Incidental Mutation 'IGL01533:Gpr22'
ID 89858
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gpr22
Ensembl Gene ENSMUSG00000044067
Gene Name G protein-coupled receptor 22
Synonyms 2900068K05Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01533
Quality Score
Status
Chromosome 12
Chromosomal Location 31756866-31763882 bp(-) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) C to T at 31758709 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000134839 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000036862] [ENSMUST00000057783] [ENSMUST00000174480] [ENSMUST00000176710]
AlphaFold Q8BZL4
Predicted Effect probably benign
Transcript: ENSMUST00000036862
SMART Domains Protein: ENSMUSP00000044797
Gene: ENSMUSG00000035933

DomainStartEndE-ValueType
low complexity region 9 23 N/A INTRINSIC
Pfam:COG5 35 158 3.8e-37 PFAM
Pfam:Vps51 37 120 1.8e-12 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000057783
SMART Domains Protein: ENSMUSP00000056125
Gene: ENSMUSG00000044067

DomainStartEndE-ValueType
low complexity region 58 64 N/A INTRINSIC
Pfam:7tm_1 95 403 2.3e-23 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000174480
SMART Domains Protein: ENSMUSP00000134674
Gene: ENSMUSG00000044067

DomainStartEndE-ValueType
low complexity region 21 27 N/A INTRINSIC
Pfam:7tm_1 58 186 3.3e-11 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000176710
SMART Domains Protein: ENSMUSP00000134839
Gene: ENSMUSG00000044067

