Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01563:Zfp618'

90896

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp618

Ensembl Gene

ENSMUSG00000028358

Gene Name

zinc finger protein 618

Synonyms

Nedd10, 2810040O04Rik, D430033D05Rik, 2810031P15Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.129) question?

Stock #

IGL01563

Quality Score

Status

Chromosome

Chromosomal Location

62883810-63057945 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 62998133 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Proline to Leucine at position 45 (P45L)

Ref Sequence

ENSEMBL: ENSMUSP00000103038 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000030043] [ENSMUST00000064814] [ENSMUST00000107415]

AlphaFold

Q80YY7

Predicted Effect

probably benign
Transcript: ENSMUST00000030043

SMART Domains

Protein: ENSMUSP00000030043
Gene: ENSMUSG00000028358

Domain	Start	End	E-Value	Type
ZnF_C2H2	90	112	5.06e-2	SMART
ZnF_C2H2	131	153	8.81e-2	SMART
ZnF_C2H2	199	221	2.91e-2	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000064814
AA Change: P45L

PolyPhen 2 Score 0.074 (Sensitivity: 0.93; Specificity: 0.85)

SMART Domains

Protein: ENSMUSP00000069275
Gene: ENSMUSG00000028358
AA Change: P45L

Domain	Start	End	E-Value	Type
ZnF_C2H2	114	136	5.06e-2	SMART
ZnF_C2H2	155	177	8.81e-2	SMART
ZnF_C2H2	243	265	2.91e-2	SMART
low complexity region	288	295	N/A	INTRINSIC
ZnF_C2H2	298	320	2.53e-2	SMART
PDB:2BW3\|A	377	690	5e-8	PDB

Predicted Effect

probably benign
Transcript: ENSMUST00000107415
AA Change: P45L

PolyPhen 2 Score 0.377 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000103038
Gene: ENSMUSG00000028358
AA Change: P45L

Domain	Start	End	E-Value	Type
ZnF_C2H2	146	168	5.06e-2	SMART
ZnF_C2H2	187	209	8.81e-2	SMART
ZnF_C2H2	255	277	2.91e-2	SMART
low complexity region	381	388	N/A	INTRINSIC
ZnF_C2H2	391	413	2.53e-2	SMART
PDB:2BW3\|A	479	783	9e-8	PDB

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 33 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Alms1	A	G	6: 85,604,965 (GRCm39)	E2205G	probably damaging	Het
Arid2	G	A	15: 96,270,278 (GRCm39)	V1464I	probably damaging	Het
Axin2	A	G	11: 108,814,631 (GRCm39)	Q173R	probably damaging	Het
Best1	A	G	19: 9,964,099 (GRCm39)	F454L	probably benign	Het
CK137956	T	G	4: 127,864,428 (GRCm39)	K67T	possibly damaging	Het
Col14a1	G	A	15: 55,351,337 (GRCm39)	G1555R	unknown	Het
Csad	G	A	15: 102,095,598 (GRCm39)	S153F	probably damaging	Het
Cyp4f40	A	T	17: 32,892,930 (GRCm39)	D315V	probably damaging	Het
Galnt3	G	A	2: 65,928,101 (GRCm39)	A265V	probably damaging	Het
Gm5901	C	A	7: 105,026,722 (GRCm39)	Y163*	probably null	Het
Golga4	A	G	9: 118,356,074 (GRCm39)		probably benign	Het
Greb1l	A	G	18: 10,469,399 (GRCm39)	D138G	probably damaging	Het
Has1	A	T	17: 18,063,924 (GRCm39)		probably benign	Het
Ighv1-42	A	G	12: 114,900,804 (GRCm39)	S94P	probably damaging	Het
Katnb1	T	A	8: 95,824,787 (GRCm39)	L569Q	probably damaging	Het
Nedd1	C	T	10: 92,534,031 (GRCm39)		probably null	Het
Or2b2	A	G	13: 21,887,243 (GRCm39)	E24G	probably benign	Het
Or8c15	T	A	9: 38,120,997 (GRCm39)	I214N	probably damaging	Het
Pdcd4	G	A	19: 53,917,552 (GRCm39)	R463H	probably benign	Het
Psmg2	G	A	18: 67,786,293 (GRCm39)	V218I	probably benign	Het
Ro60	A	G	1: 143,637,120 (GRCm39)	V364A	probably benign	Het
Rps19bp1	A	G	15: 80,145,532 (GRCm39)	M84T	probably benign	Het
Sass6	A	T	3: 116,398,847 (GRCm39)	D43V	probably damaging	Het
Senp6	G	A	9: 80,029,290 (GRCm39)	S551N	probably benign	Het
Sh2d2a	A	G	3: 87,759,432 (GRCm39)	E273G	probably damaging	Het
Slc16a14	T	C	1: 84,889,908 (GRCm39)		probably benign	Het
Smcr8	C	T	11: 60,674,671 (GRCm39)	R816C	possibly damaging	Het
Trappc8	A	T	18: 20,970,103 (GRCm39)	N962K	probably benign	Het
Trpc6	A	G	9: 8,656,604 (GRCm39)	E677G	probably damaging	Het
Ubap2	G	T	4: 41,195,998 (GRCm39)	P961T	probably damaging	Het
Vmn1r23	A	G	6: 57,903,061 (GRCm39)	V239A	possibly damaging	Het
Vps41	T	C	13: 18,966,897 (GRCm39)		probably benign	Het
Vwf	A	T	6: 125,568,128 (GRCm39)	D341V	probably damaging	Het

