Incidental Mutation 'IGL01567:Map10'
| ID |
91027 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Map10
|
| Ensembl Gene |
ENSMUSG00000050930 |
| Gene Name |
microtubule-associated protein 10 |
| Synonyms |
4933403G14Rik |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.089)
|
| Stock # |
IGL01567
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
8 |
| Chromosomal Location |
126396557-126400098 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to A
at 126398232 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamine to Lysine
at position 542
(Q542K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000061679
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000053078]
|
| AlphaFold |
Q8BJS7 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000053078
AA Change: Q542K
PolyPhen 2
Score 0.317 (Sensitivity: 0.90; Specificity: 0.89)
|
| SMART Domains |
Protein: ENSMUSP00000061679
Gene: ENSMUSG00000050930
AA Change: Q542K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
38 |
54 |
N/A |
INTRINSIC |
|
low complexity region
|
68 |
91 |
N/A |
INTRINSIC |
|
Pfam:HPHLAWLY
|
243 |
535 |
1.4e-130 |
PFAM |
|
Pfam:HPHLAWLY
|
527 |
890 |
9.1e-133 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 30 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Agbl1 |
A |
G |
7: 76,071,628 (GRCm39) |
S317G |
probably benign |
Het |
| Akna |
T |
C |
4: 63,300,087 (GRCm39) |
T652A |
probably benign |
Het |
| Anxa9 |
G |
A |
3: 95,209,743 (GRCm39) |
|
probably benign |
Het |
| Bpifb4 |
T |
A |
2: 153,789,198 (GRCm39) |
|
probably benign |
Het |
| Bptf |
A |
G |
11: 106,949,600 (GRCm39) |
S2125P |
probably damaging |
Het |
| Capns2 |
C |
A |
8: 93,628,634 (GRCm39) |
H174Q |
probably benign |
Het |
| Cd200 |
A |
C |
16: 45,215,054 (GRCm39) |
L199R |
probably damaging |
Het |
| Clasp2 |
T |
C |
9: 113,709,164 (GRCm39) |
V651A |
probably damaging |
Het |
| Cox18 |
G |
A |
5: 90,365,447 (GRCm39) |
Q251* |
probably null |
Het |
| Depdc1a |
T |
C |
3: 159,232,183 (GRCm39) |
S645P |
probably damaging |
Het |
| Dio3 |
T |
A |
12: 110,245,861 (GRCm39) |
C66S |
possibly damaging |
Het |
| Dock9 |
A |
T |
14: 121,890,496 (GRCm39) |
L258Q |
probably damaging |
Het |
| Ghrhr |
A |
G |
6: 55,361,108 (GRCm39) |
D274G |
probably damaging |
Het |
| Gm5129 |
A |
G |
5: 29,940,862 (GRCm39) |
|
probably benign |
Het |
| Grb7 |
A |
G |
11: 98,345,776 (GRCm39) |
N518S |
probably damaging |
Het |
| Kdm5b |
G |
A |
1: 134,530,278 (GRCm39) |
A430T |
probably damaging |
Het |
| Metap1 |
T |
C |
3: 138,168,150 (GRCm39) |
T325A |
probably damaging |
Het |
| Ncan |
A |
T |
8: 70,560,984 (GRCm39) |
M661K |
probably benign |
Het |
| Or2f1b |
T |
C |
6: 42,739,661 (GRCm39) |
I225T |
probably benign |
Het |
| Or51h5 |
A |
G |
7: 102,577,623 (GRCm39) |
I263V |
probably benign |
Het |
| Otog |
T |
C |
7: 45,926,039 (GRCm39) |
|
probably benign |
Het |
| Pip4k2b |
T |
C |
11: 97,620,387 (GRCm39) |
D116G |
probably damaging |
Het |
| Rps15 |
T |
A |
10: 80,129,643 (GRCm39) |
L86Q |
probably benign |
Het |
| Sfxn4 |
G |
T |
19: 60,842,336 (GRCm39) |
T122K |
probably damaging |
Het |
| Slc4a3 |
T |
C |
1: 75,527,526 (GRCm39) |
V165A |
probably damaging |
Het |
| Spmip7 |
A |
G |
11: 11,465,015 (GRCm39) |
H122R |
possibly damaging |
Het |
| Synm |
A |
G |
7: 67,384,980 (GRCm39) |
V452A |
