Incidental Mutation 'IGL01609:Dync1i2'
ID 91923
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Dync1i2
Ensembl Gene ENSMUSG00000027012
Gene Name dynein cytoplasmic 1 intermediate chain 2
Synonyms 3110079H08Rik, Dncic2
Accession Numbers
Essential gene? Probably essential (E-score: 0.967) question?
Stock # IGL01609
Quality Score
Status
Chromosome 2
Chromosomal Location 71042050-71093647 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) T to A at 71077352 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000107772 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000081710] [ENSMUST00000100028] [ENSMUST00000112136] [ENSMUST00000112138] [ENSMUST00000112139] [ENSMUST00000112140] [ENSMUST00000112144] [ENSMUST00000112142]
AlphaFold O88487
Predicted Effect probably benign
Transcript: ENSMUST00000081710
SMART Domains Protein: ENSMUSP00000080410
Gene: ENSMUSG00000027012

DomainStartEndE-ValueType
coiled coil region 1 67 N/A INTRINSIC
low complexity region 73 91 N/A INTRINSIC
Pfam:Dynein_IC2 106 138 1.1e-20 PFAM
low complexity region 155 169 N/A INTRINSIC
Blast:WD40 243 291 3e-26 BLAST
WD40 296 335 5.55e-1 SMART
WD40 342 385 7.16e-1 SMART
WD40 439 484 7.39e-3 SMART
WD40 487 527 7.28e-2 SMART
WD40 532 572 8.91e-1 SMART
low complexity region 593 607 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000100028
SMART Domains Protein: ENSMUSP00000097605
Gene: ENSMUSG00000027012

DomainStartEndE-ValueType
coiled coil region 1 67 N/A INTRINSIC
low complexity region 73 91 N/A INTRINSIC
Pfam:Dynein_IC2 126 158 2.8e-21 PFAM
low complexity region 175 189 N/A INTRINSIC
Blast:WD40 263 311 4e-26 BLAST
WD40 316 355 5.55e-1 SMART
WD40 362 405 7.16e-1 SMART
WD40 459 504 7.39e-3 SMART
WD40 507 547 7.28e-2 SMART
WD40 552 592 8.91e-1 SMART
low complexity region 613 627 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000112136
SMART Domains Protein: ENSMUSP00000107764
Gene: ENSMUSG00000027012

DomainStartEndE-ValueType
coiled coil region 1 67 N/A INTRINSIC
low complexity region 83 97 N/A INTRINSIC
Pfam:Dynein_IC2 132 164 2.6e-21 PFAM
low complexity region 181 195 N/A INTRINSIC
Blast:WD40 269 317 5e-26 BLAST
WD40 322 361 5.55e-1 SMART
WD40 368 411 7.16e-1 SMART
WD40 465 510 7.39e-3 SMART
WD40 513 553 7.28e-2 SMART
WD40 558 598 8.91e-1 SMART
low complexity region 618 632 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000112138
SMART Domains Protein: ENSMUSP00000107766
Gene: ENSMUSG00000027012

DomainStartEndE-ValueType
coiled coil region 1 67 N/A INTRINSIC
low complexity region 73 91 N/A INTRINSIC
Pfam:Dynein_IC2 106 138 1.1e-20 PFAM
low complexity region 155 169 N/A INTRINSIC
Blast:WD40 243 291 3e-26 BLAST
WD40 296 335 5.55e-1 SMART
WD40 342 385 7.16e-1 SMART
WD40 439 484 7.39e-3 SMART
WD40 487 527 7.28e-2 SMART
WD40 532 572 8.91e-1 SMART
low complexity region 593 607 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000112139
SMART Domains Protein: ENSMUSP00000107767
Gene: ENSMUSG00000027012

DomainStartEndE-ValueType
coiled coil region 1 67 N/A INTRINSIC
low complexity region 73 91 N/A INTRINSIC
Pfam:Dynein_IC2 106 138 4.5e-21 PFAM
low complexity region 155 169 N/A INTRINSIC
Blast:WD40 243 291 3e-26 BLAST
WD40 296 335 5.55e-1 SMART
WD40 342 385 7.16e-1 SMART
WD40 439 484 7.39e-3 SMART
WD40 487 527 7.28e-2 SMART
WD40 532 572 8.91e-1 SMART
low complexity region 592 606 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000112140
SMART Domains Protein: ENSMUSP00000107768
Gene: ENSMUSG00000027012

