Incidental Mutation 'IGL01577:Cyp2j8'
ID 91279
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Cyp2j8
Ensembl Gene ENSMUSG00000082932
Gene Name cytochrome P450, family 2, subfamily j, polypeptide 8
Synonyms OTTMUSG00000007938, Cyp2j8-ps
Accession Numbers
Essential gene? Probably non essential (E-score: 0.055) question?
Stock # IGL01577
Quality Score
Status
Chromosome 4
Chromosomal Location 96332833-96395623 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 96367308 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Alanine at position 270 (D270A)
Ref Sequence ENSEMBL: ENSMUSP00000134591 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000124729]
AlphaFold G3UZ38
Predicted Effect probably damaging
Transcript: ENSMUST00000124729
AA Change: D270A

PolyPhen 2 Score 0.960 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000134591
Gene: ENSMUSG00000082932
AA Change: D270A

DomainStartEndE-ValueType
transmembrane domain 13 35 N/A INTRINSIC
Pfam:p450 44 500 1.2e-134 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actr8 A G 14: 29,709,232 (GRCm39) T279A probably benign Het
Adamts9 T G 6: 92,835,128 (GRCm39) probably benign Het
Apba3 G A 10: 81,108,053 (GRCm39) G403D probably damaging Het
Atp13a4 C T 16: 29,260,102 (GRCm39) V235I possibly damaging Het
Brca2 T A 5: 150,465,085 (GRCm39) C1616* probably null Het
Ccdc7a T A 8: 129,715,244 (GRCm39) E280V probably damaging Het
Cdc42bpb A G 12: 111,268,477 (GRCm39) I1241T possibly damaging Het
Cplx4 G T 18: 66,103,015 (GRCm39) A35E probably damaging Het
Cyp7a1 T C 4: 6,273,618 (GRCm39) D96G probably damaging Het
Ddx11 G A 17: 66,446,398 (GRCm39) R429H possibly damaging Het
Depdc5 C A 5: 33,113,241 (GRCm39) T419N possibly damaging Het
Diaph3 A C 14: 87,143,467 (GRCm39) I737R probably damaging Het
Elf2 C T 3: 51,163,773 (GRCm39) probably benign Het
Epha6 T A 16: 59,777,289 (GRCm39) I673L possibly damaging Het
Ephx1 A G 1: 180,829,545 (GRCm39) M1T probably null Het
Fndc3a A T 14: 72,827,298 (GRCm39) M84K probably damaging Het
Gad2 T C 2: 22,571,292 (GRCm39) probably benign Het
Gba2 G A 4: 43,573,753 (GRCm39) Q180* probably null Het
Gga2 A G 7: 121,589,006 (GRCm39) Y574H probably damaging Het
Gm7168 A T 17: 14,169,649 (GRCm39) R339W probably damaging Het
Hdac10 T C 15: 89,010,416 (GRCm39) E302G possibly damaging Het
Ighv1-72 A G 12: 115,721,893 (GRCm39) V21A possibly damaging Het
Kif15 A G 9: 122,825,399 (GRCm39) E774G probably benign Het
Lig3 A G 11: 82,674,303 (GRCm39) N43S probably benign Het
Nmnat1 T A 4: 149,554,135 (GRCm39) D135V possibly damaging Het
Or1s2 A G 19: 13,758,162 (GRCm39) Y62C probably damaging Het
Or52n2 A G 7: 104,542,730 (GRCm39) F35S probably benign Het
Pak6 A C 2: 118,524,129 (GRCm39) K428T probably benign Het
Pou2f3 G A 9: 43,058,178 (GRCm39) Q56* probably null Het
Prep T C 10: 44,948,144 (GRCm39) probably benign Het
Psd4 C T 2: 24,293,234 (GRCm39) P700S probably damaging Het
Rad18 A T 6: 112,642,302 (GRCm39) probably benign Het
Rbbp5 A G 1: 132,420,393 (GRCm39) K209E possibly damaging Het
Smurf1 G A 5: 144,829,998 (GRCm39) T335I probably damaging Het
Tbcd G A 11: 121,387,838 (GRCm39) R72Q probably damaging Het
Tsga10 T C 1: 37,874,538 (GRCm39) T116A possibly damaging Het
Unc80 A G 1: 66,569,127 (GRCm39) probably null Het
Vmn1r87 C A 7: 12,865,775 (GRCm39) V171F probably benign Het
