Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01521:Lipo3'

90526

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Lipo3

Ensembl Gene

ENSMUSG00000024766

Gene Name

lipase, member O3

Synonyms

Lipo1

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.054) question?

Stock #

IGL01521

Quality Score

Status

Chromosome

Chromosomal Location

33532560-33568069 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 33763083 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glutamic Acid at position 53 (D53E)

Ref Sequence

ENSEMBL: ENSMUSP00000136249 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000178735]

AlphaFold

Q3UT41

Predicted Effect

probably benign
Transcript: ENSMUST00000148137
AA Change: D56E

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

SMART Domains

Protein: ENSMUSP00000118385
Gene: ENSMUSG00000079342
AA Change: D56E

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:Abhydro_lipase	37	99	2.8e-21	PFAM
Pfam:Hydrolase_4	76	239	4.3e-8	PFAM
Pfam:Abhydrolase_1	80	219	2.2e-17	PFAM
Pfam:Abhydrolase_5	80	233	8.7e-8	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000178735
AA Change: D53E

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000136249
Gene: ENSMUSG00000079342
AA Change: D53E

Domain	Start	End	E-Value	Type
Pfam:Abhydro_lipase	33	95	1.3e-20	PFAM
Pfam:Hydrolase_4	72	231	3.5e-8	PFAM
Pfam:Abhydrolase_5	76	370	3.7e-10	PFAM
Pfam:Abhydrolase_1	76	376	6.8e-21	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 35 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aars1	A	T	8: 111,770,419 (GRCm39)	I406F	possibly damaging	Het
Adgrb2	A	G	4: 129,886,085 (GRCm39)	E75G	probably damaging	Het
Angptl2	T	C	2: 33,136,215 (GRCm39)	Y467H	probably damaging	Het
Arap1	G	T	7: 101,049,812 (GRCm39)		probably null	Het
Arfgap1	G	A	2: 180,613,371 (GRCm39)	C22Y	probably damaging	Het
Artn	G	A	4: 117,784,484 (GRCm39)	P25S	probably damaging	Het
Bicra	G	T	7: 15,723,113 (GRCm39)	Q135K	probably benign	Het
Clpx	T	C	9: 65,226,026 (GRCm39)	V367A	probably damaging	Het
Clstn3	C	T	6: 124,434,990 (GRCm39)	W308*	probably null	Het
Cpb2	T	A	14: 75,495,071 (GRCm39)	V67D	probably damaging	Het
Cyp2c38	A	G	19: 39,449,114 (GRCm39)	Y80H	probably damaging	Het
Dbt	A	G	3: 116,327,032 (GRCm39)	D127G	probably benign	Het
Elp1	T	A	4: 56,771,059 (GRCm39)	E961D	probably benign	Het
Fhod1	G	A	8: 106,057,055 (GRCm39)	A973V	probably benign	Het
Flacc1	T	G	1: 58,709,553 (GRCm39)	K201Q	probably damaging	Het
Focad	A	T	4: 88,328,927 (GRCm39)	*1713C	probably null	Het
Gemin5	A	T	11: 58,025,744 (GRCm39)		probably benign	Het
Gpr22	C	T	12: 31,758,709 (GRCm39)		probably benign	Het
Kif23	T	A	9: 61,827,182 (GRCm39)	T890S	probably damaging	Het
Kmt5b	T	A	19: 3,836,618 (GRCm39)	S52T	possibly damaging	Het
Lrrc14b	G	A	13: 74,511,691 (GRCm39)	R130C	probably damaging	Het
Myt1	T	A	2: 181,467,704 (GRCm39)	I1046K	probably damaging	Het
Napsa	A	T	7: 44,236,061 (GRCm39)	I367F	probably damaging	Het
Or5aq1b	C	T	2: 86,902,077 (GRCm39)	V134I	probably benign	Het
Or8b56	A	T	9: 38,739,185 (GRCm39)	Y66F	probably damaging	Het
Rgcc	T	G	14: 79,538,185 (GRCm39)	S69R	probably damaging	Het
Rin3	T	A	12: 102,335,307 (GRCm39)	I326N	probably benign	Het
Sipa1	C	A	19: 5,711,006 (GRCm39)	M1I	probably null	Het
Sirpb1a	T	A	3: 15,475,561 (GRCm39)	M325L	probably benign	Het
Sult1a1	C	A	7: 126,274,451 (GRCm39)	V71F	possibly damaging	Het
Tgds	G	T	14: 118,350,506 (GRCm39)	P349Q	probably damaging	Het
Tmem63c	T	A	12: 87,115,918 (GRCm39)	H186Q	probably damaging	Het
Trappc9	A	G	15: 72,924,016 (GRCm39)	L242S	probably damaging	Het
Trip12	T	A	1: 84,743,919 (GRCm39)		probably benign	Het
Zfp451	T	C	1: 33,816,412 (GRCm39)		probably null	Het

