Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01533:Gm28557'

89840

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gm28557

Ensembl Gene

ENSMUSG00000100235

Gene Name

predicted gene 28557

Synonyms

Accession Numbers

Essential gene?

Not available question?

Stock #

IGL01533

Quality Score

Status

Chromosome

Chromosomal Location

67217463-67256668 bp(-) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

A to T at 67219396 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Stop codon at position 109 (C109*)

Ref Sequence

ENSEMBL: ENSMUSP00000139928 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000109742] [ENSMUST00000109743] [ENSMUST00000186303] [ENSMUST00000190566]

AlphaFold

no structure available at present

Predicted Effect

probably null
Transcript: ENSMUST00000109742
AA Change: C142*

SMART Domains

Protein: ENSMUSP00000105364
Gene: ENSMUSG00000058883
AA Change: C142*

Domain	Start	End	E-Value	Type
KRAB	5	65	3.75e-28	SMART
ZnF_C2H2	81	103	1.12e-3	SMART
ZnF_C2H2	109	131	5.14e-3	SMART
ZnF_C2H2	137	159	1.1e-2	SMART
ZnF_C2H2	165	187	6.78e-3	SMART
ZnF_C2H2	193	215	1.47e-3	SMART
ZnF_C2H2	221	243	7.78e-3	SMART
ZnF_C2H2	249	271	1.95e-3	SMART
ZnF_C2H2	277	299	5.21e-4	SMART
ZnF_C2H2	305	327	7.9e-4	SMART
ZnF_C2H2	333	355	8.34e-3	SMART
ZnF_C2H2	361	383	1.3e-4	SMART
ZnF_C2H2	389	411	4.87e-4	SMART
ZnF_C2H2	417	439	5.14e-3	SMART
ZnF_C2H2	445	467	1.2e-3	SMART
ZnF_C2H2	473	495	1.72e-4	SMART
ZnF_C2H2	501	523	1.6e-4	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000109743
AA Change: C154*

SMART Domains

Protein: ENSMUSP00000105365
Gene: ENSMUSG00000058883
AA Change: C154*

Domain	Start	End	E-Value	Type
KRAB	17	77	3.75e-28	SMART
ZnF_C2H2	93	115	1.12e-3	SMART
ZnF_C2H2	121	143	5.14e-3	SMART
ZnF_C2H2	149	171	1.1e-2	SMART
ZnF_C2H2	177	199	6.78e-3	SMART
ZnF_C2H2	205	227	1.47e-3	SMART
ZnF_C2H2	233	255	7.78e-3	SMART
ZnF_C2H2	261	283	1.95e-3	SMART
ZnF_C2H2	289	311	5.21e-4	SMART
ZnF_C2H2	317	339	7.9e-4	SMART
ZnF_C2H2	345	367	8.34e-3	SMART
ZnF_C2H2	373	395	1.3e-4	SMART
ZnF_C2H2	401	423	4.87e-4	SMART
ZnF_C2H2	429	451	5.14e-3	SMART
ZnF_C2H2	457	479	1.2e-3	SMART
ZnF_C2H2	485	507	1.72e-4	SMART
ZnF_C2H2	513	535	1.6e-4	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000185856

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000185954

Predicted Effect

probably benign
Transcript: ENSMUST00000186303

SMART Domains

Protein: ENSMUSP00000140296
Gene: ENSMUSG00000100235

Domain	Start	End	E-Value	Type
KRAB	1	32	9.7e-3	SMART
ZnF_C2H2	47	69	1.8e-6	SMART
ZnF_C2H2	75	97	6.7e-5	SMART
ZnF_C2H2	103	125	7.6e-6	SMART
ZnF_C2H2	131	153	7.6e-6	SMART
ZnF_C2H2	159	181	1.4e-7	SMART
ZnF_C2H2	187	209	7.6e-6	SMART
ZnF_C2H2	215	237	5.5e-5	SMART
ZnF_C2H2	243	265	8.9e-7	SMART
ZnF_C2H2	271	293	2e-6	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000190566
AA Change: C109*

SMART Domains

Protein: ENSMUSP00000139928
Gene: ENSMUSG00000058883
AA Change: C109*

Domain	Start	End	E-Value	Type
KRAB	1	32	1.6e-3	SMART
ZnF_C2H2	48	70	4.7e-6	SMART
ZnF_C2H2	76	98	2.1e-5	SMART
ZnF_C2H2	104	126	4.6e-5	SMART
ZnF_C2H2	132	154	2.9e-5	SMART
ZnF_C2H2	160	182	6.3e-6	SMART
ZnF_C2H2	188	210	3.3e-5	SMART
ZnF_C2H2	216	238	8.2e-6	SMART
ZnF_C2H2	244	266	2.2e-6	SMART
ZnF_C2H2	272	294	3.4e-6	SMART
ZnF_C2H2	300	322	3.6e-5	SMART
ZnF_C2H2	328	350	5.5e-7	SMART
ZnF_C2H2	356	378	2.1e-6	SMART
ZnF_C2H2	384	406	2.1e-5	SMART
ZnF_C2H2	412	434	5e-6	SMART
ZnF_C2H2	440	462	7.2e-7	SMART
ZnF_C2H2	468	490	6.8e-7	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000223556

