Incidental Mutation 'IGL01558:G0s2'
ID 90773
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol G0s2
Ensembl Gene ENSMUSG00000009633
Gene Name G0/G1 switch gene 2
Synonyms
Accession Numbers
Essential gene? Probably non essential (E-score: 0.123) question?
Stock # IGL01558
Quality Score
Status
Chromosome 1
Chromosomal Location 192954468-192955496 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 192955003 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 27 (Y27C)
Ref Sequence ENSEMBL: ENSMUSP00000009777 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000009777] [ENSMUST00000192322] [ENSMUST00000194677]
AlphaFold Q61585
Predicted Effect probably damaging
Transcript: ENSMUST00000009777
AA Change: Y27C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000009777
Gene: ENSMUSG00000009633
AA Change: Y27C

DomainStartEndE-ValueType
Pfam:G0-G1_switch_2 1 103 1.8e-46 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000192322
SMART Domains Protein: ENSMUSP00000141302
Gene: ENSMUSG00000026639

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
LamNT 20 244 2.9e-80 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000193128
Predicted Effect probably benign
Transcript: ENSMUST00000194677
SMART Domains Protein: ENSMUSP00000142053
Gene: ENSMUSG00000026639

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
LamNT 20 248 7.63e-84 SMART
EGF_Lam 250 310 1.67e-7 SMART
EGF_Lam 313 373 1.14e-9 SMART
EGF_Lam 376 425 5.56e-13 SMART
EGF_Lam 428 475 6.05e-14 SMART
EGF_Lam 478 528 5e-6 SMART
EGF_Lam 531 575 3.01e-9 SMART
low complexity region 662 673 N/A INTRINSIC
low complexity region 727 763 N/A INTRINSIC
coiled coil region 830 879 N/A INTRINSIC
coiled coil region 949 979 N/A INTRINSIC
coiled coil region 1037 1090 N/A INTRINSIC
low complexity region 1116 1126 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygous null mice are lean, glucose tolerant and insulin sensitive, and show reduced liver triglyceride levels, enhanced lipolysis, reduced white fat cell size, resistance to diet-induced obesity and liver steatosis, increased oxygen consumption and thermogenesis, and enhanced cold tolerance. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 21 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aasdh T C 5: 77,036,464 (GRCm39) E359G possibly damaging Het
Agtr1b T C 3: 20,370,424 (GRCm39) T61A probably damaging Het
Casd1 T A 6: 4,624,143 (GRCm39) I312N possibly damaging Het
Cebpz A T 17: 79,242,734 (GRCm39) F307I probably damaging Het
Dhx33 T C 11: 70,890,579 (GRCm39) R207G probably benign Het
Glg1 A T 8: 111,914,362 (GRCm39) M474K probably benign Het
Macf1 T C 4: 123,346,798 (GRCm39) N2490S probably benign Het
Mpdz C A 4: 81,213,767 (GRCm39) E1565* probably null Het
Mthfsl A G 9: 88,570,870 (GRCm39) I126T possibly damaging Het
Nectin4 A G 1: 171,212,257 (GRCm39) D285G probably benign Het
Neurod1 T C 2: 79,284,363 (GRCm39) H340R possibly damaging Het
Nop53 G A 7: 15,679,751 (GRCm39) probably benign Het
Siglec1 A G 2: 130,920,419 (GRCm39) L795P probably damaging Het
Sntg1 A T 1: 8,533,612 (GRCm39) probably benign Het
Stk33 T C 7: 108,940,491 (GRCm39) probably benign Het
Stox1 C T 10: 62,503,651 (GRCm39) V135M probably damaging Het
Sult2a8 C A 7: 14,159,377 (GRCm39) E81* probably null Het
Tdrd6 A G 17: 43,936,659 (GRCm39) V1463A probably damaging Het
Tdrd6 C T 17: 43,935,657 (GRCm39) G1797D probably benign Het
Trmt2b C A X: 133,139,305 (GRCm39) R389I possibly damaging Het
Ttc28 G T 5: 111,431,828 (GRCm39) V1903L probably damaging Het
Other mutations in G0s2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01602:G0s2 APN 1 192,954,964 (GRCm39) missense probably damaging 1.00
IGL01605:G0s2 APN 1 192,954,964 (GRCm39) missense probably damaging 1.00
R5070:G0s2 UTSW 1 192,954,870 (GRCm39) missense probably damaging 0.96
R5638:G0s2 UTSW 1 192,954,859 (GRCm39) missense probably damaging 0.98
R7566:G0s2 UTSW 1 192,955,076 (GRCm39) missense probably benign 0.16
R7838:G0s2 UTSW 1 192,955,081 (GRCm39) start codon destroyed probably null 1.00
Posted On 2013-12-09