Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01586:Ank1'

91801

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ank1

Ensembl Gene

ENSMUSG00000031543

Gene Name

ankyrin 1, erythroid

Synonyms

Ank-1, pale

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.447) question?

Stock #

IGL01586

Quality Score

Status

Chromosome

Chromosomal Location

23464860-23640513 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 23610928 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 1411 (D1411G)

Ref Sequence

ENSEMBL: ENSMUSP00000133322 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000084038] [ENSMUST00000110688] [ENSMUST00000117270] [ENSMUST00000117296] [ENSMUST00000117662] [ENSMUST00000118733] [ENSMUST00000121802] [ENSMUST00000152511] [ENSMUST00000141784] [ENSMUST00000173248] [ENSMUST00000123418] [ENSMUST00000173573]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000084038
AA Change: D1411G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000081051
Gene: ENSMUSG00000031543
AA Change: D1411G

Domain	Start	End	E-Value	Type
ANK	15	44	2.5e3	SMART
ANK	48	77	3.26e0	SMART
ANK	81	110	3.15e-7	SMART
ANK	114	143	9.05e-8	SMART
ANK	147	175	4.67e-1	SMART
ANK	176	205	1.42e0	SMART
ANK	209	238	4.39e-6	SMART
ANK	242	271	1.33e-5	SMART
ANK	275	304	7.53e-5	SMART
ANK	308	337	2.35e-6	SMART
ANK	341	370	6.65e-6	SMART
ANK	374	403	5.2e-8	SMART
ANK	407	436	8.78e-6	SMART
ANK	440	469	7.53e-5	SMART
ANK	473	502	5.49e-7	SMART
ANK	506	535	2.58e-3	SMART
ANK	539	568	1.88e-5	SMART
ANK	572	601	1.02e-6	SMART
ANK	605	634	7.64e-6	SMART
ANK	638	669	3.23e-4	SMART
ANK	671	700	1.38e-3	SMART
ANK	704	733	1.58e-7	SMART
ANK	737	766	2.85e-5	SMART
ZU5	923	1027	1.9e-60	SMART
low complexity region	1050	1059	N/A	INTRINSIC
low complexity region	1387	1397	N/A	INTRINSIC
DEATH	1405	1499	3.21e-26	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000110688
AA Change: D1432G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000106316
Gene: ENSMUSG00000031543
AA Change: D1432G

Domain	Start	End	E-Value	Type
coiled coil region	1	39	N/A	INTRINSIC
ANK	44	73	2.5e3	SMART
ANK	77	106	3.26e0	SMART
ANK	110	139	3.15e-7	SMART
ANK	143	172	9.05e-8	SMART
ANK	176	204	4.67e-1	SMART
ANK	205	234	1.42e0	SMART
ANK	238	267	4.39e-6	SMART
ANK	271	300	1.33e-5	SMART
ANK	304	333	7.53e-5	SMART
ANK	337	366	2.35e-6	SMART
ANK	370	399	6.65e-6	SMART
ANK	403	432	5.2e-8	SMART
ANK	436	465	8.78e-6	SMART
ANK	469	498	7.53e-5	SMART
ANK	502	531	5.49e-7	SMART
ANK	535	564	2.58e-3	SMART
ANK	568	597	1.88e-5	SMART
ANK	601	630	1.02e-6	SMART
ANK	634	663	7.64e-6	SMART
ANK	667	698	3.23e-4	SMART
ANK	700	729	1.38e-3	SMART
ANK	733	762	1.58e-7	SMART
ANK	766	795	2.85e-5	SMART
ZU5	944	1048	1.9e-60	SMART
low complexity region	1071	1080	N/A	INTRINSIC
low complexity region	1408	1418	N/A	INTRINSIC
DEATH	1426	1520	3.21e-26	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000117270
AA Change: D1440G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000113495
Gene: ENSMUSG00000031543
AA Change: D1440G