probably damaging |
Het |
| Tdpoz1 |
T |
C |
3: 93,578,013 (GRCm39) |
H257R |
possibly damaging |
Het |
| Tmem26 |
A |
G |
10: 68,587,061 (GRCm39) |
T170A |
probably damaging |
Het |
| Wdfy4 |
T |
G |
14: 32,873,618 (GRCm39) |
E230D |
probably benign |
Het |
|
| Other mutations in Map10 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00813:Map10
|
APN |
8 |
126,398,671 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02566:Map10
|
APN |
8 |
126,398,494 (GRCm39) |
missense |
probably benign |
|
|
IGL03088:Map10
|
APN |
8 |
126,397,809 (GRCm39) |
missense |
probably benign |
0.14 |
|
debauched
|
UTSW |
8 |
126,397,984 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1083:Map10
|
UTSW |
8 |
126,397,178 (GRCm39) |
nonsense |
probably null |
|
|
R1543:Map10
|
UTSW |
8 |
126,397,611 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3155:Map10
|
UTSW |
8 |
126,398,313 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R4076:Map10
|
UTSW |
8 |
126,398,584 (GRCm39) |
missense |
probably benign |
0.23 |
|
R4559:Map10
|
UTSW |
8 |
126,398,553 (GRCm39) |
missense |
probably benign |
|
|
R4856:Map10
|
UTSW |
8 |
126,397,431 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4886:Map10
|
UTSW |
8 |
126,397,431 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5412:Map10
|
UTSW |
8 |
126,397,724 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6034:Map10
|
UTSW |
8 |
126,399,205 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6034:Map10
|
UTSW |
8 |
126,399,205 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6150:Map10
|
UTSW |
8 |
126,398,328 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6351:Map10
|
UTSW |
8 |
126,397,984 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6466:Map10
|
UTSW |
8 |
126,399,123 (GRCm39) |
nonsense |
probably null |
|
|
R6544:Map10
|
UTSW |
8 |
126,398,113 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6557:Map10
|
UTSW |
8 |
126,396,991 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6821:Map10
|
UTSW |
8 |
126,397,138 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7096:Map10
|
UTSW |
8 |
126,398,662 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7128:Map10
|
UTSW |
8 |
126,398,592 (GRCm39) |
missense |
probably benign |
|
|
R7177:Map10
|
UTSW |
8 |
126,398,584 (GRCm39) |
missense |
probably benign |
0.23 |
|
R7237:Map10
|
UTSW |
8 |
126,397,963 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7814:Map10
|
UTSW |
8 |
126,398,350 (GRCm39) |
missense |
probably benign |
0.14 |
|
R7819:Map10
|
UTSW |
8 |
126,397,260 (GRCm39) |
frame shift |
probably null |
|
|
R8202:Map10
|
UTSW |
8 |
126,397,647 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8812:Map10
|
UTSW |
8 |
126,396,664 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8859:Map10
|
UTSW |
8 |
126,397,291 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8947:Map10
|
UTSW |
8 |
126,397,839 (GRCm39) |
missense |
probably benign |
0.06 |
|
R9178:Map10
|
UTSW |
8 |
126,397,649 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9698:Map10
|
UTSW |
8 |
126,398,723 (GRCm39) |
missense |
probably benign |
0.16 |
|
Z1088:Map10
|
UTSW |
8 |
126,398,670 (GRCm39) |
frame shift |
probably null |
|
|
Z1177:Map10
|
UTSW |
8 |
126,396,809 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2013-12-09 |
Incidental Mutation