Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01557:Cyp3a25'

90750

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Cyp3a25

Ensembl Gene

ENSMUSG00000029630

Gene Name

cytochrome P450, family 3, subfamily a, polypeptide 25

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.096) question?

Stock #

IGL01557

Quality Score

Status

Chromosome

Chromosomal Location

145914004-145946428 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 145921711 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tryptophan to Arginine at position 408 (W408R)

Ref Sequence

ENSEMBL: ENSMUSP00000065585 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000068317] [ENSMUST00000138870] [ENSMUST00000145062]

AlphaFold

O09158

Predicted Effect

probably damaging
Transcript: ENSMUST00000068317
AA Change: W408R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000065585
Gene: ENSMUSG00000029630
AA Change: W408R

Domain	Start	End	E-Value	Type
Pfam:p450	38	493	9.4e-129	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000138870

SMART Domains

Protein: ENSMUSP00000116077
Gene: ENSMUSG00000029630

Domain	Start	End	E-Value	Type
Pfam:p450	38	126	2e-13	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000145062

SMART Domains

Protein: ENSMUSP00000123615
Gene: ENSMUSG00000029630

Domain	Start	End	E-Value	Type
Pfam:p450	38	148	3.9e-21	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000153808

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 24 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamts19	T	A	18: 59,101,792 (GRCm39)		probably null	Het
Arl9	T	G	5: 77,151,948 (GRCm39)		probably null	Het
Ces3a	C	A	8: 105,784,383 (GRCm39)	T439K	probably damaging	Het
Defb22	T	G	2: 152,327,999 (GRCm39)	D62A	possibly damaging	Het
Dnah17	C	T	11: 117,964,512 (GRCm39)	R2422Q	probably damaging	Het
Ehd3	A	G	17: 74,112,275 (GRCm39)	K13R	probably benign	Het
Fndc1	T	C	17: 7,975,221 (GRCm39)	E1406G	probably damaging	Het
Gak	A	C	5: 108,732,203 (GRCm39)	Y762D	probably damaging	Het
Igf2r	A	G	17: 12,923,522 (GRCm39)	S1187P	possibly damaging	Het
Ighmbp2	T	C	19: 3,331,472 (GRCm39)	E68G	probably benign	Het
Itpr2	T	C	6: 146,060,474 (GRCm39)	T2448A	probably damaging	Het
Lrrk2	T	G	15: 91,584,192 (GRCm39)	C317W	probably damaging	Het
Morc1	T	A	16: 48,319,129 (GRCm39)	S278T	probably damaging	Het
Mrps9	T	C	1: 42,890,510 (GRCm39)	V20A	probably benign	Het
Nutm1	A	T	2: 112,082,163 (GRCm39)	N304K	probably benign	Het
Or14j8	G	A	17: 38,263,742 (GRCm39)	P58S	probably damaging	Het
Pcdhb9	T	C	18: 37,536,100 (GRCm39)	V698A	probably damaging	Het
Pitrm1	C	A	13: 6,602,720 (GRCm39)	D70E	probably benign	Het
Pkhd1	T	C	1: 20,187,203 (GRCm39)	T3702A	possibly damaging	Het
Ppm1h	A	T	10: 122,618,086 (GRCm39)		probably null	Het
Psmg2	G	A	18: 67,786,293 (GRCm39)	V218I	probably benign	Het
Ptpn5	T	C	7: 46,731,636 (GRCm39)	Y411C	probably damaging	Het
Spon2	G	A	5: 33,374,047 (GRCm39)	A112V	probably damaging	Het
Zfp648	T	A	1: 154,080,426 (GRCm39)	V195D	probably benign	Het

