Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01564:Zmym4'

90931

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zmym4

Ensembl Gene

ENSMUSG00000042446

Gene Name

zinc finger, MYM-type 4

Synonyms

Zfp262, 6330503C17Rik

Accession Numbers

Essential gene?

Possibly essential (E-score: 0.513) question?

Stock #

IGL01564

Quality Score

Status

Chromosome

Chromosomal Location

126755732-126861928 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 126805073 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Valine at position 396 (I396V)

Ref Sequence

ENSEMBL: ENSMUSP00000101714 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000106108]

AlphaFold

A2A791

Predicted Effect

possibly damaging
Transcript: ENSMUST00000106108
AA Change: I396V

PolyPhen 2 Score 0.843 (Sensitivity: 0.83; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000101714
Gene: ENSMUSG00000042446
AA Change: I396V

Domain	Start	End	E-Value	Type
TRASH	341	377	6.53e-4	SMART
TRASH	389	429	7.22e-6	SMART
TRASH	441	479	1.77e0	SMART
TRASH	486	525	4.95e-4	SMART
TRASH	531	569	1.05e-2	SMART
TRASH	579	615	2.82e1	SMART
low complexity region	640	649	N/A	INTRINSIC
TRASH	687	723	8.49e-3	SMART
TRASH	729	764	1.14e-3	SMART
TRASH	772	810	4.48e-2	SMART
TRASH	816	851	2.06e-1	SMART
low complexity region	974	993	N/A	INTRINSIC
low complexity region	1002	1021	N/A	INTRINSIC
Pfam:DUF3504	1357	1527	1.7e-68	PFAM

Predicted Effect

unknown
Transcript: ENSMUST00000135003
AA Change: I144V

SMART Domains

Protein: ENSMUSP00000120813
Gene: ENSMUSG00000042446
AA Change: I144V

Domain	Start	End	E-Value	Type
TRASH	90	126	6.53e-4	SMART
TRASH	138	178	7.22e-6	SMART
TRASH	190	228	1.77e0	SMART
TRASH	235	274	3.05e-4	SMART
low complexity region	300	309	N/A	INTRINSIC
TRASH	347	383	8.49e-3	SMART
TRASH	389	424	1.14e-3	SMART
TRASH	432	470	4.48e-2	SMART
TRASH	476	511	2.06e-1	SMART
low complexity region	634	653	N/A	INTRINSIC
low complexity region	662	681	N/A	INTRINSIC
Pfam:DUF3504	1017	1187	1.5e-68	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000151026

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000152489

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000152952

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 34 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adat3	T	A	10: 80,442,693 (GRCm39)	M177K	probably damaging	Het
Ankrd28	G	T	14: 31,477,724 (GRCm39)	T48K	probably damaging	Het
Capn3	T	C	2: 120,311,189 (GRCm39)	I112T	probably damaging	Het
Clec3a	T	A	8: 115,152,282 (GRCm39)	I96N	probably damaging	Het
Clic4	C	T	4: 134,944,504 (GRCm39)	A224T	probably damaging	Het
Eif2b3	T	C	4: 116,885,739 (GRCm39)	Y94H	probably benign	Het
Ep300	A	T	15: 81,516,665 (GRCm39)		probably benign	Het
Errfi1	C	A	4: 150,951,487 (GRCm39)	T305N	probably damaging	Het
Fam131c	T	A	4: 141,106,984 (GRCm39)		probably null	Het
Fbxo11	G	A	17: 88,310,324 (GRCm39)	T494I	probably benign	Het
Homer2	T	C	7: 81,268,320 (GRCm39)		probably null	Het
Hpf1	C	A	8: 61,343,513 (GRCm39)		probably benign	Het
Hspa1b	T	C	17: 35,176,525 (GRCm39)	N487D	probably benign	Het
Ikbke	C	A	1: 131,185,658 (GRCm39)	A617S	probably benign	Het
Jade1	G	T	3: 41,551,084 (GRCm39)	R174S	possibly damaging	Het
Lcmt1	T	C	7: 123,003,663 (GRCm39)	F139S	probably benign	Het
Lipo2	T	C	19: 33,698,424 (GRCm39)	T318A	probably benign	Het
Lrp1b	C	T	2: 40,567,498 (GRCm39)		probably benign	Het
Lsm14a	T	C	7: 34,088,780 (GRCm39)		probably benign	Het
Mpp2	T	C	11: 101,952,345 (GRCm39)	D393G	probably benign	Het
Nfyb	T	C	10: 82,588,260 (GRCm39)	Y137C	probably damaging	Het
Or10g1	T	C	14: 52,648,299 (GRCm39)	D10G	probably benign	Het
Or5d35	A	T	2: 87,855,648 (GRCm39)	H194L	probably benign	Het
Or5p55	T	C	7: 107,567,198 (GRCm39)	I198T	probably benign	Het
Scn3a	A	C	2: 65,291,790 (GRCm39)	I1652S	probably damaging	Het
Slc33a1	C	T	3: 63,850,768 (GRCm39)	V519I	probably benign	Het
Strada	G	T	11: 106,064,118 (GRCm39)	N66K	probably damaging	Het
Thoc2l	A	T	5: 104,668,529 (GRCm39)	Y1017F	probably benign	Het
Tlr1	T	A	5: 65,083,189 (GRCm39)	I463F	probably damaging	Het
Tnfrsf19	G	T	14: 61,212,058 (GRCm39)	F197L	possibly damaging	Het
Tph1	T	A	7: 46,300,305 (GRCm39)		probably benign	Het
Ttn	A	T	2: 76,646,922 (GRCm39)	L3287H	probably damaging	Het
Vmn2r18	A	T	5: 151,508,633 (GRCm39)	S164T	possibly damaging	Het
Zan	C	T	5: 137,444,995 (GRCm39)	V1755I	unknown	Het