Domain	Start	End	E-Value	Type
coiled coil region	1	39	N/A	INTRINSIC
ANK	44	73	2.5e3	SMART
ANK	77	106	3.26e0	SMART
ANK	110	139	3.15e-7	SMART
ANK	143	172	9.05e-8	SMART
ANK	176	204	4.67e-1	SMART
ANK	205	234	1.42e0	SMART
ANK	238	267	4.39e-6	SMART
ANK	271	300	1.33e-5	SMART
ANK	304	333	7.53e-5	SMART
ANK	337	366	2.35e-6	SMART
ANK	370	399	6.65e-6	SMART
ANK	403	432	5.2e-8	SMART
ANK	436	465	8.78e-6	SMART
ANK	469	498	7.53e-5	SMART
ANK	502	531	5.49e-7	SMART
ANK	535	564	2.58e-3	SMART
ANK	568	597	1.88e-5	SMART
ANK	601	630	1.02e-6	SMART
ANK	634	663	7.64e-6	SMART
ANK	667	698	3.23e-4	SMART
ANK	700	729	1.38e-3	SMART
ANK	733	762	1.58e-7	SMART
ANK	766	795	2.85e-5	SMART
ZU5	952	1056	1.9e-60	SMART
low complexity region	1079	1088	N/A	INTRINSIC
low complexity region	1416	1426	N/A	INTRINSIC
DEATH	1434	1528	3.21e-26	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000117296
AA Change: D1395G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000113656
Gene: ENSMUSG00000031543
AA Change: D1395G

Domain	Start	End	E-Value	Type
ANK	7	36	2.5e3	SMART
ANK	40	69	3.26e0	SMART
ANK	73	102	3.15e-7	SMART
ANK	106	135	9.05e-8	SMART
ANK	139	167	4.67e-1	SMART
ANK	168	197	1.42e0	SMART
ANK	201	230	4.39e-6	SMART
ANK	234	263	1.33e-5	SMART
ANK	267	296	7.53e-5	SMART
ANK	300	329	2.35e-6	SMART
ANK	333	362	6.65e-6	SMART
ANK	366	395	5.2e-8	SMART
ANK	399	428	8.78e-6	SMART
ANK	432	461	7.53e-5	SMART
ANK	465	494	5.49e-7	SMART
ANK	498	527	2.58e-3	SMART
ANK	531	560	1.88e-5	SMART
ANK	564	593	1.02e-6	SMART
ANK	597	626	7.64e-6	SMART
ANK	630	661	3.23e-4	SMART
ANK	663	692	1.38e-3	SMART
ANK	696	725	1.58e-7	SMART
ANK	729	758	2.85e-5	SMART
ZU5	907	1011	1.9e-60	SMART
low complexity region	1034	1043	N/A	INTRINSIC
low complexity region	1371	1381	N/A	INTRINSIC
DEATH	1389	1483	3.21e-26	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000117662
AA Change: D1395G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000113531
Gene: ENSMUSG00000031543
AA Change: D1395G

Domain	Start	End	E-Value	Type
ANK	7	36	2.5e3	SMART
ANK	40	69	3.26e0	SMART
ANK	73	102	3.15e-7	SMART
ANK	106	135	9.05e-8	SMART
ANK	139	167	4.67e-1	SMART
ANK	168	197	1.42e0	SMART
ANK	201	230	4.39e-6	SMART
ANK	234	263	1.33e-5	SMART
ANK	267	296	7.53e-5	SMART
ANK	300	329	2.35e-6	SMART
ANK	333	362	6.65e-6	SMART
ANK	366	395	5.2e-8	SMART
ANK	399	428	8.78e-6	SMART
ANK	432	461	7.53e-5	SMART
ANK	465	494	5.49e-7	SMART
ANK	498	527	2.58e-3	SMART
ANK	531	560	1.88e-5	SMART
ANK	564	593	1.02e-6	SMART
ANK	597	626	7.64e-6	SMART
ANK	630	661	3.23e-4	SMART
ANK	663	692	1.38e-3	SMART
ANK	696	725	1.58e-7	SMART
ANK	729	758	2.85e-5	SMART
ZU5	907	1011	1.9e-60	SMART
low complexity region	1034	1043	N/A	INTRINSIC
low complexity region	1371	1381	N/A	INTRINSIC
DEATH	1389	1483	3.21e-26	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000118733
AA Change: D1411G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000112850
Gene: ENSMUSG00000031543
AA Change: D1411G