DomainStartEndE-ValueType
coiled coil region 1 67 N/A INTRINSIC
low complexity region 83 97 N/A INTRINSIC
Pfam:Dynein_IC2 132 164 2.6e-21 PFAM
low complexity region 181 195 N/A INTRINSIC
Blast:WD40 269 317 4e-26 BLAST
WD40 322 361 5.55e-1 SMART
WD40 368 411 7.16e-1 SMART
WD40 465 510 7.39e-3 SMART
WD40 513 553 7.28e-2 SMART
WD40 558 598 8.91e-1 SMART
low complexity region 619 633 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000112144
SMART Domains Protein: ENSMUSP00000107772
Gene: ENSMUSG00000027012

DomainStartEndE-ValueType
coiled coil region 1 67 N/A INTRINSIC
low complexity region 83 97 N/A INTRINSIC
Pfam:Dynein_IC2 133 163 6.5e-19 PFAM
low complexity region 181 195 N/A INTRINSIC
Blast:WD40 269 317 4e-26 BLAST
WD40 322 361 5.55e-1 SMART
WD40 368 411 7.16e-1 SMART
WD40 465 510 7.39e-3 SMART
WD40 513 553 7.28e-2 SMART
WD40 558 598 8.91e-1 SMART
low complexity region 619 633 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000112142
SMART Domains Protein: ENSMUSP00000107770
Gene: ENSMUSG00000027012

DomainStartEndE-ValueType
coiled coil region 1 67 N/A INTRINSIC
low complexity region 73 91 N/A INTRINSIC
Pfam:Dynein_IC2 126 158 2.8e-21 PFAM
low complexity region 175 189 N/A INTRINSIC
Blast:WD40 263 311 4e-26 BLAST
WD40 316 355 5.55e-1 SMART
WD40 362 405 7.16e-1 SMART
WD40 459 504 7.39e-3 SMART
WD40 507 547 7.28e-2 SMART
WD40 552 592 8.91e-1 SMART
low complexity region 613 627 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137683
Predicted Effect noncoding transcript
Transcript: ENSMUST00000141619
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for an ENU-induced allele exhibit a trend towards slight locomotor deficit. [provided by MGI curators]
Allele List at MGI

All alleles(50) : Targeted, other(2) Gene trapped(48)

Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ablim3 A G 18: 61,955,092 (GRCm39) V299A probably benign Het
Actr5 T C 2: 158,478,722 (GRCm39) probably null Het
Arhgap18 A G 10: 26,756,744 (GRCm39) D448G possibly damaging Het
Bcl9 T C 3: 97,116,291 (GRCm39) E801G probably benign Het
Bin1 A G 18: 32,552,978 (GRCm39) N232S probably damaging Het
Brf1 A C 12: 112,927,211 (GRCm39) Y459D probably damaging Het
Clca4a T A 3: 144,659,541 (GRCm39) I772F probably damaging Het
Cyp2a4 G A 7: 26,008,088 (GRCm39) probably null Het
Frem3 T A 8: 81,339,333 (GRCm39) M542K probably benign Het
Gpbp1 T C 13: 111,575,736 (GRCm39) T256A possibly damaging Het
Ighm T C 12: 113,384,854 (GRCm39) probably benign Het
Igkv3-12 A G 6: 70,495,232 (GRCm39) probably benign Het
Kdm4d A G 9: 14,375,714 (GRCm39) V48A probably damaging Het
Lama2 T C 10: 27,220,417 (GRCm39) S483G probably benign Het
Lbp A C 2: 158,170,332 (GRCm39) Q464P probably damaging Het
Lipo4 T C 19: 33,476,654 (GRCm39) T365A probably benign Het
Mark3 T C 12: 111,593,956 (GRCm39) F274S probably damaging Het
Mcm3 A T 1: 20,884,904 (GRCm39) probably benign Het
Mrpl9 T A 3: 94,352,001 (GRCm39) F137I probably damaging Het
Msh4 G T 3: 153,603,034 (GRCm39) A93E probably damaging Het
Mthfd1l T A 10: 3,968,567 (GRCm39) D407E probably benign Het
Or10j7 G A 1: 173,011,843 (GRCm39) H53Y probably benign Het
Or12d12 C T 17: 37,610,629 (GRCm39) R228H probably benign Het
Or1i2 A C 10: 78,447,960 (GRCm39) S172A probably benign Het
Pcsk2 G T 2: 143,643,078 (GRCm39) V452L possibly damaging Het
Pcsk6 G A 7: 65,685,021 (GRCm39) probably null Het
Pmfbp1 A G 8: 110,254,348 (GRCm39) E461G probably benign Het
Pole2 A G 12: 69,254,631 (GRCm39) probably null Het
Postn T C 3: 54,276,649 (GRCm39) M176T probably damaging Het
Prss12 T A 3: 123,276,483 (GRCm39) C371S probably damaging Het
Rnf11 T A 4: 109,314,173 (GRCm39) Q72L possibly damaging Het
Rrad A G 8: 105,356,456 (GRCm39) probably null Het
Slitrk3 T A 3: 72,957,570 (GRCm39) I401F probably damaging Het
Themis A G 10: 28,544,749 (GRCm39) probably benign Het
Tmem45a A G 16: 56,631,928 (GRCm39) I230T probably benign Het
Tnni1 C A 1: 135,733,234 (GRCm39) probably null Het
Trpa1 A T 1: 14,982,607 (GRCm39) I83N probably damaging Het
Uggt1 T C 1: 36,221,555 (GRCm39) Y54C probably damaging Het
Umodl1 C T 17: 31,217,800 (GRCm39) T1202I possibly damaging Het
Unc93a2 A G 17: 7,637,138 (GRCm39) V130A probably damaging Het
Usp37 G A 1: 74,514,199 (GRCm39) A324V probably benign Het
Zfp808 T A 13: 62,321,023 (GRCm39) C751S probably damaging Het
Other mutations in Dync1i2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00789:Dync1i2 APN 2 71,078,299 (GRCm39) splice site probably benign
IGL02479:Dync1i2 APN 2 71,066,323 (GRCm39) missense probably damaging 1.00
IGL02545:Dync1i2 APN 2 71,093,095 (GRCm39) missense possibly damaging 0.95
3-1:Dync1i2 UTSW 2 71,078,172 (GRCm39) missense probably damaging 1.00
R0015:Dync1i2 UTSW 2 71,044,828 (GRCm39) missense probably damaging 1.00
R0015:Dync1i2 UTSW 2 71,044,828 (GRCm39) missense probably damaging 1.00
R0437:Dync1i2 UTSW 2 71,058,169 (GRCm39) critical splice acceptor site probably null
R0555:Dync1i2 UTSW 2 71,044,862 (GRCm39) frame shift probably null
R0835:Dync1i2 UTSW 2 71,081,316 (GRCm39) missense probably damaging 1.00
R1146:Dync1i2 UTSW 2 71,058,164 (GRCm39) splice site probably benign
R1452:Dync1i2 UTSW 2 71,080,207 (GRCm39) splice site probably benign
R1662:Dync1i2 UTSW 2 71,081,323 (GRCm39) missense possibly damaging 0.87
R1765:Dync1i2 UTSW 2 71,079,759 (GRCm39) missense probably benign
R2059:Dync1i2 UTSW 2 71,080,197 (GRCm39) critical splice donor site probably null
R2145:Dync1i2 UTSW 2 71,044,907 (GRCm39) splice site probably benign
R2233:Dync1i2 UTSW 2 71,079,764 (GRCm39) nonsense probably null
R2234:Dync1i2 UTSW 2 71,079,764 (GRCm39) nonsense probably null
R2235:Dync1i2 UTSW 2 71,079,764 (GRCm39) nonsense probably null
R3151:Dync1i2 UTSW 2 71,064,060 (GRCm39) splice site probably benign
R3916:Dync1i2 UTSW 2 71,079,716 (GRCm39) missense probably damaging 1.00
R4653:Dync1i2 UTSW 2 71,078,199 (GRCm39) missense probably damaging 1.00
R4720:Dync1i2 UTSW 2 71,064,018 (GRCm39) missense probably damaging 1.00
R4920:Dync1i2 UTSW 2 71,077,668 (GRCm39) missense probably damaging 1.00
R5574:Dync1i2 UTSW 2 71,063,994 (GRCm39) missense probably benign 0.15
R5620:Dync1i2 UTSW 2 71,088,483 (GRCm39) missense probably benign 0.00
R5677:Dync1i2 UTSW 2 71,058,967 (GRCm39) missense probably benign 0.00
R5711:Dync1i2 UTSW 2 71,081,326 (GRCm39) missense probably benign 0.31
R6730:Dync1i2 UTSW 2 71,077,484 (GRCm39) missense probably benign 0.18
R6911:Dync1i2 UTSW 2 71,077,446 (GRCm39) missense probably benign
R7140:Dync1i2 UTSW 2 71,078,283 (GRCm39) missense probably benign 0.03
R7257:Dync1i2 UTSW 2 71,079,700 (GRCm39) missense possibly damaging 0.92
R7460:Dync1i2 UTSW 2 71,081,230 (GRCm39) missense probably damaging 0.97
R7808:Dync1i2 UTSW 2 71,081,178 (GRCm39) splice site probably null
R8187:Dync1i2 UTSW 2 71,044,865 (GRCm39) missense probably benign 0.13
R9340:Dync1i2 UTSW 2 71,093,019 (GRCm39) missense probably damaging 0.99
Z1176:Dync1i2 UTSW 2 71,078,228 (GRCm39) missense probably benign 0.06
Posted On 2013-12-09