Incidental Mutation 'IGL01586:Kif11'
ID 91823
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Kif11
Ensembl Gene ENSMUSG00000012443
Gene Name kinesin family member 11
Synonyms Eg5, Knsl1, Kifl1
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # IGL01586
Quality Score
Status
Chromosome 19
Chromosomal Location 37364851-37410307 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) T to C at 37372681 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000012587 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000012587]
AlphaFold Q6P9P6
Predicted Effect probably benign
Transcript: ENSMUST00000012587
SMART Domains Protein: ENSMUSP00000012587
Gene: ENSMUSG00000012443

DomainStartEndE-ValueType
KISc 15 366 8.21e-180 SMART
Blast:KISc 372 417 1e-16 BLAST
low complexity region 453 465 N/A INTRINSIC
Pfam:Microtub_bind 915 1049 1.2e-44 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a motor protein that belongs to the kinesin-like protein family. Members of this protein family are known to be involved in various kinds of spindle dynamics. The function of this gene product includes chromosome positioning, centrosome separation and establishing a bipolar spindle during cell mitosis. [provided by RefSeq, Jul 2008]
PHENOTYPE: Deletion of Kif11 results in early embryonic lethality of homozygotes, with developmental growth arrest at E3.5. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9830107B12Rik A T 17: 48,439,125 (GRCm39) Y144N unknown Het
Abca9 A C 11: 110,045,243 (GRCm39) C363W probably damaging Het
Acmsd G A 1: 127,687,447 (GRCm39) R243H probably damaging Het
Adam33 T C 2: 130,895,970 (GRCm39) T490A probably damaging Het
Ank1 A G 8: 23,610,928 (GRCm39) D1411G probably benign Het
Arhgap39 T C 15: 76,614,638 (GRCm39) E842G probably benign Het
Asgr2 T C 11: 69,996,193 (GRCm39) probably benign Het
Bbs9 T C 9: 22,557,293 (GRCm39) V14A possibly damaging Het
Cer1 A G 4: 82,803,080 (GRCm39) S81P probably damaging Het
Cln6 T A 9: 62,751,900 (GRCm39) H41Q probably damaging Het
Dock1 A G 7: 134,355,106 (GRCm39) D334G probably damaging Het
Dpy19l2 A G 9: 24,578,271 (GRCm39) I261T probably benign Het
Fhod3 T G 18: 25,223,804 (GRCm39) I1050S probably damaging Het
Gbgt1 T C 2: 28,387,842 (GRCm39) V22A probably benign Het
Izumo3 A G 4: 92,034,532 (GRCm39) probably null Het
Krt1c C A 15: 101,719,825 (GRCm39) G615V unknown Het
Midn A G 10: 79,992,477 (GRCm39) probably benign Het
Mier1 C T 4: 103,012,769 (GRCm39) T342I probably damaging Het
Mycbp2 A T 14: 103,378,305 (GRCm39) probably null Het
Nrp1 A T 8: 129,158,513 (GRCm39) S267C possibly damaging Het
Or8b8 A G 9: 37,809,272 (GRCm39) T191A possibly damaging Het
Pcdh20 A T 14: 88,708,344 (GRCm39) M28K probably benign Het
Prmt5 G A 14: 54,747,408 (GRCm39) probably benign Het
Psmg2 G A 18: 67,786,293 (GRCm39) V218I probably benign Het
Rps6ka5 T C 12: 100,537,173 (GRCm39) E519G probably damaging Het
Samm50 T A 15: 84,080,039 (GRCm39) I39N probably benign Het
Shc2 A T 10: 79,458,138 (GRCm39) M515K probably damaging Het
Sorbs2 T A 8: 46,248,631 (GRCm39) F608L probably damaging Het
Sos2 T C 12: 69,654,172 (GRCm39) K727E probably damaging Het
Sox13 A T 1: 133,317,182 (GRCm39) H150Q possibly damaging Het
Tmem132e T C 11: 82,325,495 (GRCm39) V165A probably damaging Het
Trmt11 T C 10: 30,473,747 (GRCm39) T43A probably benign Het
Tyrp1 G T 4: 80,763,135 (GRCm39) V341L probably benign Het
Ugt2b35 C A 5: 87,159,250 (GRCm39) H481Q probably benign Het
Zzz3 T A 3: 152,161,476 (GRCm39) I290N possibly damaging Het