Domain	Start	End	E-Value	Type
ANK	15	44	2.5e3	SMART
ANK	48	77	3.26e0	SMART
ANK	81	110	3.15e-7	SMART
ANK	114	143	9.05e-8	SMART
ANK	147	175	4.67e-1	SMART
ANK	176	205	1.42e0	SMART
ANK	209	238	4.39e-6	SMART
ANK	242	271	1.33e-5	SMART
ANK	275	304	7.53e-5	SMART
ANK	308	337	2.35e-6	SMART
ANK	341	370	6.65e-6	SMART
ANK	374	403	5.2e-8	SMART
ANK	407	436	8.78e-6	SMART
ANK	440	469	7.53e-5	SMART
ANK	473	502	5.49e-7	SMART
ANK	506	535	2.58e-3	SMART
ANK	539	568	1.88e-5	SMART
ANK	572	601	1.02e-6	SMART
ANK	605	634	7.64e-6	SMART
ANK	638	669	3.23e-4	SMART
ANK	671	700	1.38e-3	SMART
ANK	704	733	1.58e-7	SMART
ANK	737	766	2.85e-5	SMART
ZU5	923	1027	1.9e-60	SMART
low complexity region	1050	1059	N/A	INTRINSIC
low complexity region	1387	1397	N/A	INTRINSIC
DEATH	1405	1499	3.21e-26	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000121802
AA Change: D1440G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000113571
Gene: ENSMUSG00000031543
AA Change: D1440G

Domain	Start	End	E-Value	Type
coiled coil region	1	39	N/A	INTRINSIC
ANK	44	73	2.5e3	SMART
ANK	77	106	3.26e0	SMART
ANK	110	139	3.15e-7	SMART
ANK	143	172	9.05e-8	SMART
ANK	176	204	4.67e-1	SMART
ANK	205	234	1.42e0	SMART
ANK	238	267	4.39e-6	SMART
ANK	271	300	1.33e-5	SMART
ANK	304	333	7.53e-5	SMART
ANK	337	366	2.35e-6	SMART
ANK	370	399	6.65e-6	SMART
ANK	403	432	5.2e-8	SMART
ANK	436	465	8.78e-6	SMART
ANK	469	498	7.53e-5	SMART
ANK	502	531	5.49e-7	SMART
ANK	535	564	2.58e-3	SMART
ANK	568	597	1.88e-5	SMART
ANK	601	630	1.02e-6	SMART
ANK	634	663	7.64e-6	SMART
ANK	667	698	3.23e-4	SMART
ANK	700	729	1.38e-3	SMART
ANK	733	762	1.58e-7	SMART
ANK	766	795	2.85e-5	SMART
ZU5	952	1056	1.9e-60	SMART
low complexity region	1079	1088	N/A	INTRINSIC
low complexity region	1416	1426	N/A	INTRINSIC
DEATH	1434	1528	3.21e-26	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000152511
AA Change: D996G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000116533
Gene: ENSMUSG00000031543
AA Change: D996G

Domain	Start	End	E-Value	Type
ANK	1	29	4.82e-3	SMART
ANK	33	62	7.53e-5	SMART
ANK	66	95	5.49e-7	SMART
ANK	99	128	2.58e-3	SMART
ANK	132	161	1.88e-5	SMART
ANK	165	194	1.02e-6	SMART
ANK	198	227	7.64e-6	SMART
ANK	231	262	3.23e-4	SMART
ANK	264	293	1.38e-3	SMART
ANK	297	326	1.58e-7	SMART
ANK	330	359	2.85e-5	SMART
ZU5	508	612	1.9e-60	SMART
low complexity region	635	644	N/A	INTRINSIC
low complexity region	972	982	N/A	INTRINSIC
DEATH	990	1090	4.31e-18	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000141784
AA Change: D1395G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000117966
Gene: ENSMUSG00000031543
AA Change: D1395G