Other mutations in Zfp618

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01301:Zfp618	APN	4	63,051,063 (GRCm39)	missense	probably damaging	1.00
IGL01726:Zfp618	APN	4	63,050,872 (GRCm39)	missense	probably damaging	1.00
IGL02139:Zfp618	APN	4	63,051,773 (GRCm39)	missense	probably damaging	1.00
IGL02182:Zfp618	APN	4	63,013,798 (GRCm39)	splice site	probably benign
IGL02533:Zfp618	APN	4	63,007,642 (GRCm39)	missense	probably damaging	1.00
IGL03231:Zfp618	APN	4	63,012,716 (GRCm39)	missense	probably damaging	1.00
IGL03257:Zfp618	APN	4	63,050,908 (GRCm39)	missense	probably damaging	1.00
ANU18:Zfp618	UTSW	4	63,051,063 (GRCm39)	missense	probably damaging	1.00
IGL03014:Zfp618	UTSW	4	62,998,325 (GRCm39)	missense	probably damaging	1.00
R0288:Zfp618	UTSW	4	63,051,171 (GRCm39)	missense	possibly damaging	0.57
R0408:Zfp618	UTSW	4	63,004,809 (GRCm39)	missense	probably damaging	0.97
R0685:Zfp618	UTSW	4	63,052,011 (GRCm39)	missense	probably benign	0.21
R1482:Zfp618	UTSW	4	63,033,685 (GRCm39)	missense	possibly damaging	0.64
R1585:Zfp618	UTSW	4	63,051,175 (GRCm39)	missense	probably damaging	1.00
R1649:Zfp618	UTSW	4	63,013,774 (GRCm39)	missense	probably damaging	1.00
R1744:Zfp618	UTSW	4	63,004,871 (GRCm39)	splice site	probably benign
R1793:Zfp618	UTSW	4	63,051,474 (GRCm39)	missense	probably damaging	0.97
R1952:Zfp618	UTSW	4	63,050,555 (GRCm39)	splice site	probably null
R1996:Zfp618	UTSW	4	63,049,452 (GRCm39)	splice site	probably null
R3792:Zfp618	UTSW	4	63,033,728 (GRCm39)	intron	probably benign
R3803:Zfp618	UTSW	4	63,051,256 (GRCm39)	missense	probably damaging	1.00
R3821:Zfp618	UTSW	4	63,051,801 (GRCm39)	missense	probably benign	0.00
R3838:Zfp618	UTSW	4	63,051,801 (GRCm39)	missense	probably benign	0.00
R4009:Zfp618	UTSW	4	63,051,801 (GRCm39)	missense	probably benign	0.00
R4010:Zfp618	UTSW	4	63,051,801 (GRCm39)	missense	probably benign	0.00
R4565:Zfp618	UTSW	4	63,039,588 (GRCm39)	missense	probably damaging	1.00
R4611:Zfp618	UTSW	4	63,051,216 (GRCm39)	missense	probably damaging	1.00
R5019:Zfp618	UTSW	4	63,021,789 (GRCm39)	missense	probably damaging	1.00