Other mutations in Zmym4

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00537:Zmym4	APN	4	126,783,851 (GRCm39)	missense	probably benign
IGL00845:Zmym4	APN	4	126,794,406 (GRCm39)	missense	probably benign	0.28
IGL01122:Zmym4	APN	4	126,758,045 (GRCm39)	missense	probably damaging	1.00
IGL01374:Zmym4	APN	4	126,762,750 (GRCm39)	missense	probably damaging	1.00
IGL02014:Zmym4	APN	4	126,794,462 (GRCm39)	missense	possibly damaging	0.67
IGL02187:Zmym4	APN	4	126,764,066 (GRCm39)	missense	probably damaging	0.97
IGL02887:Zmym4	APN	4	126,842,268 (GRCm39)	missense	probably damaging	0.96
IGL03371:Zmym4	APN	4	126,808,881 (GRCm39)	missense	possibly damaging	0.90
IGL03400:Zmym4	APN	4	126,816,920 (GRCm39)	missense	probably benign	0.12
arriba	UTSW	4	126,809,415 (GRCm39)	missense	probably damaging	0.97
foreclosed	UTSW	4	126,789,099 (GRCm39)	missense	probably damaging	1.00
Foreshortened	UTSW	4	126,804,729 (GRCm39)	missense	possibly damaging	0.75
levantese	UTSW	4	126,757,961 (GRCm39)	missense	probably damaging	0.99
terminated	UTSW	4	126,819,588 (GRCm39)	missense	probably benign	0.02
BB004:Zmym4	UTSW	4	126,799,170 (GRCm39)	missense	probably benign	0.42
BB014:Zmym4	UTSW	4	126,799,170 (GRCm39)	missense	probably benign	0.42
R0149:Zmym4	UTSW	4	126,804,938 (GRCm39)	missense	probably benign	0.00
R0361:Zmym4	UTSW	4	126,804,938 (GRCm39)	missense	probably benign	0.00
R0423:Zmym4	UTSW	4	126,776,112 (GRCm39)	splice site	probably benign
R0532:Zmym4	UTSW	4	126,792,194 (GRCm39)	nonsense	probably null
R0745:Zmym4	UTSW	4	126,796,496 (GRCm39)	splice site	probably benign
R1183:Zmym4	UTSW	4	126,819,632 (GRCm39)	missense	probably damaging	0.99
R1401:Zmym4	UTSW	4	126,804,962 (GRCm39)	missense	probably benign	0.00
R1446:Zmym4	UTSW	4	126,776,275 (GRCm39)	missense	probably damaging	1.00
R1491:Zmym4	UTSW	4	126,776,105 (GRCm39)	critical splice acceptor site	probably null
R1566:Zmym4	UTSW	4	126,804,940 (GRCm39)	missense	possibly damaging	0.94
R1962:Zmym4	UTSW	4	126,796,463 (GRCm39)	missense	possibly damaging	0.47
R2398:Zmym4	UTSW	4	126,816,929 (GRCm39)	missense	probably damaging	1.00
R2930:Zmym4	UTSW	4	126,819,316 (GRCm39)	missense	probably benign	0.00
R3891:Zmym4	UTSW	4	126,798,269 (GRCm39)	missense	probably benign	0.04
R3892:Zmym4	UTSW	4	126,798,269 (GRCm39)	missense	probably benign	0.04
R4659:Zmym4	UTSW	4	126,842,221 (GRCm39)	splice site	probably null
R4702:Zmym4	UTSW	4	126,816,958 (GRCm39)	missense	probably benign	0.01