Domain	Start	End	E-Value	Type
ANK	7	36	2.5e3	SMART
ANK	40	69	3.26e0	SMART
ANK	73	102	3.15e-7	SMART
ANK	106	135	9.05e-8	SMART
ANK	139	167	4.67e-1	SMART
ANK	168	197	1.42e0	SMART
ANK	201	230	4.39e-6	SMART
ANK	234	263	1.33e-5	SMART
ANK	267	296	7.53e-5	SMART
ANK	300	329	2.35e-6	SMART
ANK	333	362	6.65e-6	SMART
ANK	366	395	5.2e-8	SMART
ANK	399	428	8.78e-6	SMART
ANK	432	461	7.53e-5	SMART
ANK	465	494	5.49e-7	SMART
ANK	498	527	2.58e-3	SMART
ANK	531	560	1.88e-5	SMART
ANK	564	593	1.02e-6	SMART
ANK	597	626	7.64e-6	SMART
ANK	630	661	3.23e-4	SMART
ANK	663	692	1.38e-3	SMART
ANK	696	725	1.58e-7	SMART
ANK	729	758	2.85e-5	SMART
ZU5	907	1011	1.9e-60	SMART
low complexity region	1034	1043	N/A	INTRINSIC
low complexity region	1371	1381	N/A	INTRINSIC
DEATH	1389	1483	3.21e-26	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000173248
AA Change: D1411G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000133322
Gene: ENSMUSG00000031543
AA Change: D1411G

Domain	Start	End	E-Value	Type
ANK	15	44	2.5e3	SMART
ANK	48	77	3.26e0	SMART
ANK	81	110	3.15e-7	SMART
ANK	114	143	9.05e-8	SMART
ANK	147	175	4.67e-1	SMART
ANK	176	205	1.42e0	SMART
ANK	209	238	4.39e-6	SMART
ANK	242	271	1.33e-5	SMART
ANK	275	304	7.53e-5	SMART
ANK	308	337	2.35e-6	SMART
ANK	341	370	6.65e-6	SMART
ANK	374	403	5.2e-8	SMART
ANK	407	436	8.78e-6	SMART
ANK	440	469	7.53e-5	SMART
ANK	473	502	5.49e-7	SMART
ANK	506	535	2.58e-3	SMART
ANK	539	568	1.88e-5	SMART
ANK	572	601	1.02e-6	SMART
ANK	605	634	7.64e-6	SMART
ANK	638	669	3.23e-4	SMART
ANK	671	700	1.38e-3	SMART
ANK	704	733	1.58e-7	SMART
ANK	737	766	2.85e-5	SMART
ZU5	923	1027	1.9e-60	SMART
low complexity region	1050	1059	N/A	INTRINSIC
low complexity region	1387	1397	N/A	INTRINSIC
DEATH	1405	1499	3.21e-26	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000135206

Predicted Effect

probably benign
Transcript: ENSMUST00000123418

SMART Domains

Protein: ENSMUSP00000121785
Gene: ENSMUSG00000031543

Domain	Start	End	E-Value	Type
ANK	15	44	2.5e3	SMART
ANK	48	77	3.26e0	SMART
ANK	81	110	3.15e-7	SMART
ANK	114	143	9.05e-8	SMART
ANK	147	175	4.67e-1	SMART
ANK	176	205	1.42e0	SMART
ANK	209	238	4.39e-6	SMART
ANK	242	271	1.33e-5	SMART
ANK	275	304	7.53e-5	SMART
ANK	308	337	2.35e-6	SMART
ANK	341	370	6.65e-6	SMART
ANK	374	403	5.2e-8	SMART
ANK	407	436	8.78e-6	SMART
ANK	440	469	7.53e-5	SMART
ANK	473	502	5.49e-7	SMART
ANK	506	535	2.58e-3	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000173573

SMART Domains

Protein: ENSMUSP00000133901
Gene: ENSMUSG00000031543

Domain	Start	End	E-Value	Type
ANK	15	44	2.5e3	SMART
ANK	48	77	3.26e0	SMART
ANK	81	110	3.15e-7	SMART
ANK	114	143	9.05e-8	SMART
ANK	147	175	4.67e-1	SMART
ANK	176	205	1.42e0	SMART
ANK	209	238	4.39e-6	SMART
ANK	242	271	1.33e-5	SMART
ANK	275	304	7.53e-5	SMART
ANK	308	337	2.35e-6	SMART
ANK	341	370	6.65e-6	SMART
ANK	374	403	5.2e-8	SMART
ANK	407	436	8.78e-6	SMART
ANK	440	469	7.53e-5	SMART
ANK	473	502	5.49e-7	SMART
ANK	506	535	2.58e-3	SMART
ANK	539	568	1.88e-5	SMART
ANK	572	601	1.02e-6	SMART
ANK	605	634	7.64e-6	SMART
ANK	638	669	3.23e-4	SMART
ANK	671	700	1.38e-3	SMART
ANK	704	733	1.58e-7	SMART
ANK	737	766	2.85e-5	SMART
ZU5	923	1027	1.9e-60	SMART

