Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01593:Tmem101'

91652

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tmem101

Ensembl Gene

ENSMUSG00000020921

Gene Name

transmembrane protein 101

Synonyms

2610511E22Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.163) question?

Stock #

IGL01593

Quality Score

Status

Chromosome

Chromosomal Location

102043372-102047230 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 102046704 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Glutamine at position 55 (L55Q)

Ref Sequence

ENSEMBL: ENSMUSP00000021296 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000021296]

AlphaFold

Q91VP7

Predicted Effect

probably damaging
Transcript: ENSMUST00000021296
AA Change: L55Q

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000021296
Gene: ENSMUSG00000020921
AA Change: L55Q

Domain	Start	End	E-Value	Type
Pfam:TMEM101	8	256	9.9e-122	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000136434

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000143986

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 32 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcc12	A	T	8: 87,284,279 (GRCm39)	I310N	probably damaging	Het
Abtb3	T	A	10: 85,490,339 (GRCm39)		probably benign	Het
Ackr4	C	T	9: 103,963,130 (GRCm39)		probably benign	Het
Ankib1	A	T	5: 3,782,590 (GRCm39)	D346E	probably benign	Het
Asap2	G	T	12: 21,263,203 (GRCm39)	A273S	probably null	Het
Atp6v0d2	C	A	4: 19,881,436 (GRCm39)	R219L	probably damaging	Het
Atp6v1e2	A	T	17: 87,251,727 (GRCm39)	F224I	probably damaging	Het
Bnc2	T	C	4: 84,194,478 (GRCm39)		probably null	Het
Cd33	A	G	7: 43,179,705 (GRCm39)	L241P	possibly damaging	Het
Clec4g	A	T	8: 3,769,474 (GRCm39)		probably null	Het
Dym	C	T	18: 75,247,852 (GRCm39)		probably benign	Het
Enpp5	A	G	17: 44,391,612 (GRCm39)	T14A	probably benign	Het
Ggt1	T	C	10: 75,421,121 (GRCm39)		probably null	Het
Gm17541	T	A	12: 4,739,868 (GRCm39)		probably benign	Het
Gpr39	A	T	1: 125,605,188 (GRCm39)	I39F	probably benign	Het
Kcnb1	G	T	2: 166,948,127 (GRCm39)	F240L	probably damaging	Het
Kcnt1	T	A	2: 25,788,766 (GRCm39)	V400E	probably damaging	Het
Klhdc7a	A	G	4: 139,694,125 (GRCm39)	I274T	probably damaging	Het
Lrwd1	A	T	5: 136,163,483 (GRCm39)	L71Q	probably damaging	Het
Mycbp2	A	T	14: 103,528,723 (GRCm39)		probably null	Het
Nckap1	A	T	2: 80,350,914 (GRCm39)	M725K	probably benign	Het
Odad2	T	C	18: 7,127,345 (GRCm39)	K956R	probably benign	Het
Or2b7	T	A	13: 21,739,389 (GRCm39)	I268F	probably damaging	Het
Pole2	C	T	12: 69,269,873 (GRCm39)		probably null	Het
Prss32	A	G	17: 24,074,982 (GRCm39)	T111A	probably benign	Het
Rgs9	A	G	11: 109,139,875 (GRCm39)		probably benign	Het
Slc2a4	A	G	11: 69,835,654 (GRCm39)	C361R	probably damaging	Het
Ston1	G	A	17: 88,944,438 (GRCm39)	G615R	probably null	Het
Tas2r139	T	G	6: 42,117,891 (GRCm39)	W8G	probably benign	Het
Tnni3k	T	C	3: 154,646,666 (GRCm39)		probably null	Het
Uba2	A	G	7: 33,845,689 (GRCm39)	V478A	probably damaging	Het
Vps13a	T	C	19: 16,739,545 (GRCm39)	D52G	probably damaging	Het

Other mutations in Tmem101

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01085:Tmem101	APN	11	102,045,486 (GRCm39)	missense	probably damaging	0.99
IGL01096:Tmem101	APN	11	102,045,378 (GRCm39)	splice site	probably null
IGL01814:Tmem101	APN	11	102,044,284 (GRCm39)	missense	possibly damaging	0.58
IGL02451:Tmem101	APN	11	102,044,119 (GRCm39)	missense	probably damaging	1.00
IGL03238:Tmem101	APN	11	102,046,611 (GRCm39)	missense	probably damaging	1.00
R0462:Tmem101	UTSW	11	102,046,693 (GRCm39)	missense	probably benign	0.08
R0848:Tmem101	UTSW	11	102,046,692 (GRCm39)	missense	possibly damaging	0.65
R1465:Tmem101	UTSW	11	102,044,155 (GRCm39)	missense	probably damaging	0.97
R1465:Tmem101	UTSW	11	102,044,155 (GRCm39)	missense	probably damaging	0.97
R1722:Tmem101	UTSW	11	102,045,519 (GRCm39)	missense	probably damaging	1.00
R1928:Tmem101	UTSW	11	102,044,222 (GRCm39)	missense	probably benign
R2082:Tmem101	UTSW	11	102,044,203 (GRCm39)	missense	probably benign	0.17
R4577:Tmem101	UTSW	11	102,046,663 (GRCm39)	missense	possibly damaging	0.48
R4724:Tmem101	UTSW	11	102,044,269 (GRCm39)	missense	probably benign	0.32
R4729:Tmem101	UTSW	11	102,047,155 (GRCm39)	missense	probably benign	0.25
R5146:Tmem101	UTSW	11	102,045,450 (GRCm39)	missense	probably benign
R5184:Tmem101	UTSW	11	102,047,059 (GRCm39)	missense	possibly damaging	0.78
R7381:Tmem101	UTSW	11	102,044,176 (GRCm39)	missense	possibly damaging	0.91
R8799:Tmem101	UTSW	11	102,044,336 (GRCm39)	missense	probably benign	0.08
R9612:Tmem101	UTSW	11	102,044,194 (GRCm39)	missense	probably damaging	1.00

Posted On

2013-12-09