Incidental Mutation 'IGL01547:Tas2r123'
| ID |
90359 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Tas2r123
|
| Ensembl Gene |
ENSMUSG00000057381 |
| Gene Name |
taste receptor, type 2, member 123 |
| Synonyms |
mt2r55, mGR23, STC 9-2, T2R23, Tas2r23 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.055)
|
| Stock # |
IGL01547
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
6 |
| Chromosomal Location |
132824105-132825106 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 132824421 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Isoleucine
at position 106
(T106I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000071615
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000071696]
|
| AlphaFold |
P59528 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000071696
AA Change: T106I
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000071615
Gene: ENSMUSG00000057381
AA Change: T106I
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TAS2R
|
7 |
322 |
4.6e-79 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 22 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700013G24Rik |
G |
A |
4: 137,182,573 (GRCm39) |
G243R |
possibly damaging |
Het |
| Afg3l1 |
T |
C |
8: 124,228,090 (GRCm39) |
V625A |
probably benign |
Het |
| Arhgap39 |
T |
C |
15: 76,622,015 (GRCm39) |
|
probably benign |
Het |
| Bag1 |
A |
G |
4: 40,936,661 (GRCm39) |
C332R |
probably damaging |
Het |
| Bcas2 |
T |
C |
3: 103,079,315 (GRCm39) |
Y49H |
probably damaging |
Het |
| Cacna1b |
C |
A |
2: 24,522,047 (GRCm39) |
|
probably benign |
Het |
| Cdyl |
A |
G |
13: 35,974,145 (GRCm39) |
D53G |
possibly damaging |
Het |
| Csmd3 |
T |
C |
15: 47,747,013 (GRCm39) |
I1322V |
probably benign |
Het |
| Evc2 |
C |
A |
5: 37,550,431 (GRCm39) |
A815E |
probably benign |
Het |
| Gm6309 |
C |
T |
5: 146,105,221 (GRCm39) |
D231N |
probably benign |
Het |
| Mtfr2 |
C |
T |
10: 20,233,345 (GRCm39) |
P305S |
probably damaging |
Het |
| Or14c44 |
A |
G |
7: 86,062,079 (GRCm39) |
N170D |
possibly damaging |
Het |
| Or51k1 |
A |
T |
7: 103,661,867 (GRCm39) |
I14N |
probably benign |
Het |
| Or7d10 |
A |
T |
9: 19,832,197 (GRCm39) |
I231F |
probably benign |
Het |
| Pcdhb1 |
A |
G |
18: 37,400,395 (GRCm39) |
H782R |
probably benign |
Het |
| Polr2a |
A |
G |
11: 69,635,768 (GRCm39) |
S480P |
probably damaging |
Het |
| Scaf11 |
T |
C |
15: 96,316,310 (GRCm39) |
T1085A |
probably benign |
Het |
| Sema6c |
C |
T |
3: 95,079,709 (GRCm39) |
R668C |
probably damaging |
Het |
| Tgm5 |
A |
G |
2: 120,879,683 (GRCm39) |
|
probably benign |
Het |
| Vmn2r23 |
T |
A |
6: 123,681,383 (GRCm39) |
I97N |
possibly damaging |
Het |
| Vmn2r6 |
T |
A |
3: 64,445,525 (GRCm39) |
K644N |
probably damaging |
Het |
| Zfp608 |
A |
G |
18: 55,027,521 (GRCm39) |
|
probably null |
Het |
|
| Other mutations in Tas2r123 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01021:Tas2r123
|
APN |
6 |
132,824,369 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02576:Tas2r123
|
APN |
6 |
132,824,703 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
IGL03303:Tas2r123
|
APN |
6 |
132,824,401 (GRCm39) |
missense |
probably damaging |
1.00 |
|
G1patch:Tas2r123
|
UTSW |
6 |
132,824,801 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0068:Tas2r123
|
UTSW |
6 |
132,824,955 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R0068:Tas2r123
|
UTSW |
6 |
132,824,955 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R0110:Tas2r123
|
UTSW |
6 |
132,824,295 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0364:Tas2r123
|
UTSW |
6 |
132,824,644 (GRCm39) |
missense |
probably benign |
|
|
R0415:Tas2r123
|
UTSW |
6 |
132,824,801 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0469:Tas2r123
|
UTSW |
6 |
132,824,295 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1791:Tas2r123
|
UTSW |
6 |
132,824,528 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1976:Tas2r123
|
UTSW |
6 |
132,824,295 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R2328:Tas2r123
|
UTSW |
6 |
132,824,279 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4282:Tas2r123
|
UTSW |
6 |
132,825,008 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R4283:Tas2r123
|
UTSW |
6 |
132,825,008 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R4939:Tas2r123
|
UTSW |
6 |
132,824,808 (GRCm39) |
missense |
probably benign |
0.32 |
|
R5079:Tas2r123
|
UTSW |
6 |
132,824,681 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5241:Tas2r123
|
UTSW |
6 |
132,824,181 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5288:Tas2r123
|
UTSW |
6 |
132,824,190 (GRCm39) |
missense |
probably benign |
0.17 |
|
R5851:Tas2r123
|
UTSW |
6 |
132,824,271 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6725:Tas2r123
|
UTSW |
6 |
132,824,801 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6895:Tas2r123
|
UTSW |
6 |
132,824,133 (GRCm39) |
missense |
probably benign |
|
|
R7017:Tas2r123
|
UTSW |
6 |
132,824,513 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7183:Tas2r123
|
UTSW |
6 |
132,824,661 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8972:Tas2r123
|
UTSW |
6 |
132,824,333 (GRCm39) |
missense |
probably benign |
0.30 |
|
R9321:Tas2r123
|
UTSW |
6 |
132,825,095 (GRCm39) |
missense |
probably benign |
|
|
| Posted On |
2013-12-03 |
Incidental Mutation