Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01608:Or5t18'

91850

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or5t18

Ensembl Gene

ENSMUSG00000078420

Gene Name

olfactory receptor family 5 subfamily T member 18

Synonyms

MOR179-5, K17, GA_x6K02T2Q125-48299679-48298702, Olfr141

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.053) question?

Stock #

IGL01608

Quality Score

Status

Chromosome

Chromosomal Location

86636365-86637341 bp(-) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

A to C at 86636769 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Stop codon at position 191 (Y191*)

Ref Sequence

ENSEMBL: ENSMUSP00000150485 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000216117]

AlphaFold

no structure available at present

Predicted Effect

probably null
Transcript: ENSMUST00000105212
AA Change: Y191*

SMART Domains

Protein: ENSMUSP00000100847
Gene: ENSMUSG00000078420
AA Change: Y191*

Domain	Start	End	E-Value	Type
Pfam:7tm_4	29	303	3.3e-48	PFAM
Pfam:7tm_1	39	288	2.7e-18	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000216117
AA Change: Y191*

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 60 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca1	A	T	4: 53,038,158 (GRCm39)	L2068Q	probably damaging	Het
Abca12	G	T	1: 71,298,601 (GRCm39)	D2340E	probably damaging	Het
Adcy5	A	G	16: 35,092,535 (GRCm39)	Y632C	probably damaging	Het
Adgrb3	A	G	1: 25,592,855 (GRCm39)	S311P	probably damaging	Het
Adh4	C	T	3: 138,134,788 (GRCm39)		probably benign	Het
Atf2	G	T	2: 73,649,422 (GRCm39)	H396Q	probably damaging	Het
Atp8a1	G	A	5: 67,970,479 (GRCm39)	R74*	probably null	Het
Brpf3	T	C	17: 29,040,491 (GRCm39)	S971P	probably benign	Het
Btn1a1	T	C	13: 23,645,778 (GRCm39)	E197G	probably benign	Het
Ccdc136	C	T	6: 29,406,113 (GRCm39)	A87V	possibly damaging	Het
Celf4	A	G	18: 25,630,560 (GRCm39)	L376P	probably damaging	Het
Chrm3	G	A	13: 9,928,634 (GRCm39)	A134V	possibly damaging	Het
Col19a1	G	A	1: 24,321,626 (GRCm39)	R961C	probably damaging	Het
Cr2	A	G	1: 194,837,528 (GRCm39)	V1190A	possibly damaging	Het
Dop1a	T	A	9: 86,389,614 (GRCm39)	S515T	probably benign	Het
Eprs1	T	A	1: 185,117,311 (GRCm39)		probably benign	Het
Fbn2	G	T	18: 58,186,776 (GRCm39)	Y1708*	probably null	Het
Glt1d1	A	G	5: 127,741,746 (GRCm39)	N148S	possibly damaging	Het
Gm20425	T	A	9: 103,068,293 (GRCm39)	I44F	probably damaging	Het
Gpr22	T	A	12: 31,758,779 (GRCm39)	K411*	probably null	Het
Ipo11	A	G	13: 106,971,002 (GRCm39)		probably benign	Het
Klri1	T	A	6: 129,675,130 (GRCm39)	N210I	possibly damaging	Het
Kmt2c	C	T	5: 25,559,809 (GRCm39)	V950M	probably damaging	Het
Knop1	T	C	7: 118,445,019 (GRCm39)	K315R	probably benign	Het
Krt90	A	G	15: 101,471,064 (GRCm39)	I66T	probably benign	Het
Lrrc32	T	A	7: 98,148,564 (GRCm39)	V448D	probably benign	Het
Met	T	C	6: 17,558,729 (GRCm39)	V1119A	probably damaging	Het
Minar1	T	C	9: 89,478,551 (GRCm39)	T832A	probably benign	Het
Mipep	T	A	14: 61,039,679 (GRCm39)	I236N	possibly damaging	Het
Mrpl45	A	G	11: 97,207,747 (GRCm39)	T81A	probably benign	Het
Mtbp	G	T	15: 55,421,085 (GRCm39)	E24*	probably null	Het
Muc5b	C	T	7: 141,400,174 (GRCm39)	T476I	unknown	Het
Mup6	C	T	4: 60,006,021 (GRCm39)	T163I	probably benign	Het
Myo1g	T	A	11: 6,466,780 (GRCm39)	I278F	possibly damaging	Het
Myo9a	A	T	9: 59,778,119 (GRCm39)	K1292*	probably null	Het
Nbeal1	T	A	1: 60,281,694 (GRCm39)		probably benign	Het
Nck1	C	A	9: 100,379,440 (GRCm39)	R270S	probably benign	Het
Neb	T	C	2: 52,060,548 (GRCm39)	E6035G	probably damaging	Het
Nlrp4f	A	C	13: 65,343,357 (GRCm39)	L96*	probably null	Het
Or11g1	A	T	14: 50,651,910 (GRCm39)	H303L	probably benign	Het
Or4a77	A	T	2: 89,486,835 (GRCm39)		probably benign	Het
Or51l14	A	T	7: 103,101,011 (GRCm39)	I156F	probably benign	Het
Padi2	A	G	4: 140,659,541 (GRCm39)	E282G	probably damaging	Het
Pcdhb4	A	G	18: 37,441,803 (GRCm39)	D371G	probably damaging	Het
Pcdhb8	A	G	18: 37,489,978 (GRCm39)	D552G	probably damaging	Het
Peli3	A	G	19: 4,982,855 (GRCm39)	I270T	probably damaging	Het
Phf20	A	G	2: 156,118,516 (GRCm39)	M407V	probably benign	Het
Ppm1h	C	T	10: 122,777,185 (GRCm39)	R103*	probably null	Het
Rangap1	C	T	15: 81,593,705 (GRCm39)	V457M	probably benign	Het
Scube2	A	G	7: 109,442,461 (GRCm39)	V257A	probably benign	Het
Shc1	C	A	3: 89,332,156 (GRCm39)	Q204K	probably damaging	Het
Slc6a4	T	A	11: 76,917,961 (GRCm39)	Y568N	probably damaging	Het
Srgap3	A	G	6: 112,923,439 (GRCm39)	F7L	probably benign	Het
St6galnac4	T	A	2: 32,484,098 (GRCm39)	C99S	probably damaging	Het
Strc	T	C	2: 121,206,075 (GRCm39)	D779G	probably benign	Het
Supt6	A	T	11: 78,116,309 (GRCm39)	Y685N	probably damaging	Het
Traf3ip3	T	C	1: 192,869,418 (GRCm39)	T256A	probably benign	Het
Vmn1r74	A	T	7: 11,581,560 (GRCm39)	I287F	probably damaging	Het
Zmym2	C	A	14: 57,185,472 (GRCm39)	Q1035K	possibly damaging	Het
Zswim3	G	A	2: 164,663,440 (GRCm39)	R640H	probably damaging	Het

