Incidental Mutation 'IGL01539:Eif3b'
ID 90114
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Eif3b
Ensembl Gene ENSMUSG00000056076
Gene Name eukaryotic translation initiation factor 3, subunit B
Synonyms EIF3-P116, Eif3s9, D5Wsu45e
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # IGL01539
Quality Score
Status
Chromosome 5
Chromosomal Location 140405083-140429115 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) T to C at 140416008 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000098076 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000100507]
AlphaFold Q8JZQ9
Predicted Effect probably benign
Transcript: ENSMUST00000100507
SMART Domains Protein: ENSMUSP00000098076
Gene: ENSMUSG00000056076

DomainStartEndE-ValueType
low complexity region 4 25 N/A INTRINSIC
low complexity region 46 59 N/A INTRINSIC
low complexity region 111 128 N/A INTRINSIC
RRM 175 253 4.14e-7 SMART
Blast:WD40 317 350 4e-7 BLAST
Blast:WD40 354 397 2e-7 BLAST
Pfam:eIF2A 496 691 1.3e-68 PFAM
low complexity region 700 719 N/A INTRINSIC
low complexity region 784 797 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000184833
Predicted Effect noncoding transcript
Transcript: ENSMUST00000197632
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygous embryos die prenatally prior to the blastocyst stage. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 27 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Clca4b T A 3: 144,631,918 (GRCm39) M196L probably benign Het
Cyp4a14 T C 4: 115,344,374 (GRCm39) N497S possibly damaging Het
Grin2c T C 11: 115,140,932 (GRCm39) Q1062R probably benign Het
Ina A G 19: 47,003,903 (GRCm39) E237G probably damaging Het
Lmx1b T C 2: 33,529,510 (GRCm39) D83G possibly damaging Het
Macf1 A G 4: 123,289,701 (GRCm39) probably benign Het
Muc6 T A 7: 141,236,306 (GRCm39) M406L probably benign Het
Myo15b T C 11: 115,754,299 (GRCm39) I933T probably benign Het
Or4c121 A G 2: 89,023,836 (GRCm39) F181L possibly damaging Het
Or6c204 T C 10: 129,022,804 (GRCm39) N162S probably benign Het
Pde1b A T 15: 103,433,772 (GRCm39) probably benign Het
Rab29 G A 1: 131,798,445 (GRCm39) R75Q probably damaging Het
Scn10a A T 9: 119,467,764 (GRCm39) I792N probably damaging Het
Serpinb6a A T 13: 34,114,117 (GRCm39) V70D probably damaging Het
Slco1a7 A G 6: 141,673,333 (GRCm39) S402P possibly damaging Het
Spart A G 3: 55,024,723 (GRCm39) D106G possibly damaging Het
Sucla2 A G 14: 73,828,561 (GRCm39) E359G probably damaging Het
Sycp2 T C 2: 178,016,488 (GRCm39) Y658C probably damaging Het
Tenm2 T A 11: 35,997,654 (GRCm39) T811S possibly damaging Het
Trim66 C A 7: 109,054,273 (GRCm39) M1312I probably benign Het
Tspan18 A G 2: 93,041,198 (GRCm39) S135P probably damaging Het
Ube2j1 T C 4: 33,043,993 (GRCm39) probably benign Het
Ubr1 A C 2: 120,756,494 (GRCm39) V711G possibly damaging Het
Veph1 T C 3: 66,065,496 (GRCm39) T524A probably benign Het
Vmn1r222 A T 13: 23,417,059 (GRCm39) F51L probably benign Het
Vwf G T 6: 125,567,225 (GRCm39) V338L possibly damaging Het
Zfp770 G T 2: 114,027,574 (GRCm39) A165E probably damaging Het
Other mutations in Eif3b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01087:Eif3b APN 5 140,426,862 (GRCm39) missense probably damaging 0.99
IGL01295:Eif3b APN 5 140,427,495 (GRCm39) missense possibly damaging 0.77
IGL01897:Eif3b APN 5 140,411,202 (GRCm39) missense possibly damaging 0.69
IGL02166:Eif3b APN 5 140,425,705 (GRCm39) missense possibly damaging 0.72
IGL02169:Eif3b APN 5 140,415,836 (GRCm39) missense possibly damaging 0.92
hangman UTSW 5 140,405,592 (GRCm39) splice site probably benign
hemp UTSW 5 140,411,077 (GRCm39) missense probably damaging 0.97
R0783:Eif3b UTSW 5 140,405,592 (GRCm39) splice site probably benign
R1727:Eif3b UTSW 5 140,411,077 (GRCm39) missense probably damaging 0.97
R1909:Eif3b UTSW 5 140,418,692 (GRCm39) missense probably damaging 1.00
R2062:Eif3b UTSW 5 140,412,208 (GRCm39) missense probably damaging 1.00
R2258:Eif3b UTSW 5 140,413,258 (GRCm39) missense possibly damaging 0.79
R4738:Eif3b UTSW 5 140,415,833 (GRCm39) missense probably benign 0.01
R4752:Eif3b UTSW 5 140,426,856 (GRCm39) missense probably benign 0.08
R4774:Eif3b UTSW 5 140,405,255 (GRCm39) missense probably benign
R5342:Eif3b UTSW 5 140,411,035 (GRCm39) missense probably damaging 1.00
R5790:Eif3b UTSW 5 140,427,886 (GRCm39) missense probably benign 0.42
R6286:Eif3b UTSW 5 140,405,566 (GRCm39) missense probably damaging 0.99
R7027:Eif3b UTSW 5 140,411,043 (GRCm39) missense probably damaging 0.99
R7293:Eif3b UTSW 5 140,405,183 (GRCm39) missense probably benign
R7561:Eif3b UTSW 5 140,428,109 (GRCm39) missense probably benign 0.04
R7585:Eif3b UTSW 5 140,425,757 (GRCm39) missense probably damaging 1.00
R8170:Eif3b UTSW 5 140,412,530 (GRCm39) splice site probably null
R8853:Eif3b UTSW 5 140,425,774 (GRCm39) missense probably damaging 0.99
R8864:Eif3b UTSW 5 140,412,287 (GRCm39) missense probably benign 0.16
R8958:Eif3b UTSW 5 140,411,194 (GRCm39) missense probably benign 0.08
R9286:Eif3b UTSW 5 140,411,064 (GRCm39) missense probably benign
Z1177:Eif3b UTSW 5 140,415,883 (GRCm39) missense probably damaging 1.00
Posted On 2013-12-03