Incidental Mutation 'IGL01558:G0s2'
ID |
90773 |
Institutional Source |
Australian Phenomics Network
(link to record)
|
Gene Symbol |
G0s2
|
Ensembl Gene |
ENSMUSG00000009633 |
Gene Name |
G0/G1 switch gene 2 |
Synonyms |
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.123)
|
Stock # |
IGL01558
|
Quality Score |
|
Status
|
|
Chromosome |
1 |
Chromosomal Location |
192954468-192955496 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to C
at 192955003 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Tyrosine to Cysteine
at position 27
(Y27C)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000009777
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000009777]
[ENSMUST00000192322]
[ENSMUST00000194677]
|
AlphaFold |
Q61585 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000009777
AA Change: Y27C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000009777 Gene: ENSMUSG00000009633 AA Change: Y27C
Domain | Start | End | E-Value | Type |
Pfam:G0-G1_switch_2
|
1 |
103 |
1.8e-46 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000192322
|
SMART Domains |
Protein: ENSMUSP00000141302 Gene: ENSMUSG00000026639
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
17 |
N/A |
INTRINSIC |
LamNT
|
20 |
244 |
2.9e-80 |
SMART |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000193128
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000194677
|
SMART Domains |
Protein: ENSMUSP00000142053 Gene: ENSMUSG00000026639
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
17 |
N/A |
INTRINSIC |
LamNT
|
20 |
248 |
7.63e-84 |
SMART |
EGF_Lam
|
250 |
310 |
1.67e-7 |
SMART |
EGF_Lam
|
313 |
373 |
1.14e-9 |
SMART |
EGF_Lam
|
376 |
425 |
5.56e-13 |
SMART |
EGF_Lam
|
428 |
475 |
6.05e-14 |
SMART |
EGF_Lam
|
478 |
528 |
5e-6 |
SMART |
EGF_Lam
|
531 |
575 |
3.01e-9 |
SMART |
low complexity region
|
662 |
673 |
N/A |
INTRINSIC |
low complexity region
|
727 |
763 |
N/A |
INTRINSIC |
coiled coil region
|
830 |
879 |
N/A |
INTRINSIC |
coiled coil region
|
949 |
979 |
N/A |
INTRINSIC |
coiled coil region
|
1037 |
1090 |
N/A |
INTRINSIC |
low complexity region
|
1116 |
1126 |
N/A |
INTRINSIC |
|
Coding Region Coverage |
|
Validation Efficiency |
|
MGI Phenotype |
PHENOTYPE: Homozygous null mice are lean, glucose tolerant and insulin sensitive, and show reduced liver triglyceride levels, enhanced lipolysis, reduced white fat cell size, resistance to diet-induced obesity and liver steatosis, increased oxygen consumption and thermogenesis, and enhanced cold tolerance. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 21 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Aasdh |
T |
C |
5: 77,036,464 (GRCm39) |
E359G |
possibly damaging |
Het |
Agtr1b |
T |
C |
3: 20,370,424 (GRCm39) |
T61A |
probably damaging |
Het |
Casd1 |
T |
A |
6: 4,624,143 (GRCm39) |
I312N |
possibly damaging |
Het |
Cebpz |
A |
T |
17: 79,242,734 (GRCm39) |
F307I |
probably damaging |
Het |
Dhx33 |
T |
C |
11: 70,890,579 (GRCm39) |
R207G |
probably benign |
Het |
Glg1 |
A |
T |
8: 111,914,362 (GRCm39) |
M474K |
probably benign |
Het |
Macf1 |
T |
C |
4: 123,346,798 (GRCm39) |
N2490S |
probably benign |
Het |
Mpdz |
C |
A |
4: 81,213,767 (GRCm39) |
E1565* |
probably null |
Het |
Mthfsl |
A |
G |
9: 88,570,870 (GRCm39) |
I126T |
possibly damaging |
Het |
Nectin4 |
A |
G |
1: 171,212,257 (GRCm39) |
D285G |
probably benign |
Het |
Neurod1 |
T |
C |
2: 79,284,363 (GRCm39) |
H340R |
possibly damaging |
Het |
Nop53 |
G |
A |
7: 15,679,751 (GRCm39) |
|
probably benign |
Het |
Siglec1 |
A |
G |
2: 130,920,419 (GRCm39) |
L795P |
probably damaging |
Het |
Sntg1 |
A |
T |
1: 8,533,612 (GRCm39) |
|
probably benign |
Het |
Stk33 |
T |
C |
7: 108,940,491 (GRCm39) |
|
probably benign |
Het |
Stox1 |
C |
T |
10: 62,503,651 (GRCm39) |
V135M |
probably damaging |
Het |
Sult2a8 |
C |
A |
7: 14,159,377 (GRCm39) |
E81* |
probably null |
Het |
Tdrd6 |
A |
G |
17: 43,936,659 (GRCm39) |
V1463A |
probably damaging |
Het |
Tdrd6 |
C |
T |
17: 43,935,657 (GRCm39) |
G1797D |
probably benign |
Het |
Trmt2b |
C |
A |
X: 133,139,305 (GRCm39) |
R389I |
possibly damaging |
Het |
Ttc28 |
G |
T |
5: 111,431,828 (GRCm39) |
V1903L |
probably damaging |
Het |
|
Other mutations in G0s2 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01602:G0s2
|
APN |
1 |
192,954,964 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01605:G0s2
|
APN |
1 |
192,954,964 (GRCm39) |
missense |
probably damaging |
1.00 |
R5070:G0s2
|
UTSW |
1 |
192,954,870 (GRCm39) |
missense |
probably damaging |
0.96 |
R5638:G0s2
|
UTSW |
1 |
192,954,859 (GRCm39) |
missense |
probably damaging |
0.98 |
R7566:G0s2
|
UTSW |
1 |
192,955,076 (GRCm39) |
missense |
probably benign |
0.16 |
R7838:G0s2
|
UTSW |
1 |
192,955,081 (GRCm39) |
start codon destroyed |
probably null |
1.00 |
|
Posted On |
2013-12-09 |