Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01516:Limd2'

90388

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Limd2

Ensembl Gene

ENSMUSG00000040699

Gene Name

LIM domain containing 2

Synonyms

0610025L06Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.108) question?

Stock #

IGL01516

Quality Score

Status

Chromosome

Chromosomal Location

106047080-106051555 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 106049870 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 40 (T40A)

Ref Sequence

ENSEMBL: ENSMUSP00000102488 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000002044] [ENSMUST00000007444] [ENSMUST00000045923] [ENSMUST00000064545] [ENSMUST00000100326] [ENSMUST00000103072] [ENSMUST00000106875]

AlphaFold

Q8BGB5

Predicted Effect

probably benign
Transcript: ENSMUST00000002044

SMART Domains

Protein: ENSMUSP00000002044
Gene: ENSMUSG00000020700

Domain	Start	End	E-Value	Type
PB1	44	123	1.04e-18	SMART
S_TKc	362	622	4.23e-95	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000007444

SMART Domains

Protein: ENSMUSP00000007444
Gene: ENSMUSG00000069631

Domain	Start	End	E-Value	Type
Pfam:Pkinase	69	379	2.4e-37	PFAM
Pfam:Pkinase_Tyr	70	302	2.1e-24	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000045923
AA Change: T40A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000045357
Gene: ENSMUSG00000040699
AA Change: T40A

Domain	Start	End	E-Value	Type
LIM	40	92	3.93e-13	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000064545
AA Change: T40A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000067070
Gene: ENSMUSG00000040699
AA Change: T40A

Domain	Start	End	E-Value	Type
LIM	40	92	3.93e-13	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000100326

SMART Domains

Protein: ENSMUSP00000097900
Gene: ENSMUSG00000075480

Domain	Start	End	E-Value	Type
low complexity region	39	54	N/A	INTRINSIC
low complexity region	61	74	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000103072

SMART Domains

Protein: ENSMUSP00000099361
Gene: ENSMUSG00000069631

Domain	Start	End	E-Value	Type
Pfam:Pkinase	32	342	2.2e-35	PFAM
Pfam:Pkinase_Tyr	33	266	2.5e-24	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000106875
AA Change: T40A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000102488
Gene: ENSMUSG00000040699
AA Change: T40A

Domain	Start	End	E-Value	Type
LIM	40	92	3.93e-13	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000124449

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000122989

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000138094

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 44 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4921517D22Rik	A	G	13: 59,838,548 (GRCm39)	S95P	probably benign	Het
Abca6	T	A	11: 110,109,043 (GRCm39)	H709L	possibly damaging	Het
Bpifb1	A	G	2: 154,060,172 (GRCm39)	Y455C	probably benign	Het
Clk1	G	A	1: 58,453,563 (GRCm39)	T341I	probably damaging	Het
Corin	A	T	5: 72,611,830 (GRCm39)	Y77*	probably null	Het
Cps1	C	T	1: 67,269,443 (GRCm39)	R1481C	probably damaging	Het
Cspg5	A	G	9: 110,075,761 (GRCm39)	K166E	probably benign	Het
Dcxr	A	G	11: 120,616,584 (GRCm39)		probably null	Het
Epha5	C	A	5: 84,534,135 (GRCm39)	L65F	probably damaging	Het
Erbb4	T	A	1: 68,367,404 (GRCm39)	K438*	probably null	Het
Gldc	A	T	19: 30,076,432 (GRCm39)	C1005S	probably damaging	Het
Hs3st5	C	T	10: 36,709,047 (GRCm39)	T194I	probably damaging	Het
Hspa12a	T	A	19: 58,816,108 (GRCm39)	D45V	probably benign	Het
Il1rn	C	T	2: 24,239,551 (GRCm39)	T130I	probably damaging	Het
Klk1b22	G	T	7: 43,765,732 (GRCm39)	C196F	probably damaging	Het
Lamp1	C	T	8: 13,223,863 (GRCm39)	H332Y	probably damaging	Het
Lztr1	G	A	16: 17,340,255 (GRCm39)		probably null	Het
Mbd4	T	C	6: 115,826,491 (GRCm39)	T167A	probably damaging	Het
Mitf	T	A	6: 97,987,351 (GRCm39)		probably null	Het
Mlph	A	G	1: 90,867,112 (GRCm39)	D378G	probably damaging	Het
Mrgprb5	A	T	7: 47,818,132 (GRCm39)	L201Q	probably damaging	Het
Myo5b	A	T	18: 74,760,266 (GRCm39)	I261F	probably damaging	Het
Or8b3b	C	T	9: 38,584,159 (GRCm39)	V207I	probably benign	Het
Or9s23	A	T	1: 92,501,165 (GRCm39)	I91F	probably benign	Het
Paics	T	A	5: 77,104,578 (GRCm39)	L68I	probably damaging	Het
Pramel15	A	G	4: 144,104,337 (GRCm39)	V56A	probably damaging	Het
Prkca	C	T	11: 107,852,428 (GRCm39)	V102M	probably null	Het
Ptpn21	G	A	12: 98,681,448 (GRCm39)	T62I	probably damaging	Het
Ptpre	A	T	7: 135,266,728 (GRCm39)	E212V	probably damaging	Het
Rufy2	A	C	10: 62,847,212 (GRCm39)	K539Q	possibly damaging	Het
Serpinb9d	T	A	13: 33,386,654 (GRCm39)		probably null	Het
Smarcd1	T	C	15: 99,610,094 (GRCm39)	F442L	probably benign	Het
Tas2r115	A	G	6: 132,714,576 (GRCm39)	V125A	probably damaging	Het
Tmem154	C	T	3: 84,591,897 (GRCm39)	H120Y	probably benign	Het
Tnrc6b	A	G	15: 80,786,823 (GRCm39)	K1321E	possibly damaging	Het
Trmt13	A	G	3: 116,383,459 (GRCm39)		probably benign	Het
Tsbp1	A	G	17: 34,668,234 (GRCm39)	D168G	possibly damaging	Het
Vmn1r19	T	C	6: 57,381,857 (GRCm39)	F137L	probably benign	Het
Vmn1r202	T	A	13: 22,685,632 (GRCm39)	T262S	possibly damaging	Het
Vmn2r57	A	G	7: 41,049,370 (GRCm39)	V793A	probably damaging	Het
Wapl	A	G	14: 34,414,038 (GRCm39)	N300S	probably damaging	Het
Xpot	T	A	10: 121,426,127 (GRCm39)		probably null	Het
Zfp784	G	A	7: 5,039,036 (GRCm39)		probably benign	Het
Zfyve26	G	T	12: 79,334,625 (GRCm39)	P131Q	probably benign	Het

Other mutations in Limd2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00551:Limd2	APN	11	106,050,031 (GRCm39)	missense	probably benign
R2088:Limd2	UTSW	11	106,049,568 (GRCm39)	missense	probably damaging	0.99
R4870:Limd2	UTSW	11	106,050,215 (GRCm39)	start codon destroyed	probably null	0.36
R6807:Limd2	UTSW	11	106,049,771 (GRCm39)	missense	probably benign
R6846:Limd2	UTSW	11	106,050,213 (GRCm39)	start codon destroyed	probably null	0.57
R6998:Limd2	UTSW	11	106,049,516 (GRCm39)	missense	probably benign	0.11
R7877:Limd2	UTSW	11	106,050,004 (GRCm39)	missense	probably benign	0.29
R8859:Limd2	UTSW	11	106,049,576 (GRCm39)	missense	probably damaging	1.00

Posted On

2013-12-09