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000223904

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000224641

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Afg3l2	C	A	18: 67,538,488 (GRCm39)	E757*	probably null	Het
Arhgap15	T	C	2: 44,133,165 (GRCm39)	V357A	probably damaging	Het
Asb13	T	C	13: 3,692,164 (GRCm39)	V48A	probably benign	Het
Bbs7	T	C	3: 36,664,384 (GRCm39)	R74G	possibly damaging	Het
Capn11	T	C	17: 45,943,830 (GRCm39)	H568R	probably benign	Het
Cbx5	T	C	15: 103,114,061 (GRCm39)	E61G	probably damaging	Het
Ccdc158	T	C	5: 92,757,815 (GRCm39)		probably null	Het
Col14a1	C	A	15: 55,284,236 (GRCm39)	N832K	unknown	Het
Cyp2a4	A	T	7: 26,007,969 (GRCm39)	K125N	probably damaging	Het
Dhx16	T	C	17: 36,192,939 (GRCm39)	L215P	probably damaging	Het
Dtx4	T	C	19: 12,455,579 (GRCm39)	M480V	possibly damaging	Het
Edaradd	A	G	13: 12,493,463 (GRCm39)		probably benign	Het
Galnt13	T	A	2: 54,770,144 (GRCm39)	M312K	probably damaging	Het
Gcdh	T	A	8: 85,615,991 (GRCm39)	R337W	probably damaging	Het
Gpr22	C	T	12: 31,758,709 (GRCm39)		probably benign	Het
Gria4	T	G	9: 4,502,395 (GRCm39)	L379F	probably damaging	Het
Gxylt2	T	C	6: 100,760,098 (GRCm39)	L211P	probably damaging	Het
Igsf10	T	A	3: 59,226,651 (GRCm39)	I2341F	probably damaging	Het
Macf1	T	C	4: 123,367,666 (GRCm39)	D2365G	probably damaging	Het
Morc2b	A	G	17: 33,354,695 (GRCm39)		probably benign	Het
Ncoa3	T	C	2: 165,896,945 (GRCm39)	S579P	probably benign	Het
Nlgn1	T	C	3: 25,490,527 (GRCm39)	N400S	possibly damaging	Het
Or5w17	C	A	2: 87,583,412 (GRCm39)	R308S	probably benign	Het
Or8g17	C	T	9: 38,930,097 (GRCm39)	A247T	probably damaging	Het
Pi4ka	A	G	16: 17,126,065 (GRCm39)	S1102P	probably benign	Het
Polr1e	A	G	4: 45,019,328 (GRCm39)	Y59C	probably damaging	Het
Prex2	C	T	1: 11,256,965 (GRCm39)	Q1226*	probably null	Het
Rab12	A	T	17: 66,804,430 (GRCm39)	I176K	probably damaging	Het
Ryr2	A	T	13: 11,736,676 (GRCm39)	N2250K	probably damaging	Het
Sbf1	T	C	15: 89,172,919 (GRCm39)	T1865A	probably damaging	Het
Sema6b	G	A	17: 56,436,499 (GRCm39)		probably benign	Het
Smarcb1	C	T	10: 75,752,602 (GRCm39)		probably null	Het
Sos1	A	G	17: 80,722,511 (GRCm39)	L845S	probably damaging	Het
Stat4	T	A	1: 52,137,578 (GRCm39)	N456K	probably damaging	Het
Tex264	A	G	9: 106,550,798 (GRCm39)	I133T	probably benign	Het
Thoc1	T	C	18: 9,962,376 (GRCm39)	V87A	probably benign	Het
Tmem131	C	T	1: 36,857,803 (GRCm39)	D778N	probably damaging	Het
Tspan14	A	G	14: 40,638,776 (GRCm39)	I88T	probably benign	Het
Ttn	C	A	2: 76,562,918 (GRCm39)	V28679L	possibly damaging	Het
Ttn	A	G	2: 76,782,285 (GRCm39)	S984P	probably damaging	Het
Vangl1	T	C	3: 102,070,667 (GRCm39)	E423G	possibly damaging	Het

Other mutations in Gm28557

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02013:Gm28557	APN	13	67,219,116 (GRCm39)	missense	probably benign	0.01
IGL02609:Gm28557	APN	13	67,219,083 (GRCm39)	nonsense	probably null
IGL02626:Gm28557	APN	13	67,223,008 (GRCm39)	missense	probably benign	0.01

Posted On

2013-12-03