R5154:Zfp618	UTSW	4	63,051,446 (GRCm39)	missense	probably damaging	1.00
R5183:Zfp618	UTSW	4	63,017,519 (GRCm39)	missense	probably benign
R5354:Zfp618	UTSW	4	62,998,265 (GRCm39)	missense	probably damaging	1.00
R5383:Zfp618	UTSW	4	63,013,729 (GRCm39)	missense	probably benign	0.33
R5774:Zfp618	UTSW	4	63,050,799 (GRCm39)	missense	probably damaging	1.00
R5932:Zfp618	UTSW	4	63,036,803 (GRCm39)	nonsense	probably null
R6101:Zfp618	UTSW	4	63,051,478 (GRCm39)	missense	probably benign	0.09
R6105:Zfp618	UTSW	4	63,051,478 (GRCm39)	missense	probably benign	0.09
R6478:Zfp618	UTSW	4	63,050,943 (GRCm39)	missense	probably damaging	1.00
R6598:Zfp618	UTSW	4	63,007,636 (GRCm39)	missense	probably damaging	1.00
R7386:Zfp618	UTSW	4	63,013,622 (GRCm39)	critical splice donor site	probably null
R7666:Zfp618	UTSW	4	63,050,954 (GRCm39)	nonsense	probably null
R7678:Zfp618	UTSW	4	63,004,858 (GRCm39)	missense	probably benign	0.07
R7975:Zfp618	UTSW	4	63,049,352 (GRCm39)	missense	possibly damaging	0.93
R8276:Zfp618	UTSW	4	63,051,193 (GRCm39)	missense	probably damaging	1.00
R8421:Zfp618	UTSW	4	63,051,483 (GRCm39)	missense	probably damaging	1.00
R8988:Zfp618	UTSW	4	63,012,708 (GRCm39)	missense	probably benign	0.09
R9022:Zfp618	UTSW	4	63,012,687 (GRCm39)	missense	probably damaging	1.00
R9150:Zfp618	UTSW	4	63,039,603 (GRCm39)	nonsense	probably null
R9163:Zfp618	UTSW	4	63,051,511 (GRCm39)	missense	probably damaging	1.00
R9364:Zfp618	UTSW	4	63,036,824 (GRCm39)	missense	probably damaging	0.99
R9382:Zfp618	UTSW	4	63,051,258 (GRCm39)	missense	probably damaging	0.97
R9424:Zfp618	UTSW	4	63,051,282 (GRCm39)	missense	probably benign	0.00
R9462:Zfp618	UTSW	4	63,051,510 (GRCm39)	missense	possibly damaging	0.94
R9576:Zfp618	UTSW	4	63,051,282 (GRCm39)	missense	probably benign	0.00
R9587:Zfp618	UTSW	4	63,051,916 (GRCm39)	missense
X0011:Zfp618	UTSW	4	62,998,243 (GRCm39)	missense	probably damaging	0.99
Z1176:Zfp618	UTSW	4	63,051,000 (GRCm39)	missense	probably benign	0.12
Z1176:Zfp618	UTSW	4	63,013,734 (GRCm39)	missense	probably benign	0.29

Posted On

2013-12-09