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Ankyrins are a family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 1, the prototype of this family, was first discovered in the erythrocytes, but since has also been found in brain and muscles. Mutations in erythrocytic ankyrin 1 have been associated in approximately half of all patients with hereditary spherocytosis. Complex patterns of alternative splicing in the regulatory domain, giving rise to different isoforms of ankyrin 1 have been described. Truncated muscle-specific isoforms of ankyrin 1 resulting from usage of an alternate promoter have also been identified. [provided by RefSeq, Dec 2008]
PHENOTYPE: Homozygous mutant animals are anemic, infertile, and have reduced body size. Mutant animals also exhibit jaundice, bone marrow hyperplasia, splenomegaly, hepatomegaly, enlarged lymph nodes, increased white blood cell count, and cardiac hypertrophy. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 35 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
9830107B12Rik	A	T	17: 48,439,125 (GRCm39)	Y144N	unknown	Het
Abca9	A	C	11: 110,045,243 (GRCm39)	C363W	probably damaging	Het
Acmsd	G	A	1: 127,687,447 (GRCm39)	R243H	probably damaging	Het
Adam33	T	C	2: 130,895,970 (GRCm39)	T490A	probably damaging	Het
Arhgap39	T	C	15: 76,614,638 (GRCm39)	E842G	probably benign	Het
Asgr2	T	C	11: 69,996,193 (GRCm39)		probably benign	Het
Bbs9	T	C	9: 22,557,293 (GRCm39)	V14A	possibly damaging	Het
Cer1	A	G	4: 82,803,080 (GRCm39)	S81P	probably damaging	Het
Cln6	T	A	9: 62,751,900 (GRCm39)	H41Q	probably damaging	Het
Dock1	A	G	7: 134,355,106 (GRCm39)	D334G	probably damaging	Het
Dpy19l2	A	G	9: 24,578,271 (GRCm39)	I261T	probably benign	Het
Fhod3	T	G	18: 25,223,804 (GRCm39)	I1050S	probably damaging	Het
Gbgt1	T	C	2: 28,387,842 (GRCm39)	V22A	probably benign	Het
Izumo3	A	G	4: 92,034,532 (GRCm39)		probably null	Het
Kif11	T	C	19: 37,372,681 (GRCm39)		probably benign	Het
Krt1c	C	A	15: 101,719,825 (GRCm39)	G615V	unknown	Het
Midn	A	G	10: 79,992,477 (GRCm39)		probably benign	Het
Mier1	C	T	4: 103,012,769 (GRCm39)	T342I	probably damaging	Het
Mycbp2	A	T	14: 103,378,305 (GRCm39)		probably null	Het
Nrp1	A	T	8: 129,158,513 (GRCm39)	S267C	possibly damaging	Het
Or8b8	A	G	9: 37,809,272 (GRCm39)	T191A	possibly damaging	Het
Pcdh20	A	T	14: 88,708,344 (GRCm39)	M28K	probably benign	Het
Prmt5	G	A	14: 54,747,408 (GRCm39)		probably benign	Het
Psmg2	G	A	18: 67,786,293 (GRCm39)	V218I	probably benign	Het
Rps6ka5	T	C	12: 100,537,173 (GRCm39)	E519G	probably damaging	Het
Samm50	T	A	15: 84,080,039 (GRCm39)	I39N	probably benign	Het
Shc2	A	T	10: 79,458,138 (GRCm39)	M515K	probably damaging	Het
Sorbs2	T	A	8: 46,248,631 (GRCm39)	F608L	probably damaging	Het
Sos2	T	C	12: 69,654,172 (GRCm39)	K727E	probably damaging	Het
Sox13	A	T	1: 133,317,182 (GRCm39)	H150Q	possibly damaging	Het
Tmem132e	T	C	11: 82,325,495 (GRCm39)	V165A	probably damaging	Het
Trmt11	T	C	10: 30,473,747 (GRCm39)	T43A	probably benign	Het
Tyrp1	G	T	4: 80,763,135 (GRCm39)	V341L	probably benign	Het
Ugt2b35	C	A	5: 87,159,250 (GRCm39)	H481Q	probably benign	Het
Zzz3	T	A	3: 152,161,476 (GRCm39)	I290N	possibly damaging	Het

