Incidental Mutation 'IGL01593:Clec4g'
ID 91668
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Clec4g
Ensembl Gene ENSMUSG00000074491
Gene Name C-type lectin domain family 4, member g
Synonyms 4930572L20Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01593
Quality Score
Status
Chromosome 8
Chromosomal Location 3757064-3770651 bp(-) (GRCm39)
Type of Mutation critical splice donor site (2 bp from exon)
DNA Base Change (assembly) A to T at 3769474 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000059574 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000058040] [ENSMUST00000062037]
AlphaFold Q8BNX1
Predicted Effect probably benign
Transcript: ENSMUST00000058040
Predicted Effect probably null
Transcript: ENSMUST00000062037
SMART Domains Protein: ENSMUSP00000059574
Gene: ENSMUSG00000074491

DomainStartEndE-ValueType
transmembrane domain 31 53 N/A INTRINSIC
coiled coil region 98 153 N/A INTRINSIC
CLECT 165 288 8.85e-35 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000159612
Predicted Effect noncoding transcript
Transcript: ENSMUST00000160490
Predicted Effect probably benign
Transcript: ENSMUST00000160527
SMART Domains Protein: ENSMUSP00000124493
Gene: ENSMUSG00000074491

DomainStartEndE-ValueType
CLECT 2 97 7.75e-8 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a glycan-binding receptor and member of the C-type lectin family which plays a role in the T-cell immune response. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased intrahepatic T cell immunity, enhanced immune-mediated liver injury during Con A-induced experimental acute hepatitis, and accelerated CTL-dependent adenovirus clearance. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc12 A T 8: 87,284,279 (GRCm39) I310N probably damaging Het
Abtb3 T A 10: 85,490,339 (GRCm39) probably benign Het
Ackr4 C T 9: 103,963,130 (GRCm39) probably benign Het
Ankib1 A T 5: 3,782,590 (GRCm39) D346E probably benign Het
Asap2 G T 12: 21,263,203 (GRCm39) A273S probably null Het
Atp6v0d2 C A 4: 19,881,436 (GRCm39) R219L probably damaging Het
Atp6v1e2 A T 17: 87,251,727 (GRCm39) F224I probably damaging Het
Bnc2 T C 4: 84,194,478 (GRCm39) probably null Het
Cd33 A G 7: 43,179,705 (GRCm39) L241P possibly damaging Het
Dym C T 18: 75,247,852 (GRCm39) probably benign Het
Enpp5 A G 17: 44,391,612 (GRCm39) T14A probably benign Het
Ggt1 T C 10: 75,421,121 (GRCm39) probably null Het
Gm17541 T A 12: 4,739,868 (GRCm39) probably benign Het
Gpr39 A T 1: 125,605,188 (GRCm39) I39F probably benign Het
Kcnb1 G T 2: 166,948,127 (GRCm39) F240L probably damaging Het
Kcnt1 T A 2: 25,788,766 (GRCm39) V400E probably damaging Het
Klhdc7a A G 4: 139,694,125 (GRCm39) I274T probably damaging Het
Lrwd1 A T 5: 136,163,483 (GRCm39) L71Q probably damaging Het
Mycbp2 A T 14: 103,528,723 (GRCm39) probably null Het
Nckap1 A T 2: 80,350,914 (GRCm39) M725K probably benign Het
Odad2 T C 18: 7,127,345 (GRCm39) K956R probably benign Het
Or2b7 T A 13: 21,739,389 (GRCm39) I268F probably damaging Het
Pole2 C T 12: 69,269,873 (GRCm39) probably null Het
Prss32 A G 17: 24,074,982 (GRCm39) T111A probably benign Het
Rgs9 A G 11: 109,139,875 (GRCm39) probably benign Het
Slc2a4 A G 11: 69,835,654 (GRCm39) C361R probably damaging Het
Ston1 G A 17: 88,944,438 (GRCm39) G615R probably null Het
Tas2r139 T G 6: 42,117,891 (GRCm39) W8G probably benign Het
Tmem101 A T 11: 102,046,704 (GRCm39) L55Q probably damaging Het
Tnni3k T C 3: 154,646,666 (GRCm39) probably null Het
Uba2 A G 7: 33,845,689 (GRCm39) V478A probably damaging Het
Vps13a T C 19: 16,739,545 (GRCm39) D52G probably damaging Het
Other mutations in Clec4g
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00566:Clec4g APN 8 3,766,410 (GRCm39) intron probably benign
IGL01090:Clec4g APN 8 3,769,482 (GRCm39) missense probably damaging 1.00
IGL01331:Clec4g APN 8 3,767,190 (GRCm39) splice site probably benign
IGL02942:Clec4g APN 8 3,768,356 (GRCm39) missense probably damaging 0.96
IGL03176:Clec4g APN 8 3,768,441 (GRCm39) missense possibly damaging 0.90
bluedog UTSW 8 3,768,766 (GRCm39) critical splice donor site probably null
R0071:Clec4g UTSW 8 3,767,489 (GRCm39) start gained probably benign
R0379:Clec4g UTSW 8 3,768,440 (GRCm39) missense probably benign 0.00
R4571:Clec4g UTSW 8 3,768,766 (GRCm39) critical splice donor site probably null
R4854:Clec4g UTSW 8 3,766,534 (GRCm39) missense probably damaging 1.00
R4856:Clec4g UTSW 8 3,766,419 (GRCm39) intron probably benign
R4886:Clec4g UTSW 8 3,766,419 (GRCm39) intron probably benign
R5370:Clec4g UTSW 8 3,768,344 (GRCm39) missense probably benign 0.13
R5390:Clec4g UTSW 8 3,768,441 (GRCm39) missense probably benign 0.02
R6522:Clec4g UTSW 8 3,768,803 (GRCm39) missense probably benign 0.11
R6737:Clec4g UTSW 8 3,757,716 (GRCm39) utr 3 prime probably benign
R7097:Clec4g UTSW 8 3,769,518 (GRCm39) missense possibly damaging 0.58
R7834:Clec4g UTSW 8 3,766,500 (GRCm39) missense probably damaging 1.00
R8372:Clec4g UTSW 8 3,757,990 (GRCm39) utr 3 prime probably benign
R9297:Clec4g UTSW 8 3,766,500 (GRCm39) missense probably damaging 1.00
R9312:Clec4g UTSW 8 3,768,371 (GRCm39) missense probably null 1.00
R9318:Clec4g UTSW 8 3,766,500 (GRCm39) missense probably damaging 1.00
R9517:Clec4g UTSW 8 3,767,452 (GRCm39) missense probably damaging 0.98
R9526:Clec4g UTSW 8 3,768,565 (GRCm39) missense probably benign 0.33
R9682:Clec4g UTSW 8 3,757,713 (GRCm39) missense unknown
Z1088:Clec4g UTSW 8 3,766,548 (GRCm39) missense probably damaging 1.00
Z1088:Clec4g UTSW 8 3,757,796 (GRCm39) utr 3 prime probably benign
Posted On 2013-12-09