Incidental Mutation 'IGL01538:Vmn2r12'
| ID |
90027 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Vmn2r12
|
| Ensembl Gene |
ENSMUSG00000090688 |
| Gene Name |
vomeronasal 2, receptor 12 |
| Synonyms |
Gm6769 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.070)
|
| Stock # |
IGL01538
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
5 |
| Chromosomal Location |
109233715-109245730 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to A
at 109239716 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Arginine to Serine
at position 282
(R282S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000093612
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000095922]
|
| AlphaFold |
L7N217 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000095922
AA Change: R282S
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000093612
Gene: ENSMUSG00000090688
AA Change: R282S
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
76 |
466 |
8.8e-30 |
PFAM |
|
Pfam:NCD3G
|
505 |
559 |
1.7e-18 |
PFAM |
|
Pfam:7tm_3
|
591 |
827 |
3.9e-54 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 63 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930533K18Rik |
A |
G |
10: 70,708,032 (GRCm39) |
|
noncoding transcript |
Het |
| Abca3 |
G |
T |
17: 24,595,447 (GRCm39) |
C328F |
possibly damaging |
Het |
| Aldh5a1 |
T |
C |
13: 25,102,495 (GRCm39) |
N323D |
possibly damaging |
Het |
| Atp5f1c |
T |
C |
2: 10,073,477 (GRCm39) |
Y32C |
probably damaging |
Het |
| Capn3 |
T |
G |
2: 120,332,667 (GRCm39) |
|
probably null |
Het |
| Ccdc113 |
C |
A |
8: 96,277,866 (GRCm39) |
D275E |
probably benign |
Het |
| Ccdc40 |
T |
A |
11: 119,133,545 (GRCm39) |
F562I |
possibly damaging |
Het |
| Ccn6 |
A |
G |
10: 39,034,306 (GRCm39) |
Y99H |
probably damaging |
Het |
| Cd96 |
T |
C |
16: 45,929,490 (GRCm39) |
T152A |
possibly damaging |
Het |
| Cdh20 |
T |
A |
1: 109,988,870 (GRCm39) |
D257E |
probably damaging |
Het |
| Cilp2 |
T |
C |
8: 70,333,854 (GRCm39) |
D1048G |
probably benign |
Het |
| Clrn2 |
T |
G |
5: 45,617,408 (GRCm39) |
L93R |
probably damaging |
Het |
| Crat |
C |
A |
2: 30,299,978 (GRCm39) |
G134V |
probably damaging |
Het |
| Dis3 |
A |
T |
14: 99,335,181 (GRCm39) |
N140K |
probably benign |
Het |
| Dmxl2 |
T |
A |
9: 54,352,660 (GRCm39) |
|
probably benign |
Het |
| Dus1l |
T |
A |
11: 120,683,905 (GRCm39) |
Q181L |
probably damaging |
Het |
| Ece1 |
A |
G |
4: 137,675,855 (GRCm39) |
T410A |
probably benign |
Het |
| Gcc1 |
T |
A |
6: 28,421,047 (GRCm39) |
H90L |
probably damaging |
Het |
| Gpr152 |
T |
A |
19: 4,192,951 (GRCm39) |
V164E |
probably damaging |
Het |
| Grik3 |
A |
C |
4: 125,587,829 (GRCm39) |
I650L |
possibly damaging |
Het |
| Gvin3 |
T |
C |
7: 106,201,744 (GRCm39) |
D500G |
probably damaging |
Het |
| Gzmm |
A |
T |
10: 79,530,896 (GRCm39) |
T233S |
probably benign |
Het |
| H2-Q4 |
T |
A |
17: 35,602,288 (GRCm39) |
V341D |
probably benign |
Het |
| Igsf21 |
A |
G |
4: 139,755,029 (GRCm39) |
|
probably benign |
Het |
| Kmt2d |
T |
C |
15: 98,758,538 (GRCm39) |
|
probably benign |
Het |
| Kntc1 |
T |
G |
5: 123,919,721 (GRCm39) |
V864G |
probably damaging |
Het |
| Lnx1 |
T |
C |
5: 74,780,816 (GRCm39) |
E235G |
possibly damaging |
Het |
| Man2b1 |
G |
T |
8: 85,824,059 (GRCm39) |
K985N |
probably benign |