Other mutations in Ank1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00972:Ank1	APN	8	23,631,660 (GRCm39)	missense	probably damaging	1.00
IGL01099:Ank1	APN	8	23,598,265 (GRCm39)	missense	probably damaging	0.97
IGL01866:Ank1	APN	8	23,583,871 (GRCm39)	missense	possibly damaging	0.88
IGL01977:Ank1	APN	8	23,605,449 (GRCm39)	missense	probably benign	0.01
IGL02109:Ank1	APN	8	23,586,200 (GRCm39)	missense	probably damaging	1.00
IGL02182:Ank1	APN	8	23,603,868 (GRCm39)	missense	possibly damaging	0.89
IGL02261:Ank1	APN	8	23,578,015 (GRCm39)	missense	probably damaging	1.00
IGL02283:Ank1	APN	8	23,609,450 (GRCm39)	critical splice donor site	probably null
IGL02335:Ank1	APN	8	23,625,654 (GRCm39)	missense	possibly damaging	0.86
IGL02933:Ank1	APN	8	23,612,881 (GRCm39)	missense	possibly damaging	0.52
IGL03056:Ank1	APN	8	23,631,195 (GRCm39)	missense	probably damaging	1.00
IGL03089:Ank1	APN	8	23,594,848 (GRCm39)	missense	probably benign	0.00
IGL03257:Ank1	APN	8	23,612,914 (GRCm39)	missense	probably damaging	1.00
IGL03389:Ank1	APN	8	23,578,076 (GRCm39)	critical splice donor site	probably null
Hema6	UTSW	8	23,587,653 (GRCm39)	intron	probably benign
BB006:Ank1	UTSW	8	23,606,123 (GRCm39)	missense	probably damaging	1.00
BB016:Ank1	UTSW	8	23,606,123 (GRCm39)	missense	probably damaging	1.00
R0030:Ank1	UTSW	8	23,583,909 (GRCm39)	missense	probably damaging	1.00
R0077:Ank1	UTSW	8	23,630,183 (GRCm39)	missense	probably damaging	1.00
R0081:Ank1	UTSW	8	23,606,258 (GRCm39)	missense	possibly damaging	0.95
R0147:Ank1	UTSW	8	23,613,993 (GRCm39)	missense	probably damaging	1.00
R0148:Ank1	UTSW	8	23,613,993 (GRCm39)	missense	probably damaging	1.00
R0200:Ank1	UTSW	8	23,586,828 (GRCm39)	missense	probably damaging	1.00
R0270:Ank1	UTSW	8	23,578,941 (GRCm39)	splice site	probably benign
R0309:Ank1	UTSW	8	23,594,825 (GRCm39)	missense	probably damaging	1.00
R0490:Ank1	UTSW	8	23,597,890 (GRCm39)	splice site	probably benign
R0675:Ank1	UTSW	8	23,600,400 (GRCm39)	splice site	probably benign
R0738:Ank1	UTSW	8	23,604,130 (GRCm39)	missense	probably damaging	0.98
R1051:Ank1	UTSW	8	23,583,956 (GRCm39)	missense	probably damaging	1.00
R1239:Ank1	UTSW	8	23,586,171 (GRCm39)	missense	probably damaging	1.00
R1265:Ank1	UTSW	8	23,607,053 (GRCm39)	missense	possibly damaging	0.64
R1367:Ank1	UTSW	8	23,601,819 (GRCm39)	splice site	probably benign
R1413:Ank1	UTSW	8	23,609,393 (GRCm39)	missense	probably damaging	1.00
R1539:Ank1	UTSW	8	23,583,935 (GRCm39)	missense	probably damaging	1.00
R1682:Ank1	UTSW	8	23,599,343 (GRCm39)	missense	probably damaging	1.00
R1732:Ank1	UTSW	8	23,601,479 (GRCm39)	splice site	probably benign
