Incidental Mutation 'IGL01568:Fcrl2'
ID 91050
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Fcrl2
Ensembl Gene ENSMUSG00000015852
Gene Name Fc receptor like 2
Synonyms Fcrls, IFGP2, 2810439C17Rik, Msr2, Fcrh2, moFcRH2sc
Accession Numbers
Essential gene? Probably non essential (E-score: 0.053) question?
Stock # IGL01568
Quality Score
Status
Chromosome 3
Chromosomal Location 87158318-87171046 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 87163986 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Serine at position 381 (N381S)
Ref Sequence ENSEMBL: ENSMUSP00000088508 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000090986] [ENSMUST00000146512]
AlphaFold Q9EQY5
Predicted Effect probably damaging
Transcript: ENSMUST00000090986
AA Change: N381S

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000088508
Gene: ENSMUSG00000015852
AA Change: N381S

DomainStartEndE-ValueType
IG 23 106 1.32e-3 SMART
IGc2 122 186 2.77e-6 SMART
IGc2 226 291 1.09e-4 SMART
IG 315 396 1e-3 SMART
SR 402 503 7.29e-36 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000146512
SMART Domains Protein: ENSMUSP00000115780
Gene: ENSMUSG00000015852

DomainStartEndE-ValueType
IG 23 106 1.32e-3 SMART
Pfam:Ig_2 111 176 6.1e-6 PFAM
Pfam:Ig_3 111 176 1.4e-4 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Female homozygous mutant mice are larger than controls and show increased mean body weight, total tissue mass, lean body mass and total body fat. Homozygous mutant mice eshow a decreased mean percentage of CD8 cells in the peripheral blood. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akap13 T A 7: 75,258,270 (GRCm39) L298* probably null Het
Capn15 G T 17: 26,184,419 (GRCm39) R21S probably damaging Het
Cbs A G 17: 31,840,488 (GRCm39) L290P possibly damaging Het
Dnah5 T C 15: 28,229,798 (GRCm39) I144T probably benign Het
Dok4 T A 8: 95,593,430 (GRCm39) I119F probably benign Het
Dpp9 T C 17: 56,498,159 (GRCm39) N599S probably benign Het
Ep400 T C 5: 110,867,361 (GRCm39) T984A unknown Het
Fhod3 A G 18: 25,253,219 (GRCm39) I1390V probably benign Het
Gabbr1 A G 17: 37,381,561 (GRCm39) Y775C probably damaging Het
Gimap9 A G 6: 48,654,550 (GRCm39) T46A probably benign Het
Gm3696 T C 14: 18,435,020 (GRCm39) N88S probably benign Het
Gm5277 A G 3: 78,799,743 (GRCm39) noncoding transcript Het
Gpr153 C A 4: 152,366,825 (GRCm39) probably null Het
Hgf A T 5: 16,769,812 (GRCm39) K95N probably damaging Het
Igf2r A G 17: 12,902,872 (GRCm39) S2393P possibly damaging Het
Ikbke C A 1: 131,185,633 (GRCm39) probably null Het
Il17re G T 6: 113,447,013 (GRCm39) R588L probably damaging Het
Itch T C 2: 155,054,382 (GRCm39) probably benign Het
Krt1c T A 15: 101,721,646 (GRCm39) D465V probably damaging Het
Krt28 G T 11: 99,262,243 (GRCm39) P249Q probably damaging Het
Lax1 A T 1: 133,608,038 (GRCm39) D234E probably benign Het
Mtmr3 A G 11: 4,477,861 (GRCm39) I61T probably damaging Het
Naip5 G T 13: 100,353,609 (GRCm39) Q1217K probably benign Het
Nt5dc3 A G 10: 86,669,802 (GRCm39) T466A probably benign Het
Or5bw2 A T 7: 6,573,569 (GRCm39) H193L possibly damaging Het
Or8s2 T C 15: 98,276,787 (GRCm39) D68G probably damaging Het
Pcdhb3 T C 18: 37,435,054 (GRCm39) V340A possibly damaging Het
Pclo C T 5: 14,728,443 (GRCm39) probably benign Het
Piezo2 C T 18: 63,163,463 (GRCm39) V2152I probably benign Het
Pip4k2b A T 11: 97,620,378 (GRCm39) probably null Het
Ptprs G A 17: 56,720,958 (GRCm39) H1432Y probably damaging Het
Rars1 A G 11: 35,716,808 (GRCm39) probably benign Het
Scrn1 A G 6: 54,499,739 (GRCm39) probably benign Het
Sdr42e1 T C 8: 118,390,182 (GRCm39) Y153C probably damaging Het
Slc18a1 A T 8: 69,518,278 (GRCm39) S245R probably damaging Het
Spmip4 A G 6: 50,550,678 (GRCm39) probably benign Het