DomainStartEndE-ValueType
low complexity region 21 27 N/A INTRINSIC
Pfam:7tm_1 58 366 1.4e-26 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the G-protein coupled receptor 1 family and encodes a multi-pass membrane protein. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a null allele exhibit increased response to aortic banding including decreased fractional shortening and decompensated heart failure. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Afg3l2 C A 18: 67,538,488 (GRCm39) E757* probably null Het
Arhgap15 T C 2: 44,133,165 (GRCm39) V357A probably damaging Het
Asb13 T C 13: 3,692,164 (GRCm39) V48A probably benign Het
Bbs7 T C 3: 36,664,384 (GRCm39) R74G possibly damaging Het
Capn11 T C 17: 45,943,830 (GRCm39) H568R probably benign Het
Cbx5 T C 15: 103,114,061 (GRCm39) E61G probably damaging Het
Ccdc158 T C 5: 92,757,815 (GRCm39) probably null Het
Col14a1 C A 15: 55,284,236 (GRCm39) N832K unknown Het
Cyp2a4 A T 7: 26,007,969 (GRCm39) K125N probably damaging Het
Dhx16 T C 17: 36,192,939 (GRCm39) L215P probably damaging Het
Dtx4 T C 19: 12,455,579 (GRCm39) M480V possibly damaging Het
Edaradd A G 13: 12,493,463 (GRCm39) probably benign Het
Galnt13 T A 2: 54,770,144 (GRCm39) M312K probably damaging Het
Gcdh T A 8: 85,615,991 (GRCm39) R337W probably damaging Het
Gm28557 A T 13: 67,219,396 (GRCm39) C109* probably null Het
Gria4 T G 9: 4,502,395 (GRCm39) L379F probably damaging Het
Gxylt2 T C 6: 100,760,098 (GRCm39) L211P probably damaging Het
Igsf10 T A 3: 59,226,651 (GRCm39) I2341F probably damaging Het
Macf1 T C 4: 123,367,666 (GRCm39) D2365G probably damaging Het
Morc2b A G 17: 33,354,695 (GRCm39) probably benign Het
Ncoa3 T C 2: 165,896,945 (GRCm39) S579P probably benign Het
Nlgn1 T C 3: 25,490,527 (GRCm39) N400S possibly damaging Het
Or5w17 C A 2: 87,583,412 (GRCm39) R308S probably benign Het
Or8g17 C T 9: 38,930,097 (GRCm39) A247T probably damaging Het
Pi4ka A G 16: 17,126,065 (GRCm39) S1102P probably benign Het
Polr1e A G 4: 45,019,328 (GRCm39) Y59C probably damaging Het
Prex2 C T 1: 11,256,965 (GRCm39) Q1226* probably null Het
Rab12 A T 17: 66,804,430 (GRCm39) I176K probably damaging Het
Ryr2 A T 13: 11,736,676 (GRCm39) N2250K probably damaging Het
Sbf1 T C 15: 89,172,919 (GRCm39) T1865A probably damaging Het
Sema6b G A 17: 56,436,499 (GRCm39) probably benign Het
Smarcb1 C T 10: 75,752,602 (GRCm39) probably null Het
Sos1 A G 17: 80,722,511 (GRCm39) L845S probably damaging Het
Stat4 T A 1: 52,137,578 (GRCm39) N456K probably damaging Het
Tex264 A G 9: 106,550,798 (GRCm39) I133T probably benign Het
Thoc1 T C 18: 9,962,376 (GRCm39) V87A probably benign Het
Tmem131 C T 1: 36,857,803 (GRCm39) D778N probably damaging Het
Tspan14 A G 14: 40,638,776 (GRCm39) I88T probably benign Het
Ttn C A 2: 76,562,918 (GRCm39) V28679L possibly damaging Het
Ttn A G 2: 76,782,285 (GRCm39) S984P probably damaging Het
Vangl1 T C 3: 102,070,667 (GRCm39) E423G possibly damaging Het
Other mutations in Gpr22
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01517:Gpr22 APN 12 31,758,709 (GRCm39) unclassified probably benign
IGL01521:Gpr22 APN 12 31,758,709 (GRCm39) unclassified probably benign
IGL01585:Gpr22 APN 12 31,759,336 (GRCm39) missense probably benign 0.23
IGL01601:Gpr22 APN 12 31,760,044 (GRCm39) splice site probably benign
IGL01608:Gpr22 APN 12 31,758,779 (GRCm39) nonsense probably null
IGL02307:Gpr22 APN 12 31,758,739 (GRCm39) missense possibly damaging 0.95
IGL02440:Gpr22 APN 12 31,759,139 (GRCm39) missense probably damaging 0.99
IGL02863:Gpr22 APN 12 31,760,006 (GRCm39) missense probably benign 0.36
IGL03163:Gpr22 APN 12 31,759,171 (GRCm39) missense possibly damaging 0.68
R0078:Gpr22 UTSW 12 31,761,640 (GRCm39) missense probably benign
R0358:Gpr22 UTSW 12 31,759,981 (GRCm39) missense probably benign 0.03
R0395:Gpr22 UTSW 12 31,759,461 (GRCm39) missense possibly damaging 0.48
R0452:Gpr22 UTSW 12 31,758,793 (GRCm39) missense possibly damaging 0.69
R0729:Gpr22 UTSW 12 31,759,312 (GRCm39) missense probably damaging 1.00
R1295:Gpr22 UTSW 12 31,759,513 (GRCm39) missense probably benign 0.01
R1991:Gpr22 UTSW 12 31,759,202 (GRCm39) missense probably benign
R4201:Gpr22 UTSW 12 31,758,912 (GRCm39) nonsense probably null
R5203:Gpr22 UTSW 12 31,759,787 (GRCm39) missense probably damaging 1.00
R5505:Gpr22 UTSW 12 31,759,724 (GRCm39) missense probably damaging 1.00
R5541:Gpr22 UTSW 12 31,759,348 (GRCm39) missense probably damaging 0.97
R6218:Gpr22 UTSW 12 31,761,616 (GRCm39) nonsense probably null
R6844:Gpr22 UTSW 12 31,759,951 (GRCm39) missense probably benign
R7448:Gpr22 UTSW 12 31,759,514 (GRCm39) missense probably benign 0.06
R7956:Gpr22 UTSW 12 31,759,219 (GRCm39) missense possibly damaging 0.75
R8709:Gpr22 UTSW 12 31,759,829 (GRCm39) missense probably damaging 1.00
R9042:Gpr22 UTSW 12 31,759,853 (GRCm39) missense probably benign 0.01
R9162:Gpr22 UTSW 12 31,758,724 (GRCm39) missense probably benign
Posted On 2013-12-03