R1911:Ank1	UTSW	8	23,589,666 (GRCm39)	missense	probably damaging	1.00
R2087:Ank1	UTSW	8	23,583,827 (GRCm39)	missense	probably damaging	1.00
R2184:Ank1	UTSW	8	23,599,270 (GRCm39)	missense	probably damaging	0.98
R2302:Ank1	UTSW	8	23,609,415 (GRCm39)	missense	probably damaging	1.00
R2356:Ank1	UTSW	8	23,575,688 (GRCm39)	missense	probably damaging	1.00
R2495:Ank1	UTSW	8	23,622,280 (GRCm39)	missense	probably damaging	1.00
R3000:Ank1	UTSW	8	23,609,447 (GRCm39)	missense	probably damaging	1.00
R3113:Ank1	UTSW	8	23,574,813 (GRCm39)	missense	probably damaging	1.00
R3710:Ank1	UTSW	8	23,577,095 (GRCm39)	missense	probably damaging	1.00
R3768:Ank1	UTSW	8	23,606,202 (GRCm39)	missense	possibly damaging	0.92
R3771:Ank1	UTSW	8	23,613,913 (GRCm39)	missense	probably benign	0.03
R4002:Ank1	UTSW	8	23,629,479 (GRCm39)	missense	probably damaging	0.98
R4478:Ank1	UTSW	8	23,610,594 (GRCm39)	missense	probably benign	0.30
R4755:Ank1	UTSW	8	23,594,990 (GRCm39)	missense	probably damaging	1.00
R4756:Ank1	UTSW	8	23,612,893 (GRCm39)	missense	probably benign
R4979:Ank1	UTSW	8	23,622,212 (GRCm39)	missense	probably damaging	0.98
R4989:Ank1	UTSW	8	23,631,134 (GRCm39)	intron	probably benign
R5011:Ank1	UTSW	8	23,572,300 (GRCm39)	missense	probably damaging	1.00
R5013:Ank1	UTSW	8	23,572,300 (GRCm39)	missense	probably damaging	1.00
R5031:Ank1	UTSW	8	23,589,696 (GRCm39)	missense	probably damaging	1.00
R5051:Ank1	UTSW	8	23,609,397 (GRCm39)	missense	probably damaging	1.00
R5059:Ank1	UTSW	8	23,586,204 (GRCm39)	missense	probably damaging	0.99
R5086:Ank1	UTSW	8	23,578,634 (GRCm39)	missense	probably damaging	1.00
R5108:Ank1	UTSW	8	23,622,571 (GRCm39)	missense	probably benign	0.11
R5235:Ank1	UTSW	8	23,572,212 (GRCm39)	missense	probably damaging	1.00
R5300:Ank1	UTSW	8	23,622,517 (GRCm39)	missense	probably benign	0.00
R5408:Ank1	UTSW	8	23,572,209 (GRCm39)	missense	probably damaging	1.00
R5537:Ank1	UTSW	8	23,604,892 (GRCm39)	missense	probably damaging	1.00
R5728:Ank1	UTSW	8	23,612,783 (GRCm39)	critical splice acceptor site	probably null
R5746:Ank1	UTSW	8	23,606,612 (GRCm39)	missense	probably damaging	1.00
R5837:Ank1	UTSW	8	23,594,806 (GRCm39)	missense	probably damaging	0.99
R5907:Ank1	UTSW	8	23,630,220 (GRCm39)	missense	probably damaging	1.00
R5997:Ank1	UTSW	8	23,589,678 (GRCm39)	missense	probably damaging	1.00
R6005:Ank1	UTSW	8	23,622,218 (GRCm39)	missense	probably damaging	1.00
R6046:Ank1	UTSW	8	23,606,114 (GRCm39)	missense	probably damaging	1.00
R6103:Ank1	UTSW	8	23,603,999 (GRCm39)	missense	probably damaging	1.00
R6268:Ank1	UTSW	8	23,599,687 (GRCm39)	missense	probably damaging	1.00
R6430:Ank1	UTSW	8	23,622,125 (GRCm39)	missense	probably damaging	1.00