Het |
| Map4k1 |
C |
A |
7: 28,701,044 (GRCm39) |
P670Q |
probably damaging |
Het |
| Mapk8ip1 |
C |
A |
2: 92,219,319 (GRCm39) |
|
probably null |
Het |
| Mettl16 |
T |
A |
11: 74,683,093 (GRCm39) |
Y178* |
probably null |
Het |
| Mrpl11 |
T |
A |
19: 5,013,449 (GRCm39) |
|
probably null |
Het |
| Nup85 |
T |
C |
11: 115,460,540 (GRCm39) |
S140P |
possibly damaging |
Het |
| Or14c44 |
T |
C |
7: 86,062,167 (GRCm39) |
L199P |
possibly damaging |
Het |
| Or1j20 |
T |
C |
2: 36,760,532 (GRCm39) |
|
probably benign |
Het |
| Or4k51 |
T |
A |
2: 111,585,350 (GRCm39) |
V252E |
probably damaging |
Het |
| Or5w16 |
T |
C |
2: 87,576,942 (GRCm39) |
V134A |
probably benign |
Het |
| Pcdhb2 |
T |
A |
18: 37,428,375 (GRCm39) |
L116* |
probably null |
Het |
| Pdcd7 |
C |
A |
9: 65,253,985 (GRCm39) |
R188S |
probably damaging |
Het |
| Pdk2 |
T |
C |
11: 94,918,111 (GRCm39) |
Y374C |
probably damaging |
Het |
| Ppp1r12a |
G |
T |
10: 108,069,882 (GRCm39) |
D224Y |
probably damaging |
Het |
| Ppp2r2d |
T |
A |
7: 138,478,364 (GRCm39) |
Y169N |
probably damaging |
Het |
| Prcp |
A |
C |
7: 92,559,421 (GRCm39) |
T162P |
probably benign |
Het |
| Prkd1 |
A |
G |
12: 50,388,925 (GRCm39) |
S873P |
probably benign |
Het |
| Ptpn2 |
T |
C |
18: 67,814,623 (GRCm39) |
T129A |
probably benign |
Het |
| Rtkn |
G |
A |
6: 83,123,042 (GRCm39) |
R68H |
probably damaging |
Het |
| Sall4 |
C |
T |
2: 168,597,776 (GRCm39) |
D355N |
probably damaging |
Het |
| Scn7a |
A |
G |
2: 66,534,196 (GRCm39) |
V493A |
probably benign |
Het |
| Sema4b |
G |
A |
7: 79,865,444 (GRCm39) |
A140T |
probably damaging |
Het |
| Shisa6 |
C |
A |
11: 66,108,654 (GRCm39) |
G408C |
possibly damaging |
Het |
| Slc7a9 |
G |
T |
7: 35,153,589 (GRCm39) |
V197F |
probably damaging |
Het |
| Spata2 |
A |
T |
2: 167,326,071 (GRCm39) |
D249E |
probably damaging |
Het |
| Stk36 |
T |
A |
1: 74,672,797 (GRCm39) |
V1013E |
probably benign |
Het |
| Tcp10a |
T |
C |
17: 7,610,899 (GRCm39) |
V336A |
probably damaging |
Het |
| Tfb2m |
A |
T |
1: 179,365,409 (GRCm39) |
V185D |
possibly damaging |
Het |
| Tgm7 |
T |
A |
2: 120,937,396 (GRCm39) |
Y76F |
probably benign |
Het |
| Tph1 |
T |
C |
7: 46,303,177 (GRCm39) |
Y267C |
probably damaging |
Het |
| Trgv1 |
G |
A |
13: 19,520,740 (GRCm39) |
|
probably benign |
Het |
| Ube2d1 |
A |
G |
10: 71,091,656 (GRCm39) |
|
probably benign |
Het |
| Vps4a |
A |
G |
8: 107,763,556 (GRCm39) |
D72G |
probably benign |
Het |
| Wipf2 |
T |
A |
11: 98,781,629 (GRCm39) |
V56D |
possibly damaging |
Het |
| Zfp750 |
C |
A |
11: 121,402,991 (GRCm39) |
V586L |
probably benign |
Het |
| Zfp831 |
A |
G |
2: 174,486,399 (GRCm39) |
E358G |
possibly damaging |
Het |
|
| Other mutations in Vmn2r12 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00948:Vmn2r12
|
APN |
5 |
109,245,541 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
IGL01096:Vmn2r12
|
APN |
5 |
109,234,125 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01548:Vmn2r12
|
APN |
5 |
109,240,893 (GRCm39) |
nonsense |
probably null |
|
|
IGL01762:Vmn2r12
|
APN |
5 |
109,234,430 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01860:Vmn2r12
|
APN |
5 |
109,240,025 (GRCm39) |
missense |
probably benign |
0.10 |
|
IGL02269:Vmn2r12
|
APN |
5 |
109,234,343 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02530:Vmn2r12