Other mutations in Lipo3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01697:Lipo3	APN	19	33,536,965 (GRCm39)	missense	probably damaging	1.00
IGL01916:Lipo3	APN	19	33,762,182 (GRCm39)	missense	probably damaging	1.00
IGL02027:Lipo3	APN	19	33,557,919 (GRCm39)	nonsense	probably null
IGL02047:Lipo3	APN	19	33,534,562 (GRCm39)	missense	probably benign	0.00
IGL02586:Lipo3	APN	19	33,559,539 (GRCm39)	missense	possibly damaging	0.95
IGL03005:Lipo3	APN	19	33,763,136 (GRCm39)	missense	possibly damaging	0.65
IGL03111:Lipo3	APN	19	33,559,637 (GRCm39)	missense	probably damaging	0.96
IGL03404:Lipo3	APN	19	33,560,440 (GRCm39)	splice site	probably benign
R0122:Lipo3	UTSW	19	33,600,086 (GRCm39)	intron	probably benign
R0128:Lipo3	UTSW	19	33,534,506 (GRCm39)	critical splice donor site	probably null
R0540:Lipo3	UTSW	19	33,536,967 (GRCm39)	missense	possibly damaging	0.62
R0551:Lipo3	UTSW	19	33,557,951 (GRCm39)	missense	probably damaging	1.00
R0568:Lipo3	UTSW	19	33,559,442 (GRCm39)	splice site	probably benign
R0646:Lipo3	UTSW	19	33,762,169 (GRCm39)	nonsense	probably null
R0669:Lipo3	UTSW	19	33,537,025 (GRCm39)	missense	probably benign	0.05
R1704:Lipo3	UTSW	19	33,757,743 (GRCm39)	missense	possibly damaging	0.87
R1772:Lipo3	UTSW	19	33,764,821 (GRCm39)	missense	probably benign	0.45
R1862:Lipo3	UTSW	19	33,762,092 (GRCm39)	missense	probably damaging	1.00
R1863:Lipo3	UTSW	19	33,762,092 (GRCm39)	missense	probably damaging	1.00
R2911:Lipo3	UTSW	19	33,556,767 (GRCm39)	missense	probably benign	0.00
R3801:Lipo3	UTSW	19	33,762,257 (GRCm39)	missense	probably damaging	0.99
R3802:Lipo3	UTSW	19	33,762,257 (GRCm39)	missense	probably damaging	0.99
R3803:Lipo3	UTSW	19	33,762,257 (GRCm39)	missense	probably damaging	0.99
R3973:Lipo3	UTSW	19	33,535,723 (GRCm39)	missense	probably damaging	1.00
R4020:Lipo3	UTSW	19	33,764,804 (GRCm39)	missense	probably benign	0.00
R4648:Lipo3	UTSW	19	33,760,860 (GRCm39)	missense	probably damaging	1.00
R4660:Lipo3	UTSW	19	33,598,360 (GRCm39)	intron	probably benign
R4775:Lipo3	UTSW	19	33,757,795 (GRCm39)	missense	probably damaging	1.00
R4787:Lipo3	UTSW	19	33,757,749 (GRCm39)	missense	probably benign	0.00
R4820:Lipo3	UTSW	19	33,560,497 (GRCm39)	missense	probably damaging	1.00
R4830:Lipo3	UTSW	19	33,753,987 (GRCm39)	missense	probably damaging	0.99
R4951:Lipo3	UTSW	19	33,759,621 (GRCm39)	missense	probably benign	0.01
R5117:Lipo3	UTSW	19	33,536,952 (GRCm39)	missense	probably benign
R5258:Lipo3	UTSW	19	33,591,243 (GRCm39)	intron	probably benign
R5799:Lipo3	UTSW	19	33,755,093 (GRCm39)	intron	probably benign
R5853:Lipo3	UTSW	19	33,759,630 (GRCm39)	missense	probably benign	0.37
R6235:Lipo3	UTSW	19	33,760,963 (GRCm39)	missense	probably damaging	0.96
R6296:Lipo3	UTSW	19	33,757,737 (GRCm39)	missense	probably benign	0.10
R6383:Lipo3	UTSW	19	33,533,831 (GRCm39)	missense	probably benign	0.02
R6659:Lipo3	UTSW	19	33,533,828 (GRCm39)	missense	possibly damaging	0.55
R6913:Lipo3	UTSW	19	33,757,705 (GRCm39)	missense	probably benign	0.00
R6915:Lipo3	UTSW	19	33,562,293 (GRCm39)	missense	probably damaging	1.00
R7092:Lipo3	UTSW	19	33,591,092 (GRCm39)	splice site	probably null
R7444:Lipo3	UTSW	19	33,535,663 (GRCm39)	critical splice donor site	probably null
R7532:Lipo3	UTSW	19	33,560,464 (GRCm39)	missense	possibly damaging	0.90
R7672:Lipo3	UTSW	19	33,757,785 (GRCm39)	missense	probably benign	0.23
R7796:Lipo3	UTSW	19	33,759,634 (GRCm39)	missense	possibly damaging	0.75
R7945:Lipo3	UTSW	19	33,533,831 (GRCm39)	missense	probably benign	0.02
R8683:Lipo3	UTSW	19	33,759,604 (GRCm39)	missense	probably benign	0.04
R8936:Lipo3	UTSW	19	33,557,880 (GRCm39)	missense	probably damaging	1.00
R9062:Lipo3	UTSW	19	33,757,714 (GRCm39)	missense	probably damaging	1.00
R9086:Lipo3	UTSW	19	33,534,529 (GRCm39)	missense	probably benign	0.44
R9432:Lipo3	UTSW	19	33,533,864 (GRCm39)	missense	probably damaging	1.00
R9615:Lipo3	UTSW	19	33,754,047 (GRCm39)	missense	probably benign	0.02
R9620:Lipo3	UTSW	19	33,559,629 (GRCm39)	nonsense	probably null
Z1176:Lipo3	UTSW	19	33,562,328 (GRCm39)	missense	probably null	0.97

Posted On

2013-12-09