R6457:Ank1	UTSW	8	23,577,983 (GRCm39)	missense	probably damaging	1.00
R6626:Ank1	UTSW	8	23,465,207 (GRCm39)	missense	probably damaging	0.98
R6935:Ank1	UTSW	8	23,598,247 (GRCm39)	missense	probably damaging	1.00
R7091:Ank1	UTSW	8	23,548,679 (GRCm39)	missense	probably benign
R7162:Ank1	UTSW	8	23,622,370 (GRCm39)	missense	possibly damaging	0.94
R7475:Ank1	UTSW	8	23,622,646 (GRCm39)	missense	probably benign
R7546:Ank1	UTSW	8	23,555,011 (GRCm39)	missense	probably damaging	1.00
R7678:Ank1	UTSW	8	23,607,074 (GRCm39)	missense	probably damaging	0.98
R7768:Ank1	UTSW	8	23,588,013 (GRCm39)	missense	probably benign	0.01
R7779:Ank1	UTSW	8	23,586,763 (GRCm39)	critical splice acceptor site	probably null
R7864:Ank1	UTSW	8	23,577,976 (GRCm39)	missense	probably damaging	1.00
R7929:Ank1	UTSW	8	23,606,123 (GRCm39)	missense	probably damaging	1.00
R7982:Ank1	UTSW	8	23,609,397 (GRCm39)	missense	probably damaging	1.00
R7984:Ank1	UTSW	8	23,578,982 (GRCm39)	missense	probably damaging	1.00
R8273:Ank1	UTSW	8	23,575,668 (GRCm39)	missense	probably damaging	1.00
R8318:Ank1	UTSW	8	23,605,567 (GRCm39)	missense	probably damaging	0.99
R8349:Ank1	UTSW	8	23,629,302 (GRCm39)	missense	possibly damaging	0.66
R8449:Ank1	UTSW	8	23,629,302 (GRCm39)	missense	possibly damaging	0.66
R8459:Ank1	UTSW	8	23,605,528 (GRCm39)	missense	probably damaging	1.00
R8506:Ank1	UTSW	8	23,586,851 (GRCm39)	missense	probably damaging	1.00
R8889:Ank1	UTSW	8	23,606,990 (GRCm39)	missense	probably damaging	1.00
R8893:Ank1	UTSW	8	23,598,241 (GRCm39)	missense	probably damaging	1.00
R8924:Ank1	UTSW	8	23,589,011 (GRCm39)	missense	probably benign	0.00
R8993:Ank1	UTSW	8	23,588,955 (GRCm39)	missense	probably damaging	1.00
R9016:Ank1	UTSW	8	23,606,264 (GRCm39)	missense	probably null	0.99
R9017:Ank1	UTSW	8	23,606,264 (GRCm39)	missense	probably null	0.99
R9018:Ank1	UTSW	8	23,606,264 (GRCm39)	missense	probably null	0.99
R9086:Ank1	UTSW	8	23,589,636 (GRCm39)	missense	probably damaging	0.96
R9154:Ank1	UTSW	8	23,605,387 (GRCm39)	missense	probably damaging	0.96
R9194:Ank1	UTSW	8	23,606,255 (GRCm39)	missense	possibly damaging	0.64
R9347:Ank1	UTSW	8	23,607,076 (GRCm39)	missense	possibly damaging	0.65
R9419:Ank1	UTSW	8	23,574,825 (GRCm39)	missense	probably damaging	1.00
R9452:Ank1	UTSW	8	23,622,429 (GRCm39)	missense	probably benign	0.00
R9568:Ank1	UTSW	8	23,609,381 (GRCm39)	missense	probably benign
R9689:Ank1	UTSW	8	23,631,253 (GRCm39)	missense	probably benign
R9747:Ank1	UTSW	8	23,576,993 (GRCm39)	missense	probably damaging	0.97
RF024:Ank1	UTSW	8	23,609,360 (GRCm39)	missense	probably benign	0.37
X0066:Ank1	UTSW	8	23,631,600 (GRCm39)	splice site	probably null

Posted On

2013-12-09