Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01540:Gstcd'

90132

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gstcd

Ensembl Gene

ENSMUSG00000028018

Gene Name

glutathione S-transferase, C-terminal domain containing

Synonyms

4933434L15Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01540

Quality Score

Status

Chromosome

Chromosomal Location

132687513-132797794 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 132692175 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Aspartic acid at position 580 (V580D)

Ref Sequence

ENSEMBL: ENSMUSP00000079421 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000029651] [ENSMUST00000080583]

AlphaFold

Q5RL51

Predicted Effect

probably damaging
Transcript: ENSMUST00000029651
AA Change: V580D

PolyPhen 2 Score 0.963 (Sensitivity: 0.78; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000029651
Gene: ENSMUSG00000028018
AA Change: V580D

Domain	Start	End	E-Value	Type
low complexity region	52	62	N/A	INTRINSIC
low complexity region	168	181	N/A	INTRINSIC
low complexity region	195	205	N/A	INTRINSIC
low complexity region	208	229	N/A	INTRINSIC
Pfam:GidB	417	515	9e-9	PFAM
Pfam:Methyltransf_32	424	548	1.1e-15	PFAM
Pfam:MTS	430	508	5.3e-6	PFAM
Pfam:Methyltransf_31	440	571	2.6e-11	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000080583
AA Change: V580D

PolyPhen 2 Score 0.963 (Sensitivity: 0.78; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000079421
Gene: ENSMUSG00000028018
AA Change: V580D

Domain	Start	End	E-Value	Type
low complexity region	52	62	N/A	INTRINSIC
low complexity region	168	181	N/A	INTRINSIC
low complexity region	195	205	N/A	INTRINSIC
low complexity region	208	229	N/A	INTRINSIC
Pfam:GidB	418	516	1.5e-8	PFAM
Pfam:Methyltransf_32	424	548	1.1e-15	PFAM
Pfam:Methyltransf_31	440	569	2.5e-11	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 20 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgrb3	A	G	1: 25,151,252 (GRCm39)		probably null	Het
Ceacam12	T	C	7: 17,805,727 (GRCm39)		probably benign	Het
Cyp2j13	A	T	4: 95,956,959 (GRCm39)		probably benign	Het
Golim4	T	G	3: 75,794,047 (GRCm39)	E538A	possibly damaging	Het
Hspg2	A	G	4: 137,247,017 (GRCm39)	T1115A	probably damaging	Het
Maea	T	C	5: 33,515,910 (GRCm39)	S18P	probably benign	Het
Mertk	T	C	2: 128,625,887 (GRCm39)	L674P	probably damaging	Het
Nol8	A	T	13: 49,815,146 (GRCm39)	Q400L	probably benign	Het
Nt5el	T	C	13: 105,218,761 (GRCm39)	S32P	possibly damaging	Het
Or10a3b	G	T	7: 108,444,887 (GRCm39)	T110N	probably damaging	Het
Or6b2	A	G	1: 92,408,202 (GRCm39)	L47P	probably damaging	Het
Pycard	T	A	7: 127,592,002 (GRCm39)	D113V	probably benign	Het
S100z	G	A	13: 95,613,861 (GRCm39)	T83M	probably damaging	Het
Sacs	A	G	14: 61,429,084 (GRCm39)	D381G	possibly damaging	Het
Spata31h1	A	T	10: 82,120,016 (GRCm39)	H4331Q	possibly damaging	Het
Tbpl2	T	C	2: 23,984,985 (GRCm39)	H53R	probably benign	Het
Tlr6	T	C	5: 65,112,629 (GRCm39)	R93G	probably damaging	Het
Trabd	A	G	15: 88,968,998 (GRCm39)	E172G	probably benign	Het
Vrk3	A	G	7: 44,416,568 (GRCm39)	H277R	probably damaging	Het
Zfp512	T	C	5: 31,630,840 (GRCm39)	V338A	probably damaging	Het

