Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01608:Or51l14'

91833

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or51l14

Ensembl Gene

ENSMUSG00000073949

Gene Name

olfactory receptor family 51 subfamily L member 14

Synonyms

Olfr606, GA_x6K02T2PBJ9-6173009-6173968, MOR17-2

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.085) question?

Stock #

IGL01608

Quality Score

Status

Chromosome

Chromosomal Location

103100546-103101505 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 103101011 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Phenylalanine at position 156 (I156F)

Ref Sequence

ENSEMBL: ENSMUSP00000151177 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000098200] [ENSMUST00000214347] [ENSMUST00000214631] [ENSMUST00000217250]

AlphaFold

Q8VGZ8

Predicted Effect

probably benign
Transcript: ENSMUST00000098200
AA Change: I156F

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000095802
Gene: ENSMUSG00000073949
AA Change: I156F

Domain	Start	End	E-Value	Type
low complexity region	4	12	N/A	INTRINSIC
Pfam:7tm_4	33	312	7.1e-116	PFAM
Pfam:7TM_GPCR_Srsx	37	307	9e-8	PFAM
Pfam:7tm_1	43	294	7.4e-16	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000214347

Predicted Effect

probably benign
Transcript: ENSMUST00000214631
AA Change: I156F

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

Predicted Effect

probably benign
Transcript: ENSMUST00000217250
AA Change: I156F

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 60 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca1	A	T	4: 53,038,158 (GRCm39)	L2068Q	probably damaging	Het
Abca12	G	T	1: 71,298,601 (GRCm39)	D2340E	probably damaging	Het
Adcy5	A	G	16: 35,092,535 (GRCm39)	Y632C	probably damaging	Het
Adgrb3	A	G	1: 25,592,855 (GRCm39)	S311P	probably damaging	Het
Adh4	C	T	3: 138,134,788 (GRCm39)		probably benign	Het
Atf2	G	T	2: 73,649,422 (GRCm39)	H396Q	probably damaging	Het
Atp8a1	G	A	5: 67,970,479 (GRCm39)	R74*	probably null	Het
Brpf3	T	C	17: 29,040,491 (GRCm39)	S971P	probably benign	Het
Btn1a1	T	C	13: 23,645,778 (GRCm39)	E197G	probably benign	Het
Ccdc136	C	T	6: 29,406,113 (GRCm39)	A87V	possibly damaging	Het
Celf4	A	G	18: 25,630,560 (GRCm39)	L376P	probably damaging	Het
Chrm3	G	A	13: 9,928,634 (GRCm39)	A134V	possibly damaging	Het
Col19a1	G	A	1: 24,321,626 (GRCm39)	R961C	probably damaging	Het
Cr2	A	G	1: 194,837,528 (GRCm39)	V1190A	possibly damaging	Het
Dop1a	T	A	9: 86,389,614 (GRCm39)	S515T	probably benign	Het
Eprs1	T	A	1: 185,117,311 (GRCm39)		probably benign	Het
Fbn2	G	T	18: 58,186,776 (GRCm39)	Y1708*	probably null	Het
Glt1d1	A	G	5: 127,741,746 (GRCm39)	N148S	possibly damaging	Het
Gm20425	T	A	9: 103,068,293 (GRCm39)	I44F	probably damaging	Het
Gpr22	T	A	12: 31,758,779 (GRCm39)	K411*	probably null	Het
Ipo11	A	G	13: 106,971,002 (GRCm39)		probably benign	Het
Klri1	T	A	6: 129,675,130 (GRCm39)	N210I	possibly damaging	Het
Kmt2c	C	T	5: 25,559,809 (GRCm39)	V950M	probably damaging	Het
Knop1	T	C	7: 118,445,019 (GRCm39)	K315R	probably benign	Het
Krt90	A	G	15: 101,471,064 (GRCm39)	I66T	probably benign	Het
Lrrc32	T	A	7: 98,148,564 (GRCm39)	V448D	probably benign	Het
Met	T	C	6: 17,558,729 (GRCm39)	V1119A	probably damaging	Het
Minar1	T	C	9: 89,478,551 (GRCm39)	T832A	probably benign	Het
Mipep	T	A	14: 61,039,679 (GRCm39)	I236N	possibly damaging	Het
Mrpl45	A	G	11: 97,207,747 (GRCm39)	T81A	probably benign	Het
Mtbp	G	T	15: 55,421,085 (GRCm39)	E24*	probably null	Het
Muc5b	C	T	7: 141,400,174 (GRCm39)	T476I	unknown	Het
Mup6	C	T	4: 60,006,021 (GRCm39)	T163I	probably benign	Het
Myo1g	T	A	11: 6,466,780 (GRCm39)	I278F	possibly damaging	Het
Myo9a	A	T	9: 59,778,119 (GRCm39)	K1292*	probably null	Het
Nbeal1	T	A	1: 60,281,694 (GRCm39)		probably benign	Het
Nck1	C	A	9: 100,379,440 (GRCm39)	R270S	probably benign	Het
Neb	T	C	2: 52,060,548 (GRCm39)	E6035G	probably damaging	Het
Nlrp4f	A	C	13: 65,343,357 (GRCm39)	L96*	probably null	Het
Or11g1	A	T	14: 50,651,910 (GRCm39)	H303L	probably benign	Het
Or4a77	A	T	2: 89,486,835 (GRCm39)		probably benign	Het
Or5t18	A	C	2: 86,636,769 (GRCm39)	Y191*	probably null	Het
Padi2	A	G	4: 140,659,541 (GRCm39)	E282G	probably damaging	Het
Pcdhb4	A	G	18: 37,441,803 (GRCm39)	D371G	probably damaging	Het
Pcdhb8	A	G	18: 37,489,978 (GRCm39)	D552G	probably damaging	Het
Peli3	A	G	19: 4,982,855 (GRCm39)	I270T	probably damaging	Het
Phf20	A	G	2: 156,118,516 (GRCm39)	M407V	probably benign	Het
Ppm1h	C	T	10: 122,777,185 (GRCm39)	R103*	probably null	Het
Rangap1	C	T	15: 81,593,705 (GRCm39)	V457M	probably benign	Het
Scube2	A	G	7: 109,442,461 (GRCm39)	V257A	probably benign	Het
Shc1	C	A	3: 89,332,156 (GRCm39)	Q204K	probably damaging	Het
Slc6a4	T	A	11: 76,917,961 (GRCm39)	Y568N	probably damaging	Het
Srgap3	A	G	6: 112,923,439 (GRCm39)	F7L	probably benign	Het
St6galnac4	T	A	2: 32,484,098 (GRCm39)	C99S	probably damaging	Het
Strc	T	C	2: 121,206,075 (GRCm39)	D779G	probably benign	Het
Supt6	A	T	11: 78,116,309 (GRCm39)	Y685N	probably damaging	Het
Traf3ip3	T	C	1: 192,869,418 (GRCm39)	T256A	probably benign	Het
Vmn1r74	A	T	7: 11,581,560 (GRCm39)	I287F	probably damaging	Het
Zmym2	C	A	14: 57,185,472 (GRCm39)	Q1035K	possibly damaging	Het
Zswim3	G	A	2: 164,663,440 (GRCm39)	R640H	probably damaging	Het

