Incidental Mutation 'IGL01558:Sult2a8'
ID90774
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Sult2a8
Ensembl Gene ENSMUSG00000030378
Gene Namesulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 8
Synonyms2810007J24Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.130) question?
Stock #IGL01558
Quality Score
Status
Chromosome7
Chromosomal Location14410686-14446769 bp(-) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) C to A at 14425452 bp
ZygosityHeterozygous
Amino Acid Change Glutamic Acid to Stop codon at position 81 (E81*)
Ref Sequence ENSEMBL: ENSMUSP00000148036 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000063509] [ENSMUST00000125941] [ENSMUST00000168252] [ENSMUST00000209425] [ENSMUST00000209972] [ENSMUST00000210396] [ENSMUST00000211800]
Predicted Effect probably null
Transcript: ENSMUST00000063509
AA Change: E81*
SMART Domains Protein: ENSMUSP00000066897
Gene: ENSMUSG00000030378
AA Change: E81*

DomainStartEndE-ValueType
Pfam:Sulfotransfer_1 34 275 1.6e-73 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000125941
AA Change: E81*
SMART Domains Protein: ENSMUSP00000116469
Gene: ENSMUSG00000030378
AA Change: E81*

DomainStartEndE-ValueType
Pfam:Sulfotransfer_1 34 189 4e-47 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000168252
AA Change: E81*
SMART Domains Protein: ENSMUSP00000128428
Gene: ENSMUSG00000030378
AA Change: E81*

DomainStartEndE-ValueType
Pfam:Sulfotransfer_1 34 275 1.6e-73 PFAM
Pfam:Sulfotransfer_3 36 205 6.3e-10 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000209425
AA Change: E81*
Predicted Effect probably benign
Transcript: ENSMUST00000209972
Predicted Effect noncoding transcript
Transcript: ENSMUST00000210366
Predicted Effect probably null
Transcript: ENSMUST00000210396
AA Change: E81*
Predicted Effect probably null
Transcript: ENSMUST00000211800
AA Change: E81*
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 21 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aasdh T C 5: 76,888,617 E359G possibly damaging Het
Agtr1b T C 3: 20,316,260 T61A probably damaging Het
Casd1 T A 6: 4,624,143 I312N possibly damaging Het
Cebpz A T 17: 78,935,305 F307I probably damaging Het
Dhx33 T C 11: 70,999,753 R207G probably benign Het
G0s2 T C 1: 193,272,695 Y27C probably damaging Het
Glg1 A T 8: 111,187,730 M474K probably benign Het
Macf1 T C 4: 123,453,005 N2490S probably benign Het
Mpdz C A 4: 81,295,530 E1565* probably null Het
Mthfsl A G 9: 88,688,817 I126T possibly damaging Het
Nectin4 A G 1: 171,384,689 D285G probably benign Het
Neurod1 T C 2: 79,454,019 H340R possibly damaging Het
Nop53 G A 7: 15,945,826 probably benign Het
Siglec1 A G 2: 131,078,499 L795P probably damaging Het
Sntg1 A T 1: 8,463,388 probably benign Het
Stk33 T C 7: 109,341,284 probably benign Het
Stox1 C T 10: 62,667,872 V135M probably damaging Het
Tdrd6 A G 17: 43,625,768 V1463A probably damaging Het
Tdrd6 C T 17: 43,624,766 G1797D probably benign Het
Trmt2b C A X: 134,238,556 R389I possibly damaging Het
Ttc28 G T 5: 111,283,962 V1903L probably damaging Het
Other mutations in Sult2a8
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01904:Sult2a8 APN 7 14425457 missense probably damaging 1.00
IGL02060:Sult2a8 APN 7 14425401 missense probably damaging 1.00
IGL02532:Sult2a8 APN 7 14416258 missense probably benign 0.01
IGL02663:Sult2a8 APN 7 14425443 missense possibly damaging 0.52
IGL02803:Sult2a8 APN 7 14411705 utr 3 prime probably benign
R1070:Sult2a8 UTSW 7 14413773 missense probably damaging 0.99
R1251:Sult2a8 UTSW 7 14425425 nonsense probably null
R1465:Sult2a8 UTSW 7 14416283 missense probably benign 0.00
R1465:Sult2a8 UTSW 7 14416283 missense probably benign 0.00
R1799:Sult2a8 UTSW 7 14423526 missense probably damaging 1.00
R2196:Sult2a8 UTSW 7 14427853 missense probably benign 0.00
R4233:Sult2a8 UTSW 7 14413683 missense probably benign 0.01
R4713:Sult2a8 UTSW 7 14425477 missense probably benign 0.02
R4964:Sult2a8 UTSW 7 14425532 missense probably damaging 0.98
R5114:Sult2a8 UTSW 7 14413659 missense probably benign 0.01
R5330:Sult2a8 UTSW 7 14413754 missense possibly damaging 0.53
R5439:Sult2a8 UTSW 7 14425514 missense probably damaging 1.00
R5662:Sult2a8 UTSW 7 14427840 missense probably benign 0.13
Posted On2013-12-09