|
APN |
5 |
109,233,858 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02887:Vmn2r12
|
APN |
5 |
109,238,351 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL03265:Vmn2r12
|
APN |
5 |
109,239,936 (GRCm39) |
missense |
probably benign |
0.05 |
|
R0396:Vmn2r12
|
UTSW |
5 |
109,240,765 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0497:Vmn2r12
|
UTSW |
5 |
109,239,755 (GRCm39) |
nonsense |
probably null |
|
|
R0529:Vmn2r12
|
UTSW |
5 |
109,240,714 (GRCm39) |
missense |
probably benign |
|
|
R0715:Vmn2r12
|
UTSW |
5 |
109,238,373 (GRCm39) |
missense |
probably benign |
0.10 |
|
R0742:Vmn2r12
|
UTSW |
5 |
109,234,281 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R0894:Vmn2r12
|
UTSW |
5 |
109,235,716 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1173:Vmn2r12
|
UTSW |
5 |
109,240,720 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1174:Vmn2r12
|
UTSW |
5 |
109,240,720 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1259:Vmn2r12
|
UTSW |
5 |
109,239,763 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1349:Vmn2r12
|
UTSW |
5 |
109,234,452 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1388:Vmn2r12
|
UTSW |
5 |
109,240,840 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R1549:Vmn2r12
|
UTSW |
5 |
109,240,696 (GRCm39) |
missense |
probably benign |
0.06 |
|
R1766:Vmn2r12
|
UTSW |
5 |
109,239,910 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1781:Vmn2r12
|
UTSW |
5 |
109,239,594 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1885:Vmn2r12
|
UTSW |
5 |
109,239,942 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2159:Vmn2r12
|
UTSW |
5 |
109,239,340 (GRCm39) |
missense |
probably benign |
0.02 |
|
R2420:Vmn2r12
|
UTSW |
5 |
109,234,398 (GRCm39) |
missense |
probably benign |
0.39 |
|
R2421:Vmn2r12
|
UTSW |
5 |
109,234,398 (GRCm39) |
missense |
probably benign |
0.39 |
|
R2422:Vmn2r12
|
UTSW |
5 |
109,234,398 (GRCm39) |
missense |
probably benign |
0.39 |
|
R2937:Vmn2r12
|
UTSW |
5 |
109,239,397 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2938:Vmn2r12
|
UTSW |
5 |
109,239,397 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3898:Vmn2r12
|
UTSW |
5 |
109,238,370 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4061:Vmn2r12
|
UTSW |
5 |
109,240,058 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4063:Vmn2r12
|
UTSW |
5 |
109,240,058 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4090:Vmn2r12
|
UTSW |
5 |
109,239,412 (GRCm39) |
missense |
probably benign |
0.06 |
|
R4297:Vmn2r12
|
UTSW |
5 |
109,239,830 (GRCm39) |
missense |
probably benign |
0.12 |
|
R4298:Vmn2r12
|
UTSW |
5 |
109,239,830 (GRCm39) |
missense |
probably benign |
0.12 |
|
R4299:Vmn2r12
|
UTSW |
5 |
109,239,830 (GRCm39) |
missense |
probably benign |
0.12 |
|
R4304:Vmn2r12
|
UTSW |
5 |
109,233,872 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4306:Vmn2r12
|
UTSW |
5 |
109,233,872 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4307:Vmn2r12
|
UTSW |
5 |
109,233,872 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4308:Vmn2r12
|
UTSW |
5 |
109,233,872 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4594:Vmn2r12
|
UTSW |
5 |
109,234,301 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4783:Vmn2r12
|
UTSW |
5 |
109,234,379 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4900:Vmn2r12
