Incidental Mutation 'IGL01592:Wnt8a'
ID 91617
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Wnt8a
Ensembl Gene ENSMUSG00000012282
Gene Name wingless-type MMTV integration site family, member 8A
Synonyms Stra11
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01592
Quality Score
Status
Chromosome 18
Chromosomal Location 34675380-34681114 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 34677846 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 85 (T85A)
Ref Sequence ENSEMBL: ENSMUSP00000012426 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000012426]
AlphaFold Q64527
Predicted Effect probably damaging
Transcript: ENSMUST00000012426
AA Change: T85A

PolyPhen 2 Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000012426
Gene: ENSMUSG00000012282
AA Change: T85A

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
WNT1 21 337 2.26e-155 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and may be implicated in development of early embryos as well as germ cell tumors. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2014]
PHENOTYPE: Mice homozygous for a knock-out allele are viable and fertile. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 28 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akap6 A G 12: 53,188,925 (GRCm39) D2113G probably damaging Het
Atf6b T A 17: 34,868,111 (GRCm39) V125E probably damaging Het
Cdan1 T A 2: 120,556,466 (GRCm39) Y653F probably damaging Het
Ces1d A G 8: 93,921,717 (GRCm39) probably benign Het
Dnah2 G T 11: 69,321,913 (GRCm39) N3802K probably benign Het
Dnah5 A G 15: 28,236,783 (GRCm39) I370V probably benign Het
Dpp10 T C 1: 123,262,099 (GRCm39) E761G probably damaging Het
Dusp19 A G 2: 80,447,825 (GRCm39) E33G probably damaging Het
E2f7 T A 10: 110,582,267 (GRCm39) D25E possibly damaging Het
E2f8 T C 7: 48,517,605 (GRCm39) T733A probably damaging Het
Golga1 T C 2: 38,953,294 (GRCm39) E32G probably damaging Het
Grip1 T A 10: 119,765,908 (GRCm39) V80E probably damaging Het
Igsf6 T C 7: 120,670,016 (GRCm39) Y42C probably damaging Het
Katna1 T G 10: 7,617,218 (GRCm39) M70R probably damaging Het
Limk2 T C 11: 3,309,052 (GRCm39) K102R probably benign Het
Lypla1 T A 1: 4,898,874 (GRCm39) probably null Het
Or2z9 T A 8: 72,854,356 (GRCm39) F251I probably damaging Het
Or6c69b A G 10: 129,627,188 (GRCm39) I90T probably damaging Het
Pgap1 G A 1: 54,560,470 (GRCm39) P444L probably damaging Het
Pigr G A 1: 130,776,795 (GRCm39) V657M probably damaging Het
Plscr1 T A 9: 92,148,803 (GRCm39) Y214* probably null Het
Polq A C 16: 36,855,212 (GRCm39) I436L probably benign Het
Ppfia2 T A 10: 106,671,909 (GRCm39) probably benign Het
Serpina12 A G 12: 104,004,381 (GRCm39) S84P probably damaging Het
Slc30a6 T A 17: 74,726,523 (GRCm39) probably benign Het
Trim38 A G 13: 23,975,410 (GRCm39) T450A possibly damaging Het
Ubqlnl A T 7: 103,799,496 (GRCm39) probably benign Het
Vmn2r24 A G 6: 123,764,445 (GRCm39) K441E probably benign Het
Other mutations in Wnt8a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01823:Wnt8a APN 18 34,677,846 (GRCm39) missense possibly damaging 0.85
IGL02964:Wnt8a APN 18 34,675,474 (GRCm39) missense possibly damaging 0.86
PIT4486001:Wnt8a UTSW 18 34,680,636 (GRCm39) missense probably damaging 1.00
R0496:Wnt8a UTSW 18 34,677,900 (GRCm39) missense probably damaging 1.00
R0646:Wnt8a UTSW 18 34,680,618 (GRCm39) missense probably benign 0.02
R1813:Wnt8a UTSW 18 34,675,422 (GRCm39) start codon destroyed probably null 0.89
R1990:Wnt8a UTSW 18 34,677,937 (GRCm39) missense probably damaging 1.00
R1991:Wnt8a UTSW 18 34,677,937 (GRCm39) missense probably damaging 1.00
R1992:Wnt8a UTSW 18 34,677,937 (GRCm39) missense probably damaging 1.00
R4927:Wnt8a UTSW 18 34,680,525 (GRCm39) missense probably damaging 1.00
R5085:Wnt8a UTSW 18 34,678,656 (GRCm39) nonsense probably null
R6161:Wnt8a UTSW 18 34,678,599 (GRCm39) missense possibly damaging 0.86
R7719:Wnt8a UTSW 18 34,680,588 (GRCm39) missense probably damaging 1.00
R8001:Wnt8a UTSW 18 34,678,569 (GRCm39) missense probably damaging 0.98
R9022:Wnt8a UTSW 18 34,680,298 (GRCm39) missense probably damaging 1.00
R9617:Wnt8a UTSW 18 34,680,163 (GRCm39) missense probably benign 0.00
Posted On 2013-12-09