Incidental Mutation 'IGL01580:Or10ag2'
ID 91352
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or10ag2
Ensembl Gene ENSMUSG00000043274
Gene Name olfactory receptor family 10 subfamily AG member 2
Synonyms Olfr1123, MOR264-17, GA_x6K02T2Q125-48917235-48918206
Accession Numbers
Essential gene? Probably non essential (E-score: 0.244) question?
Stock # IGL01580
Quality Score
Status
Chromosome 2
Chromosomal Location 87248394-87249365 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 87248880 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 163 (I163F)
Ref Sequence ENSEMBL: ENSMUSP00000058786 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000054974] [ENSMUST00000216208]
AlphaFold A2AT85
Predicted Effect probably benign
Transcript: ENSMUST00000054974
AA Change: I163F

PolyPhen 2 Score 0.064 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000058786
Gene: ENSMUSG00000043274
AA Change: I163F

DomainStartEndE-ValueType
Pfam:7tm_4 44 321 4.4e-52 PFAM
Pfam:7tm_1 54 303 2.6e-21 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213950
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214663
Predicted Effect probably benign
Transcript: ENSMUST00000216208
AA Change: I161F

PolyPhen 2 Score 0.051 (Sensitivity: 0.94; Specificity: 0.83)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 19 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 G A 11: 9,243,527 (GRCm39) V1797I probably benign Het
Abi3bp A G 16: 56,495,573 (GRCm39) E865G probably damaging Het
Ahnak A G 19: 8,980,203 (GRCm39) T496A probably benign Het
BC030500 T C 8: 59,366,054 (GRCm39) probably benign Het
Col6a4 A C 9: 105,945,397 (GRCm39) Y906D probably damaging Het
Dip2c T G 13: 9,687,124 (GRCm39) probably null Het
Frem2 A G 3: 53,562,596 (GRCm39) I637T probably damaging Het
Guf1 T C 5: 69,722,764 (GRCm39) probably benign Het
Htr1f G A 16: 64,746,198 (GRCm39) R365* probably null Het
Oog4 T C 4: 143,165,682 (GRCm39) N155S probably benign Het
Or52x1 T C 7: 104,853,113 (GRCm39) I146V probably benign Het
Phactr3 C A 2: 177,911,297 (GRCm39) probably benign Het
Pi4k2b T C 5: 52,912,003 (GRCm39) V300A possibly damaging Het
Pik3c2g A G 6: 139,599,514 (GRCm39) D210G probably damaging Het
Pxdn A G 12: 30,034,492 (GRCm39) T182A probably benign Het
Scn10a A G 9: 119,456,225 (GRCm39) V1199A probably damaging Het
Scrn2 A G 11: 96,922,956 (GRCm39) H133R probably benign Het
Shq1 G A 6: 100,550,705 (GRCm39) S411L possibly damaging Het
Tmcc1 A C 6: 116,019,946 (GRCm39) V462G possibly damaging Het
Other mutations in Or10ag2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00231:Or10ag2 APN 2 87,248,910 (GRCm39) missense possibly damaging 0.75
IGL01067:Or10ag2 APN 2 87,248,714 (GRCm39) missense probably benign 0.00
IGL01526:Or10ag2 APN 2 87,249,319 (GRCm39) missense probably damaging 0.99
IGL01986:Or10ag2 APN 2 87,248,880 (GRCm39) missense probably benign 0.00
IGL02503:Or10ag2 APN 2 87,248,636 (GRCm39) missense probably benign 0.03
IGL02527:Or10ag2 APN 2 87,249,181 (GRCm39) missense probably damaging 1.00
IGL02731:Or10ag2 APN 2 87,249,051 (GRCm39) missense probably benign 0.00
IGL03215:Or10ag2 APN 2 87,248,412 (GRCm39) missense probably benign 0.05
IGL03366:Or10ag2 APN 2 87,248,587 (GRCm39) missense possibly damaging 0.88
R0645:Or10ag2 UTSW 2 87,248,612 (GRCm39) nonsense probably null
R1857:Or10ag2 UTSW 2 87,248,992 (GRCm39) missense probably damaging 1.00
R2175:Or10ag2 UTSW 2 87,248,500 (GRCm39) missense probably damaging 1.00
R3691:Or10ag2 UTSW 2 87,248,514 (GRCm39) missense probably benign 0.20
R4082:Or10ag2 UTSW 2 87,248,801 (GRCm39) nonsense probably null
R4635:Or10ag2 UTSW 2 87,249,043 (GRCm39) missense probably benign 0.05
R4877:Or10ag2 UTSW 2 87,248,907 (GRCm39) nonsense probably null
R5190:Or10ag2 UTSW 2 87,249,187 (GRCm39) missense probably damaging 1.00
R5253:Or10ag2 UTSW 2 87,249,012 (GRCm39) missense possibly damaging 0.64
R6266:Or10ag2 UTSW 2 87,249,350 (GRCm39) missense probably benign 0.01
R6784:Or10ag2 UTSW 2 87,248,796 (GRCm39) missense probably benign 0.20
R6909:Or10ag2 UTSW 2 87,248,959 (GRCm39) missense probably damaging 1.00
R7255:Or10ag2 UTSW 2 87,249,286 (GRCm39) missense probably damaging 0.96
R8076:Or10ag2 UTSW 2 87,248,889 (GRCm39) missense probably benign 0.00
R8116:Or10ag2 UTSW 2 87,249,081 (GRCm39) missense probably damaging 1.00
R8315:Or10ag2 UTSW 2 87,248,995 (GRCm39) missense probably damaging 1.00
R8888:Or10ag2 UTSW 2 87,248,659 (GRCm39) missense probably benign 0.00
R8895:Or10ag2 UTSW 2 87,248,659 (GRCm39) missense probably benign 0.00
Posted On 2013-12-09