Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01563:Trappc8'

90889

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Trappc8

Ensembl Gene

ENSMUSG00000033382

Gene Name

trafficking protein particle complex 8

Synonyms

5033403J15Rik, D030074E01Rik, Trs85

Accession Numbers

Essential gene?

Probably essential (E-score: 0.950) question?

Stock #

IGL01563

Quality Score

Status

Chromosome

Chromosomal Location

20950280-21029150 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 20970103 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Lysine at position 962 (N962K)

Ref Sequence

ENSEMBL: ENSMUSP00000153183 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000025177] [ENSMUST00000225661]

AlphaFold

A0A286YCX6

Predicted Effect

probably benign
Transcript: ENSMUST00000025177
AA Change: N963K

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

SMART Domains

Protein: ENSMUSP00000025177
Gene: ENSMUSG00000033382
AA Change: N963K

Domain	Start	End	E-Value	Type
Pfam:TRAPPC-Trs85	157	604	1e-167	PFAM
low complexity region	769	777	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000225502

Predicted Effect

probably benign
Transcript: ENSMUST00000225661
AA Change: N962K

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)

Coding Region Coverage

Validation Efficiency

Allele List at MGI

All alleles(11) : Gene trapped(11)

Other mutations in this stock

Total: 33 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Alms1	A	G	6: 85,604,965 (GRCm39)	E2205G	probably damaging	Het
Arid2	G	A	15: 96,270,278 (GRCm39)	V1464I	probably damaging	Het
Axin2	A	G	11: 108,814,631 (GRCm39)	Q173R	probably damaging	Het
Best1	A	G	19: 9,964,099 (GRCm39)	F454L	probably benign	Het
CK137956	T	G	4: 127,864,428 (GRCm39)	K67T	possibly damaging	Het
Col14a1	G	A	15: 55,351,337 (GRCm39)	G1555R	unknown	Het
Csad	G	A	15: 102,095,598 (GRCm39)	S153F	probably damaging	Het
Cyp4f40	A	T	17: 32,892,930 (GRCm39)	D315V	probably damaging	Het
Galnt3	G	A	2: 65,928,101 (GRCm39)	A265V	probably damaging	Het
Gm5901	C	A	7: 105,026,722 (GRCm39)	Y163*	probably null	Het
Golga4	A	G	9: 118,356,074 (GRCm39)		probably benign	Het
Greb1l	A	G	18: 10,469,399 (GRCm39)	D138G	probably damaging	Het
Has1	A	T	17: 18,063,924 (GRCm39)		probably benign	Het
Ighv1-42	A	G	12: 114,900,804 (GRCm39)	S94P	probably damaging	Het
Katnb1	T	A	8: 95,824,787 (GRCm39)	L569Q	probably damaging	Het
Nedd1	C	T	10: 92,534,031 (GRCm39)		probably null	Het
Or2b2	A	G	13: 21,887,243 (GRCm39)	E24G	probably benign	Het
Or8c15	T	A	9: 38,120,997 (GRCm39)	I214N	probably damaging	Het
Pdcd4	G	A	19: 53,917,552 (GRCm39)	R463H	probably benign	Het
Psmg2	G	A	18: 67,786,293 (GRCm39)	V218I	probably benign	Het
Ro60	A	G	1: 143,637,120 (GRCm39)	V364A	probably benign	Het
Rps19bp1	A	G	15: 80,145,532 (GRCm39)	M84T	probably benign	Het
Sass6	A	T	3: 116,398,847 (GRCm39)	D43V	probably damaging	Het
Senp6	G	A	9: 80,029,290 (GRCm39)	S551N	probably benign	Het
Sh2d2a	A	G	3: 87,759,432 (GRCm39)	E273G	probably damaging	Het
Slc16a14	T	C	1: 84,889,908 (GRCm39)		probably benign	Het
Smcr8	C	T	11: 60,674,671 (GRCm39)	R816C	possibly damaging	Het
Trpc6	A	G	9: 8,656,604 (GRCm39)	E677G	probably damaging	Het
Ubap2	G	T	4: 41,195,998 (GRCm39)	P961T	probably damaging	Het
Vmn1r23	A	G	6: 57,903,061 (GRCm39)	V239A	possibly damaging	Het
Vps41	T	C	13: 18,966,897 (GRCm39)		probably benign	Het
Vwf	A	T	6: 125,568,128 (GRCm39)	D341V	probably damaging	Het
Zfp618	C	T	4: 62,998,133 (GRCm39)	P45L	probably benign	Het