|
UTSW |
5 |
109,240,852 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4929:Vmn2r12
|
UTSW |
5 |
109,239,544 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4974:Vmn2r12
|
UTSW |
5 |
109,239,372 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5389:Vmn2r12
|
UTSW |
5 |
109,238,261 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5431:Vmn2r12
|
UTSW |
5 |
109,239,684 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5527:Vmn2r12
|
UTSW |
5 |
109,234,483 (GRCm39) |
nonsense |
probably null |
|
|
R5639:Vmn2r12
|
UTSW |
5 |
109,240,666 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5753:Vmn2r12
|
UTSW |
5 |
109,239,670 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5797:Vmn2r12
|
UTSW |
5 |
109,233,736 (GRCm39) |
nonsense |
probably null |
|
|
R6142:Vmn2r12
|
UTSW |
5 |
109,240,763 (GRCm39) |
missense |
probably benign |
|
|
R6162:Vmn2r12
|
UTSW |
5 |
109,234,430 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6176:Vmn2r12
|
UTSW |
5 |
109,233,866 (GRCm39) |
missense |
probably benign |
0.43 |
|
R6853:Vmn2r12
|
UTSW |
5 |
109,240,771 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7238:Vmn2r12
|
UTSW |
5 |
109,245,655 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R7341:Vmn2r12
|
UTSW |
5 |
109,239,811 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7341:Vmn2r12
|
UTSW |
5 |
109,234,113 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R7383:Vmn2r12
|
UTSW |
5 |
109,240,684 (GRCm39) |
missense |
probably benign |
0.19 |
|
R7740:Vmn2r12
|
UTSW |
5 |
109,239,615 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7749:Vmn2r12
|
UTSW |
5 |
109,233,920 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7861:Vmn2r12
|
UTSW |
5 |
109,235,829 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7908:Vmn2r12
|
UTSW |
5 |
109,234,307 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8128:Vmn2r12
|
UTSW |
5 |
109,239,747 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R8175:Vmn2r12
|
UTSW |
5 |
109,238,349 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8234:Vmn2r12
|
UTSW |
5 |
109,234,074 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8771:Vmn2r12
|
UTSW |
5 |
109,239,952 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8947:Vmn2r12
|
UTSW |
5 |
109,234,522 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R8991:Vmn2r12
|
UTSW |
5 |
109,234,033 (GRCm39) |
nonsense |
probably null |
|
|
R9116:Vmn2r12
|
UTSW |
5 |
109,233,885 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9122:Vmn2r12
|
UTSW |
5 |
109,240,910 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9153:Vmn2r12
|
UTSW |
5 |
109,234,203 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9371:Vmn2r12
|
UTSW |
5 |
109,234,452 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9375:Vmn2r12
|
UTSW |
5 |
109,233,986 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9524:Vmn2r12
|
UTSW |
5 |
109,239,823 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9587:Vmn2r12
|
UTSW |
5 |
109,239,322 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1088:Vmn2r12
|
UTSW |
5 |
109,240,646 (GRCm39) |
missense |
probably benign |
|
|
Z1176:Vmn2r12
|
UTSW |
5 |
109,239,303 (GRCm39) |
missense |
probably benign |
0.01 |
|
| Posted On |
2013-12-03 |
Incidental Mutation