Other mutations in Gstcd

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01800:Gstcd	APN	3	132,790,335 (GRCm39)	critical splice donor site	probably null
IGL02434:Gstcd	APN	3	132,701,963 (GRCm39)	splice site	probably benign
IGL02720:Gstcd	APN	3	132,777,722 (GRCm39)	missense	probably benign	0.00
R0367:Gstcd	UTSW	3	132,692,138 (GRCm39)	splice site	probably benign
R0378:Gstcd	UTSW	3	132,692,169 (GRCm39)	missense	probably damaging	1.00
R0382:Gstcd	UTSW	3	132,692,169 (GRCm39)	missense	probably damaging	1.00
R0465:Gstcd	UTSW	3	132,688,905 (GRCm39)	missense	probably benign	0.04
R1295:Gstcd	UTSW	3	132,711,389 (GRCm39)	missense	probably damaging	1.00
R1861:Gstcd	UTSW	3	132,688,868 (GRCm39)	missense	probably damaging	1.00
R2056:Gstcd	UTSW	3	132,787,814 (GRCm39)	missense	probably benign	0.00
R2331:Gstcd	UTSW	3	132,704,641 (GRCm39)	missense	probably damaging	0.98
R2513:Gstcd	UTSW	3	132,788,082 (GRCm39)	missense	possibly damaging	0.87
R2513:Gstcd	UTSW	3	132,788,081 (GRCm39)	missense	possibly damaging	0.59
R3547:Gstcd	UTSW	3	132,790,599 (GRCm39)	missense	possibly damaging	0.86
R4022:Gstcd	UTSW	3	132,787,829 (GRCm39)	missense	probably damaging	1.00
R4713:Gstcd	UTSW	3	132,688,860 (GRCm39)	missense	probably damaging	1.00
R4877:Gstcd	UTSW	3	132,711,314 (GRCm39)	splice site	probably benign
R5152:Gstcd	UTSW	3	132,790,717 (GRCm39)	missense	possibly damaging	0.95
R5165:Gstcd	UTSW	3	132,790,440 (GRCm39)	missense	probably damaging	0.99
R6106:Gstcd	UTSW	3	132,704,675 (GRCm39)	missense	probably benign	0.02
R6177:Gstcd	UTSW	3	132,787,834 (GRCm39)	missense	probably damaging	1.00
R7100:Gstcd	UTSW	3	132,790,704 (GRCm39)	missense	probably benign	0.01
R7264:Gstcd	UTSW	3	132,790,540 (GRCm39)	missense	probably benign	0.00
R7785:Gstcd	UTSW	3	132,787,868 (GRCm39)	missense	probably damaging	0.99
R7786:Gstcd	UTSW	3	132,787,868 (GRCm39)	missense	probably damaging	0.99
R7972:Gstcd	UTSW	3	132,777,894 (GRCm39)	missense	probably benign	0.10
R7975:Gstcd	UTSW	3	132,777,863 (GRCm39)	missense	probably damaging	1.00
R8029:Gstcd	UTSW	3	132,787,868 (GRCm39)	missense	probably damaging	0.99
R8036:Gstcd	UTSW	3	132,787,868 (GRCm39)	missense	probably damaging	0.99
R8088:Gstcd	UTSW	3	132,787,868 (GRCm39)	missense	probably damaging	0.99
R8716:Gstcd	UTSW	3	132,688,950 (GRCm39)	missense	probably damaging	1.00
R8722:Gstcd	UTSW	3	132,777,822 (GRCm39)	nonsense	probably null
R9276:Gstcd	UTSW	3	132,777,665 (GRCm39)	missense	probably damaging	1.00
R9575:Gstcd	UTSW	3	132,704,708 (GRCm39)	missense	probably damaging	1.00
R9789:Gstcd	UTSW	3	132,790,357 (GRCm39)	missense	probably damaging	1.00

Posted On

2013-12-03