Ythdc2 A T 18: 44,991,349 (GRCm39) M786L probably benign Het
Zmym6 C A 4: 126,999,223 (GRCm39) T469K probably damaging Het
Other mutations in Cyp2j8
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00088:Cyp2j8 APN 4 96,392,079 (GRCm39) missense probably benign 0.06
IGL00418:Cyp2j8 APN 4 96,332,853 (GRCm39) missense possibly damaging 0.85
IGL01629:Cyp2j8 APN 4 96,387,840 (GRCm39) missense probably damaging 1.00
IGL01928:Cyp2j8 APN 4 96,358,713 (GRCm39) splice site probably benign
IGL01978:Cyp2j8 APN 4 96,392,246 (GRCm39) splice site probably null
IGL02053:Cyp2j8 APN 4 96,358,891 (GRCm39) missense probably damaging 1.00
IGL02500:Cyp2j8 APN 4 96,358,887 (GRCm39) missense probably damaging 1.00
IGL02947:Cyp2j8 APN 4 96,358,815 (GRCm39) missense probably damaging 1.00
cyprus UTSW 4 96,387,840 (GRCm39) missense probably damaging 1.00
R0558:Cyp2j8 UTSW 4 96,332,871 (GRCm39) missense probably benign 0.01
R0718:Cyp2j8 UTSW 4 96,389,433 (GRCm39) missense probably benign
R1553:Cyp2j8 UTSW 4 96,363,794 (GRCm39) missense probably benign
R1557:Cyp2j8 UTSW 4 96,358,713 (GRCm39) splice site probably benign
R1632:Cyp2j8 UTSW 4 96,335,561 (GRCm39) missense probably benign 0.02
R1708:Cyp2j8 UTSW 4 96,387,832 (GRCm39) missense probably damaging 1.00
R2119:Cyp2j8 UTSW 4 96,395,438 (GRCm39) missense probably benign
R2220:Cyp2j8 UTSW 4 96,332,862 (GRCm39) missense probably benign 0.03
R3123:Cyp2j8 UTSW 4 96,389,450 (GRCm39) splice site probably benign
R3735:Cyp2j8 UTSW 4 96,332,836 (GRCm39) missense probably damaging 1.00
R3736:Cyp2j8 UTSW 4 96,332,836 (GRCm39) missense probably damaging 1.00
R4326:Cyp2j8 UTSW 4 96,395,566 (GRCm39) missense probably benign 0.10
R4327:Cyp2j8 UTSW 4 96,395,566 (GRCm39) missense probably benign 0.10
R4762:Cyp2j8 UTSW 4 96,358,886 (GRCm39) missense probably damaging 1.00
R4901:Cyp2j8 UTSW 4 96,367,323 (GRCm39) missense probably benign 0.16
R4960:Cyp2j8 UTSW 4 96,395,614 (GRCm39) missense probably benign
R5260:Cyp2j8 UTSW 4 96,389,301 (GRCm39) missense possibly damaging 0.65
R5562:Cyp2j8 UTSW 4 96,358,890 (GRCm39) missense probably damaging 1.00
R5596:Cyp2j8 UTSW 4 96,395,578 (GRCm39) missense probably benign 0.00
R5741:Cyp2j8 UTSW 4 96,332,880 (GRCm39) missense probably benign 0.00
R5825:Cyp2j8 UTSW 4 96,395,451 (GRCm39) missense probably benign 0.01
R5903:Cyp2j8 UTSW 4 96,395,514 (GRCm39) missense possibly damaging 0.46
R6122:Cyp2j8 UTSW 4 96,332,877 (GRCm39) missense probably benign
R6232:Cyp2j8 UTSW 4 96,395,427 (GRCm39) missense possibly damaging 0.94
R6748:Cyp2j8 UTSW 4 96,363,782 (GRCm39) missense probably benign 0.01
R6931:Cyp2j8 UTSW 4 96,333,018 (GRCm39) splice site probably null
R7000:Cyp2j8 UTSW 4 96,335,588 (GRCm39) missense probably benign 0.06
R7183:Cyp2j8 UTSW 4 96,367,418 (GRCm39) missense probably damaging 0.97
R7186:Cyp2j8 UTSW 4 96,363,787 (GRCm39) missense probably benign 0.00
R7348:Cyp2j8 UTSW 4 96,332,877 (GRCm39) missense probably benign 0.00
R7575:Cyp2j8 UTSW 4 96,358,785 (GRCm39) missense possibly damaging 0.63
R7648:Cyp2j8 UTSW 4 96,387,840 (GRCm39) missense probably damaging 1.00
R7975:Cyp2j8 UTSW 4 96,358,776 (GRCm39) missense possibly damaging 0.65
R7993:Cyp2j8 UTSW 4 96,335,456 (GRCm39) critical splice donor site probably null
R8878:Cyp2j8 UTSW 4 96,358,807 (GRCm39) missense possibly damaging 0.56
Posted On 2013-12-09