Tns1 T G 1: 73,992,668 (GRCm39) D670A probably damaging Het
Trim16 T A 11: 62,711,684 (GRCm39) D118E probably benign Het
Trpv1 A G 11: 73,129,269 (GRCm39) D62G probably benign Het
Tyr A G 7: 87,087,156 (GRCm39) L452P probably damaging Het
Ubr4 T C 4: 139,148,684 (GRCm39) C1723R probably damaging Het
Uqcrb G A 13: 67,049,459 (GRCm39) probably benign Het
Vax2 G T 6: 83,688,519 (GRCm39) V81L possibly damaging Het
Zan A G 5: 137,463,106 (GRCm39) V691A unknown Het
Zfp335 A G 2: 164,736,708 (GRCm39) S976P possibly damaging Het
Zfp384 C T 6: 125,001,095 (GRCm39) P56S probably damaging Het
Other mutations in Fcrl2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01959:Fcrl2 APN 3 87,166,939 (GRCm39) missense probably damaging 0.97
IGL02409:Fcrl2 APN 3 87,160,030 (GRCm39) missense probably benign 0.00
IGL02677:Fcrl2 APN 3 87,166,694 (GRCm39) missense probably benign 0.01
IGL02957:Fcrl2 APN 3 87,169,501 (GRCm39) missense possibly damaging 0.59
IGL02974:Fcrl2 APN 3 87,164,704 (GRCm39) missense possibly damaging 0.89
IGL02992:Fcrl2 APN 3 87,166,773 (GRCm39) missense probably damaging 0.99
BB001:Fcrl2 UTSW 3 87,166,840 (GRCm39) missense probably damaging 0.99
BB011:Fcrl2 UTSW 3 87,166,840 (GRCm39) missense probably damaging 0.99
R0052:Fcrl2 UTSW 3 87,164,085 (GRCm39) missense possibly damaging 0.94
R0052:Fcrl2 UTSW 3 87,164,085 (GRCm39) missense possibly damaging 0.94
R0131:Fcrl2 UTSW 3 87,166,266 (GRCm39) missense possibly damaging 0.90
R1171:Fcrl2 UTSW 3 87,164,167 (GRCm39) missense probably benign 0.24
R1319:Fcrl2 UTSW 3 87,169,484 (GRCm39) critical splice donor site probably null
R1522:Fcrl2 UTSW 3 87,164,014 (GRCm39) missense possibly damaging 0.64
R1696:Fcrl2 UTSW 3 87,166,825 (GRCm39) missense possibly damaging 0.95
R1742:Fcrl2 UTSW 3 87,166,350 (GRCm39) missense possibly damaging 0.76
R2156:Fcrl2 UTSW 3 87,164,648 (GRCm39) missense probably benign 0.43
R2255:Fcrl2 UTSW 3 87,164,655 (GRCm39) nonsense probably null
R2257:Fcrl2 UTSW 3 87,166,928 (GRCm39) missense probably damaging 0.99
R2434:Fcrl2 UTSW 3 87,164,005 (GRCm39) missense probably damaging 1.00
R2680:Fcrl2 UTSW 3 87,164,656 (GRCm39) missense probably damaging 0.99
R3552:Fcrl2 UTSW 3 87,166,717 (GRCm39) missense possibly damaging 0.73
R4866:Fcrl2 UTSW 3 87,170,773 (GRCm39) missense possibly damaging 0.65
R4883:Fcrl2 UTSW 3 87,166,922 (GRCm39) missense possibly damaging 0.48
R5654:Fcrl2 UTSW 3 87,164,851 (GRCm39) missense probably benign
R5771:Fcrl2 UTSW 3 87,170,775 (GRCm39) missense probably damaging 0.98
R5917:Fcrl2 UTSW 3 87,164,094 (GRCm39) missense probably damaging 0.99
R6349:Fcrl2 UTSW 3 87,159,803 (GRCm39) missense probably damaging 0.99
R6562:Fcrl2 UTSW 3 87,164,635 (GRCm39) missense probably benign
R6954:Fcrl2 UTSW 3 87,170,983 (GRCm39) critical splice donor site probably benign
R7059:Fcrl2 UTSW 3 87,164,647 (GRCm39) missense possibly damaging 0.82
R7188:Fcrl2 UTSW 3 87,166,830 (GRCm39) missense probably benign 0.13
R7201:Fcrl2 UTSW 3 87,159,934 (GRCm39) missense probably damaging 0.99
R7369:Fcrl2 UTSW 3 87,164,008 (GRCm39) missense possibly damaging 0.59
R7431:Fcrl2 UTSW 3 87,166,233 (GRCm39) missense probably damaging 0.99
R7610:Fcrl2 UTSW 3 87,160,004 (GRCm39) missense probably damaging 1.00
R7924:Fcrl2 UTSW 3 87,166,840 (GRCm39) missense probably damaging 0.99
R8018:Fcrl2 UTSW 3 87,166,933 (GRCm39) nonsense probably null
R8280:Fcrl2 UTSW 3 87,166,364 (GRCm39) nonsense probably null
R8981:Fcrl2 UTSW 3 87,164,677 (GRCm39) missense probably damaging 1.00
R9368:Fcrl2 UTSW 3 87,164,906 (GRCm39) missense possibly damaging 0.59
R9477:Fcrl2 UTSW 3 87,159,803 (GRCm39) missense probably damaging 0.98
R9522:Fcrl2 UTSW 3 87,164,101 (GRCm39) missense possibly damaging 0.95
Posted On 2013-12-09