Incidental Mutation 'IGL00090:Fam91a1'
ID 921
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Fam91a1
Ensembl Gene ENSMUSG00000037119
Gene Name family with sequence similarity 91, member A1
Synonyms D15Ertd621e
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL00090
Quality Score
Status
Chromosome 15
Chromosomal Location 58287317-58329589 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 58302584 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Leucine at position 308 (H308L)
Ref Sequence ENSEMBL: ENSMUSP00000036524 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000037270]
AlphaFold Q3UVG3
Predicted Effect probably damaging
Transcript: ENSMUST00000037270
AA Change: H308L

PolyPhen 2 Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000036524
Gene: ENSMUSG00000037119
AA Change: H308L

DomainStartEndE-ValueType
Pfam:FAM91_N 8 312 2.8e-149 PFAM
Pfam:FAM91_C 374 821 3.8e-182 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000227770
Predicted Effect noncoding transcript
Transcript: ENSMUST00000227796
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a transgenic gene disruption exhibit male infertility. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb5 T C 12: 118,854,345 (GRCm39) T857A probably benign Het
Abcc9 A T 6: 142,578,916 (GRCm39) probably benign Het
Adam11 A G 11: 102,667,657 (GRCm39) T709A probably benign Het
Adgre1 A G 17: 57,757,055 (GRCm39) I771V probably benign Het
Adgrv1 T G 13: 81,553,527 (GRCm39) probably null Het
Adgrv1 C T 13: 81,726,220 (GRCm39) D602N probably damaging Het
Adra1d G T 2: 131,403,597 (GRCm39) D164E possibly damaging Het
Ago3 A G 4: 126,265,334 (GRCm39) L319P probably damaging Het
Aim2 A G 1: 173,283,031 (GRCm39) S38G probably benign Het
Apoh A G 11: 108,286,660 (GRCm39) D28G probably benign Het
Atm C T 9: 53,435,743 (GRCm39) R189K probably damaging Het
Bbs1 T C 19: 4,943,038 (GRCm39) T451A probably benign Het
BC034090 T C 1: 155,101,193 (GRCm39) D719G possibly damaging Het
Bcr T C 10: 74,992,903 (GRCm39) probably benign Het
Bmp2 A T 2: 133,402,947 (GRCm39) Q166L probably benign Het
Bms1 A T 6: 118,381,544 (GRCm39) S665T probably benign Het
Ccser1 A T 6: 62,357,126 (GRCm39) T855S possibly damaging Het
Cfap36 C T 11: 29,172,875 (GRCm39) V217M probably benign Het
Clca3b T C 3: 144,542,393 (GRCm39) N470D probably damaging Het
Cort A G 4: 149,209,752 (GRCm39) F100S probably damaging Het
Cyp4f14 G T 17: 33,133,540 (GRCm39) D105E probably benign Het
Dnah1 A G 14: 31,009,830 (GRCm39) S1913P probably benign Het
Fbn1 A C 2: 125,166,867 (GRCm39) I2016M probably damaging Het
Fibcd1 T A 2: 31,723,886 (GRCm39) Q251L possibly damaging Het
Flg2 T A 3: 93,109,416 (GRCm39) Y481* probably null Het
Ly9 A T 1: 171,421,019 (GRCm39) I624N probably damaging Het
Mapt C T 11: 104,213,311 (GRCm39) S301L probably damaging Het
Meiob G A 17: 25,042,603 (GRCm39) V144I probably benign Het
Muc4 G A 16: 32,754,086 (GRCm38) G1321R probably benign Het
Myo5a T A 9: 75,068,779 (GRCm39) C660* probably null Het
Necab3 G T 2: 154,389,488 (GRCm39) probably benign Het
Nr2c2ap A G 8: 70,585,279 (GRCm39) Y93C probably damaging Het
Nxpe5 A G 5: 138,247,096 (GRCm39) D356G probably benign Het
Or10ak9 T A 4: 118,726,484 (GRCm39) Y168N probably damaging Het
Or2w25 A T 11: 59,504,147 (GRCm39) Y119F possibly damaging Het
Plce1 A G 19: 38,734,232 (GRCm39) Q1544R probably damaging Het
Plppr4 T A 3: 117,115,869 (GRCm39) T605S probably benign Het