R5160:Zmym4	UTSW	4	126,763,977 (GRCm39)	missense	probably damaging	0.97
R5614:Zmym4	UTSW	4	126,804,729 (GRCm39)	missense	possibly damaging	0.75
R5773:Zmym4	UTSW	4	126,799,163 (GRCm39)	missense	possibly damaging	0.52
R6450:Zmym4	UTSW	4	126,789,099 (GRCm39)	missense	probably damaging	1.00
R6741:Zmym4	UTSW	4	126,808,878 (GRCm39)	missense	possibly damaging	0.80
R7023:Zmym4	UTSW	4	126,762,593 (GRCm39)	missense	probably damaging	1.00
R7315:Zmym4	UTSW	4	126,776,385 (GRCm39)	missense	probably benign	0.09
R7468:Zmym4	UTSW	4	126,776,029 (GRCm39)	missense	probably benign	0.40
R7546:Zmym4	UTSW	4	126,757,961 (GRCm39)	missense	probably damaging	0.99
R7609:Zmym4	UTSW	4	126,819,588 (GRCm39)	missense	probably benign	0.02
R7764:Zmym4	UTSW	4	126,819,409 (GRCm39)	missense	probably benign	0.06
R7897:Zmym4	UTSW	4	126,783,332 (GRCm39)	missense	possibly damaging	0.76
R7918:Zmym4	UTSW	4	126,804,797 (GRCm39)	critical splice acceptor site	probably null
R7927:Zmym4	UTSW	4	126,799,170 (GRCm39)	missense	probably benign	0.42
R8129:Zmym4	UTSW	4	126,808,956 (GRCm39)	missense	possibly damaging	0.87
R8240:Zmym4	UTSW	4	126,798,188 (GRCm39)	critical splice donor site	probably null
R8248:Zmym4	UTSW	4	126,799,162 (GRCm39)	missense	possibly damaging	0.56
R8261:Zmym4	UTSW	4	126,798,360 (GRCm39)	missense	probably damaging	1.00
R8313:Zmym4	UTSW	4	126,804,762 (GRCm39)	missense	probably benign	0.19
R8353:Zmym4	UTSW	4	126,800,905 (GRCm39)	missense	possibly damaging	0.46
R8747:Zmym4	UTSW	4	126,787,198 (GRCm39)	missense	probably damaging	1.00
R8787:Zmym4	UTSW	4	126,816,953 (GRCm39)	missense	probably benign	0.41
R8795:Zmym4	UTSW	4	126,799,819 (GRCm39)	missense	probably benign	0.35
R8948:Zmym4	UTSW	4	126,758,060 (GRCm39)	missense	probably damaging	1.00
R9218:Zmym4	UTSW	4	126,809,415 (GRCm39)	missense	probably damaging	0.97
R9233:Zmym4	UTSW	4	126,776,310 (GRCm39)	missense	probably damaging	0.99
R9286:Zmym4	UTSW	4	126,783,812 (GRCm39)	missense	probably damaging	1.00
R9468:Zmym4	UTSW	4	126,800,993 (GRCm39)	missense	probably benign	0.01
R9542:Zmym4	UTSW	4	126,799,164 (GRCm39)	missense	probably benign	0.00
R9756:Zmym4	UTSW	4	126,771,502 (GRCm39)	missense	probably damaging	1.00
R9776:Zmym4	UTSW	4	126,804,942 (GRCm39)	missense	possibly damaging	0.51
U24488:Zmym4	UTSW	4	126,819,453 (GRCm39)	missense	possibly damaging	0.69
Z1177:Zmym4	UTSW	4	126,801,005 (GRCm39)	missense	probably benign	0.00

Posted On

2013-12-09