Incidental Mutation 'IGL01570:Memo1'
ID91126
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Memo1
Ensembl Gene ENSMUSG00000058704
Gene Namemediator of cell motility 1
Synonyms0610016J10Rik, D930048L02Rik
Accession Numbers
Is this an essential gene? Essential (E-score: 1.000) question?
Stock #IGL01570
Quality Score
Status
Chromosome17
Chromosomal Location74200706-74294883 bp(-) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) A to G at 74217108 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000077553 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078459]
Predicted Effect probably benign
Transcript: ENSMUST00000078459
SMART Domains Protein: ENSMUSP00000077553
Gene: ENSMUSG00000058704

DomainStartEndE-ValueType
Pfam:Memo 9 293 3.7e-84 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a floxed allele activated postnatally exhibit a reduced life span, increased insulin sensitivity, small stature, graying hair, alopecia, kyphosis, loss of subcutaneous fat, loss of spermatozoa in the epididymis and increased active vitamin D. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 27 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcf3 T C 16: 20,559,998 S54P probably damaging Het
Adam5 A G 8: 24,810,823 V230A probably damaging Het
Arid4b T A 13: 14,186,809 probably benign Het
Cep250 T G 2: 155,967,663 probably benign Het
Col28a1 T A 6: 8,014,540 D955V probably damaging Het
Gm7676 A G 8: 13,896,311 noncoding transcript Het
Hao1 A G 2: 134,554,200 S45P probably damaging Het
Hars2 A T 18: 36,787,592 I163L probably benign Het
Iqgap1 T C 7: 80,723,061 Y1510C possibly damaging Het
Itga4 G A 2: 79,322,634 probably null Het
Kif18b G A 11: 102,912,391 H498Y probably benign Het
Kin C T 2: 10,091,952 T204M probably benign Het
Lmo7 T C 14: 101,902,371 probably null Het
Ltbp2 G A 12: 84,794,033 T1009I probably benign Het
Mad1l1 A G 5: 140,117,277 S489P probably benign Het
Myocd T A 11: 65,200,807 H103L probably benign Het
Nhlrc2 T A 19: 56,574,787 F273I possibly damaging Het
Olfr385 C A 11: 73,589,383 M118I probably benign Het
Olfr481 A T 7: 108,081,273 T160S probably benign Het
Olfr978 T C 9: 39,994,329 I173T probably damaging Het
Pappa2 A C 1: 158,814,540 Y1315* probably null Het
Pdzk1ip1 C T 4: 115,089,017 P25S possibly damaging Het
Ppp2r5d A T 17: 46,687,917 V73D possibly damaging Het
Psmg2 G A 18: 67,653,223 V218I probably benign Het
Qars C T 9: 108,511,539 T266M probably damaging Het
Slc26a2 A C 18: 61,198,260 C700G possibly damaging Het
Zfp638 C A 6: 83,947,847 A724E probably damaging Het
Other mutations in Memo1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01410:Memo1 APN 17 74241981 nonsense probably null
IGL02709:Memo1 APN 17 74245032 missense probably damaging 1.00
IGL03172:Memo1 APN 17 74245001 missense probably damaging 1.00
R0067:Memo1 UTSW 17 74225458 missense probably damaging 1.00
R1068:Memo1 UTSW 17 74225555 missense probably damaging 1.00
R1962:Memo1 UTSW 17 74245008 missense possibly damaging 0.54
R1964:Memo1 UTSW 17 74245008 missense possibly damaging 0.54
R2029:Memo1 UTSW 17 74245054 missense probably null 0.99
R3236:Memo1 UTSW 17 74202352 missense probably damaging 1.00
R4284:Memo1 UTSW 17 74255298 critical splice acceptor site probably null
R4285:Memo1 UTSW 17 74255298 critical splice acceptor site probably null
R4287:Memo1 UTSW 17 74255298 critical splice acceptor site probably null
R4427:Memo1 UTSW 17 74202307 missense probably benign 0.01
R4583:Memo1 UTSW 17 74258461 nonsense probably null
R4607:Memo1 UTSW 17 74258461 nonsense probably null
R4608:Memo1 UTSW 17 74258461 nonsense probably null
R6118:Memo1 UTSW 17 74202307 missense possibly damaging 0.52
R6769:Memo1 UTSW 17 74201278 missense probably damaging 1.00
R6771:Memo1 UTSW 17 74201278 missense probably damaging 1.00
R7226:Memo1 UTSW 17 74202343 missense probably damaging 1.00
Posted On2013-12-09