3	UTSW	7	65,308,672 (GRCm39)	missense	probably damaging	1.00
R7549:Tars3	UTSW	7	65,297,341 (GRCm39)	missense	probably damaging	0.96
R7592:Tars3	UTSW	7	65,308,619 (GRCm39)	missense	probably benign	0.01
R7634:Tars3	UTSW	7	65,325,760 (GRCm39)	missense	probably damaging	0.99
R7710:Tars3	UTSW	7	65,314,717 (GRCm39)	missense	probably benign	0.19
R7808:Tars3	UTSW	7	65,302,009 (GRCm39)	missense	probably benign	0.01
R7875:Tars3	UTSW	7	65,327,899 (GRCm39)	missense	probably benign	0.05
R8254:Tars3	UTSW	7	65,325,809 (GRCm39)	missense	probably benign
R8793:Tars3	UTSW	7	65,294,673 (GRCm39)	start gained	probably benign
R9162:Tars3	UTSW	7	65,332,518 (GRCm39)	missense	probably benign	0.01
R9200:Tars3	UTSW	7	65,302,013 (GRCm39)	missense	probably benign
R9461:Tars3	UTSW	7	65,339,719 (GRCm39)	missense	possibly damaging	0.68
R9533:Tars3	UTSW	7	65,333,808 (GRCm39)	critical splice acceptor site	probably null
Z1177:Tars3	UTSW	7	65,302,012 (GRCm39)	nonsense	probably null

Posted On

2013-12-03