Other mutations in Or5t18

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R0400:Or5t18	UTSW	2	86,636,995 (GRCm39)	missense	probably damaging	1.00
R0609:Or5t18	UTSW	2	86,637,205 (GRCm39)	missense	probably damaging	0.98
R1650:Or5t18	UTSW	2	86,637,091 (GRCm39)	missense	possibly damaging	0.62
R1918:Or5t18	UTSW	2	86,637,171 (GRCm39)	missense	probably damaging	1.00
R3975:Or5t18	UTSW	2	86,636,804 (GRCm39)	missense	possibly damaging	0.95
R4567:Or5t18	UTSW	2	86,637,146 (GRCm39)	missense	probably damaging	0.99
R6090:Or5t18	UTSW	2	86,636,701 (GRCm39)	missense	possibly damaging	0.85
R7286:Or5t18	UTSW	2	86,636,967 (GRCm39)	missense	possibly damaging	0.62
R7910:Or5t18	UTSW	2	86,637,191 (GRCm39)	missense	probably benign	0.00
R8048:Or5t18	UTSW	2	86,636,515 (GRCm39)	missense	probably damaging	0.99
R8193:Or5t18	UTSW	2	86,637,209 (GRCm39)	missense	noncoding transcript
R8799:Or5t18	UTSW	2	86,636,575 (GRCm39)	missense	probably damaging	0.98
R8973:Or5t18	UTSW	2	86,637,200 (GRCm39)	missense	probably benign
R9398:Or5t18	UTSW	2	86,637,160 (GRCm39)	missense	possibly damaging	0.54
R9444:Or5t18	UTSW	2	86,636,486 (GRCm39)	missense

Posted On

2013-12-09