Other mutations in Trappc8

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01077:Trappc8	APN	18	20,970,035 (GRCm39)	missense	probably benign	0.20
IGL01367:Trappc8	APN	18	20,999,176 (GRCm39)	missense	probably benign	0.01
IGL01537:Trappc8	APN	18	20,968,061 (GRCm39)	missense	probably benign
IGL01982:Trappc8	APN	18	21,007,769 (GRCm39)	splice site	probably benign
IGL02709:Trappc8	APN	18	20,970,235 (GRCm39)	missense	possibly damaging	0.94
IGL03126:Trappc8	APN	18	20,996,652 (GRCm39)	missense	probably damaging	1.00
IGL03290:Trappc8	APN	18	20,953,992 (GRCm39)	missense	probably damaging	1.00
IGL03348:Trappc8	APN	18	20,985,838 (GRCm39)	missense	probably damaging	1.00
hoppa	UTSW	18	20,969,957 (GRCm39)	missense	probably benign	0.05
Lagomorpha	UTSW	18	20,951,247 (GRCm39)	missense	probably benign	0.11
rabbit	UTSW	18	21,007,737 (GRCm39)	missense	probably damaging	1.00
E7848:Trappc8	UTSW	18	20,983,975 (GRCm39)	missense	probably damaging	0.99
R0483:Trappc8	UTSW	18	20,978,658 (GRCm39)	missense	possibly damaging	0.60
R0492:Trappc8	UTSW	18	20,999,243 (GRCm39)	missense	probably benign	0.07
R0506:Trappc8	UTSW	18	20,977,245 (GRCm39)	missense	possibly damaging	0.49
R0610:Trappc8	UTSW	18	20,970,245 (GRCm39)	missense	probably damaging	1.00
R0892:Trappc8	UTSW	18	20,964,665 (GRCm39)	critical splice donor site	probably null
R1561:Trappc8	UTSW	18	20,974,680 (GRCm39)	nonsense	probably null
R1589:Trappc8	UTSW	18	20,996,608 (GRCm39)	missense	probably damaging	1.00
R1700:Trappc8	UTSW	18	20,966,055 (GRCm39)	missense	probably damaging	1.00
R1785:Trappc8	UTSW	18	20,967,997 (GRCm39)	splice site	probably null
R1786:Trappc8	UTSW	18	20,967,997 (GRCm39)	splice site	probably null
R1989:Trappc8	UTSW	18	20,978,708 (GRCm39)	missense	probably benign	0.04
R2181:Trappc8	UTSW	18	20,952,279 (GRCm39)	critical splice donor site	probably null
R2294:Trappc8	UTSW	18	20,999,211 (GRCm39)	nonsense	probably null
R4551:Trappc8	UTSW	18	21,007,729 (GRCm39)	missense	probably benign	0.10
R4594:Trappc8	UTSW	18	20,970,005 (GRCm39)	missense	probably benign
R4631:Trappc8	UTSW	18	21,000,865 (GRCm39)	missense	probably benign	0.22
R4734:Trappc8	UTSW	18	20,974,629 (GRCm39)	nonsense	probably null
R4834:Trappc8	UTSW	18	20,958,122 (GRCm39)	missense	probably damaging	0.99
R5114:Trappc8	UTSW	18	20,977,237 (GRCm39)	missense	probably benign	0.04
R5262:Trappc8	UTSW	18	20,951,247 (GRCm39)	missense	probably benign	0.11
R5384:Trappc8	UTSW	18	20,966,119 (GRCm39)	splice site	probably null
R5476:Trappc8	UTSW	18	20,998,165 (GRCm39)	missense	probably damaging	1.00
R5503:Trappc8	UTSW	18	20,969,957 (GRCm39)	missense	probably benign	0.05
R5577:Trappc8	UTSW	18	20,969,836 (GRCm39)	nonsense	probably null
R5809:Trappc8	UTSW	18	20,951,139 (GRCm39)	missense	probably benign	0.08
R5825:Trappc8	UTSW	18	21,006,977 (GRCm39)	missense	probably damaging	1.00
R5886:Trappc8	UTSW	18	21,007,737 (GRCm39)	missense	probably damaging	1.00
R5936:Trappc8	UTSW	18	21,007,745 (GRCm39)	missense	probably damaging	1.00
R6024:Trappc8	UTSW	18	20,966,066 (GRCm39)	missense	probably damaging	0.98
R6105:Trappc8	UTSW	18	20,979,504 (GRCm39)	critical splice donor site	probably null
R6229:Trappc8	UTSW	18	21,003,802 (GRCm39)	missense	probably benign	0.00
R6376:Trappc8	UTSW	18	20,970,132 (GRCm39)	missense	probably benign	0.07
R6403:Trappc8	UTSW	18	20,999,128 (GRCm39)	missense	probably benign
R6459:Trappc8	UTSW	18	20,969,925 (GRCm39)	missense	probably benign	0.40
R6673:Trappc8	UTSW	18	21,018,314 (GRCm39)	missense	probably benign	0.01
R7041:Trappc8	UTSW	18	21,007,729 (GRCm39)	missense	probably benign	0.10
R7276:Trappc8	UTSW	18	20,951,148 (GRCm39)	missense	probably damaging	0.99
R7341:Trappc8	UTSW	18	20,985,704 (GRCm39)	missense	probably damaging	1.00
R7684:Trappc8	UTSW	18	20,996,559 (GRCm39)	missense	probably benign	0.01
R7702:Trappc8	UTSW	18	20,958,119 (GRCm39)	missense	probably damaging	0.99
R8210:Trappc8	UTSW	18	21,006,938 (GRCm39)	critical splice donor site	probably null
R8958:Trappc8	UTSW	18	21,003,667 (GRCm39)	missense	probably benign	0.02
R9037:Trappc8	UTSW	18	20,961,539 (GRCm39)	missense	probably benign	0.00
R9217:Trappc8	UTSW	18	21,000,822 (GRCm39)	missense	probably benign	0.01
R9246:Trappc8	UTSW	18	20,993,590 (GRCm39)	missense	possibly damaging	0.64
R9623:Trappc8	UTSW	18	20,983,975 (GRCm39)	missense	possibly damaging	0.91
R9766:Trappc8	UTSW	18	20,979,630 (GRCm39)	missense	possibly damaging	0.68
X0065:Trappc8	UTSW	18	20,993,579 (GRCm39)	missense	probably benign	0.03
Z1177:Trappc8	UTSW	18	20,964,720 (GRCm39)	frame shift	probably null

Posted On

2013-12-09