Incidental Mutation 'IGL01533:Morc2b'
ID 89860
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Morc2b
Ensembl Gene ENSMUSG00000048602
Gene Name microrchidia 2B
Synonyms 4932411A10Rik
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.274) question?
Stock # IGL01533
Quality Score
Status
Chromosome 17
Chromosomal Location 33354562-33369473 bp(-) (GRCm39)
Type of Mutation utr 3 prime
DNA Base Change (assembly) A to G at 33354695 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000123354 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053896] [ENSMUST00000131954]
AlphaFold Q8C5W4
Predicted Effect probably benign
Transcript: ENSMUST00000053896
SMART Domains Protein: ENSMUSP00000056879
Gene: ENSMUSG00000048602

DomainStartEndE-ValueType
HATPase_c 24 134 5.78e0 SMART
coiled coil region 285 321 N/A INTRINSIC
Pfam:zf-CW 495 541 1.9e-16 PFAM
coiled coil region 555 584 N/A INTRINSIC
low complexity region 680 695 N/A INTRINSIC
coiled coil region 961 1001 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000131954
SMART Domains Protein: ENSMUSP00000123354
Gene: ENSMUSG00000048602

DomainStartEndE-ValueType
HATPase_c 24 134 5.78e0 SMART
coiled coil region 285 321 N/A INTRINSIC
Pfam:zf-CW 494 543 7.7e-18 PFAM
coiled coil region 555 584 N/A INTRINSIC
low complexity region 680 695 N/A INTRINSIC
coiled coil region 961 1001 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a null mutation display male and female infertility with failure of chromosomal synapsis, double strand break repair, and recombination in meiosis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Afg3l2 C A 18: 67,538,488 (GRCm39) E757* probably null Het
Arhgap15 T C 2: 44,133,165 (GRCm39) V357A probably damaging Het
Asb13 T C 13: 3,692,164 (GRCm39) V48A probably benign Het
Bbs7 T C 3: 36,664,384 (GRCm39) R74G possibly damaging Het
Capn11 T C 17: 45,943,830 (GRCm39) H568R probably benign Het
Cbx5 T C 15: 103,114,061 (GRCm39) E61G probably damaging Het
Ccdc158 T C 5: 92,757,815 (GRCm39) probably null Het
Col14a1 C A 15: 55,284,236 (GRCm39) N832K unknown Het
Cyp2a4 A T 7: 26,007,969 (GRCm39) K125N probably damaging Het
Dhx16 T C 17: 36,192,939 (GRCm39) L215P probably damaging Het
Dtx4 T C 19: 12,455,579 (GRCm39) M480V possibly damaging Het
Edaradd A G 13: 12,493,463 (GRCm39) probably benign Het
Galnt13 T A 2: 54,770,144 (GRCm39) M312K probably damaging Het
Gcdh T A 8: 85,615,991 (GRCm39) R337W probably damaging Het
Gm28557 A T 13: 67,219,396 (GRCm39) C109* probably null Het
Gpr22 C T 12: 31,758,709 (GRCm39) probably benign Het
Gria4 T G 9: 4,502,395 (GRCm39) L379F probably damaging Het
Gxylt2 T C 6: 100,760,098 (GRCm39) L211P probably damaging Het
Igsf10 T A 3: 59,226,651 (GRCm39) I2341F probably damaging Het
Macf1 T C 4: 123,367,666 (GRCm39) D2365G probably damaging Het
Ncoa3 T C 2: 165,896,945 (GRCm39) S579P probably benign Het
Nlgn1 T C 3: 25,490,527 (GRCm39) N400S possibly damaging Het
Or5w17 C A 2: 87,583,412 (GRCm39) R308S probably benign Het
Or8g17 C T 9: 38,930,097 (GRCm39) A247T probably damaging Het