Poglut1 C A 16: 38,363,278 (GRCm39) W167L possibly damaging Het
Pou2f1 G T 1: 165,729,867 (GRCm39) R162S probably damaging Het
Ptprf A G 4: 118,080,417 (GRCm39) probably benign Het
Reln C A 5: 22,244,563 (GRCm39) G805V possibly damaging Het
Rexo2 A G 9: 48,385,747 (GRCm39) S126P probably damaging Het
Robo4 A G 9: 37,322,400 (GRCm39) S844G probably damaging Het
Scn7a A G 2: 66,513,671 (GRCm39) probably benign Het
Sdc1 A G 12: 8,840,459 (GRCm39) T75A possibly damaging Het
Slc38a4 C T 15: 96,917,690 (GRCm39) E12K probably benign Het
Spata31h1 T G 10: 82,119,586 (GRCm39) M4475L probably benign Het
Tbck T C 3: 132,448,854 (GRCm39) probably null Het
Tex2 A T 11: 106,459,361 (GRCm39) V23E probably damaging Het
Zfp770 A G 2: 114,026,413 (GRCm39) V552A probably benign Het
Zfyve26 T C 12: 79,296,234 (GRCm39) probably benign Het
Other mutations in Fam91a1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00590:Fam91a1 APN 15 58,287,565 (GRCm39) missense possibly damaging 0.66
IGL01301:Fam91a1 APN 15 58,314,720 (GRCm39) missense probably damaging 0.99
IGL01372:Fam91a1 APN 15 58,301,911 (GRCm39) missense probably damaging 1.00
IGL01979:Fam91a1 APN 15 58,304,433 (GRCm39) missense probably damaging 1.00
IGL02085:Fam91a1 APN 15 58,313,505 (GRCm39) missense possibly damaging 0.95
IGL02553:Fam91a1 APN 15 58,304,831 (GRCm39) critical splice donor site probably null
IGL02605:Fam91a1 APN 15 58,303,045 (GRCm39) splice site probably benign
IGL02882:Fam91a1 APN 15 58,324,910 (GRCm39) splice site probably benign
IGL02894:Fam91a1 APN 15 58,315,080 (GRCm39) missense probably benign 0.09
ANU18:Fam91a1 UTSW 15 58,314,720 (GRCm39) missense probably damaging 0.99
H8562:Fam91a1 UTSW 15 58,298,970 (GRCm39) splice site probably null
R0395:Fam91a1 UTSW 15 58,326,641 (GRCm39) missense probably benign
R1165:Fam91a1 UTSW 15 58,302,518 (GRCm39) missense possibly damaging 0.90
R1699:Fam91a1 UTSW 15 58,304,797 (GRCm39) missense probably benign 0.04
R1749:Fam91a1 UTSW 15 58,298,443 (GRCm39) missense probably benign 0.02
R1997:Fam91a1 UTSW 15 58,296,044 (GRCm39) critical splice acceptor site probably null
R2042:Fam91a1 UTSW 15 58,298,443 (GRCm39) missense probably benign 0.02
R2188:Fam91a1 UTSW 15 58,302,512 (GRCm39) missense probably damaging 0.98
R2518:Fam91a1 UTSW 15 58,322,449 (GRCm39) missense possibly damaging 0.92
R3124:Fam91a1 UTSW 15 58,293,738 (GRCm39) missense probably benign 0.34
R3916:Fam91a1 UTSW 15 58,302,583 (GRCm39) missense probably damaging 1.00
R4810:Fam91a1 UTSW 15 58,306,589 (GRCm39) missense probably damaging 1.00
R4959:Fam91a1 UTSW 15 58,303,059 (GRCm39) missense probably benign 0.16
R4973:Fam91a1 UTSW 15 58,303,059 (GRCm39) missense probably benign 0.16
R5288:Fam91a1 UTSW 15 58,320,243 (GRCm39) missense probably benign
R5385:Fam91a1 UTSW 15 58,320,243 (GRCm39) missense probably benign
R5386:Fam91a1 UTSW 15 58,320,243 (GRCm39) missense probably benign
R5941:Fam91a1 UTSW 15 58,303,166 (GRCm39) missense probably benign 0.01
R6415:Fam91a1 UTSW 15 58,314,766 (GRCm39) missense probably damaging 1.00
R6869:Fam91a1 UTSW 15 58,303,117 (GRCm39) missense probably benign 0.00
R7175:Fam91a1 UTSW 15 58,302,527 (GRCm39) missense probably benign 0.06
R7872:Fam91a1 UTSW 15 58,320,209 (GRCm39) missense probably benign 0.01
X0024:Fam91a1 UTSW 15 58,302,038 (GRCm39) missense probably damaging 0.98
Z1177:Fam91a1 UTSW 15 58,304,397 (GRCm39) missense possibly damaging 0.68
Posted On 2011-07-12