Incidental Mutation 'IGL01519:Dock11'
ID 89410
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Dock11
Ensembl Gene ENSMUSG00000031093
Gene Name dedicator of cytokinesis 11
Synonyms 5033414A21Rik, Zizimin2
Accession Numbers
Essential gene? Probably non essential (E-score: 0.234) question?
Stock # IGL01519
Quality Score
Status
Chromosome X
Chromosomal Location 35152485-35340215 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 35227006 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 86 (I86V)
Ref Sequence ENSEMBL: ENSMUSP00000110921 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000033419] [ENSMUST00000115266]
AlphaFold A2AF47
Predicted Effect probably benign
Transcript: ENSMUST00000033419
AA Change: I270V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000033419
Gene: ENSMUSG00000031093
AA Change: I270V

DomainStartEndE-ValueType
Pfam:DUF3398 52 145 4.2e-39 PFAM
PH 166 274 1.4e-17 SMART
Blast:PH 329 440 4e-58 BLAST
Pfam:DOCK-C2 636 827 2.4e-53 PFAM
low complexity region 1254 1270 N/A INTRINSIC
Pfam:DHR-2 1510 2029 7.3e-210 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000115266
AA Change: I86V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000110921
Gene: ENSMUSG00000031093
AA Change: I86V

DomainStartEndE-ValueType
PH 1 90 6.82e-7 SMART
Blast:PH 145 256 5e-58 BLAST
Pfam:DOCK-C2 451 644 1.3e-60 PFAM
low complexity region 1083 1099 N/A INTRINSIC
low complexity region 1521 1529 N/A INTRINSIC
Pfam:Ded_cyto 1681 1858 1.2e-68 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akap17b T C X: 35,875,503 (GRCm39) D668G probably damaging Het
Btbd3 A G 2: 138,121,697 (GRCm39) M127V probably benign Het
Btbd9 T C 17: 30,518,575 (GRCm39) T462A possibly damaging Het
Ces1a G T 8: 93,771,726 (GRCm39) P24T probably damaging Het
Chd1 G A 17: 17,598,831 (GRCm39) G98R probably damaging Het
Ckap2 G A 8: 22,658,914 (GRCm39) R610C probably benign Het
Col18a1 C T 10: 76,895,157 (GRCm39) R1168H probably damaging Het
Csmd3 G A 15: 47,460,246 (GRCm39) T3515I probably benign Het
Dcn A G 10: 97,319,385 (GRCm39) Q54R probably damaging Het
Dram2 T A 3: 106,478,945 (GRCm39) I179N possibly damaging Het
Fbn1 C T 2: 125,158,939 (GRCm39) M2275I probably benign Het
Gga2 A G 7: 121,601,411 (GRCm39) S231P probably damaging Het
Gk2 T A 5: 97,603,646 (GRCm39) L397F probably damaging Het
Gm8122 T A 14: 43,092,696 (GRCm39) I22L unknown Het
Golga4 A G 9: 118,356,160 (GRCm39) E104G probably damaging Het
Herc2 G A 7: 55,753,698 (GRCm39) R699H probably damaging Het
Hrh1 A C 6: 114,457,262 (GRCm39) E181A probably damaging Het
Lsm8 T C 6: 18,851,699 (GRCm39) F50S probably damaging Het
Or1f19 T A 16: 3,410,398 (GRCm39) I46N probably damaging Het
Pard6g A G 18: 80,123,071 (GRCm39) D35G probably benign Het
Plod2 G A 9: 92,477,348 (GRCm39) V347I probably benign Het
Pramel51 T C 12: 88,144,331 (GRCm39) R161G probably benign Het
Snx13 T C 12: 35,188,471 (GRCm39) probably benign Het
Taf1 T A X: 100,606,412 (GRCm39) probably benign Het
Tars3 A G 7: 65,313,634 (GRCm39) Y351C probably damaging Het
Tenm4 C A 7: 96,544,384 (GRCm39) D2133E probably damaging Het
Thap7 A C 16: 17,346,609 (GRCm39) probably benign Het
Tpr T A 1: 150,306,919 (GRCm39) S1505T probably benign Het
Trav9-2 C T 14: 53,828,809 (GRCm39) R60W probably damaging Het
Ttn A G 2: 76,708,692 (GRCm39) probably benign Het
Other mutations in Dock11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00536:Dock11 APN X 35,258,087 (GRCm39) missense probably benign 0.15
IGL00650:Dock11 APN X 35,270,246 (GRCm39) splice site probably benign
IGL00769:Dock11 APN X 35,267,715 (GRCm39) missense possibly damaging 0.74
IGL00963:Dock11 APN X 35,296,035 (GRCm39) missense possibly damaging 0.63
IGL01389:Dock11 APN X 35,256,701 (GRCm39) missense probably benign 0.43
IGL01410:Dock11 APN X 35,301,296 (GRCm39) missense probably damaging 1.00
IGL02023:Dock11 APN X 35,232,422 (GRCm39) missense probably benign 0.09
IGL02253:Dock11 APN X 35,304,781 (GRCm39) missense probably damaging 1.00
IGL02416:Dock11 APN X 35,283,739 (GRCm39) missense probably damaging 0.97
IGL02583:Dock11 APN X 35,270,370 (GRCm39) missense possibly damaging 0.48
IGL03014:Dock11 APN X 35,310,699 (GRCm39) splice site probably benign
IGL03037:Dock11 APN X 35,310,699 (GRCm39) splice site probably benign
IGL03065:Dock11 APN X 35,310,699 (GRCm39) splice site probably benign
IGL03277:Dock11 APN X 35,277,603 (GRCm39) missense probably benign 0.32
R0816:Dock11 UTSW X 35,283,688 (GRCm39) missense probably damaging 1.00
R0819:Dock11 UTSW X 35,283,688 (GRCm39) missense probably damaging 1.00
R0820:Dock11 UTSW X 35,283,688 (GRCm39) missense probably damaging 1.00
R1430:Dock11 UTSW X 35,333,565 (GRCm39) missense probably benign 0.00
R1512:Dock11 UTSW X 35,283,688 (GRCm39) missense probably damaging 1.00
Z1088:Dock11 UTSW X 35,266,186 (GRCm39) missense probably benign 0.01
Z1176:Dock11 UTSW X 35,248,501 (GRCm39) missense possibly damaging 0.69
Posted On 2013-12-03