Pi4ka A G 16: 17,126,065 (GRCm39) S1102P probably benign Het
Polr1e A G 4: 45,019,328 (GRCm39) Y59C probably damaging Het
Prex2 C T 1: 11,256,965 (GRCm39) Q1226* probably null Het
Rab12 A T 17: 66,804,430 (GRCm39) I176K probably damaging Het
Ryr2 A T 13: 11,736,676 (GRCm39) N2250K probably damaging Het
Sbf1 T C 15: 89,172,919 (GRCm39) T1865A probably damaging Het
Sema6b G A 17: 56,436,499 (GRCm39) probably benign Het
Smarcb1 C T 10: 75,752,602 (GRCm39) probably null Het
Sos1 A G 17: 80,722,511 (GRCm39) L845S probably damaging Het
Stat4 T A 1: 52,137,578 (GRCm39) N456K probably damaging Het
Tex264 A G 9: 106,550,798 (GRCm39) I133T probably benign Het
Thoc1 T C 18: 9,962,376 (GRCm39) V87A probably benign Het
Tmem131 C T 1: 36,857,803 (GRCm39) D778N probably damaging Het
Tspan14 A G 14: 40,638,776 (GRCm39) I88T probably benign Het
Ttn C A 2: 76,562,918 (GRCm39) V28679L possibly damaging Het
Ttn A G 2: 76,782,285 (GRCm39) S984P probably damaging Het
Vangl1 T C 3: 102,070,667 (GRCm39) E423G possibly damaging Het
Other mutations in Morc2b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01323:Morc2b APN 17 33,356,293 (GRCm39) missense possibly damaging 0.47
IGL01369:Morc2b APN 17 33,357,139 (GRCm39) missense probably benign 0.12
IGL02003:Morc2b APN 17 33,357,298 (GRCm39) missense probably benign 0.07
IGL02028:Morc2b APN 17 33,356,387 (GRCm39) missense possibly damaging 0.78
IGL02152:Morc2b APN 17 33,356,917 (GRCm39) missense probably damaging 1.00
IGL02341:Morc2b APN 17 33,356,281 (GRCm39) missense probably damaging 1.00
IGL02976:Morc2b APN 17 33,356,497 (GRCm39) missense possibly damaging 0.90
IGL03293:Morc2b APN 17 33,357,337 (GRCm39) missense probably damaging 1.00
twinkle UTSW 17 33,354,906 (GRCm39) nonsense probably null
PIT4283001:Morc2b UTSW 17 33,355,042 (GRCm39) missense probably benign 0.00
R0056:Morc2b UTSW 17 33,357,733 (GRCm39) missense possibly damaging 0.78
R0116:Morc2b UTSW 17 33,356,015 (GRCm39) missense probably damaging 1.00
R0179:Morc2b UTSW 17 33,355,956 (GRCm39) nonsense probably null
R0533:Morc2b UTSW 17 33,354,906 (GRCm39) nonsense probably null
R0556:Morc2b UTSW 17 33,356,812 (GRCm39) missense probably benign 0.05
R0629:Morc2b UTSW 17 33,354,781 (GRCm39) missense probably benign 0.00
R0635:Morc2b UTSW 17 33,356,661 (GRCm39) missense possibly damaging 0.90
R0840:Morc2b UTSW 17 33,355,086 (GRCm39) missense probably benign 0.01
R1205:Morc2b UTSW 17 33,354,908 (GRCm39) missense probably damaging 1.00
R1566:Morc2b UTSW 17 33,355,948 (GRCm39) missense probably benign 0.02
R1676:Morc2b UTSW 17 33,354,955 (GRCm39) missense possibly damaging 0.82
R1892:Morc2b UTSW 17 33,354,748 (GRCm39) missense probably damaging 1.00
R1954:Morc2b UTSW 17 33,356,464 (GRCm39) missense probably damaging 1.00
R1955:Morc2b UTSW 17 33,356,464 (GRCm39) missense probably damaging 1.00
R1969:Morc2b UTSW 17 33,356,065 (GRCm39) missense probably benign 0.00
R2069:Morc2b UTSW 17 33,355,734 (GRCm39) missense probably benign 0.13
R3609:Morc2b UTSW 17 33,355,252 (GRCm39) missense probably damaging 1.00
R3610:Morc2b UTSW 17 33,355,252 (GRCm39) missense probably damaging 1.00
