Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01574:Ccl7'

91194

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ccl7

Ensembl Gene

ENSMUSG00000035373

Gene Name

C-C motif chemokine ligand 7

Synonyms

mcp3, Scya7, MCP-3, marc, fic

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.067) question?

Stock #

IGL01574

Quality Score

Status

Chromosome

Chromosomal Location

81936538-81938351 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 81937451 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Isoleucine at position 62 (V62I)

Ref Sequence

ENSEMBL: ENSMUSP00000021011 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000021011]

AlphaFold

Q03366

Predicted Effect

probably damaging
Transcript: ENSMUST00000021011
AA Change: V62I

PolyPhen 2 Score 0.974 (Sensitivity: 0.76; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000021011
Gene: ENSMUSG00000035373
AA Change: V62I

Domain	Start	End	E-Value	Type
low complexity region	5	16	N/A	INTRINSIC
SCY	30	88	3.33e-24	SMART

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for a knock-out allele exhibit alterations in blood monocyte counts and in the monocytic response to thioglycollate-induced inflammation. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 29 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ankrd26	T	G	6: 118,516,659 (GRCm39)	T502P	probably damaging	Het
Apoa4	C	A	9: 46,154,283 (GRCm39)	Q295K	probably benign	Het
Asxl3	T	G	18: 22,656,621 (GRCm39)	C1544G	probably benign	Het
Ceacam20	C	A	7: 19,708,247 (GRCm39)	T284K	possibly damaging	Het
Ces4a	A	T	8: 105,871,859 (GRCm39)		probably benign	Het
Col4a2	G	T	8: 11,489,306 (GRCm39)	G1147V	probably damaging	Het
Gtf3c4	T	C	2: 28,724,448 (GRCm39)	D428G	possibly damaging	Het
Itgb2	G	A	10: 77,393,798 (GRCm39)	V413I	possibly damaging	Het
Itgb7	T	G	15: 102,135,975 (GRCm39)	E20A	possibly damaging	Het
Kank2	C	A	9: 21,705,900 (GRCm39)	G373W	probably damaging	Het
Kif1a	T	A	1: 93,010,062 (GRCm39)	I28F	probably damaging	Het
Klhdc7b	T	C	15: 89,271,572 (GRCm39)	V818A	probably benign	Het
Klhl20	T	C	1: 160,921,296 (GRCm39)	Y53C	probably damaging	Het
Matcap2	T	C	9: 22,355,426 (GRCm39)	V487A	possibly damaging	Het
Mroh1	A	G	15: 76,316,488 (GRCm39)	N772S	probably benign	Het
Mtmr4	C	T	11: 87,491,473 (GRCm39)	T146I	probably benign	Het
Nup210	C	T	6: 91,017,546 (GRCm39)	V1152I	probably benign	Het
Pclo	T	A	5: 14,763,462 (GRCm39)	D3978E	unknown	Het
Pkd1l3	T	C	8: 110,350,403 (GRCm39)	L416P	probably benign	Het
Pkn2	T	C	3: 142,544,992 (GRCm39)	M161V	possibly damaging	Het
Plxnb2	T	C	15: 89,046,886 (GRCm39)		probably null	Het
Polr2e	C	A	10: 79,875,467 (GRCm39)	D3Y	probably damaging	Het
Prss27	A	T	17: 24,257,345 (GRCm39)		probably benign	Het
Psmg2	G	A	18: 67,786,293 (GRCm39)	V218I	probably benign	Het
Tmem30c	T	A	16: 57,097,105 (GRCm39)	I152F	possibly damaging	Het
Usp2	G	A	9: 44,005,100 (GRCm39)	R378H	probably damaging	Het
Vmn2r106	A	T	17: 20,488,572 (GRCm39)	I609N	possibly damaging	Het
Vmn2r51	T	A	7: 9,836,381 (GRCm39)	E133D	probably damaging	Het
Zkscan3	A	T	13: 21,578,261 (GRCm39)		probably benign	Het

Other mutations in Ccl7

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00540:Ccl7	APN	11	81,937,888 (GRCm39)	missense	probably damaging	1.00
IGL00819:Ccl7	APN	11	81,937,401 (GRCm39)	missense	probably benign	0.08
IGL03341:Ccl7	APN	11	81,936,661 (GRCm39)	missense	probably benign	0.02
seoraksan	UTSW	11	81,937,412 (GRCm39)	missense	probably damaging	1.00
R0416:Ccl7	UTSW	11	81,936,692 (GRCm39)	splice site	probably benign
R1864:Ccl7	UTSW	11	81,937,378 (GRCm39)	missense	probably benign	0.00
R6161:Ccl7	UTSW	11	81,937,412 (GRCm39)	missense	probably damaging	1.00

Posted On

2013-12-09