Other mutations in Cyp3a25

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00091:Cyp3a25	APN	5	145,938,273 (GRCm39)	nonsense	probably null
IGL00430:Cyp3a25	APN	5	145,930,170 (GRCm39)	missense	probably damaging	1.00
IGL00803:Cyp3a25	APN	5	145,938,253 (GRCm39)	splice site	probably benign
IGL00928:Cyp3a25	APN	5	145,923,764 (GRCm39)	missense	possibly damaging	0.94
IGL01997:Cyp3a25	APN	5	145,931,766 (GRCm39)	missense	possibly damaging	0.92
IGL02140:Cyp3a25	APN	5	145,946,273 (GRCm39)	splice site	probably benign
IGL02267:Cyp3a25	APN	5	145,935,362 (GRCm39)	missense	possibly damaging	0.48
IGL02272:Cyp3a25	APN	5	145,930,075 (GRCm39)	intron	probably benign
IGL02327:Cyp3a25	APN	5	145,923,731 (GRCm39)	missense	possibly damaging	0.50
IGL02411:Cyp3a25	APN	5	145,938,257 (GRCm39)	critical splice donor site	probably benign
IGL02504:Cyp3a25	APN	5	145,930,141 (GRCm39)	missense	probably benign	0.03
IGL02653:Cyp3a25	APN	5	145,939,920 (GRCm39)	missense	possibly damaging	0.95
R0378:Cyp3a25	UTSW	5	145,923,652 (GRCm39)	missense	probably damaging	1.00
R0403:Cyp3a25	UTSW	5	145,935,323 (GRCm39)	missense	probably damaging	1.00
R0685:Cyp3a25	UTSW	5	145,935,356 (GRCm39)	missense	probably damaging	1.00
R0725:Cyp3a25	UTSW	5	145,931,746 (GRCm39)	missense	probably damaging	1.00
R0798:Cyp3a25	UTSW	5	145,928,343 (GRCm39)	missense	probably damaging	0.98
R1061:Cyp3a25	UTSW	5	145,923,643 (GRCm39)	missense	probably benign
R1519:Cyp3a25	UTSW	5	145,938,257 (GRCm39)	critical splice donor site	probably null
R1628:Cyp3a25	UTSW	5	145,938,273 (GRCm39)	nonsense	probably null
R1822:Cyp3a25	UTSW	5	145,921,763 (GRCm39)	missense	probably damaging	1.00
R1824:Cyp3a25	UTSW	5	145,921,763 (GRCm39)	missense	probably damaging	1.00
R1864:Cyp3a25	UTSW	5	145,931,739 (GRCm39)	missense	probably damaging	0.98
R2062:Cyp3a25	UTSW	5	145,923,779 (GRCm39)	splice site	probably benign
R2401:Cyp3a25	UTSW	5	145,923,778 (GRCm39)	critical splice acceptor site	probably null
R2516:Cyp3a25	UTSW	5	145,939,837 (GRCm39)	splice site	probably null
R3080:Cyp3a25	UTSW	5	145,935,341 (GRCm39)	missense	probably benign	0.33
R3236:Cyp3a25	UTSW	5	145,939,938 (GRCm39)	splice site	probably benign
R3694:Cyp3a25	UTSW	5	145,926,786 (GRCm39)	splice site	probably null
R3730:Cyp3a25	UTSW	5	145,939,891 (GRCm39)	missense	probably damaging	1.00
R4112:Cyp3a25	UTSW	5	145,939,841 (GRCm39)	missense	probably benign	0.18
R4258:Cyp3a25	UTSW	5	145,928,248 (GRCm39)	missense	probably damaging	1.00
R4651:Cyp3a25	UTSW	5	145,931,701 (GRCm39)	missense	probably benign	0.01
R4788:Cyp3a25	UTSW	5	145,921,892 (GRCm39)	nonsense	probably null
R4899:Cyp3a25	UTSW	5	145,914,481 (GRCm39)	missense	possibly damaging	0.59
R4926:Cyp3a25	UTSW	5	145,928,266 (GRCm39)	missense	probably damaging	1.00
R4952:Cyp3a25	UTSW	5	145,928,334 (GRCm39)	missense	probably benign	0.01
R5270:Cyp3a25	UTSW	5	145,918,312 (GRCm39)	missense	probably benign	0.36
R5595:Cyp3a25	UTSW	5	145,931,673 (GRCm39)	critical splice donor site	probably null
R5659:Cyp3a25	UTSW	5	145,928,356 (GRCm39)	missense	possibly damaging	0.69
R5787:Cyp3a25	UTSW	5	145,935,313 (GRCm39)	missense	probably benign	0.14
R6307:Cyp3a25	UTSW	5	145,931,766 (GRCm39)	missense	possibly damaging	0.92
R6380:Cyp3a25	UTSW	5	145,935,357 (GRCm39)	missense	probably damaging	0.99
R7055:Cyp3a25	UTSW	5	145,929,801 (GRCm39)	missense	probably benign	0.00
R7140:Cyp3a25	UTSW	5	145,939,855 (GRCm39)	missense	probably benign
R7189:Cyp3a25	UTSW	5	145,939,870 (GRCm39)	missense	probably benign	0.37
R7201:Cyp3a25	UTSW	5	145,939,868 (GRCm39)	missense	probably benign	0.00
R7201:Cyp3a25	UTSW	5	145,928,257 (GRCm39)	missense	probably benign	0.22
R7332:Cyp3a25	UTSW	5	145,929,817 (GRCm39)	missense	probably damaging	1.00
R7404:Cyp3a25	UTSW	5	145,923,635 (GRCm39)	missense	probably damaging	1.00
R7548:Cyp3a25	UTSW	5	145,923,735 (GRCm39)	missense	probably damaging	0.98
R7607:Cyp3a25	UTSW	5	145,921,791 (GRCm39)	missense	possibly damaging	0.87
R8022:Cyp3a25	UTSW	5	145,914,478 (GRCm39)	missense	probably benign	0.33
R8266:Cyp3a25	UTSW	5	145,929,796 (GRCm39)	missense	probably damaging	1.00
R8894:Cyp3a25	UTSW	5	145,931,670 (GRCm39)	splice site	probably benign
R9249:Cyp3a25	UTSW	5	145,928,356 (GRCm39)	missense	possibly damaging	0.69
R9588:Cyp3a25	UTSW	5	145,921,699 (GRCm39)	missense	probably benign
R9691:Cyp3a25	UTSW	5	145,931,732 (GRCm39)	missense	probably benign	0.41
R9694:Cyp3a25	UTSW	5	145,923,685 (GRCm39)	nonsense	probably null

Posted On

2013-12-09