R3831:Morc2b UTSW 17 33,356,233 (GRCm39) missense probably benign 0.01
R4156:Morc2b UTSW 17 33,357,401 (GRCm39) missense probably benign 0.43
R4243:Morc2b UTSW 17 33,355,375 (GRCm39) missense probably benign 0.03
R4877:Morc2b UTSW 17 33,357,712 (GRCm39) missense probably benign 0.26
R4911:Morc2b UTSW 17 33,356,351 (GRCm39) missense probably damaging 1.00
R5230:Morc2b UTSW 17 33,355,226 (GRCm39) missense probably benign 0.00
R5264:Morc2b UTSW 17 33,357,353 (GRCm39) missense probably benign 0.03
R5326:Morc2b UTSW 17 33,355,907 (GRCm39) missense probably benign 0.01
R5455:Morc2b UTSW 17 33,357,584 (GRCm39) missense probably benign 0.29
R5933:Morc2b UTSW 17 33,357,583 (GRCm39) missense possibly damaging 0.84
R5973:Morc2b UTSW 17 33,356,446 (GRCm39) missense probably damaging 0.97
R6026:Morc2b UTSW 17 33,356,957 (GRCm39) missense possibly damaging 0.55
R6113:Morc2b UTSW 17 33,357,042 (GRCm39) nonsense probably null
R6393:Morc2b UTSW 17 33,356,750 (GRCm39) missense probably damaging 0.97
R7066:Morc2b UTSW 17 33,355,610 (GRCm39) missense probably benign 0.00
R7117:Morc2b UTSW 17 33,356,926 (GRCm39) missense probably benign 0.00
R7120:Morc2b UTSW 17 33,354,787 (GRCm39) missense probably damaging 1.00
R7130:Morc2b UTSW 17 33,355,262 (GRCm39) missense possibly damaging 0.68
R7498:Morc2b UTSW 17 33,356,833 (GRCm39) missense possibly damaging 0.55
R7516:Morc2b UTSW 17 33,356,435 (GRCm39) missense probably benign 0.03
R7664:Morc2b UTSW 17 33,355,376 (GRCm39) missense probably benign 0.12
R7754:Morc2b UTSW 17 33,356,218 (GRCm39) missense probably benign 0.33
R7756:Morc2b UTSW 17 33,355,981 (GRCm39) missense probably damaging 1.00
R7758:Morc2b UTSW 17 33,355,981 (GRCm39) missense probably damaging 1.00
R7766:Morc2b UTSW 17 33,357,397 (GRCm39) missense probably benign 0.19
R7957:Morc2b UTSW 17 33,354,747 (GRCm39) missense probably benign 0.39
R7965:Morc2b UTSW 17 33,354,746 (GRCm39) missense possibly damaging 0.91
R8164:Morc2b UTSW 17 33,357,014 (GRCm39) missense probably damaging 0.99
R8283:Morc2b UTSW 17 33,355,675 (GRCm39) missense probably benign 0.00
R8338:Morc2b UTSW 17 33,355,387 (GRCm39) missense probably benign
R8349:Morc2b UTSW 17 33,355,775 (GRCm39) missense probably benign 0.13
R8352:Morc2b UTSW 17 33,356,476 (GRCm39) missense probably damaging 1.00
R8362:Morc2b UTSW 17 33,357,295 (GRCm39) missense possibly damaging 0.91
R8364:Morc2b UTSW 17 33,357,214 (GRCm39) missense probably benign 0.01
R8449:Morc2b UTSW 17 33,355,775 (GRCm39) missense probably benign 0.13
R8452:Morc2b UTSW 17 33,356,476 (GRCm39) missense probably damaging 1.00
R8476:Morc2b UTSW 17 33,354,833 (GRCm39) missense possibly damaging 0.87
R8844:Morc2b UTSW 17 33,354,742 (GRCm39) missense probably damaging 1.00
R9277:Morc2b UTSW 17 33,354,997 (GRCm39) missense probably benign 0.10
R9571:Morc2b UTSW 17 33,355,178 (GRCm39) missense probably benign 0.00
Z1088:Morc2b UTSW 17 33,355,060 (GRCm39) missense possibly damaging 0.49
Z1177:Morc2b UTSW 17 33,356,376 (GRCm39) missense probably damaging 1.00
Posted On 2013-12-03