Other mutations in Or51l14

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01287:Or51l14	APN	7	103,101,002 (GRCm39)	missense	probably damaging	1.00
IGL02251:Or51l14	APN	7	103,100,978 (GRCm39)	nonsense	probably null
IGL02319:Or51l14	APN	7	103,101,474 (GRCm39)	missense	probably benign	0.01
R0369:Or51l14	UTSW	7	103,101,423 (GRCm39)	missense	probably damaging	1.00
R0480:Or51l14	UTSW	7	103,100,835 (GRCm39)	missense	probably benign	0.07
R1759:Or51l14	UTSW	7	103,101,356 (GRCm39)	missense	probably benign	0.11
R1858:Or51l14	UTSW	7	103,101,332 (GRCm39)	missense	probably benign	0.16
R2156:Or51l14	UTSW	7	103,101,371 (GRCm39)	missense	probably benign	0.01
R4226:Or51l14	UTSW	7	103,100,784 (GRCm39)	missense	probably benign	0.31
R4422:Or51l14	UTSW	7	103,101,450 (GRCm39)	missense	probably damaging	0.99
R5071:Or51l14	UTSW	7	103,100,617 (GRCm39)	missense	probably benign
R5074:Or51l14	UTSW	7	103,100,617 (GRCm39)	missense	probably benign
R5137:Or51l14	UTSW	7	103,100,920 (GRCm39)	nonsense	probably null
R5137:Or51l14	UTSW	7	103,100,919 (GRCm39)	missense	probably damaging	1.00
R8914:Or51l14	UTSW	7	103,101,090 (GRCm39)	missense	probably damaging	1.00
R9457:Or51l14	UTSW	7	103,100,618 (GRCm39)	missense	probably benign	0.00
X0018:Or51l14	UTSW	7	103,101,005 (GRCm39)	missense	possibly damaging	0.72

Posted On

2013-12-09