Other mutations in Kif11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00434:Kif11 APN 19 37,399,857 (GRCm39) missense possibly damaging 0.82
IGL00785:Kif11 APN 19 37,392,746 (GRCm39) missense probably damaging 0.99
IGL00785:Kif11 APN 19 37,392,745 (GRCm39) missense probably benign 0.01
IGL01883:Kif11 APN 19 37,372,791 (GRCm39) missense probably benign 0.01
IGL02138:Kif11 APN 19 37,373,057 (GRCm39) missense probably damaging 1.00
IGL03197:Kif11 APN 19 37,395,475 (GRCm39) missense probably benign 0.00
PIT4151001:Kif11 UTSW 19 37,373,045 (GRCm39) missense probably damaging 1.00
R0027:Kif11 UTSW 19 37,395,431 (GRCm39) splice site probably benign
R0027:Kif11 UTSW 19 37,395,431 (GRCm39) splice site probably benign
R0104:Kif11 UTSW 19 37,401,663 (GRCm39) missense probably benign 0.00
R0254:Kif11 UTSW 19 37,399,957 (GRCm39) missense probably benign 0.00
R0631:Kif11 UTSW 19 37,401,565 (GRCm39) splice site probably benign
R1607:Kif11 UTSW 19 37,375,648 (GRCm39) nonsense probably null
R1895:Kif11 UTSW 19 37,375,847 (GRCm39) missense probably damaging 1.00
R1983:Kif11 UTSW 19 37,379,224 (GRCm39) missense possibly damaging 0.78
R2056:Kif11 UTSW 19 37,390,660 (GRCm39) missense probably benign 0.17
R2158:Kif11 UTSW 19 37,399,062 (GRCm39) missense probably benign
R2291:Kif11 UTSW 19 37,395,451 (GRCm39) missense probably benign
R2300:Kif11 UTSW 19 37,399,987 (GRCm39) missense probably benign 0.01
R2850:Kif11 UTSW 19 37,397,941 (GRCm39) missense probably benign
R2904:Kif11 UTSW 19 37,392,103 (GRCm39) splice site probably benign
R3035:Kif11 UTSW 19 37,395,501 (GRCm39) missense possibly damaging 0.92
R3908:Kif11 UTSW 19 37,379,169 (GRCm39) missense probably damaging 1.00
R4319:Kif11 UTSW 19 37,373,033 (GRCm39) missense probably damaging 0.99
R4356:Kif11 UTSW 19 37,399,883 (GRCm39) missense probably benign 0.00
R4469:Kif11 UTSW 19 37,404,940 (GRCm39) missense probably benign 0.05
R4623:Kif11 UTSW 19 37,398,195 (GRCm39) missense probably benign
R4779:Kif11 UTSW 19 37,406,397 (GRCm39) missense probably benign 0.00
R4911:Kif11 UTSW 19 37,406,385 (GRCm39) missense probably benign 0.00
R4980:Kif11 UTSW 19 37,375,819 (GRCm39) nonsense probably null
R5109:Kif11 UTSW 19 37,373,063 (GRCm39) missense possibly damaging 0.81
R5770:Kif11 UTSW 19 37,379,313 (GRCm39) missense probably benign 0.03
R6023:Kif11 UTSW 19 37,379,158 (GRCm39) missense probably damaging 1.00
R6666:Kif11 UTSW 19 37,398,214 (GRCm39) missense probably benign
R6755:Kif11 UTSW 19 37,398,199 (GRCm39) missense probably benign 0.01
R6845:Kif11 UTSW 19 37,392,565 (GRCm39) missense probably damaging 1.00
R7052:Kif11 UTSW 19 37,373,040 (GRCm39) nonsense probably null
R7367:Kif11 UTSW 19 37,408,789 (GRCm39) missense probably benign
R7387:Kif11 UTSW 19 37,398,204 (GRCm39) missense probably damaging 1.00
R7485:Kif11 UTSW 19 37,399,072 (GRCm39) missense possibly damaging 0.94
R7502:Kif11 UTSW 19 37,398,255 (GRCm39) missense possibly damaging 0.53
R7591:Kif11 UTSW 19 37,372,711 (GRCm39) missense probably damaging 1.00
R7618:Kif11 UTSW 19 37,400,008 (GRCm39) missense probably benign 0.32
R7809:Kif11 UTSW 19 37,373,057 (GRCm39) missense probably damaging 1.00
R8181:Kif11 UTSW 19 37,379,095 (GRCm39) critical splice acceptor site probably null
R8274:Kif11 UTSW 19 37,391,994 (GRCm39) missense probably damaging 0.99
R8323:Kif11 UTSW 19 37,372,692 (GRCm39) missense possibly damaging 0.77
R8948:Kif11 UTSW 19 37,386,602 (GRCm39) missense probably damaging 0.96
R9372:Kif11 UTSW 19 37,399,892 (GRCm39) missense probably benign 0.00
Z1177:Kif11 UTSW 19 37,401,735 (GRCm39) missense possibly damaging 0.62
Posted On 2013-12-09