Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01564:Hpf1'

90944

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Hpf1

Ensembl Gene

ENSMUSG00000038005

Gene Name

histone PARylation factor 1

Synonyms

2700029M09Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01564

Quality Score

Status

Chromosome

Chromosomal Location

61342533-61360615 bp(+) (GRCm39)

Type of Mutation

utr 5 prime

DNA Base Change (assembly)

C to A at 61343513 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000118277 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000037190] [ENSMUST00000136098] [ENSMUST00000146863] [ENSMUST00000149267]

AlphaFold

Q8CFE2

Predicted Effect

probably benign
Transcript: ENSMUST00000037190

SMART Domains

Protein: ENSMUSP00000047235
Gene: ENSMUSG00000038005

Domain	Start	End	E-Value	Type
low complexity region	3	14	N/A	INTRINSIC
Pfam:DUF2228	77	328	7e-117	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000134886

Predicted Effect

probably benign
Transcript: ENSMUST00000136098

SMART Domains

Protein: ENSMUSP00000119448
Gene: ENSMUSG00000038005

Domain	Start	End	E-Value	Type
low complexity region	3	14	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000146863

Predicted Effect

probably benign
Transcript: ENSMUST00000149267

SMART Domains

Protein: ENSMUSP00000118277
Gene: ENSMUSG00000038005

Domain	Start	End	E-Value	Type
low complexity region	3	14	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 34 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adat3	T	A	10: 80,442,693 (GRCm39)	M177K	probably damaging	Het
Ankrd28	G	T	14: 31,477,724 (GRCm39)	T48K	probably damaging	Het
Capn3	T	C	2: 120,311,189 (GRCm39)	I112T	probably damaging	Het
Clec3a	T	A	8: 115,152,282 (GRCm39)	I96N	probably damaging	Het
Clic4	C	T	4: 134,944,504 (GRCm39)	A224T	probably damaging	Het
Eif2b3	T	C	4: 116,885,739 (GRCm39)	Y94H	probably benign	Het
Ep300	A	T	15: 81,516,665 (GRCm39)		probably benign	Het
Errfi1	C	A	4: 150,951,487 (GRCm39)	T305N	probably damaging	Het
Fam131c	T	A	4: 141,106,984 (GRCm39)		probably null	Het
Fbxo11	G	A	17: 88,310,324 (GRCm39)	T494I	probably benign	Het
Homer2	T	C	7: 81,268,320 (GRCm39)		probably null	Het
Hspa1b	T	C	17: 35,176,525 (GRCm39)	N487D	probably benign	Het
Ikbke	C	A	1: 131,185,658 (GRCm39)	A617S	probably benign	Het
Jade1	G	T	3: 41,551,084 (GRCm39)	R174S	possibly damaging	Het
Lcmt1	T	C	7: 123,003,663 (GRCm39)	F139S	probably benign	Het
Lipo2	T	C	19: 33,698,424 (GRCm39)	T318A	probably benign	Het
Lrp1b	C	T	2: 40,567,498 (GRCm39)		probably benign	Het
Lsm14a	T	C	7: 34,088,780 (GRCm39)		probably benign	Het
Mpp2	T	C	11: 101,952,345 (GRCm39)	D393G	probably benign	Het
Nfyb	T	C	10: 82,588,260 (GRCm39)	Y137C	probably damaging	Het
Or10g1	T	C	14: 52,648,299 (GRCm39)	D10G	probably benign	Het
Or5d35	A	T	2: 87,855,648 (GRCm39)	H194L	probably benign	Het
Or5p55	T	C	7: 107,567,198 (GRCm39)	I198T	probably benign	Het
Scn3a	A	C	2: 65,291,790 (GRCm39)	I1652S	probably damaging	Het
Slc33a1	C	T	3: 63,850,768 (GRCm39)	V519I	probably benign	Het
Strada	G	T	11: 106,064,118 (GRCm39)	N66K	probably damaging	Het
Thoc2l	A	T	5: 104,668,529 (GRCm39)	Y1017F	probably benign	Het
Tlr1	T	A	5: 65,083,189 (GRCm39)	I463F	probably damaging	Het
Tnfrsf19	G	T	14: 61,212,058 (GRCm39)	F197L	possibly damaging	Het
Tph1	T	A	7: 46,300,305 (GRCm39)		probably benign	Het
Ttn	A	T	2: 76,646,922 (GRCm39)	L3287H	probably damaging	Het
Vmn2r18	A	T	5: 151,508,633 (GRCm39)	S164T	possibly damaging	Het
Zan	C	T	5: 137,444,995 (GRCm39)	V1755I	unknown	Het
Zmym4	T	C	4: 126,805,073 (GRCm39)	I396V	possibly damaging	Het

Other mutations in Hpf1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00767:Hpf1	APN	8	61,349,836 (GRCm39)	missense	probably benign
IGL00977:Hpf1	APN	8	61,358,753 (GRCm39)	missense	probably benign	0.10
IGL01688:Hpf1	APN	8	61,349,830 (GRCm39)	missense	probably benign
IGL02352:Hpf1	APN	8	61,349,836 (GRCm39)	missense	probably benign
IGL02359:Hpf1	APN	8	61,349,836 (GRCm39)	missense	probably benign
R0571:Hpf1	UTSW	8	61,353,147 (GRCm39)	missense	probably benign	0.02
R1016:Hpf1	UTSW	8	61,348,678 (GRCm39)	missense	possibly damaging	0.95
R1522:Hpf1	UTSW	8	61,349,783 (GRCm39)	missense	probably damaging	0.96
R1806:Hpf1	UTSW	8	61,353,154 (GRCm39)	missense	probably benign	0.01
R4652:Hpf1	UTSW	8	61,346,764 (GRCm39)	missense	possibly damaging	0.48
R4814:Hpf1	UTSW	8	61,346,841 (GRCm39)	missense	probably damaging	1.00
R5268:Hpf1	UTSW	8	61,346,768 (GRCm39)	missense	possibly damaging	0.92
R5645:Hpf1	UTSW	8	61,349,834 (GRCm39)	missense	possibly damaging	0.85
R6221:Hpf1	UTSW	8	61,346,808 (GRCm39)	missense	probably damaging	1.00
R7712:Hpf1	UTSW	8	61,358,613 (GRCm39)	nonsense	probably null
R8742:Hpf1	UTSW	8	61,346,748 (GRCm39)	missense	probably benign	0.00
R9388:Hpf1	UTSW	8	61,353,182 (GRCm39)	missense	probably benign	0.00
R9447:Hpf1	UTSW	8	61,348,618 (GRCm39)	missense	probably damaging	1.00
Z1177:Hpf1	UTSW	8	61,348,669 (GRCm39)	missense	probably damaging	1.00

Posted On

2013-12-09